A Destiny for Degradation: Interplay between Cullin-RING E3 Ligases and Autophagy

Oncogenic role of MIR516A in human bladder cancer was mediated by its attenuating PHLPP2 expression and BECN1-dependent autophagy

(2020) Honglei Jin et al.   Autophagy

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation

(2020) Jin Rui Liang et al.   CELL

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology

(2020) Ayeshah A. Rosdah et al.   PHARMACOLOGY & THERAPEUTICS

Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes

(2020) Qing Yu et al.   NEOPLASIA

Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1

(2020) Yuan Liu et al.   JCI Insight

Coronavirus interactions with the cellular autophagy machinery

(2020) Katelyn Miller et al.   Autophagy

The Roles of Ubiquitin in Mediating Autophagy

(2020) Zhangyuan Yin et al.   Cells

Linear ubiquitination at a glance

(2019) Maureen Spit et al.   JOURNAL OF CELL SCIENCE

The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways

(2019) Chuan-Ming Xie et al.   Cell Reports

Autophagy in cardiomyopathies

(2019) Antonia T.L. Zech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation

(2019) Guang Lu et al.   Autophagy

HECT E3 Ligases: A Tale With Multiple Facets

(2019) Janine Weber et al.   Frontiers in Physiology

Diverse Cellular Roles of Autophagy

(2019) Hideaki Morishita et al.   Annual Review of Cell and Developmental Biology

SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy

(2019) Tatsuya Yamada et al.   Autophagy

The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth

(2019) Danrui Cui et al.   CELL DEATH AND DIFFERENTIATION

Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation

(2019) Ho Shin Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1

(2019) Mi-Jeong Kim et al.   Frontiers in Immunology

Autophagosome-Lysosome Fusion

(2019) Péter Lőrincz et al.   JOURNAL OF MOLECULAR BIOLOGY

Gartanin is a novel NEDDylation inhibitor for induction of Skp2 degradation, FBXW2 expression, and autophagy

(2019) Victor Pham et al.   MOLECULAR CARCINOGENESIS

Post-translational Modifications of Key Machinery in the Control of Mitophagy

(2019) Liming Wang et al.   TRENDS IN BIOCHEMICAL SCIENCES

SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

(2019) Nils C. Gassen et al.   Nature Communications

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

(2018) Tatsuya Yamada et al.   Cell Metabolism

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

(2018) Rosa Puertollano et al.   EMBO JOURNAL

Structural basis for Cullins and RING component inhibition: Targeting E3 ubiquitin pathway conductors for cancer therapeutics

(2018) Shagufta Shafique et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein–Protein Interaction

(2018) Haibin Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing

(2018) Jie Chen et al.   NATURE

ESCRT and autophagies: Endosomal functions and beyond

(2018) Christophe Lefebvre et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models

(2018) Khaled S. Abd-Elrahman et al.   Molecular Brain

KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect

(2018) Kyle A. Metz et al.   ANNALS OF NEUROLOGY

The emerging role for Cullin 4 family of E3 ligases in tumorigenesis

(2018) Ji Cheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux

(2018) Wei Wan et al.   MOLECULAR CELL

Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitylation at the crossroads of development and disease

(2017) Michael Rape   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitination of exposed glycoproteins by SCFFBXO27directs damaged lysosomes for autophagy

(2017) Yukiko Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mGluR5 antagonism increases autophagy and prevents disease progression in thezQ175mouse model of Huntington’s disease

(2017) Khaled S. Abd-Elrahman et al.   Science Signaling

Emerging Mechanisms in Initiating and Terminating Autophagy

(2017) Manuela Antonioli et al.   TRENDS IN BIOCHEMICAL SCIENCES

A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation

(2017) Haibin Zhou et al.   Nature Communications

Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination

(2017) YouJin Lee et al.   Cell Reports

mGluR5 antagonism increases autophagy and prevents disease progression in thezQ175mouse model of Huntington’s disease

(2017) Khaled S. Abd-Elrahman et al.   Science Signaling

The role of CHMP2BIntron5 in autophagy and frontotemporal dementia

(2016) Christopher S. Krasniak et al.   BRAIN RESEARCH

Recent insights into the function of autophagy in cancer: Table 1.

