标题
Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications
作者
关键词
-
出版物
Frontiers in Oncology
Volume 6, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2016-05-02
DOI
10.3389/fonc.2016.00113
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination
- (2016) Chin-Chih Liu et al. MOLECULAR CELL
- Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation
- (2015) Jian An et al. MOLECULAR CELL
- SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression
- (2015) Wenjian Gan et al. MOLECULAR CELL
- KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination
- (2015) H Y Chen et al. ONCOGENE
- Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover
- (2015) P Zhang et al. Cell Death & Disease
- SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase
- (2015) Hengrui Zhu et al. Cell Reports
- NRF2 Mutation Confers Malignant Potential and Resistance to Chemoradiation Therapy in Advanced Esophageal Squamous Cancer
- (2015) Tatsuhiro Shibata et al. NEOPLASIA
- SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer
- (2014) Guoqiang Li et al. CANCER CELL
- SCP Phosphatases Suppress Renal Cell Carcinoma by Stabilizing PML and Inhibiting mTOR/HIF Signaling
- (2014) Y.-C. Lin et al. CANCER RESEARCH
- Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms: Association with poor prognosis in head and neck cancer
- (2014) Victor D. Martinez et al. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer
- (2014) J.-P. P. Theurillat et al. SCIENCE
- Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation
- (2014) K A Kang et al. Cell Death & Disease
- USP11 regulates PML stability to control Notch-induced malignancy in brain tumours
- (2014) Hsin-Chieh Wu et al. Nature Communications
- Destruction of Full-Length Androgen Receptor by Wild-Type SPOP, but Not Prostate-Cancer-Associated Mutants
- (2014) Jian An et al. Cell Reports
- Unique Pattern of Component Gene Disruption in the NRF2 Inhibitor KEAP1/CUL3/RBX1 E3-Ubiquitin Ligase Complex in Serous Ovarian Cancer
- (2014) Victor D. Martinez et al. Biomed Research International
- DAP-kinase and autophagy
- (2013) Vered Levin-Salomon et al. APOPTOSIS
- The functions and regulations of DAPK in cancer metastasis
- (2013) Hsin-Yi Chen et al. APOPTOSIS
- DAPK and cytoskeleton-associated functions
- (2013) Jelena Ivanovska et al. APOPTOSIS
- The DAP-kinase interactome
- (2013) Shani Bialik et al. APOPTOSIS
- CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma
- (2013) A. Ooi et al. CANCER RESEARCH
- Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis
- (2013) Hironori Satoh et al. CANCER RESEARCH
- Punctuated Evolution of Prostate Cancer Genomes
- (2013) Sylvan C. Baca et al. CELL
- The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications
- (2013) Pascal Genschik et al. EMBO JOURNAL
- BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival
- (2013) Chiara Gorrini et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Impact of miRNA-Based Molecular Diagnostics and Treatment of NRF2-Stabilized Tumors
- (2013) Shinsuke Yamamoto et al. MOLECULAR CANCER RESEARCH
- Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy
- (2013) Yoshinobu Ichimura et al. MOLECULAR CELL
- Mutational landscape and significance across 12 major cancer types
- (2013) Cyriac Kandoth et al. NATURE
- Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover
- (2013) C. Geng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors
- (2013) A. M. Strohecker et al. Cancer Discovery
- Methylation of the KEAP1 gene promoter region in human colorectal cancer
- (2012) Naoyuki Hanada et al. BMC CANCER
- Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
- (2012) Yoichiro Mitsuishi et al. CANCER CELL
- miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4
- (2012) H.-Y. Chen et al. CANCER RESEARCH
- An effective strategy for increasing the radiosensitivity of Human lung Cancer cells by blocking Nrf2-dependent antioxidant responses
- (2012) Saelooom Lee et al. FREE RADICAL BIOLOGY AND MEDICINE
- Somatic mutations of the KEAP1 gene in common solid cancers
- (2012) Nam Jin Yoo et al. HISTOPATHOLOGY
- A metabolic prosurvival role for PML in breast cancer
- (2012) Arkaitz Carracedo et al. JOURNAL OF CLINICAL INVESTIGATION
- The mutational landscape of lethal castration-resistant prostate cancer
- (2012) Catherine S. Grasso et al. NATURE
- Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes
- (2012) Matthieu Le Gallo et al. NATURE GENETICS
- Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
- (2012) Christopher E Barbieri et al. NATURE GENETICS
- Clinical potential of the ERG oncoprotein in prostate cancer
- (2012) Philip Rosen et al. Nature Reviews Urology
- Keap1 degradation by autophagy for the maintenance of redox homeostasis
- (2012) K. Taguchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
- (2012) Gregg L. Semenza TRENDS IN PHARMACOLOGICAL SCIENCES
- Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3–SPOP E3 ubiquitin ligase complex
- (2011) Bogyou Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression
- (2011) Wei-Chien Yuan et al. CANCER CELL
- An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma
- (2011) Aikseng Ooi et al. CANCER CELL
- Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling
- (2011) Julie Adam et al. CANCER CELL
- Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer
- (2011) P. A. Konstantinopoulos et al. CANCER RESEARCH
- Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer
- (2011) Lucia Anna Muscarella et al. Epigenetics
- miR-200a Regulates Nrf2 Activation by TargetingKeap1mRNA in Breast Cancer Cells
- (2011) Gabriel Eades et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- (2011) Gina M. DeNicola et al. NATURE
- The genomic complexity of primary human prostate cancer
- (2011) Michael F. Berger et al. NATURE
- Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1
- (2011) C Li et al. ONCOGENE
- Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
- (2011) D. Ren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Select Heterozygous Keap1 Mutations Have a Dominant-Negative Effect on Wild-Type Keap1 In Vivo
- (2010) T. Suzuki et al. CANCER RESEARCH
- Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features
- (2010) L. M. Solis et al. CLINICAL CANCER RESEARCH
- The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
- (2010) Yu-Ru Lee et al. EMBO JOURNAL
- Promyelocytic Leukemia Protein Controls Cell Migration in Response to Hydrogen Peroxide and Insulin-like Growth Factor-1
- (2010) Erin L. Reineke et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of SRC3/AIB1 as a Preferred Coactivator for Hormone-activated Androgen Receptor
- (2010) X. Edward Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway
- (2010) Ian M. Copple et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
- (2010) Ashish Jain et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
- (2010) A. Lau et al. MOLECULAR AND CELLULAR BIOLOGY
- Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth
- (2010) P. Zhang et al. MOLECULAR CANCER THERAPEUTICS
- Diverse somatic mutation patterns and pathway alterations in human cancers
- (2010) Zhengyan Kan et al. NATURE
- The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
- (2010) Masaaki Komatsu et al. NATURE CELL BIOLOGY
- Alterations in VHL as potential biomarkers in renal-cell carcinoma
- (2010) Lucy Gossage et al. Nature Reviews Clinical Oncology
- Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response
- (2009) Weimin Chen et al. MOLECULAR CELL
- Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases
- (2009) Min Zhuang et al. MOLECULAR CELL
- Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
- (2009) G L Semenza ONCOGENE
- Analysis of Drosophila Segmentation Network Identifies a JNK Pathway Factor Overexpressed in Kidney Cancer
- (2009) J. Liu et al. SCIENCE
- Targeting NRF2 signaling for cancer chemoprevention
- (2009) Mi-Kyoung Kwak et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
- (2008) Rui Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Increased Susceptibility of Nrf2 Knockout Mice to Colitis-Associated Colorectal Cancer
- (2008) T. O. Khor et al. Cancer Prevention Research
- Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth
- (2008) T. Ohta et al. CANCER RESEARCH
- Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
- (2008) X.-J. Wang et al. CARCINOGENESIS
- New insights into the role of PML in tumour suppression
- (2008) P Salomoni et al. CELL RESEARCH
- Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer
- (2008) Tatsuhiro Shibata et al. GASTROENTEROLOGY
- PML targeting eradicates quiescent leukaemia-initiating cells
- (2008) Keisuke Ito et al. NATURE
- Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
- (2008) T. Shibata et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now