RNA 2’-O-Methylation (Nm) Modification in Human Diseases

FTSJ3 is an RNA 2′-O-methyltransferase recruited by HIV to avoid innate immune sensing

(2019) Mathieu Ringeard et al.   NATURE

Argonaute Proteins and Mechanisms of RNA Interference in Eukaryotes and Prokaryotes

(2018) A. V. Olina et al.   BIOCHEMISTRY-MOSCOW

Modifications in small nuclear RNAs and their roles in spliceosome assembly and function

(2018) Markus T. Bohnsack et al.   BIOLOGICAL CHEMISTRY

Fibrillarin is essential for S-phase progression and neuronal differentiation in zebrafish dorsal midbrain and retina

(2018) Stéphanie Bouffard et al.   DEVELOPMENTAL BIOLOGY

2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation

(2018) Junhong Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation

(2018) Junhong Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ALK- rearrangement in non-small-cell lung cancer (NSCLC)

(2018) Xue Du et al.   Thoracic Cancer

Lack of 2'-O-methylation in the tRNA anticodon loop of two phylogenetically distant yeast species activates the general amino acid control pathway

(2018) Lu Han et al.   PLoS Genetics

Proliferation, cancer, and aging-novel functions of the nucleolar methyltransferase fibrillarin?

(2018) Maria Y. Shubina et al.   CELL BIOLOGY INTERNATIONAL

Direct quantification of 3’ terminal 2'-O-methylation of small RNAs by RT-qPCR

(2018) Nan Wang et al.   RNA

Innate immune alterations are elicited in microglial cells before plaque deposition in the Alzheimer’s disease mouse model 5xFAD

(2018) Antonio Boza-Serrano et al.   Scientific Reports

Targeting the ribosome biogenesis key molecule fibrillarin to avoid chemoresistance

(2018) Btissame El Hassouni et al.   CURRENT MEDICINAL CHEMISTRY

scaRNAs and snoRNAs: Are they limited to specific classes of substrate RNAs?

(2018) Svetlana Deryusheva et al.   RNA

Detection and Analysis of RNA Ribose 2′-O-Methylations: Challenges and Solutions

(2018) Yuri Motorin et al.   Genes

PIWI family emerging as a decisive factor of cell fate: An overview

(2017) Murugavel Ponnusamy et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Hypermethylation of 28S ribosomal RNA in β-thalassemia trait carriers

(2017) Wannapa Sornjai et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia

(2017) S Degryse et al.   LEUKEMIA

Transcriptome-wide Analysis of Roles for tRNA Modifications in Translational Regulation

(2017) Hsin-Jung Chou et al.   MOLECULAR CELL

Nm-seq maps 2′-O-methylation sites in human mRNA with base precision

(2017) Qing Dai et al.   NATURE METHODS

Evidence for rRNA 2′-O-methylation plasticity: Control of intrinsic translational capabilities of human ribosomes

(2017) Jenny Erales et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations

(2017) Yazan M. Abbas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput and site-specific identification of 2′- O -methylation sites using ribose oxidation sequencing (RibOxi-seq)

(2017) Yinzhou Zhu et al.   RNA

Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas

(2017) Sagarika Banerjee et al.   Scientific Reports

Box C/D small nucleolar RNA genes and the Prader-Willi syndrome: a complex interplay

(2017) Jérôme Cavaillé   Wiley Interdisciplinary Reviews-RNA

Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements

(2017) Samuel H. Lewis et al.   Nature Ecology & Evolution

Illumina-based RiboMethSeq approach for mapping of 2′-O-Me residues in RNA

(2016) Virginie Marchand et al.   NUCLEIC ACIDS RESEARCH

mRNA capping: biological functions and applications

(2016) Anand Ramanathan et al.   NUCLEIC ACIDS RESEARCH

Regulation of mRNA capping in the cell cycle

(2016) Michael Aregger et al.   RNA Biology

Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function

(2016) Katherine E. Sloan et al.   RNA Biology

Assembly and trafficking of box C/D and H/ACA snoRNPs

(2016) Séverine Massenet et al.   RNA Biology

RNA modification in Cajal bodies

(2016) U. Thomas Meier   RNA Biology

Detection of EML4-ALK fusion gene and features associated with EGFR mutations in Chinese patients with non-small-cell lung cancer

(2016) Miaomiao Wen et al.   OncoTargets and Therapy

scaRNAs regulate splicing and vertebrate heart development

(2015) Prakash Patil et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fibrillarin from Archaea to human

(2015) Ulises Rodriguez-Corona et al.   BIOLOGY OF THE CELL

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Identification of Novel Fusion Genes in Testicular Germ Cell Tumors

(2015) A. M. Hoff et al.   CANCER RESEARCH

Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia

(2015) C. Vicente et al.   HAEMATOLOGICA

Defects in tRNA Anticodon Loop 2′-O-Methylation Are Implicated in Nonsyndromic X-Linked Intellectual Disability due to Mutations inFTSJ1

(2015) Michael P. Guy et al.   HUMAN MUTATION

JAK kinase inhibitors for the treatment of acute lymphoblastic leukemia

(2015) Sandrine Degryse et al.   Journal of Hematology & Oncology

Genomic alterations in lung adenocarcinoma

(2015) Siddhartha Devarakonda et al.   LANCET ONCOLOGY

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

(2015) Yury S Polikanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alternative Splicing in the Mammalian Nervous System: Recent Insights into Mechanisms and Functional Roles

(2015) Bushra Raj et al.   NEURON

The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs

(2015) Benedikt M. Beckmann et al.   Nature Communications

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

(2015) Yury S Polikanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology

(2015) Victor D. Martinez et al.   Scientific Reports

Fibrillarin methylates H2A in RNA polymerase I trans-active promoters in Brassica oleracea

(2015) Lloyd Loza-Muller et al.   Frontiers in Plant Science

Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia

(2015) C. Vicente et al.   HAEMATOLOGICA

RNA methyltransferases involved in 5′ cap biosynthesis

(2015) Magdalena Byszewska et al.   RNA Biology

Understanding the Effect of Locked Nucleic Acid and 2′-O-Methyl Modification on the Hybridization Thermodynamics of a miRNA–mRNA Pair in the Presence and Absence of AfPiwi Protein

(2014) Santosh Kumar et al.   BIOCHEMISTRY

Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA

(2014) Schraga Schwartz et al.   CELL

IFIT1: A dual sensor and effector molecule that detects non-2′-O methylated viral RNA and inhibits its translation

(2014) Michael S. Diamond   CYTOKINE & GROWTH FACTOR REVIEWS

Impact of age-associated increase in 2'-O-methylation of miRNAs on aging and neurodegeneration in Drosophila

(2014) M. Abe et al.   GENES & DEVELOPMENT

Interplay of LNA and 2′-O-Methyl RNA in the Structure and Thermodynamics of RNA Hybrid Systems: A Molecular Dynamics Study Using the Revised AMBER Force Field and Comparison with Experimental Results

(2014) Ilyas Yildirim et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells

(2014) Thomas M. Carlile et al.   NATURE

FTSJ2, a Heat Shock-Inducible Mitochondrial Protein, Suppresses Cell Invasion and Migration

(2014) Cheng-Wei Lai et al.   PLoS One

Transcriptome-Wide Mapping of Pseudouridines: Pseudouridine Synthases Modify Specific mRNAs in S. cerevisiae

(2014) Alexander F. Lovejoy et al.   PLoS One

Characterization of two homologous 2′-O-methyltransferases showing different specificities for their tRNA substrates

(2014) Jonathan Somme et al.   RNA

Conservation of an intricate circuit for crucial modifications of the tRNAPheanticodon loop in eukaryotes

(2014) Michael P. Guy et al.   RNA

Biosynthesis of Ribosomal RNA in Nucleoli Regulates Pluripotency and Differentiation Ability of Pluripotent Stem Cells

(2014) Kanako Watanabe-Susaki et al.   STEM CELLS

Role of tRNA modifications in human diseases

(2014) Adrian Gabriel Torres et al.   TRENDS IN MOLECULAR MEDICINE

Structural analysis of human 2′-O-ribose methyltransferases involved in mRNA cap structure formation

