LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies

(2020) Lillian B. Cohn et al.   Cell Host & Microbe

Metformin effect on gut microbiota: insights for HIV-related inflammation

(2020) Jing Ouyang et al.   AIDS Research and Therapy

Improving HIV Outgrowth by Optimizing Cell-Culture Conditions and Supplementing With all-trans Retinoic Acid

(2020) Yuwei Zhang et al.   Frontiers in Microbiology

Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy

(2020) Lin Wu et al.   CELL

mTOR Overcomes Multiple Metabolic Restrictions to Enable HIV-1 Reverse Transcription and Intracellular Transport

(2020) Harry E. Taylor et al.   Cell Reports

Repurposing metformin in non-diabetic people living with HIV: Influence on weight and gut microbiota

(2020) Stéphane Isnard et al.   Open Forum Infectious Diseases

Nonsuppressible HIV-1 viremia: a reflection of how the reservoir persists

(2020) Janet D. Siliciano et al.   JOURNAL OF CLINICAL INVESTIGATION

HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus

(2020) Elias K. Halvas et al.   JOURNAL OF CLINICAL INVESTIGATION

Immune Activation, Inflammation, and Non-AIDS Co-Morbidities in HIV-Infected Patients under Long-Term ART

(2019) Sonia Zicari et al.   Viruses-Basel

Effect of metformin on the size of the HIV reservoir in non-diabetic ART-treated individuals: single-arm non-randomised Lilac pilot study protocol

(2019) Jean-Pierre Routy et al.   BMJ Open

mTOR and other effector kinase signals that impact T cell function and activity

(2019) Darienne R. Myers et al.   IMMUNOLOGICAL REVIEWS

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

(2019) Marc Foretz et al.   Nature Reviews Endocrinology

Metformin Reduces CD4 T-Cell Exhaustion in HIV-Infected Adults on Suppressive Antiretroviral Therapy

(2019) Cecilia Shikuma et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Human Immunodeficiency Virus (HIV)–Infected CCR6+ Rectal CD4+ T Cells and HIV Persistence On Antiretroviral Therapy

(2019) Jenny L Anderson et al.   JOURNAL OF INFECTIOUS DISEASES

Dolutegravir and metformin

(2018) Dario Cattaneo et al.   AIDS

Targeting the Latent Reservoir for HIV-1

(2018) Srona Sengupta et al.   IMMUNITY

Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication

(2018) Grant R. Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAMHD1 Impairs HIV-1 Gene Expression and Negatively Modulates Reactivation of Viral Latency in CD4+ T Cells

(2018) Jenna M. Antonucci et al.   JOURNAL OF VIROLOGY

Gut microbial diversity in HIV infection post combined antiretroviral therapy

(2018) Mohamed El-Far et al.   Current Opinion in HIV and AIDS

The Role of Integrin α4β7 in HIV Pathogenesis and Treatment

(2018) James Arthos et al.   Current HIV/AIDS Reports

TSC1 and DEPDC5 regulate HIV-1 latency through the mTOR signaling pathway

(2018) Shan Jin et al.   Emerging Microbes & Infections

Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection

(2018) José Carlos Valle-Casuso et al.   Cell Metabolism

New Th17-specific therapeutic strategies for HIV remission

(2018) Delphine Planas et al.   Current Opinion in HIV and AIDS

mTORC1 and mTORC2 as regulators of cell metabolism in immunity

(2017) Monika Linke et al.   FEBS LETTERS

The loss of CCR6+ and CD161+ CD4+ T-cell homeostasis contributes to disease progression in SIV-infected rhesus macaques

(2017) C S McGary et al.   Mucosal Immunology

The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis

(2017) Vanessa Wacleche et al.   Viruses-Basel

Sirtuin-1 Activation Controls Tumor Growth by Impeding Th17 Differentiation via STAT3 Deacetylation

(2017) Emeric Limagne et al.   Cell Reports

Persistence of integrated HIV DNA in CXCR3 + CCR6 + memory CD4+ T cells in HIV-infected individuals on antiretroviral therapy

(2016) Gabriela Khoury et al.   AIDS

The mTOR Complex Controls HIV Latency

(2016) Emilie Besnard et al.   Cell Host & Microbe

Th17 Cells Are Preferentially Infected Very Early after Vaginal Transmission of SIV in Macaques

(2016) Daniel J. Stieh et al.   Cell Host & Microbe

HIV-1 Capsid Inhibitors as Antiretroviral Agents

(2016) Suzie Thenin-Houssier et al.   CURRENT HIV RESEARCH

Immunologic Biomarkers, Morbidity, and Mortality in Treated HIV Infection

(2016) Peter W. Hunt et al.   JOURNAL OF INFECTIOUS DISEASES

Human Th17 Cells Lack HIV-Inhibitory RNases and Are Highly Permissive to Productive HIV Infection

(2016) Aaron Christensen-Quick et al.   JOURNAL OF VIROLOGY

The rectal mucosa and condomless receptive anal intercourse in HIV-negative MSM: implications for HIV transmission and prevention

(2016) C F Kelley et al.   Mucosal Immunology

New insights into the heterogeneity of Th17 subsets contributing to HIV-1 persistence during antiretroviral therapy

(2016) Vanessa Sue Wacleche et al.   Retrovirology

Residual inflammation and viral reservoirs

(2016) Marta Massanella et al.   Current Opinion in HIV and AIDS

Tissue reservoirs of HIV

(2016) Joseph K. Wong et al.   Current Opinion in HIV and AIDS

Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset

(2016) Mickaël J. Ploquin et al.   PLoS Pathogens

Low SAMHD1 expression following T-cell activation and proliferation renders CD4+ T cells susceptible to HIV-1

(2015) Nicolas Ruffin et al.   AIDS

Metformin modulates human leukocyte/endothelial cell interactions and proinflammatory cytokines in polycystic ovary syndrome patients

(2015) Victor M. Victor et al.   ATHEROSCLEROSIS

Signal Strength and Metabolic Requirements Control Cytokine-Induced Th17 Differentiation of Uncommitted Human T Cells

(2015) Ilko Kastirr et al.   JOURNAL OF IMMUNOLOGY

Origin of Rebound Plasma HIV Includes Cells with Identical Proviruses That Are Transcriptionally Active before Stopping of Antiretroviral Therapy

(2015) Mary F. Kearney et al.   JOURNAL OF VIROLOGY

Th1/17 Polarization of CD4 T Cells Supports HIV-1 Persistence during Antiretroviral Therapy

(2015) Hong Sun et al.   JOURNAL OF VIROLOGY

Intrinsic host restrictions to HIV-1 and mechanisms of viral escape

(2015) Viviana Simon et al.   NATURE IMMUNOLOGY

Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice

(2015) Alonso Heredia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of novel HIV-1 dependency factors in primary CCR4+CCR6+Th17 cells via a genome-wide transcriptional approach

(2015) Aurélie Cleret-Buhot et al.   Retrovirology

A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals

(2015) Francesco Andrea Procopio et al.   EBioMedicine

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

(2014) Radha Ramesh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation

(2014) Alexandra Schuetz et al.   PLoS Pathogens

Past, present and future: 30 years of HIV research

(2013) Françoise Barré-Sinoussi et al.   NATURE REVIEWS MICROBIOLOGY

Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies Peroxisome Proliferator-Activated Receptor Gamma as an intrinsic negative regulator of viral replication

(2013) Annie Bernier et al.   Retrovirology

mTOR, metabolism, and the regulation of T-cell differentiation and function

(2012) Adam T. Waickman et al.   IMMUNOLOGICAL REVIEWS

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

(2012) Yutaka Kurebayashi et al.   Cell Reports

Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

(2011) Pawel Muranski et al.   IMMUNITY

Short Communication: Persistence of High Blood Levels of the Chemokines CCL2, CCL19, and CCL20 During the Course of HIV Infection

(2010) Julie Fontaine et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Susceptibility of Human Th17 Cells to Human Immunodeficiency Virus and Their Perturbation during Infection

(2010) Aimee El Hed et al.   JOURNAL OF INFECTIOUS DISEASES

Th17 lineage commitment and HIV-1 pathogenesis

(2010) Petronela Ancuta et al.   Current Opinion in HIV and AIDS

Metformin Attenuated the Autoimmune Disease of the Central Nervous System in Animal Models of Multiple Sclerosis

(2009) N. Nath et al.   JOURNAL OF IMMUNOLOGY

Peripheral Blood CCR4+CCR6+ and CXCR3+CCR6+ CD4+ T Cells Are Highly Permissive to HIV-1 Infection

(2009) A. Gosselin et al.   JOURNAL OF IMMUNOLOGY

The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut

(2009) C Wang et al.   Mucosal Immunology

Emerging Concepts in the Immunopathogenesis of AIDS

(2008) Daniel C. Douek et al.   Annual Review of Medicine

Microbial Translocation Is Associated with Increased Monocyte Activation and Dementia in AIDS Patients

(2008) Petronela Ancuta et al.   PLoS One