The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome

Down syndrome

(2020) Stylianos E. Antonarakis et al.   Nature Reviews Disease Primers

Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome

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O-GlcNAc regulates gene expression by controlling detained intron splicing

(2020) Zhi-Wei Tan et al.   NUCLEIC ACIDS RESEARCH

Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention

(2020) Chiara Lanzillotta et al.   PROGRESS IN NEUROBIOLOGY

Role of O‐GlcNAcylation in the Homeostasis of Metabolic Organs and its Potential Links with Diabetes and its Complications

(2020) Katsutaro Morino et al.   Journal of Diabetes Investigation

Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions

(2020) Mara Dierssen et al.   Frontiers in Neuroscience

Nutrient Regulation of Signaling & Transcription

(2019) Gerald W. Hart   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson’s disease

(2019) Paul M. Levine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome

(2019) Fabio Di Domenico et al.   Redox Biology

Dementia in Down syndrome: unique insights for Alzheimer disease research

(2019) Ira T. Lott et al.   Nature Reviews Neurology

Plasma metabolites related to cellular energy metabolism are altered in adults with Down syndrome and Alzheimer's disease

(2019) Thomas J. Gross et al.   Developmental Neurobiology

Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain

(2019) Elizabeth G. Wheatley et al.   CURRENT BIOLOGY

Modulation of O-GlcNAcylation Regulates Autophagy in Cortical Astrocytes

(2019) Md. Ataur Rahman et al.   Oxidative Medicine and Cellular Longevity

Molecular mechanisms regulating O-linked N-acetylglucosamine (O-GlcNAc)–processing enzymes

(2019) Dustin T. King et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Pharmacological Inhibition of O-GlcNAcase Enhances Autophagy in Brain through an mTOR-Independent Pathway

(2018) Yanping Zhu et al.   ACS Chemical Neuroscience

O -GlcNAcylation and neuronal energy status: Implications for Alzheimer’s disease

(2018) Tiffany S. Pinho et al.   AGEING RESEARCH REVIEWS

Down syndrome, beta-amyloid and neuroimaging

(2018) Elizabeth Head et al.   FREE RADICAL BIOLOGY AND MEDICINE

mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia

(2018) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism

(2018) Maria Caracausi et al.   Scientific Reports

Neuroimaging and other modalities to assess Alzheimer's disease in Down syndrome

(2018) Natalie Neale et al.   NeuroImage-Clinical

The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer’s disease in individuals with Down syndrome

(2018) Yvonne S. Davidson et al.   Acta Neuropathologica Communications

Dementia, Diabetes, Alzheimer's Disease, and Insulin Resistance in the Brain: Progress, Dilemmas, New Opportunities, and a Hypothesis to Tackle Intersecting Epidemics

(2018) Rodrigo O. Kuljiš et al.   JOURNAL OF ALZHEIMERS DISEASE

Therapeutic potential of rescuing protein O-GlcNAcylation in tau-related pathologies

(2018) Fabio Di Domenico et al.   Expert Review of Neurotherapeutics

Direct Crosstalk Between O-GlcNAcylation and Phosphorylation of Tau Protein Investigated by NMR Spectroscopy

(2018) Gwendoline Bourré et al.   Frontiers in Endocrinology

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome

(2018) Antonella Tramutola et al.   Translational Neurodegeneration

Early and Persistent O-GlcNAc Protein Modification in the Streptozotocin Model of Alzheimer’s Disease

(2017) João Paulo Almeida dos Santos et al.   JOURNAL OF ALZHEIMERS DISEASE

Nutrient-driven O -GlcNAc in proteostasis and neurodegeneration

(2017) Ilhan Akan et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

(2017) Nicholas B. Hastings et al.   Molecular Neurodegeneration

The Early Presentation of Dementia in People with Down Syndrome: a Systematic Review of Longitudinal Studies

(2017) Bianca Alexandra Lautarescu et al.   NEUROPSYCHOLOGY REVIEW

A Conserved Splicing Silencer Dynamically Regulates O-GlcNAc Transferase Intron Retention and O-GlcNAc Homeostasis

(2017) Sung-Kyun Park et al.   Cell Reports

Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome

(2017) Martina Parrini et al.   Scientific Reports

O-GlcNAcylation: A regulator of tau pathology and neurodegeneration

(2016) Cheng-Xin Gong et al.   Alzheimers & Dementia

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis

(2016) Darya Zibrova et al.   BIOCHEMICAL JOURNAL

New insights: A role for O-GlcNAcylation in diabetic complications

(2016) Sherket B. Peterson et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Experience-dependent reduction of soluble β-amyloid oligomers and rescue of cognitive abilities in middle-age Ts65Dn mice, a model of Down syndrome