(2014) Miroslaw Smietanski et al.   Nature Communications

Mechanistic insights into small RNA recognition and modification by the HEN1 methyltransferase

(2013) Alexandra Plotnikova et al.   BIOCHEMICAL JOURNAL

p53 Acts as a Safeguard of Translational Control by Regulating Fibrillarin and rRNA Methylation in Cancer

(2013) Virginie Marcel et al.   CANCER CELL

Beyond transposons: the epigenetic and somatic functions of the Piwi-piRNA mechanism

(2013) Jamy C Peng et al.   CURRENT OPINION IN CELL BIOLOGY

Analysis of Hydra PIWI proteins and piRNAs uncover early evolutionary origins of the piRNA pathway

(2013) Robyn S.M. Lim et al.   DEVELOPMENTAL BIOLOGY

Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification

(2013) Peter Tessarz et al.   NATURE

Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5'-terminal regions of cap0-, cap1- and 5'ppp- mRNAs

(2013) P. Kumar et al.   NUCLEIC ACIDS RESEARCH

Elevated snoRNA biogenesis is essential in breast cancer

(2013) H Su et al.   ONCOGENE

Insights into snoRNA biogenesis and processing from PAR-CLIP of snoRNA core proteins and small RNA sequencing

(2013) Shivendra Kishore et al.   GENOME BIOLOGY

Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration

(2012) Yichang Jia et al.   CELL

A Role for Neuronal piRNAs in the Epigenetic Control of Memory-Related Synaptic Plasticity

(2012) Priyamvada Rajasethupathy et al.   CELL

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

Biogenesis and Mechanism of Action of Small Non-Coding RNAs: Insights from the Point of View of Structural Biology

(2012) Marina C. Costa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proteomic Characterization of the Human FTSJ3 Preribosomal Complexes

(2012) Fernando M. Simabuco et al.   JOURNAL OF PROTEOME RESEARCH

The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts

(2012) Alexander G. Baltz et al.   MOLECULAR CELL

The SNORD115 (H/MBII-52) and SNORD116 (H/MBII-85) gene clusters at the imprinted Prader-Willi locus generate canonical box C/D snoRNAs

(2012) M.-L. Bortolin-Cavaille et al.   NUCLEIC ACIDS RESEARCH

BC1-FMRP interaction is modulated by 2′-O-methylation: RNA-binding activity of the tudor domain and translational regulation at synapses

(2012) Caroline Lacoux et al.   NUCLEIC ACIDS RESEARCH

RTL-P: a sensitive approach for detecting sites of 2′-O-methylation in RNA molecules

(2012) Zhi-Wei Dong et al.   NUCLEIC ACIDS RESEARCH

Mechanisms that impact microRNA stability in plants

(2012) Yuanyuan Zhao et al.   RNA Biology

Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop

(2012) M. P. Guy et al.   RNA

The spliceosome: a flexible, reversible macromolecular machine

(2012) Aaron A. Hoskins et al.   TRENDS IN BIOCHEMICAL SCIENCES

Alterations in Nucleolar Structure and Gene Expression Programs in Prostatic Neoplasia Are Driven by the MYC Oncogene

(2011) Cheryl M. Koh et al.   AMERICAN JOURNAL OF PATHOLOGY

Uniting Germline and Stem Cells: The Function of Piwi Proteins and the piRNA Pathway in Diverse Organisms

(2011) Celina Juliano et al.   Annual Review of Genetics

Transfer RNA Methytransferases and Their Corresponding Modifications in Budding Yeast and Humans: Activities, Predications, and Potential Roles in Human Health

(2011) William L. Towns et al.   DNA AND CELL BIOLOGY

Q8IYL2 is a candidate gene for the familial epilepsy syndrome of Partial Epilepsy with Pericentral Spikes (PEPS)

