Correcting Calcium Dysregulation in Chronic Heart Failure Using SERCA2a Gene Therapy

Therapeutic Benefit and Gene Network Regulation by Combined Gene Transfer of Apelin, FGF2, and SERCA2a into Ischemic Heart

(2018) Edith Renaud-Gabardos et al.   MOLECULAR THERAPY

Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice

(2018) Mari Merentie et al.   PLoS One

Effect of intracoronary administration of AAV1/SERCA2a on ventricular remodelling in patients with advanced systolic heart failure: results from the AGENT-HF randomized phase 2 trial

(2017) Jean-Sébastien Hulot et al.   EUROPEAN JOURNAL OF HEART FAILURE

Prevention of Atrial Fibrillation by Using Sarcoplasmic Reticulum Calcium ATPase Pump Overexpression in a Rabbit Model of Rapid Atrial Pacing

(2017) Hong li Wang et al.   MEDICAL SCIENCE MONITOR

Gene therapy for the treatment of heart failure: promise postponed

(2016) Jean-Sebastien Hulot et al.   EUROPEAN HEART JOURNAL

Risk factors for heart failure are associated with alterations of the LV end-diastolic pressure–volume relationship in non-heart failure individuals: data from a large-scale, population-based cohort

(2016) Michael Schwarzl et al.   EUROPEAN HEART JOURNAL

Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release

(2016) Julia O. Reynolds et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial

(2016) Barry Greenberg et al.   LANCET

Gene therapy for cardiovascular disease: advances in vector development, targeting, and delivery for clinical translation

(2015) Melvin Y. Rincon et al.   CARDIOVASCULAR RESEARCH

Efficacy and safety of myocardial gene transfer of adenovirus, adeno-associated virus and lentivirus vectors in the mouse heart

(2015) M Merentie et al.   GENE THERAPY

Prevalence of AAV1 neutralizing antibodies and consequences for a clinical trial of gene transfer for advanced heart failure

(2015) B Greenberg et al.   GENE THERAPY

Effect of SERCA2a overexpression in the pericardium mediated by the AAV1 gene transfer on rapid atrial pacing in rabbits

(2015) B.N. Kuken et al.   GENETICS AND MOLECULAR RESEARCH

Gene Therapy for Heart Failure: Back to the Bench

(2015) Seppo Ylä-Herttuala   MOLECULAR THERAPY

Atrial SERCA2a Overexpression Has No Affect on Cardiac Alternans but Promotes Arrhythmogenic SR Ca2+ Triggers

(2015) Michelle M. J. Nassal et al.   PLoS One

Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases

(2014) David L. Beavers et al.   CARDIOVASCULAR RESEARCH

Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte Transverse-Tubule Remodeling and Ca 2+ Handling Dysfunction in Heart Failure

(2014) Caimei Zhang et al.   CIRCULATION

Safety and efficacy of high-dose adeno-associated virus 9 encoding sarcoplasmic reticulum Ca2+ adenosine triphosphatase delivered by molecular cardiac surgery with recirculating delivery in ovine ischemic cardiomyopathy

(2014) Michael G. Katz et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress

(2014) A. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design of a Phase 2b Trial of Intracoronary Administration of AAV1/SERCA2a in Patients With Advanced Heart Failure

(2014) Barry Greenberg et al.   JACC-Heart Failure

Oxidative stress in cardiomyocytes contributes to decreased SERCA2a activity in rats with metabolic syndrome

(2013) Jaime Balderas-Villalobos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition

(2013) Mara Ferrandi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Long-Term Effects of AAV1/SERCA2a Gene Transfer in Patients With Severe Heart Failure

(2013) Krisztina Zsebo et al.   CIRCULATION RESEARCH

Forecasting the Impact of Heart Failure in the United States

(2013) Paul A. Heidenreich et al.   Circulation-Heart Failure

Benefit of SERCA2a Gene Transfer to Vascular Endothelial and Smooth Muscle Cells: A New Aspect in Therapy of Cardiovascular Diseases

(2013) Larissa Lipskaia et al.   Current Vascular Pharmacology

Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys

(2013) F. Mingozzi et al.   Science Translational Medicine

SUMO-1 Gene Transfer Improves Cardiac Function in a Large-Animal Model of Heart Failure

(2013) L. Tilemann et al.   Science Translational Medicine

Targeted Sarcoplasmic Reticulum Ca 2+ ATPase 2a Gene Delivery to Restore Electrical Stability in the Failing Heart

(2012) Michael J. Cutler et al.   CIRCULATION

SERCA2a gene transfer prevents intimal proliferation in an organ culture of human internal mammary artery

(2012) L Lipskaia et al.   GENE THERAPY

Clinical Trials Update AHA Congress 2010

(2011) John D. Horowitz et al.   CARDIOVASCULAR DRUGS AND THERAPY

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID)

(2011) Mariell Jessup et al.   CIRCULATION

SERCA2a Gene Transfer Decreases Sarcoplasmic Reticulum Calcium Leak and Reduces Ventricular Arrhythmias in a Model of Chronic Heart Failure

(2011) Alexander R. Lyon et al.   Circulation-Arrhythmia and Electrophysiology

SERCA2a gene transfer improves electrocardiographic performance in aged mdx mice

(2011) Jin-Hong Shin et al.   Journal of Translational Medicine

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(2011) Wei Xin et al.   MOLECULAR MEDICINE

SUMO1-dependent modulation of SERCA2a in heart failure

(2011) Changwon Kho et al.   NATURE

Cardiac AAV9-S100A1 Gene Therapy Rescues Post-Ischemic Heart Failure in a Preclinical Large Animal Model

(2011) S. T. Pleger et al.   Science Translational Medicine

Comparative Cardiac Gene Delivery of Adeno-Associated Virus Serotypes 1-9 reveals that AAV6 Mediates the Most Efficient Transduction in Mouse Heart

(2010) Carmela Zincarelli et al.   CTS-Clinical and Translational Science

SERCA2a Gene Transfer Enhances eNOS Expression and Activity in Endothelial Cells

(2010) Lahouaria Hadri et al.   MOLECULAR THERAPY

Development of Viral Vectors for Use in Cardiovascular Gene Therapy

(2010) Paul Williams et al.   Viruses-Basel

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID Trial), a First-in-Human Phase 1/2 Clinical Trial

(2009) Brian E. Jaski et al.   JOURNAL OF CARDIAC FAILURE

Design of a Phase 1/2 Trial of Intracoronary Administration of AAV1/SERCA2a in Patients With Heart Failure

(2008) Roger J. Hajjar et al.   JOURNAL OF CARDIAC FAILURE

Reversal of Cardiac Dysfunction After Long-Term Expression of SERCA2a by Gene Transfer in a Pre-Clinical Model of Heart Failure

(2008) Yoshiaki Kawase et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Lentiviral Vector–mediated SERCA2 Gene Transfer Protects Against Heart Failure and Left Ventricular Remodeling After Myocardial Infarction in Rats

(2008) Kazuo Niwano et al.   MOLECULAR THERAPY