(2016) Gabriele Sansevero et al.   EXPERIMENTAL NEUROLOGY

Estimation of the number of people with Down syndrome in the United States

(2016) Gert de Graaf et al.   GENETICS IN MEDICINE

Glucose Transporters in Brain: In Health and in Alzheimer’s Disease

(2016) Leszek Szablewski   JOURNAL OF ALZHEIMERS DISEASE

Dementia in Down's syndrome

(2016) Clive Ballard et al.   LANCET NEUROLOGY

Roles of O-GlcNAcylation on amyloid-β precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer’s disease

(2016) Bo-Wen Zheng et al.   NEUROLOGICAL RESEARCH

Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer’s disease

(2016) Eleonora Gatta et al.   PHARMACOLOGICAL RESEARCH

Loss ofO-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration

(2016) Andrew C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity

(2016) Yoon Kyung Jo et al.   Oncotarget

Identification of the nuclear localisation signal of O-GlcNAc transferase and its nuclear import regulation

(2016) Hyeon Gyu Seo et al.   Scientific Reports

Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome

(2015) Eric D. Hamlett et al.   Current Alzheimer Research

Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology

(2015) Elizabeth Head et al.   Current Alzheimer Research

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

(2015) Frances K. Wiseman et al.   NATURE REVIEWS NEUROSCIENCE

Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling

(2015) Yong Ryoul Yang et al.   Oncotarget

Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease

(2014) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Emerging Link betweenO-GlcNAc and Alzheimer Disease

(2014) Yanping Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-GlcNAc Modification of tau Directly Inhibits Its Aggregation without Perturbing the Conformational Properties of tau Monomers

(2014) Scott A. Yuzwa et al.   JOURNAL OF MOLECULAR BIOLOGY

Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice

(2014) Scott A Yuzwa et al.   Molecular Neurodegeneration

O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation

(2014) Bin Guo et al.   NATURE CELL BIOLOGY

Early detection of Alzheimer's disease using PiB and FDG PET

(2014) Ann D. Cohen et al.   NEUROBIOLOGY OF DISEASE

OGA heterozygosity suppresses intestinal tumorigenesis in Apcmin/+ mice

(2014) Y R Yang et al.   Oncogenesis

Glucose Sensor O-GlcNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock

(2013) Krista Kaasik et al.   Cell Metabolism

Autophagy Enhancer Carbamazepine Alleviates Memory Deficits and Cerebral Amyloid-β Pathology in a Mouse Model of Alzheimer's Disease

(2013) Lixi Li et al.   Current Alzheimer Research

People with intellectual disability: What do we know about adulthood and life expectancy?

(2013) A.M.W. Coppus   Developmental Disabilities Research Reviews

O-Linked β-N-Acetylglucosamine (O-GlcNAc) Site Thr-87 Regulates Synapsin I Localization to Synapses and Size of the Reserve Pool of Synaptic Vesicles

(2013) Yuliya Skorobogatko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy

(2013) Danielle L. Graham et al.   NEUROPHARMACOLOGY

Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice

(2013) Sefika Ozcelik et al.   PLoS One

Unraveling the complexity of neurodegeneration in brains of subjects with Down syndrome: Insights from proteomics

(2013) Marzia Perluigi et al.   Proteomics Clinical Applications

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

(2012) Véronique Schaeffer et al.   BRAIN

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

(2012) Scott A Yuzwa et al.   Nature Chemical Biology

O-linked β-N-acetylglucosaminidase inhibitor attenuates β-amyloid plaque and rescues memory impairment

(2012) Chaeyoung Kim et al.   NEUROBIOLOGY OF AGING

Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation

(2012) Yang Yu et al.   PLoS One

Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn

(2011) Laura G. Reinholdt et al.   MAMMALIAN GENOME

Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation

(2011) Caroline Smet-Nocca et al.   Molecular BioSystems

O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP)

(2010) Kristin T. Jacobsen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

O-GlcNAc modification, insulin signaling and diabetic complications

(2010) T. Issad et al.   DIABETES & METABOLISM

Early Detection of Alzheimer’s Disease with PET Imaging

(2010) V. Berti et al.   Neurodegenerative Diseases

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

(2009) F. Liu et al.   BRAIN

Regulation of Insulin Receptor Substrate 1 (IRS-1)/AKT Kinase-mediated Insulin Signaling byO-Linked β-N-Acetylglucosamine in 3T3-L1 Adipocytes

(2009) Stephen A. Whelan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

(2008) Ying Liu et al.   FEBS LETTERS

Regulation of theO-Linked β-N-Acetylglucosamine Transferase by Insulin Signaling

(2008) Stephen A. Whelan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In VivoModulation ofO-GlcNAc Levels Regulates Hippocampal Synaptic Plasticity through Interplay with Phosphorylation

(2008) Melanie K. Tallent et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

(2008) Scott A Yuzwa et al.   Nature Chemical Biology

Cross-talk between GlcNAcylation and phosphorylation: Site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc

(2008) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA