The Regulation of RNA Modification Systems: The Next Frontier in Epitranscriptomics?

METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing

(2020) Hao Chen et al.   CELL RESEARCH

A mini-review of the computational methods used in identifying RNA 5-methylcytosine sites

(2020) Jianwei Li et al.   CURRENT GENOMICS

Proximity dependent biotinylation: key enzymes and adaptation to proteomics approaches

(2020) Payman Samavarchi-Tehrani et al.   MOLECULAR & CELLULAR PROTEOMICS

N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I

(2020) Mijia Lu et al.   Nature Microbiology

Imaging of DNA and RNA in Living Eukaryotic Cells to Reveal Spatiotemporal Dynamics of Gene Expression

(2020) Hanae Sato et al.   Annual Review of Biochemistry

Advances into understanding metabolites as signaling molecules in cancer progression

(2020) Joyce Y. Liu et al.   CURRENT OPINION IN CELL BIOLOGY

SIRT1 regulates N 6 ‐methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2‐dependent FTO SUMOylation

(2020) Xiaoming Liu et al.   HEPATOLOGY

Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein

(2020) Jiexin Li et al.   NUCLEIC ACIDS RESEARCH

Limits in the detection of m6A changes using MeRIP/m6A-seq

(2020) Alexa B. R. McIntyre et al.   Scientific Reports

YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators

(2020) Qili Fei et al.   PLOS BIOLOGY

Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase

(2020) Christopher Wilson et al.   NATURE BIOTECHNOLOGY

Targeted protein degradation as a powerful research tool in basic biology and drug target discovery

(2020) Tao Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Predicting Sites of Epitranscriptome Modifications Using Unsupervised Representation Learning Based on Generative Adversarial Networks

(2020) Sirajul Salekin et al.   Frontiers in Physics

Regulation and Function of RNA Pseudouridylation in Human Cells

(2020) Erin K. Borchardt et al.   Annual Review of Genetics

m6A-Atlas: a comprehensive knowledgebase for unraveling the N6-methyladenosine (m6A) epitranscriptome

(2020) Yujiao Tang et al.   NUCLEIC ACIDS RESEARCH

Proximity‐dependent labeling methods for proteomic profiling in living cells: An update

(2020) Justin A. Bosch et al.   Wiley Interdisciplinary Reviews-Developmental Biology

m5UPred: a web server for the prediction of RNA 5-methyluridine (m5U) sites from sequences

(2020) Jie Jiang et al.   Molecular Therapy-Nucleic Acids

TRADES: Targeted RNA Demethylation by SunTag System

(2020) Jing Mo et al.   Advanced Science

METTL6 is a tRNA m3C methyltransferase that regulates pluripotency and tumor cell growth

(2020) Valentina V. Ignatova et al.   Science Advances

Single cell metabolomics using mass spectrometry: Techniques and data analysis

(2020) Renmeng Liu et al.   ANALYTICA CHIMICA ACTA

Structural and functional roles of 2’-O-ribose methylations and their enzymatic machinery across multiple classes of RNAs

(2020) Simone Höfler et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Messenger RNA 5′ NAD+ Capping Is a Dynamic Regulatory Epitranscriptome Mark That Is Required for Proper Response to Abscisic Acid in Arabidopsis

(2020) Xiang Yu et al.   DEVELOPMENTAL CELL

Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6

(2020) Tommaso Selmi et al.   NUCLEIC ACIDS RESEARCH

RNA 2’-O-Methylation (Nm) Modification in Human Diseases

(2019) Dilyana G. Dimitrova et al.   Genes

RNA Modifications Modulate Activation of Innate Toll-Like Receptors

(2019) Isabel Freund et al.   Genes

Eukaryotic 5-methylcytosine (m5C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease

(2019) Katherine Bohnsack et al.   Genes

Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells

(2019) Dali Han et al.   NATURE

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

(2019) Hailing Shi et al.   MOLECULAR CELL

Genome-wide identification of mRNA 5-methylcytosine in mammals

(2019) Tao Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nutrigenomics and RNA methylation: Role of micronutrients

(2019) Pauline Mosca et al.   BIOCHIMIE

Atlas of Subcellular RNA Localization Revealed by APEX-Seq

(2019) Furqan M. Fazal et al.   CELL

NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs

(2019) Lindsey Van Haute et al.   NUCLEIC ACIDS RESEARCH

Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs

(2019) Saori Shinoda et al.   NUCLEIC ACIDS RESEARCH

High-fidelity amplified FISH for the detection and allelic discrimination of single mRNA molecules

(2019) Salvatore A. E. Marras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequence-specific m6A demethylation in RNA by FTO fused to RCas9

(2019) Kristina Rau et al.   RNA

Discovering and Mapping the Modified Nucleotides That Comprise the Epitranscriptome of mRNA

(2019) Bastian Linder et al.   Cold Spring Harbor Perspectives in Biology

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

(2019) Seungwon Yang et al.   Nature Communications

RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail

(2019) Xinyao Lin et al.   Nature Communications

Time-resolved NMR monitoring of tRNA maturation

(2019) Pierre Barraud et al.   Nature Communications

FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export

(2019) Brittany M. Edens et al.   Cell Reports

Cytosine-5 RNA methylation links protein synthesis to cell metabolism

(2019) Nikoletta A. Gkatza et al.   PLOS BIOLOGY

Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program

(2019) Maxime Janin et al.   ACTA NEUROPATHOLOGICA

Proximity RNA Labeling by APEX-Seq Reveals the Organization of Translation Initiation Complexes and Repressive RNA Granules

(2019) Alejandro Padrón et al.   MOLECULAR CELL

Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates

(2019) Xiao-Min Liu et al.   Nature Chemical Biology

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Comprehensive review and assessment of computational methods for predicting RNA post-transcriptional modification sites from RNA sequences

(2019) Zhen Chen et al.   BRIEFINGS IN BIOINFORMATICS

Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG

(2019) Katherine I. Zhou et al.   MOLECULAR CELL

Click-encoded rolling FISH for visualizing single-cell RNA polyadenylation and structures

(2019) Feng Chen et al.   NUCLEIC ACIDS RESEARCH

Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth

(2019) Clemens Heissenberger et al.   NUCLEIC ACIDS RESEARCH

Antibody cross-reactivity accounts for widespread appearance of m1A in 5’UTRs

(2019) Anya V. Grozhik et al.   Nature Communications

Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation

(2019) Jinghui Song et al.   Nature Chemical Biology

m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination

(2019) Huan Xu et al.   NEURON

The Editor’s I on Disease Development

(2019) Mamta Jain et al.   TRENDS IN GENETICS

Limited antibody specificity compromises epitranscriptomic analyses

(2019) Mark Helm et al.   Nature Communications

Modifications in small nuclear RNAs and their roles in spliceosome assembly and function

(2018) Markus T. Bohnsack et al.   BIOLOGICAL CHEMISTRY

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m 6 A Modification

(2018) Hengyou Weng et al.   Cell Stem Cell

N6-methyladenosine-binding proteins suppress HIV-1 infectivity and viral production

(2018) Wuxun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies

(2018) Ji-Young Youn et al.   MOLECULAR CELL

Zc3h13 Regulates Nuclear RNA m 6 A Methylation and Mouse Embryonic Stem Cell Self-Renewal

(2018) Jing Wen et al.   MOLECULAR CELL

A-to-I RNA editing — immune protector and transcriptome diversifier

(2018) Eli Eisenberg et al.   NATURE REVIEWS GENETICS

2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation

(2018) Junhong Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epitranscriptomic m 6 A Regulation of Axon Regeneration in the Adult Mammalian Nervous System

(2018) Yi-Lan Weng et al.   NEURON

SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function

(2018) Yuzhang Du et al.   NUCLEIC ACIDS RESEARCH

Interactions, localization, and phosphorylation of the m 6 A generating METTL3–METTL14–WTAP complex

(2018) Eva Schöller et al.   RNA

2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation

(2018) Junhong Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transient N-6-Methyladenosine Transcriptome Sequencing Reveals a Regulatory Role of m6A in Splicing Efficiency

(2018) Annita Louloupi et al.   Cell Reports

N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herpesvirus infection

(2018) Charles R. Hesser et al.   PLoS Pathogens

REDIdb 3.0: A Comprehensive Collection of RNA Editing Events in Plant Organellar Genomes

(2018) Claudio Lo Giudice et al.   Frontiers in Plant Science

VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

(2018) Yanan Yue et al.   Cell Discovery

Queuosine‐modified tRNAs confer nutritional control of protein translation

(2018) Francesca Tuorto et al.   EMBO JOURNAL

RNA editing of Filamin A pre‐mRNA regulates vascular contraction and diastolic blood pressure

(2018) Mamta Jain et al.   EMBO JOURNAL

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

(2018) Jun Liu et al.   NATURE CELL BIOLOGY

Dynamic temperature-sensitive A-to-I RNA editing in the brain of a heterothermic mammal during hibernation

(2018) Kent A Riemondy et al.   RNA

M1A within cytoplasmic mRNAs at single nucleotide resolution: A reconciled transcriptome-wide map

(2018) Schraga Schwartz   RNA

Mechanistic insights into m6A RNA enzymes

(2018) Tina Lence et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

RNA ribose methylation (2′-O-methylation): Occurrence, biosynthesis and biological functions

(2018) Lilia Ayadi et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep

(2018) Ketty Sinigaglia et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Nucleoside analogs in the study of the epitranscriptome

(2018) Cody M. Palumbo et al.   METHODS

RNA modifications in structure prediction – Status quo and future challenges

(2018) Andrea Tanzer et al.   METHODS

m6A facilitates hippocampus-dependent learning and memory through YTHDF1

(2018) Hailing Shi et al.   NATURE

Proximity-CLIP provides a snapshot of protein-occupied RNA elements in subcellular compartments

(2018) Daniel Benhalevy et al.   NATURE METHODS

Plant editosome database: a curated database of RNA editosome in plants

(2018) Man Li et al.   NUCLEIC ACIDS RESEARCH

Imaging the Life and Death of mRNAs in Single Cells

(2018) Jeffrey A. Chao et al.   Cold Spring Harbor Perspectives in Biology

One-Carbon Metabolism: Linking Nutritional Biochemistry to Epigenetic Programming of Long-Term Development

(2018) Constance E. Clare et al.   Annual Review of Animal Biosciences

RNA Editors, Cofactors, and mRNA Targets: An Overview of the C-to-U RNA Editing Machinery and Its Implication in Human Disease

(2018) Taga Lerner et al.   Genes

m 6 A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover

(2017) Shengdong Ke et al.   GENES & DEVELOPMENT

Stable Isotope Labeling for Improved Comparative Analysis of RNA Digests by Mass Spectrometry

(2017) Mellie June Paulines et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

The RNA m 6 A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence

(2017) Ivayla Ivanova et al.   MOLECULAR CELL

Dynamic landscape and regulation of RNA editing in mammals

(2017) Meng How Tan et al.   NATURE

RNA m6A methylation regulates the ultraviolet-induced DNA damage response

(2017) Yang Xiang et al.   NATURE

m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition

(2017) Boxuan Simen Zhao et al.   NATURE

Visualizing adenosine-to-inosine RNA editing in single mammalian cells

(2017) Ian A Mellis et al.   NATURE METHODS

Epitranscriptome sequencing technologies: decoding RNA modifications

(2017) Xiaoyu Li et al.   NATURE METHODS

Epitranscriptomics: mixed messages

(2017) Michael Eisenstein   NATURE METHODS

Detecting RNA modifications in the epitranscriptome: predict and validate

(2017) Mark Helm et al.   NATURE REVIEWS GENETICS

ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay

(2017) Masayuki Sakurai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Label-free, direct localization and relative quantitation of the RNA nucleobase methylations m6A, m5C, m3U, and m5U by top-down mass spectrometry

(2017) Heidelinde Glasner et al.   NUCLEIC ACIDS RESEARCH

N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

(2017) Nian Liu et al.   NUCLEIC ACIDS RESEARCH

MODOMICS: a database of RNA modification pathways. 2017 update

(2017) Pietro Boccaletto et al.   NUCLEIC ACIDS RESEARCH

Chemical biology approaches for studying posttranslational modifications

(2017) Aerin Yang et al.   RNA Biology

Eukaryotic stand-alone pseudouridine synthases – RNA modifying enzymes and emerging regulators of gene expression?

(2017) Anne C. Rintala-Dempsey et al.   RNA Biology

Pre-mRNA processing includes N 6 methylation of adenosine residues that are retained in mRNA exons and the fallacy of “RNA epigenetics”

(2017) Robert B. Darnell et al.   RNA

Our views of dynamic N 6 -methyladenosine RNA methylation

(2017) Boxuan Simen Zhao et al.   RNA

ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay

(2017) Masayuki Sakurai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Construction of a guide-RNA for site-directed RNA mutagenesis utilising intracellular A-to-I RNA editing

(2017) Masatora Fukuda et al.   Scientific Reports

S -Adenosylmethionine Synthesis Is Regulated by Selective N 6 -Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1

(2017) Hiroki Shima et al.   Cell Reports

Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs

(2017) Chan Zhou et al.   Cell Reports

Dynamic hyper-editing underlies temperature adaptation in Drosophila

(2017) Ilana Buchumenski et al.   PLoS Genetics

Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking

(2017) Pornchai Kaewsapsak et al.   eLife

Adenosine-to-Inosine Editing of MicroRNA-487b Alters Target Gene Selection After Ischemia and Promotes Neovascularization

(2017) Reginald V.C.T. van der Kwast et al.   CIRCULATION RESEARCH

Mass spectrometry of modified RNAs: recent developments

(2016) Collin Wetzel et al.   ANALYST

Nutrition meets the microbiome: micronutrients and the microbiota

(2016) Hans K. Biesalski   Annals of the New York Academy of Sciences

N6 -Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection

(2016) Nandan S. Gokhale et al.   Cell Host & Microbe

RNA nanomedicines: the next generation drugs?

(2016) Manu Smriti Singh et al.   CURRENT OPINION IN BIOTECHNOLOGY

NSUN3 and ABH1 modify the wobble position of mt‐tRNAMetto expand codon recognition in mitochondrial translation

(2016) Sara Haag et al.   EMBO JOURNAL

Ubiquitin-dependent Turnover of Adenosine Deaminase Acting on RNA 1 (ADAR1) Is Required for Efficient Antiviral Activity of Type I Interferon

(2016) Lemin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N6-Methyladenosine Sequencing Highlights the Involvement of mRNA Methylation in Oocyte Meiotic Maturation and Embryo Development by Regulating Translation inXenopus laevis

(2016) Shu-Tao Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing

(2016) Wen Xiao et al.   MOLECULAR CELL

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases

(2016) Ping Wang et al.   MOLECULAR CELL

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination

(2016) Irmgard U. Haussmann et al.   NATURE

m6A modulates neuronal functions and sex determination in Drosophila

(2016) Tina Lence et al.   NATURE

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

(2016) Jan Mauer et al.   NATURE

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation

(2016) Konstantinos Stellos et al.   NATURE MEDICINE

m6A-LAIC-seq reveals the census and complexity of the m6A epitranscriptome

(2016) Benoit Molinie et al.   NATURE METHODS

Dynamic regulation of RNA editing in human brain development and disease

(2016) Taeyoung Hwang et al.   NATURE NEUROSCIENCE

Post-transcriptional gene regulation by mRNA modifications

(2016) Boxuan Simen Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Harnessing human ADAR2 for RNA repair – Recoding a PINK1 mutation rescues mitophagy

(2016) Jacqueline Wettengel et al.   NUCLEIC ACIDS RESEARCH

Profiling of 2′-O-Me in human rRNA reveals a subset of fractionally modified positions and provides evidence for ribosome heterogeneity

(2016) Nicolai Krogh et al.   NUCLEIC ACIDS RESEARCH

REDIportal: a comprehensive database of A-to-I RNA editing events in humans

(2016) Ernesto Picardi et al.   NUCLEIC ACIDS RESEARCH

CRISPR-Cas: biology, mechanisms and relevance

(2016) Frank Hille et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The notorious R.N.A. in the spotlight - drug or target for the treatment of disease

(2016) Philipp Reautschnig et al.   RNA Biology

Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function

(2016) Katherine E. Sloan et al.   RNA Biology

Cracking the epitranscriptome

(2016) Schraga Schwartz   RNA

YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

(2016) Hao Du et al.   Nature Communications

Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3

(2016) Lindsey Van Haute et al.   Nature Communications

Going global: the new era of mapping modifications in RNA

(2016) Patrick A. Limbach et al.   Wiley Interdisciplinary Reviews-RNA

RNA Vaccination Therapy: Advances in an Emerging Field

(2016) Sebastian Kreiter et al.   Journal of Immunology Research

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

(2015) Samantha J. Mentch et al.   Cell Metabolism

m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency

(2015) Tong Chen et al.   Cell Stem Cell

Coordination of m 6 A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming

(2015) Francesca Aguilo et al.   Cell Stem Cell

The structural biology of CRISPR-Cas systems

(2015) Fuguo Jiang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

N6-methyladenosine marks primary microRNAs for processing

(2015) Claudio R. Alarcón et al.   NATURE

Dynamic m6A mRNA methylation directs translational control of heat shock response

(2015) Jun Zhou et al.   NATURE

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs

(2015) Sara Haag et al.   RNA

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins

(2015) Alfredo Castello et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Queuine Micronutrient: Charting a Course from Microbe to Man

(2015) Claire Fergus et al.   Nutrients

Trypanosome RNA editing: the complexity of getting U in and taking U out

(2015) Laurie K. Read et al.   Wiley Interdisciplinary Reviews-RNA

To edit or not to edit: regulation of ADAR editing specificity and efficiency

(2015) Sarah N. Deffit et al.   Wiley Interdisciplinary Reviews-RNA

Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120

(2015) Gabrielle Bourgeois et al.   PLoS One

Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA

(2014) Schraga Schwartz et al.   CELL

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells

(2014) Pedro J. Batista et al.   Cell Stem Cell

A System of RNA Modifications and Biased Codon Use Controls Cellular Stress Response at the Level of Translation

(2014) Peter C. Dedon et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

(2014) S. Blanco et al.   EMBO JOURNAL

Quantitative Analysis of rRNA Modifications Using Stable Isotope Labeling and Mass Spectrometry

(2014) Anna M. Popova et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

(2014) Yang Wang et al.   NATURE CELL BIOLOGY

Absolute and relative quantification of RNA modifications via biosynthetic isotopomers

(2014) Stefanie Kellner et al.   NUCLEIC ACIDS RESEARCH

Role of tRNA modifications in human diseases

(2014) Adrian Gabriel Torres et al.   TRENDS IN MOLECULAR MEDICINE

NSUN4 Is a Dual Function Mitochondrial Protein Required for Both Methylation of 12S rRNA and Coordination of Mitoribosomal Assembly

(2014) Metodi Dimitrov Metodiev et al.   PLoS Genetics

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

(2013) Jean-Michel Fustin et al.   CELL

Posttranscriptional RNA Modifications: Playing Metabolic Games in a Cell’s Chemical Legoland

(2013) Mark Helm et al.   CHEMISTRY & BIOLOGY

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes

(2013) L. Bazak et al.   GENOME RESEARCH

S-adenosylmethionine limitation induces p38 mitogen-activated protein kinase and triggers cell cycle arrest in G1

(2013) D.-W. Lin et al.   JOURNAL OF CELL SCIENCE

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry

(2013) Martin E Hess et al.   NATURE NEUROSCIENCE

Argonaute proteins: functional insights and emerging roles

(2013) Gunter Meister   NATURE REVIEWS GENETICS

Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively

(2013) Sunny Sharma et al.   NUCLEIC ACIDS RESEARCH

Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA

(2013) N. Liu et al.   RNA

NSun2-Mediated Cytosine-5 Methylation of Vault Noncoding RNA Determines Its Processing into Regulatory Small RNAs

(2013) Shobbir Hussain et al.   Cell Reports

Discovering RNA-Protein Interactome by Using Chemical Context Profiling of the RNA-Protein Interface

(2013) Marc Parisien et al.   Cell Reports

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity

(2012) Stefanie Gehrig et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Darned in 2013: inclusion of model organisms and linking with Wikipedia

(2012) Anmol M. Kiran et al.   NUCLEIC ACIDS RESEARCH

Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling

(2012) Maria Becker et al.   NUCLEIC ACIDS RESEARCH

RNA Editing Underlies Temperature Adaptation in K+ Channels from Polar Octopuses

(2012) S. Garrett et al.   SCIENCE

Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins

(2012) Clement T.Y. Chan et al.   Nature Communications

The birth of the Epitranscriptome: deciphering the function of RNA modifications

(2012) Yogesh Saletore et al.   GENOME BIOLOGY

Pin1 and WWP2 regulateGluR2Q/R site RNA editing by ADAR2 with opposing effects

(2011) Roberto Marcucci et al.   EMBO JOURNAL

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Counting absolute numbers of molecules using unique molecular identifiers

(2011) Teemu Kivioja et al.   NATURE METHODS

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

(2011) Katalin Karikó et al.   NUCLEIC ACIDS RESEARCH

RNA nucleotide methylation

(2011) Yuri Motorin et al.   Wiley Interdisciplinary Reviews-RNA

tRNA biology charges to the front

(2010) E. M. Phizicky et al.   GENES & DEVELOPMENT

Programmable in situ amplification for multiplexed imaging of mRNA expression

(2010) Harry M T Choi et al.   NATURE BIOTECHNOLOGY

Grand Challenge Commentary: RNA epigenetics?

(2010) Chuan He   Nature Chemical Biology

Large-scale detection and analysis of RNA editing in grape mtDNA by RNA deep-sequencing

(2010) Ernesto Picardi et al.   NUCLEIC ACIDS RESEARCH

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

(2010) Clement T. Y. Chan et al.   PLoS Genetics

A Non-Heme Iron-Mediated Chemical Demethylation in DNA and RNA

(2009) Chengqi Yi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations

(2009) Sarah Boissel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cellular dynamics of tRNAs and their genes

(2009) Anita K. Hopper et al.   FEBS LETTERS

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability

(2009) Shobbir Hussain et al.   JOURNAL OF CELL BIOLOGY

RNA-Regulated Interaction of Transportin-1 and Exportin-5 with the Double-Stranded RNA-Binding Domain Regulates Nucleocytoplasmic Shuttling of ADAR1

(2009) J. Fritz et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-Wide Identification of Human RNA Editing Sites by Parallel DNA Capturing and Sequencing

(2009) J. B. Li et al.   SCIENCE

RNA major groove modifications improve siRNA stability and biological activity

(2008) Montserrat Terrazas et al.   NUCLEIC ACIDS RESEARCH

RNA cytosine methylation analysis by bisulfite sequencing

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