Article
Immunology
Lizhong Ding, Lu Sun, Melissa T. Bu, Yanjun Zhang, Lauren N. Scott, Robert M. Prins, Maureen A. Su, Melissa G. Lechner, Willy Hugo
Summary: Tumors of melanoma patients who respond to ICI or MAPKi therapies show increased T cell infiltration and IFNγ pathway activation. However, the rate of durable tumor control is higher with ICI therapy, indicating the presence of additional mechanisms beneficial for anti-tumor immunity in ICI responders.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Elise Gressier, Jonas Schulte-Schrepping, Lev Petrov, Sophia Brumhard, Paula Stubbemann, Anna Hiller, Benedikt Obermayer, Jasper Spitzer, Tomislav Kostevc, Paul G. Whitney, Annabell Bachem, Alexandru Odainic, Carolien van de Sandt, Thi H. O. Nguyen, Thomas Ashhurst, Kayla Wilson, Clare V. L. Oates, Linden. J. Gearing, Tina Meischel, Katharina Hochheiser, Marie Greyer, Michele Clarke, Maike Kreutzenbeck, Sarah S. Gabriel, Wolfgang Kastenmueller, Christian Kurts, Sarah L. Londrigan, Axel Kallies, Katherine Kedzierska, Paul J. Hertzog, Eicke Latz, Yu-Chen E. Chen, Kristen J. Radford, Michael Chopin, Jan Schroeder, Florian Kurth, Thomas Gebhardt, Leif E. Sander, Birgit Sawitzki, Joachim L. Schultze, Susanne V. Schmidt, Sammy Bedoui
Summary: Bedoui and colleagues discovered a sequential integration process in APCs that enhances their ability to activate antiviral CD8(+) T cell responses. This process involves the gradual induction of specific transcriptional regulators and co-stimulatory molecules, led by CD4(+) T cell-mediated CD40 stimulation and interferon-alpha/interferon-beta activation. These findings highlight the importance of APC-T cell interactions in antiviral immunity.
Article
Immunology
Miwa Sasai, Ji Su Ma, Masaaki Okamoto, Kohei Nishino, Hikaru Nagaoka, Eizo Takashima, Ariel Pradipta, Youngae Lee, Hidetaka Kosako, Pann-Ghill Suh, Masahiro Yamamoto
Summary: The TCR signaling in CD8(+) T cells is qualitatively different from that in CD4(+) T cells due to the involvement of PLC beta 4. PLC beta 4 plays a crucial role in activating CD8(+) T cells and promoting adaptive immunity, while deficiency of PLC beta 4 leads to impaired immune responses in CD8(+) T cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Lene S. Hoydahl, Terje Frigstad, Ingunn B. Rasmussen, Inger Oynebraten, Karoline W. Schjetne, Jan Terje Andersen, Terje E. Michaelsen, Elin Lunde, Bjarne Bogen, Inger Sandlie
Summary: Different antibody-antigen fusion modes have varying effects on inducing T-cell responses, with Troybody being more effective than fusion of antigen to the C-terminus of antibodies. This approach enhances activation of CD4 and CD8 peptide-specific T cells.
Article
Cell Biology
Leila Fonderflick, Timothee Baudu, Olivier Adotevi, Michael Guittaut, Pascale Adami, Regis Delage-Mourroux
Summary: Vaccine therapy is a promising method of research to promote T cell immune response and to develop novel antitumor immunotherapy protocols. Increasing evidence shows that autophagy plays a role in antigen processing and presentation to T cells.
Review
Immunology
Zhiheng Wu, Yu Zheng, Jin Sheng, Yicheng Han, Yanyan Yang, Hongming Pan, Junlin Yao
Summary: This article comprehensively reviews the origin, distribution, and functions of DN T cells, focusing on their roles in inflammation, immune disorders, and cancer. It also discusses the recent advances in DN T cell-based therapy for cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zhiqin Deng, Qian Zhang, Zhe Zhao, Yongshen Li, Xiaoqiang Chen, Zicong Lin, Zhenhan Deng, Jianquan Liu, Li Duan, Daping Wang, Wencui Li
Summary: Osteoimmunology studies the interactions between the immune system and the skeletal system, with different immune cells playing various roles in regulating osteoclasts and chondrocytes. These cells maintain a dynamic balance through multiple signaling mechanisms.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Seon-Hee Kim, Eunjung Cho, Yu Kim, Chungyong Han, Beom K. Choi, Byoung S. Kwon
Summary: The study demonstrates that post-conditioning treatment with anti-CD4 can enhance the anti-tumor efficacy of adoptive T cell therapy (ACT) by promoting the expansion of IL-18R alpha(hi) CD8(+) T cells. This combination treatment accelerates proliferation and differentiation of tumor-reactive CD8(+) T cells and improves tumor suppression and host survival. The enrichment of polyfunctional IL-18R alpha(hi) CD8(+) T cells plays a key role in the induced tumor suppression, mediated by IL-18 signaling and TCR-MHC I interaction.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
J. Luke Postoak, Wenqiang Song, Guan Yang, Xingyi Guo, Shiyun Xiao, Cherie E. Saffold, Jianhua Zhang, Sebastian Joyce, Nancy R. Manley, Lan Wu, Luc Van Kaer
Summary: This study reveals the important role of lipid kinase Vps34 in the development and selection of CD4 T cells during antigen processing and presentation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Claire Lhuillier, Nils-Petter Rudqvist, Takahiro Yamazaki, Tuo Zhang, Maud Charpentier, Lorenzo Galluzzi, Noah Dephoure, Cristina C. Clement, Laura Santambrogio, Xi Kathy Zhou, Silvia C. Formenti, Sandra Demaria
Summary: Radiotherapy upregulates the expression of genes containing immunogenic mutations, enhancing the therapeutic efficacy of neoantigen vaccination by promoting the killing of tumor cells through CD8 and CD4 T cells. CD4 T cells produce Th1 cytokines to promote epitope spread, while utilizing radiation to enhance the ability of MHC molecules and death receptors on tumor cells.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biotechnology & Applied Microbiology
Chiara M. M. Cattaneo, Thomas Battaglia, Jos Urbanus, Ziva Moravec, Rhianne Voogd, Rosa de Groot, Koen J. J. Hartemink, John B. A. G. Haanen, Emile E. E. Voest, Ton N. N. Schumacher, Wouter Scheper
Summary: A genetic neoantigen screening system is developed to identify CD4(+) and CD8(+) T cell-recognized neoantigens across patients' complete HLA genotypes.
NATURE BIOTECHNOLOGY
(2023)
Review
Immunology
Christine M. Wardell, Katherine N. MacDonald, Megan K. Levings, Laura Cook
Summary: Regulatory T cells (Tregs) play a crucial role in maintaining self-tolerance and immune homeostasis. The interaction between Tregs and antigen-presenting cells (APCs) is essential for optimizing Treg-based therapeutic approaches in treating autoimmune diseases.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Biology
Wei Wei, Yanjun Su
Summary: In this study, researchers used single cell sequencing technology to investigate T cells in non-small-cell lung cancer patients, identifying specific genes related to immune cell function and inferring the function of three types of T cells. The application of this technology helps to understand the mechanism of lung cancer occurrence and development, discover new diagnostic markers and therapeutic targets, and provide a theoretical reference for precise treatment of lung cancer patients in the future.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Immunology
Ichwaku Rastogi, Donghwan Jeon, Jena E. E. Moseman, Anusha Muralidhar, Hemanth K. Potluri, Douglas G. G. McNeel
Summary: This review discusses the role and function of B cells in the humoral immune system, as well as their ability to act as antigen presenting cells. B cells have been shown to activate antigen-specific T cells and have regulatory and cytotoxic effects. The importance of B cells within the tumor microenvironment is increasingly recognized, and B cells are being evaluated as cellular therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Juan Navarro-Barriuso, Maria Jose Mansilla, Bibiana Quirant-Sanchez, Aina Teniente-Serra, Cristina Ramo-Tello, Eva M. Martinez-Caceres
Summary: The use of vitamin D3-generated tolDC (vitD3-tolDC) has shown promising results in inducing antigen-specific hyporesponsiveness in T cells, reducing T(H)1 immune profiles and IFN-γ production. Transcriptomic analysis revealed a significant down-regulation of genes related to cell cycle and pro-inflammatory immune responses, with JUNB gene identified as a potential biomarker in this process. These findings highlight the regulatory properties and therapeutic potential of vitD3-tolDC in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)