(2011) Guy D. Leschziner et al.   EPILEPSY RESEARCH

Asthma exacerbations: Origin, effect, and prevention

(2011) David J. Jackson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

(2011) Roland Züst et al.   NATURE IMMUNOLOGY

2′-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family

(2011) Maria Werner et al.   NUCLEIC ACIDS RESEARCH

Loss of ribosomal RNA modification causes developmental defects in zebrafish

(2011) Sayomi Higa-Nakamine et al.   NUCLEIC ACIDS RESEARCH

Biogenesis and function of nuclear bodies

(2011) Yuntao S. Mao et al.   TRENDS IN GENETICS

Analysis of SMN-neurite granules: Core Cajal body components are absent from SMN-cytoplasmic complexes

(2010) Adrian G. Todd et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Global Patterns of Cancer Incidence and Mortality Rates and Trends

(2010) A. Jemal et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Paternally inherited microdeletion at 15q11.2 confirms a significant role for the SNORD116 C/D box snoRNA cluster in Prader–Willi syndrome

(2010) Angela L Duker et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Characterization of hMTr1, a Human Cap1 2′-O-Ribose Methyltransferase

(2010) François Bélanger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copy-number variations on the X chromosome in Japanese patients with mental retardation detected by array-based comparative genomic hybridization analysis

(2010) Shozo Honda et al.   JOURNAL OF HUMAN GENETICS

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

(2010) Stephane Daffis et al.   NATURE

Spliceosomal snRNA modifications and their function

(2010) John Karijolich et al.   RNA Biology

YibK is the 2'-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNALeu isoacceptors

(2010) A. Benitez-Paez et al.   RNA

Complex Segmental Duplications Mediate a Recurrent dup(X)(p11.22-p11.23) Associated with Mental Retardation, Speech Delay, and EEG Anomalies in Males and Females

(2009) Roberto Giorda et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour

(2009) Christine M. Doe et al.   HUMAN MOLECULAR GENETICS

Small Cajal Body–specific RNAs of Drosophila Function in the Absence of Cajal Bodies

(2009) Svetlana Deryusheva et al.   MOLECULAR BIOLOGY OF THE CELL

Dysregulation of Ribosome Biogenesis and Translational Capacity Is Associated with Tumor Progression of Human Breast Cancer Cells

(2009) Stéphane Belin et al.   PLoS One

Argonaute2 Suppresses Drosophila Fragile X Expression Preventing Neurogenesis and Oogenesis Defects

(2009) Anita S.-R. Pepper et al.   PLoS One

2'-O-methylation stabilizes Piwi-associated small RNAs and ensures DNA elimination in Tetrahymena

(2009) H. M. Kurth et al.   RNA

The human interferon-regulated ISG95 protein interacts with RNA polymerase II and shows methyltransferase activity

(2008) Thais Haline-Vaz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The post-transcriptional steps of eukaryotic ribosome biogenesis

(2008) A. K. Henras et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Integrative genomic and gene expression analysis of chromosome 7 identified novel oncogene loci in non-small cell lung cancer

(2008) Jennifer M. Campbell et al.   GENOME

A computational screen for C/D box snoRNAs in the human genomic region associated with Prader-Willi and Angelman syndromes

(2008) Padmavati Sridhar et al.   JOURNAL OF BIOMEDICAL SCIENCE

Positive association of the FTSJ1 gene polymorphisms with nonsyndromic X-linked mental retardation in young Chinese male subjects

(2008) Ling Dai et al.   JOURNAL OF HUMAN GENETICS

Genetic Variations in FTSJ1 Influence Cognitive Ability in Young Males in the Chinese Han Population

(2008) Pingyuan Gong et al.   JOURNAL OF NEUROGENETICS

Copy-number variations associated with neuropsychiatric conditions

(2008) Edwin H. Cook Jr et al.   NATURE

Prader-Willi and snoRNAs

(2008) Jo Peters   NATURE GENETICS

Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster

(2008) Trilochan Sahoo et al.   NATURE GENETICS

Exploring TAR–RNA aptamer loop–loop interaction by X-ray crystallography, UV spectroscopy and surface plasmon resonance

(2008) Isabelle Lebars et al.   NUCLEIC ACIDS RESEARCH

A loss-of-function mutation in theFTSJ1 gene causes nonsyndromic X-linked mental retardation in a japanese family

(2007) Kyoko Takano et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS