Mice lacking DKK1 in T cells exhibit high bone mass and are protected from estrogen-deficiency-induced bone loss

Osteogenic Dkk1 Mediates Glucocorticoid-Induced but Not Arthritis-Induced Bone Loss

(2019) Juliane Colditz et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Postnatal Skeletal Deletion of Dickkopf-1 Increases Bone Formation and Bone Volume in Male and Female Mice, Despite Increased Sclerostin Expression

(2018) Juliane Colditz et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Membrane-bound Dickkopf-1 in Foxp3+ regulatory T cells suppresses T-cell-mediated autoimmune colitis

(2017) Wook-Jin Chae et al.   IMMUNOLOGY

Proinflammatory T cells and IL-17 stimulate osteoblast differentiation

(2016) Michiel Croes et al.   BONE

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation

(2016) Wook-Jin Chae et al.   IMMUNITY

RANKL (Receptor Activator of NFκB Ligand) Produced by Osteocytes Is Required for the Increase in B Cells and Bone Loss Caused by Estrogen Deficiency in Mice

(2016) Yuko Fujiwara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CKAP4 is a Dickkopf1 receptor and is involved in tumor progression

(2016) Hirokazu Kimura et al.   JOURNAL OF CLINICAL INVESTIGATION

Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer

(2016) Lucia D’Amico et al.   JOURNAL OF EXPERIMENTAL MEDICINE

lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets

(2016) Berit Carow et al.   JOURNAL OF IMMUNOLOGY

Beyond canonical: The Wnt and β-catenin story

(2016) Randall T. Moon et al.   Science Signaling

Effects of Bu-Shen-Ning-Xin Decoction on immune cells of the spleen and bone marrow in ovariectomized mice

(2016) Xuemin Qiu et al.   BioScience Trends

DHEA prevents bone loss by suppressing the expansion of CD4+ T cells and TNFa production in the OVX-mouse model for postmenopausal osteoporosis

(2016) Na Zhang et al.   BioScience Trends

Beyond canonical: The Wnt and β-catenin story

(2016) Randall T. Moon et al.   Science Signaling

Postmenopausal osteoporosis

(2016) Richard Eastell et al.   Nature Reviews Disease Primers

Bone Loss in Surgically Ovariectomized Premenopausal Women Is Associated With T Lymphocyte Activation and Thymic Hypertrophy

(2016) Saira Adeel et al.   JOURNAL OF INVESTIGATIVE MEDICINE

IL-18BP is decreased in osteoporotic women: Prevents Inflammasome mediated IL-18 activation and reduces Th17 differentiation

(2016) Mohd Nizam Mansoori et al.   Scientific Reports

Platelet-derived Wnt antagonist Dickkopf-1 is implicated in ICAM-1/VCAM-1-mediated neutrophilic acute lung inflammation

(2015) Y. Guo et al.   BLOOD

Association of serum Dkk-1 levels with β-catenin in patients with postmenopausal osteoporosis

(2015) Jun Tian et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Osteoimmunology and Its Implications for Transplantation

(2013) R. Pacifici   AMERICAN JOURNAL OF TRANSPLANTATION

In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma

(2013) Samantha Pozzi et al.   BONE

Effects of the Selective Glucocorticoid Receptor Modulator Compound A on Bone Metabolism and Inflammation in Male Mice With Collagen-Induced Arthritis

(2013) Martina Rauner et al.   ENDOCRINOLOGY

Canonical Wnt Signaling Negatively Modulates Regulatory T Cell Function

(2013) Jorg van Loosdregt et al.   IMMUNITY

Osteoporosis in the European Union: medical management, epidemiology and economic burden

(2013) E. Hernlund et al.   Archives of Osteoporosis

Receptor Activator of Nuclear Factor κB Ligand (RANKL) Protein Expression by B Lymphocytes Contributes to Ovariectomy-induced Bone Loss

(2012) Melda Onal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of T cells in ovariectomy induced bone loss-revisited

(2012) Roberto Pacifici   JOURNAL OF BONE AND MINERAL RESEARCH

Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH

(2012) B. Bedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling

(2011) Ilkka Pietilä et al.   DEVELOPMENTAL BIOLOGY

Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury

(2011) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoprotegerin, RANKL and bone turnover in postmenopausal osteoporosis

(2011) S. Jabbar et al.   JOURNAL OF CLINICAL PATHOLOGY

A Rate-Limiting Role for Dickkopf-1 in Bone Formation and the Remediation of Bone Loss in Mouse and Primate Models of Postmenopausal Osteoporosis by an Experimental Therapeutic Antibody

(2011) H. Glantschnig et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Osteoporosis: now and the future

(2011) Tilman D Rachner et al.   LANCET

Daidzein Prevents the Increase in CD4+CD28null T Cells and B Lymphopoesis in Ovariectomized Mice: A Key Mechanism for Anti-Osteoclastogenic Effect

(2011) Abdul Malik Tyagi et al.   PLoS One

Cross talk between the bone and immune systems: osteoclasts function as antigen-presenting cells and activate CD4+ and CD8+ T cells

(2010) H. Li et al.   BLOOD

Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligand

(2010) J.-Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Lymphocytes Amplify the Anabolic Activity of Parathyroid Hormone through Wnt10b Signaling

(2009) Masakazu Terauchi et al.   Cell Metabolism

Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: A key mechanism in osteoporosis

(2008) Patrizia D'Amelio et al.   BONE

Modulation of Dickkopf-1 Attenuates Glucocorticoid Induction of Osteoblast Apoptosis, Adipocytic Differentiation, and Bone Mass Loss

(2008) Feng-Sheng Wang et al.   ENDOCRINOLOGY

Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells

(2008) Yi Ding et al.   NATURE MEDICINE