Article
Biochemistry & Molecular Biology
Alexandra Gyongyosi, Nikolett Csaki, Agota Peto, Kitti Szoke, Ferenc Fenyvesi, Ildiko Bacskay, Istvan Lekli
Summary: In this study, it was found that pretreatment with BGP-15 can significantly improve the cardiomyocyte damage caused by DOX. This is mainly achieved by preserving mitochondrial function, reducing mitochondrial ROS production, and modulating the autophagy process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Randa S. Eshaq, Minsup Lee, Wendy Leskova, Norman R. Harris
Summary: Hypertension is associated with changes in the retina and choroid, resulting in increased vascular permeability and microhemorrhages. This study found decreases in certain endothelial surface molecules in hypertensive rats compared to control rats. These changes were both sex-dependent and accompanied by an increase in plasma levels of the proteoglycan, suggesting possible systemic endothelial shedding.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Chemistry, Medicinal
Ye Li, Xin Wei, Shu-Li Liu, Ying Zhao, Si Jin, Xiao-Yan Yang
Summary: The study demonstrates that salidroside can improve both diabetes and diabetic cardiomyopathy, partly due to the activation of mitochondrial SIRT3, AMPK/Akt, and PGC-1 alpha/TFAM pathways, thereby improving mitochondrial function.
PHYTOTHERAPY RESEARCH
(2021)
Article
Cell Biology
Sandra Backes, Yury S. Bykov, Tamara Flohr, Markus Raeschle, Jialin Zhou, Svenja Lenhard, Lena Kraemer, Timo Muehlhaus, Chen Bibi, Cosimo Jann, Justin D. Smith, Lars M. Steinmetz, Doron Rapaport, Zuzana Storchova, Maya Schuldiner, Felix Boos, Johannes M. Herrmann
Summary: Tom70 protein functions at the interface of cytosol and mitochondria, recruiting cytosolic chaperones to the outer mitochondrial membrane to reduce proteotoxicity of mitochondrial precursor proteins.
Article
Environmental Sciences
Xuanfeng Zhu, Min Sun, Hongmei Guo, Gan Lu, Jianhua Gu, Lingling Zhang, Licheng Shi, Jia Gao, Dandan Zhang, Wenjun Wang, Jiannan Liu, Xia Wang
Summary: This study demonstrates that verbascoside can exert cardioprotective effects in septic heart injury by inhibiting oxidative stress, inflammation, and apoptosis, as well as promoting mitochondrial biogenesis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Pharmacology & Pharmacy
Xavier Sainsily, David Coquerel, Hugo Giguere, Lauralyne Dumont, Kien Tran, Christophe Noll, Andrei L. Ionescu, Jerome Cote, Jean-Michel Longpre, Andre Carpentier, Eric Marsault, Olivier Lesur, Philippe Sarret, Mannix Auger-Messier
Summary: The experiment revealed that under high-salt diet conditions, Elabela was more effective than Apelin-13 in reducing high blood pressure, cardiovascular and renal dysfunctions, and displayed better protective effects in salt-induced severe hypertension and cardiorenal failure.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jun Cheng, Wenduo Gu, Ting Lan, Jiacheng Deng, Zhichao Ni, Zhongyi Zhang, Yanhua Hu, Xiaolei Sun, Yan Yang, Qingbo Xu
Summary: This study systematically characterized vascular remodelling in hypertension using SHRs, revealing dysregulated genes specific for artery types and cell types. The expansion of MSCs in MA and increased immune cells in AA were notable findings, pointing to artery type- and cell type-specific changes during hypertensive vascular remodelling.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kanako Matsuoka, Hidenori Akaihata, Junya Hata, Ryo Tanji, Ruriko Honda-Takinami, Akifumi Onagi, Seiji Hoshi, Tomoyuki Koguchi, Yuichi Sato, Masao Kataoka, Soichiro Ogawa, Yoshiyuki Kojima
Summary: This study evaluated the effects of orally administered l-theanine in spontaneously hypertensive rats with bladder dysfunction induced by chronic sympathetic hyperactivity. The results showed that l-theanine significantly decreased sympathetic nervous system activity, increased bladder capacity, and improved bladder contractility, suggesting its potential in preventing bladder dysfunction caused by chronic sympathetic hyperactivity.
Article
Pharmacology & Pharmacy
Mate Kozma, Mariann Bombicz, Balazs Varga, Daniel Priksz, Rudolf Gesztelyi, Vera Tarjanyi, Rita Kiss, Reka Szekeres, Barbara Takacs, Akos Menes, Jozsef Balla, Gyorgy Balla, Judit Szilvassy, Zoltan Szilvassy, Bela Juhasz
Summary: Impaired mitochondrial function is associated with metabolic diseases and cardiovascular diseases. The BGP-15 derivative of vitamin B3 shows therapeutic potential in improving cardiac function and protecting mitochondrial respiration.
Article
Food Science & Technology
Yueh-Min Lin, Khan Farheen Badrealam, Wei-Wen Kuo, Pei Fang Lai, William Shao-Tsu Chen, Cecilia Hsuan Day, Tsung-Jung Ho, Vijaya Padma Viswanadha, Marthandam Asokan Shibu, Chih-Yang Huang
Summary: Nerolidol has been shown to ameliorate hypertension-induced cardiac injuries by targeting the TLR4/NF-kappa B signaling pathway, leading to reduced inflammation and oxidative stress, and providing effective cardioprotection. Echocardiography analysis demonstrated improved cardiac functional characteristics in hypertensive rats treated with nerolidol, highlighting its potential as a cardio-protective agent against hypertension-induced cardiac remodeling.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Integrative & Complementary Medicine
Yifan Guo, Mengdi Wang, Yufei Liu, Yanyu Pang, Lei Tian, Jingwen Zhao, Mengchao Liu, Cun Shen, Yuan Meng, Yuefen Wang, Zhen Cai, Wenjing Zhao
Summary: This study aimed to investigate the effects of the Chinese herbal formula BaoShenTongLuo (BSTL) on podocyte injury in diabetic kidney disease (DKD) and the role of AMPK-mediated mitochondrial biogenesis. The results showed that BSTL reduced podocyte damage and improved renal function in db/db mice, accompanied by increased mitochondrial biogenesis and suppression of podocyte apoptosis. These effects were mediated through the AMPK pathway.
Article
Pharmacology & Pharmacy
Wen Li, Luhong Li, Siyu Guan
Summary: Icariin (ICA) reduces blood pressure in rats and improves cardiac function and cardiomyocyte morphology by decreasing apoptosis in cardiomyocytes through down-regulation of mitochondrial and endoplasmic reticulum (ER) stress-related apoptosis pathways.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Wang Liao, Xinyi Cao, Tingqing Yu, Kun Lu, Hui Xia, Shaokang Wang, Guiju Sun, Evan Yiwen Yu
Summary: This study aimed to investigate the effects and mechanisms of egg white protein hydrolysate (EWH) in a female hypertensive animal model. The results showed that high-dose treatment of EWH significantly reduced blood pressure in female spontaneously hypertensive rats (SHRs). Bioinformatic analyses revealed differentially expressed RNAs and identified a central network involved in the regulation of blood pressure. These findings provide novel insights into the antihypertensive effects of food protein-derived peptides.
Article
Biochemistry & Molecular Biology
Fedor Simko, Tomas Baka, Peter Stanko, Kristina Repova, Kristina Krajcirovicova, Silvia Aziriova, Oliver Domenig, Stefan Zorad, Michaela Adamcova, Ludovit Paulis
Summary: This study investigated whether sacubitril/valsartan and ivabradine can prevent left ventricular fibrotic remodelling and dysfunction in a rat model of hypertension, and found that the protective effects of sacubitril/valsartan may be associated with RAAS alterations, while the benefits of ivabradine were not related to RAAS modulation.
Article
Critical Care Medicine
Leijing Yin, Yuting Tang, Zhengyang Luo, Ludong Yuan, Xiaofang Lin, Shuxin Wang, Pengfei Liang, Bimei Jiang
Summary: The study aimed to investigate the protective role of nucleolin (NCL) in lipopolysaccharide (LPS)-induced myocardial injury from the aspect of mitochondrial biogenesis. The study found that NCL could protect cardiomyocytes from LPS-induced injury by promoting the gene expression of PGC-1a and mitochondrial biogenesis.
Article
Immunology
Maja Bogdan, Ljilijana Peric, Katalin Ordog, Dubravka Vukovic, Edit Urban, Jozsef Soki
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA
(2018)
Article
Multidisciplinary Sciences
Gabor T. Szilagyi, Arkadiusz M. Nawrocki, Krisztian Eros, Janos Schmidt, Katalin Fekete, Maria L. Elkjaer, Kirsten H. Hyrlov, Martin R. Larsen, Zsolt Illes, Ferenc Gallyas
Article
Multidisciplinary Sciences
Zita Bognar, Anna Maria Cseh, Katalin Fekete, Csenge Antus, Rita Bognar, Antal Tapodi, Fadi H. J. Ramadan, Balazs Sumegi, Ferenc Gallyas
Article
Medicine, Research & Experimental
K. Ordog, O. Horvath, K. Eros, K. Bruszt, Sz Toth, D. Kovacs, N. Kalman, B. Radnai, L. Deres, F. Gallyas, K. Toth, R. Halmosi
Summary: The study demonstrated that PARP-1 inhibition can effectively prevent the development of left ventricular hypertrophy in SHRs, improve mitochondrial quality control processes and functions. This treatment not only inhibits mitochondrial fission, but also increases the amount of fusion proteins, maintaining mitochondrial structural stability and preserving mitochondrial genome integrity.
Article
Cell Biology
Orsolya Horvath, Katalin Ordog, Kitti Bruszt, Nikoletta Kalman, Dominika Kovacs, Balazs Radnai, Ferenc Gallyas, Kalman Toth, Robert Halmosi, Laszlo Deres
Summary: BGP-15 demonstrates protective effects on mitochondria by inhibiting fission, promoting fusion, preserving mitochondrial genome, and enhancing biogenesis. These effects help maintain mitochondrial function under oxidative stress induced by hydrogen peroxide and in an in vivo heart failure model, suggesting a novel therapeutic approach for heart failure.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Kitti Andreidesz, Aliz Szabo, Dominika Kovacs, Balazs Koszegi, Viola Bagone Vantus, Eszter Vamos, Mostafa Isbera, Tamas Kalai, Zita Bognar, Krisztina Kovacs, Ferenc Gallyas
Summary: HO-5114, a novel mitochondria-targeted compound, showed high cytotoxicity against human breast cancer cell lines by significantly reducing viability and promoting apoptosis. However, the drug did not significantly increase reactive oxygen species, indicating that oxidative stress may not play a major role in its anti-neoplastic effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Dominika Kovacs, Viola Bagone Vantus, Eszter Vamos, Nikoletta Kalman, Rudolf Schicho, Ferenc Gallyas, Balazs Radnai
Summary: The study showed that the PARP inhibitor olaparib improved experimental Crohn's disease by reducing inflammation, enhancing barrier integrity, and regulating cytokine levels. In both the TNBS-induced mouse colitis model and Caco-2 monolayer culture, olaparib demonstrated anti-inflammatory and protective effects on the epithelial barrier.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Ferenc Gallyas, Fadi H. J. Ramadan, Kitti Andreidesz, Eniko Hocsak, Aliz Szabo, Antal Tapodi, Gyongyi N. Kiss, Katalin Fekete, Rita Bognar, Arpad Szanto, Zita Bognar
Summary: The study found that desethylamiodarone (DEA) may have potential in the treatment of triple-negative breast cancer (TNBC). DEA reduced the viability, colony formation, and invasive growth of TNBC cell lines, while also affecting mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Balazs Koszegi, Gabor Balogh, Zoltan Berente, Anett Vranesics, Edit Pollak, Laszlo Molnar, Aniko Takatsy, Viktoria Poor, Matyas Wahr, Csenge Antus, Krisztian Eros, Laszlo Vigh, Ferenc Gallyas, Maria Peter, Balazs Veres
Summary: Recent studies have shown that the absence of cyclophilin D (CypD) affects glucose and lipid metabolism, resulting in lipid-specific alterations. Our analysis of CypD-/- mice compared to wild-type mice revealed significant changes in lipid species in liver and plasma samples. This study highlights the potential long-term therapeutic implications of CypD inhibition for various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eszter Vamos, Nikoletta Kalman, Eva Maria Sturm, Barsha Baisakhi Nayak, Julia Teppan, Viola Bagone Vantus, Dominika Kovacs, Lilla Makszin, Tamas Lorand, Ferenc Gallyas Jr, Balazs Radnai
Summary: Macrophage polarization plays a crucial role in autoimmunity. The study reveals that macrophage migration inhibitory factor (MIF) regulates M1 macrophage polarization and KRP-6, a potent MIF ketonase inhibitor, can prevent M1 macrophage polarization and improve mitochondrial function while reducing glycolysis. In addition, KRP-6 reduces the migration of specific blood cells and attenuates downregulation of certain mRNA expressions.