IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells

Enhancement of CD154/IL4 proliferation by the T follicular helper (Tfh) cytokine, IL21 and increased numbers of circulating cells resembling Tfh cells in chronic lymphocytic leukaemia

(2013) Matthew J. Ahearne et al.   BRITISH JOURNAL OF HAEMATOLOGY

Differential regulation of B-cell proliferation by IL21 in different subsets of chronic lymphocytic leukemia

(2013) Ghasem Ghalamfarsa et al.   CYTOKINE

T-cell independent, B-cell receptor-mediated induction of telomerase activity differs among IGHV mutation-based subgroups of chronic lymphocytic leukemia patients

(2012) R. N. Damle et al.   BLOOD

Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling

(2012) Marcus Dühren-von Minden et al.   NATURE

A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease

(2011) D. Bagnara et al.   BLOOD

Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

(2011) Steven M. Kerfoot et al.   IMMUNITY

Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help

(2011) Magdalena Hagn et al.   IMMUNOLOGY AND CELL BIOLOGY

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(2011) Iris Gehrke et al.   MOLECULAR MEDICINE

The lymph node microenvironment promotes B-cell receptor signaling, NF- B activation, and tumor proliferation in chronic lymphocytic leukemia

(2010) Y. Herishanu et al.   BLOOD

Circulating Ki-67 index in plasma as a biomarker and prognostic indicator in chronic lymphocytic leukemia

(2010) Jean-Marie Bruey et al.   LEUKEMIA RESEARCH

Dichotomy in NF-κB signaling and chemoresistance in immunoglobulin variable heavy-chain-mutated versus unmutated CLL cells upon CD40/TLR9 triggering

(2010) J M Tromp et al.   ONCOGENE

The lymphatic tissue microenvironments in chronic lymphocytic leukemia: in vitro models and the significance of CD40-CD154 interactions

(2009) J. A. Burger et al.   BLOOD

Human B Cells Secrete Granzyme B When Recognizing Viral Antigens in the Context of the Acute Phase Cytokine IL-21

(2009) M. Hagn et al.   JOURNAL OF IMMUNOLOGY

IL-21: An Executor of B Cell Fate

(2009) D. Konforte et al.   JOURNAL OF IMMUNOLOGY

Different proliferative and survival capacity of CLL-cells in a newly established in vitro model for pseudofollicles

(2009) M Plander et al.   LEUKEMIA

c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches

(2008) D. Y. H. Hallaert et al.   BLOOD

IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro

(2008) A. Gowda et al.   BLOOD

The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways

(2007) D. de Totero et al.   BLOOD