(2016) Ravi Amaravadi et al.   GENES & DEVELOPMENT

Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination

(2016) Chin-Chih Liu et al.   MOLECULAR CELL

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

(2016) Hi-Jai R. Shin et al.   NATURE

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cullin-RING ligases in regulation of autophagy

(2016) Danrui Cui et al.   Cell Division

Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications

(2016) Hsin-Yi Chen et al.   Frontiers in Oncology

COP9 Signalosome Controls the Degradation of Cytosolic Misfolded Proteins and Protects Against Cardiac ProteotoxicityNovelty and Significance

(2015) Huabo Su et al.   CIRCULATION RESEARCH

FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation

(2015) Juan Xiao et al.   GENES & DEVELOPMENT

F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy

(2015) Zhi Dong Zhou et al.   HUMAN MOLECULAR GENETICS

Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis

(2015) Chuan-Ming Xie et al.   JOURNAL OF CELL BIOLOGY

Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1

(2015) Guoxiang Jin et al.   MOLECULAR CELL

CUL3-KBTBD6/KBTBD7 Ubiquitin Ligase Cooperates with GABARAP Proteins to Spatially Restrict TIAM1-RAC1 Signaling

(2015) Heide Marika Genau et al.   MOLECULAR CELL

FBXW7-Induced MTOR Degradation Forces Autophagy to Counteract Persistent Prion Infection

(2015) Yin Xu et al.   MOLECULAR NEUROBIOLOGY

Protein neddylation: beyond cullin–RING ligases

(2015) Radoslav I. Enchev et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synergistic inhibition of autophagy and neddylation pathways as a novel therapeutic approach for targeting liver cancer

(2015) Ping Chen et al.   Oncotarget

Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors

(2015) Yong-Qiang Liu et al.   Oncotarget

G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L

(2015) Tao Zhang et al.   eLife

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

AMBRA1 Interplay with Cullin E3 Ubiquitin Ligases Regulates Autophagy Dynamics

(2014) Manuela Antonioli et al.   DEVELOPMENTAL CELL

Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy

(2014) Tania Zaglia et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

(2014) Eric S. Fischer et al.   NATURE

XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons

(2013) Hung-Li Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cullin-RING Ligases as Attractive Anti-cancer Targets

(2013) Yongchao Zhao et al.   CURRENT PHARMACEUTICAL DESIGN

WASH inhibits autophagy through suppression of Beclin 1 ubiquitination

(2013) Pengyan Xia et al.   EMBO JOURNAL

Building and remodelling Cullin-RING E3 ubiquitin ligases

(2013) John R Lydeard et al.   EMBO REPORTS

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

The Parkinson's disease–linked proteins Fbxo7 and Parkin interact to mediate mitophagy

(2013) Victoria S Burchell et al.   NATURE NEUROSCIENCE

Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells

(2012) D Yang et al.   CELL DEATH AND DIFFERENTIATION

Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis

(2012) Y Zhao et al.   Cell Death & Disease

Autophagic cell death: Loch Ness monster or endangered species?

(2011) Han-Ming Shen et al.   Autophagy

COP9 Signalosome Regulates Autophagosome Maturation

(2011) Huabo Su et al.   CIRCULATION

Autophagy Suppresses Interleukin-1β (IL-1β) Signaling by Activation of p62 Degradation via Lysosomal and Proteasomal Pathways

(2011) Jongdae Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy

(2011) Yongchao Zhao et al.   MOLECULAR CELL

mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR

(2011) Daming Gao et al.   MOLECULAR CELL

The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses

(2010) Yu-Ru Lee et al.   EMBO JOURNAL

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy

(2009) Claire Pearce et al.   BMC CELL BIOLOGY

REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A–DDB1 ubiquitin ligase

(2009) Samiksha Katiyar et al.   EMBO REPORTS

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy

(2008) Q. Chen et al.   BLOOD

WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase

(2008) J. Hu et al.   GENES & DEVELOPMENT

FBXW7 Targets mTOR for Degradation and Cooperates with PTEN in Tumor Suppression

(2008) Jian-Hua Mao et al.   SCIENCE