Modulation of Mitochondrial Quality Control Processes by BGP-15 in Oxidative Stress Scenarios: From Cell Culture to Heart Failure

Mitochondrial protective effects of PARP-inhibition in hypertension-induced myocardial remodeling and in stressed cardiomyocytes

(2021) K. Ordog et al.   LIFE SCIENCES

BGP-15 Protects against Heart Failure by Enhanced Mitochondrial Biogenesis and Decreased Fibrotic Remodelling in Spontaneously Hypertensive Rats

(2021) Orsolya Horvath et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Electron Transport: Oxidative Phosphorylation, Mitochondrial Oxidant Production, and Methods of Measurement

(2020) Deirdre Nolfi-Donegan et al.   Redox Biology

The Drug Candidate BGP-15 Delays the Onset of Diastolic Dysfunction in the Goto-Kakizaki Rat Model of Diabetic Cardiomyopathy

(2019) Mariann Bombicz et al.   MOLECULES

Mitochondrial Dysfunction in Heart Failure With Preserved Ejection Fraction

(2019) Anupam A. Kumar et al.   CIRCULATION

Mitochondrial electron transport chain, ROS generation and uncoupling (Review)

(2019) Ru‑Zhou Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

P5994Role of BGP-15 treatment in hypertensive heart failure progression and mitochondrial protection

(2019) O Horvath et al.   EUROPEAN HEART JOURNAL

Mitochondrial dysfunction and oxidative stress in heart disease

(2019) Jessica N. Peoples et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

A mitochondrial delicacy: dynamin-related protein 1 and mitochondrial dynamics

(2018) Mason T. Breitzig et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases

(2018) Aliz Szabo et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondrial dysfunction in pathophysiology of heart failure

(2018) Bo Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles

(2018) Massimo Bonora et al.   Nature Reviews Cardiology

BGP-15 Protects against Oxidative Stress- or Lipopolysaccharide-Induced Mitochondrial Destabilization and Reduces Mitochondrial Production of Reactive Oxygen Species

(2017) Katalin Sumegi et al.   PLoS One

Maintenance and Expression of Mammalian Mitochondrial DNA

(2016) Claes M. Gustafsson et al.   Annual Review of Biochemistry

Impaired mitochondrial biogenesis is a common feature to myocardial hypertrophy and end-stage ischemic heart failure

(2016) Annalinda Pisano et al.   CARDIOVASCULAR PATHOLOGY

Mitochondrial dynamics, mitophagy and cardiovascular disease

(2016) César Vásquez-Trincado et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondrial function as a therapeutic target in heart failure

(2016) David A. Brown et al.   Nature Reviews Cardiology

Skeletal Muscle Mitochondrial Content, Oxidative Capacity, and Mfn2 Expression Are Reduced in Older Patients With Heart Failure and Preserved Ejection Fraction and Are Related to Exercise Intolerance

(2016) Anthony J.A. Molina et al.   JACC-Heart Failure

Mitochondrial Fission: Regulation and ER Connection

(2014) Hakjoo Lee et al.   MOLECULES AND CELLS

The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice

(2014) Geeta Sapra et al.   Nature Communications

Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease

(2013) A R Hall et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cardiac Metabolism in Heart Failure

(2013) Torsten Doenst et al.   CIRCULATION RESEARCH

Heart Failure and Mitochondrial Dysfunction

(2013) Anne A. Knowlton et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Mitochondrial dysfunction in heart failure

(2012) Mariana G. Rosca et al.   HEART FAILURE REVIEWS

Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects

(2012) Steen Larsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

BGP-15, a PARP-inhibitor, prevents imatinib-induced cardiotoxicity by activating Akt and suppressing JNK and p38 MAP kinases

(2012) Zsolt Sarszegi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

PGC-1 Proteins and Heart Failure

(2012) Christian Riehle et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Oxidative stress and heart failure

(2011) Hiroyuki Tsutsui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1

(2010) Chuang-Rung Chang et al.   Annals of the New York Academy of Sciences

Mitochondrial morphology and cardiovascular disease

(2010) S.-B. Ong et al.   CARDIOVASCULAR RESEARCH

Regulation of mitochondrial biogenesis

(2010) François R. Jornayvaz et al.   Essays in Biochemistry

Mitochondrial DNA alterations and reduced mitochondrial function in aging

(2010) Sadie L. Hebert et al.   MECHANISMS OF AGEING AND DEVELOPMENT

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

BGP-15 inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury

(2009) Gábor Nagy et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Energy metabolism in heart failure and remodelling

(2008) J. S. Ingwall   CARDIOVASCULAR RESEARCH

Oxidative Stress and Mitochondrial DNA Damage in Heart Failure

(2008) Hiroyuki Tsutsui et al.   CIRCULATION JOURNAL

HSP72 protects against obesity-induced insulin resistance

(2008) J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA