mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy
出版年份 2019 全文链接
标题
mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy
作者
关键词
-
出版物
Cell Death & Disease
Volume 10, Issue 8, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-07-22
DOI
10.1038/s41419-019-1752-5
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-βCTF (C99)
- (2019) Jiang Ying et al. JOURNAL OF NEUROSCIENCE
- Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance
- (2018) Sarah Pickles et al. CURRENT BIOLOGY
- mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia
- (2018) Fabio Di Domenico et al. FREE RADICAL BIOLOGY AND MEDICINE
- Oxidation of Atg3 and Atg7 mediates inhibition of autophagy
- (2018) Karen Frudd et al. Nature Communications
- FoxO1 Promotes Mitophagy in the Podocytes of Diabetic Male Mice via the PINK1/Parkin Pathway
- (2017) Wen Li et al. ENDOCRINOLOGY
- Characterization of developmental defects in the forebrain resulting from hyperactivated mTOR signaling by integrative analysis of transcriptomic and proteomic data
- (2017) Jiheon Shin et al. Scientific Reports
- Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy
- (2016) Matteo Bordi et al. Autophagy
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- (2016) Daniel J Klionsky et al. Autophagy
- Mitochondrial Cristae: Where Beauty Meets Functionality
- (2016) Sara Cogliati et al. TRENDS IN BIOCHEMICAL SCIENCES
- Down syndrome and Alzheimer's disease: Common pathways, common goals
- (2015) Dean Hartley et al. Alzheimers & Dementia
- The mitochondrial voltage-dependent anion channel 1 in tumor cells
- (2015) Varda Shoshan-Barmatz et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Autophagy machinery in the context of mammalian mitophagy
- (2015) Saori R. Yoshii et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5
- (2015) Catherine L. Nezich et al. JOURNAL OF CELL BIOLOGY
- The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
- (2015) Michael Lazarou et al. NATURE
- The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
- (2015) Alicia M. Pickrell et al. NEURON
- limma powers differential expression analyses for RNA-sequencing and microarray studies
- (2015) Matthew E. Ritchie et al. NUCLEIC ACIDS RESEARCH
- Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy
- (2015) Giulia Milan et al. Nature Communications
- Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification
- (2015) Ju-Hyun Lee et al. Cell Reports
- Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain
- (2014) Marzia Perluigi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis
- (2014) José A. Martina et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy
- (2014) W. Wu et al. EMBO REPORTS
- mTOR Hyperactivation in Down Syndrome Hippocampus Appears Early During Development
- (2014) Anand M. Iyer et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Domains of genome-wide gene expression dysregulation in Down’s syndrome
- (2014) Audrey Letourneau et al. NATURE
- Ubiquitin is phosphorylated by PINK1 to activate parkin
- (2014) Fumika Koyano et al. NATURE
- Making new contacts: the mTOR network in metabolism and signalling crosstalk
- (2014) Mitsugu Shimobayashi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Epigenetics: The neglected key to minimize learning and memory deficits in Down syndrome
- (2014) Alain D. Dekker et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy
- (2014) R. M. Ivatt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
- (2014) Yvette C. Wong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of mTORC1 by amino acids
- (2014) Liron Bar-Peled et al. TRENDS IN CELL BIOLOGY
- FOXO Transcription Factors: Their Clinical Significance and Regulation
- (2014) Yu Wang et al. Biomed Research International
- After the banquet
- (2013) Jianhui Zhu et al. Autophagy
- Decreased cell proliferation and higher oxidative stress in fibroblasts from Down Syndrome fetuses. Preliminary study
- (2013) Amparo Gimeno et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Adaptive Downregulation of Mitochondrial Function in Down Syndrome
- (2013) Pablo Helguera et al. Cell Metabolism
- The machinery of macroautophagy
- (2013) Yuchen Feng et al. CELL RESEARCH
- SOD2 in mitochondrial dysfunction and neurodegeneration
- (2013) James M. Flynn et al. FREE RADICAL BIOLOGY AND MEDICINE
- Regulation of mTORC1 and its impact on gene expression at a glance
- (2013) M. Laplante et al. JOURNAL OF CELL SCIENCE
- mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
- (2013) Francesca Nazio et al. NATURE CELL BIOLOGY
- Emerging regulation and functions of autophagy
- (2013) Patricia Boya et al. NATURE CELL BIOLOGY
- The role of autophagy in neurodegenerative disease
- (2013) Ralph A Nixon NATURE MEDICINE
- The autophagosome: origins unknown, biogenesis complex
- (2013) Christopher A. Lamb et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression
- (2013) Rubén Gómez-Sánchez et al. NEUROBIOLOGY OF DISEASE
- mTOR: The Master Regulator
- (2012) CELL
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- The pathways of mitophagy for quality control and clearance of mitochondria
- (2012) G Ashrafi et al. CELL DEATH AND DIFFERENTIATION
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
- (2012) Carmine Settembre et al. EMBO JOURNAL
- Chronic pro-oxidative state and mitochondrial dysfunctions are more pronounced in fibroblasts from Down syndrome foeti with congenital heart defects
- (2012) C. Piccoli et al. HUMAN MOLECULAR GENETICS
- Phosphatase and Tensin Homolog (PTEN)-induced Putative Kinase 1 (PINK1)-dependent Ubiquitination of Endogenous Parkin Attenuates Mitophagy
- (2012) Aleksandar Rakovic et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy
- (2012) E. Itakura et al. JOURNAL OF CELL SCIENCE
- Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway
- (2011) Daniela Valenti et al. BIOCHEMICAL JOURNAL
- An Increase in Basal BDNF Provokes Hyperactivation of the Akt-Mammalian Target of Rapamycin Pathway and Deregulation of Local Dendritic Translation in a Mouse Model of Down's Syndrome
- (2011) J. A. Troca-Marin et al. JOURNAL OF NEUROSCIENCE
- Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation
- (2011) Fanjun Meng et al. Molecular Neurodegeneration
- Rapamycin passes the torch: a new generation of mTOR inhibitors
- (2011) Don Benjamin et al. NATURE REVIEWS DRUG DISCOVERY
- TFEB Links Autophagy to Lysosomal Biogenesis
- (2011) C. Settembre et al. SCIENCE
- ROAST: rotation gene set tests for complex microarray experiments
- (2010) Di Wu et al. BIOINFORMATICS
- The DNA repair complex Ku70/86 modulates Apaf1 expression upon DNA damage
- (2010) D De Zio et al. CELL DEATH AND DIFFERENTIATION
- Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress
- (2010) L Bouman et al. CELL DEATH AND DIFFERENTIATION
- Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity
- (2010) Ying Zhao et al. NATURE CELL BIOLOGY
- mTOR: from growth signal integration to cancer, diabetes and ageing
- (2010) Roberto Zoncu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
- (2010) D. F. Egan et al. SCIENCE
- AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity
- (2009) C. M. Chresta et al. CANCER RESEARCH
- FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation
- (2009) Y. Mei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started