Article
Oncology
V. Vlaeminck-Guillem
Summary: Exosomes play a significant role in cancer research, including their involvement in pathophysiological mechanisms, as biomarkers, and as therapeutic tools. However, their use in routine clinical practice and management of prostate cancer still requires further confirmation and generalization.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Xin Jin, Jin Ji, Decao Niu, Yuchen Yang, Shuchun Tao, Lilin Wan, Bin Xu, Shuqiu Chen, Fubo Wang, Ming Chen
Summary: This study aimed to identify and validate urine exosomal AMACR (UE-A) as a novel biomarker to improve the detection of prostate cancer (PCa) and clinically significant PCa (csPCa) at initial biopsy. The results demonstrated the great performance of UE-A in the early diagnosis of PCa and csPCa, suggesting that it could be a novel non-invasive diagnostic biomarker to improve the detection of PCa and csPCa.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Hangsheng Zhou, Hongyuan Wan, Yanyan Feng, Lijie Zhu, Yuanyuan Mi
Summary: This article summarizes the research on the diagnostic roles and mechanistic functions of exosomal lncRNAs in prostate cancer.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Dwaipayan Dey, Srestha Ghosh, Divya Mirgh, Siva Parsad Panda, Niraj Kumar Jha, Saurabh Kumar Jha
Summary: This review discusses the role of exosomes in prostate cancer and their association with male fertility.
DRUG DISCOVERY TODAY
(2023)
Article
Oncology
Wen Tao, Zi-Huan Luo, Ya-Di He, Bang-Yu Wang, Tao-Lin Xia, Wei-Ming Deng, Ling-Xiao Zhang, Xiu-Mei Tang, Zhan-Ao Meng, Xin Gao, Liao-Yuan Li
Summary: This study developed a plasma extracellular circRNA-based signature that can predict overall survival in mCRPC patients undergoing abiraterone therapy.
BRITISH JOURNAL OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Yohan Kim, Edwin van der Pol, Ali Arafa, Ishwor Thapa, Cameron J. Britton, Jorgena Kosti, Siyang Song, Vidhu B. Joshi, Ree M. Erickson, Hesham Ali, Fabrice Lucien
Summary: Extracellular vesicles (EVs) are microscopic particles released naturally in biofluids and can serve as promising liquid biomarkers for human diseases. Flow cytometry is a popular method for detecting, characterizing, and determining the concentration of EVs. However, the limited awareness and utilization of standardization and calibration methods in the scientific community pose challenges for data reproducibility and inter-laboratory comparison. This study presents guidelines and best practices for flow cytometry in EV research, providing a systematic approach to evaluate performance and improve detection sensitivity for EVs.
Review
Pharmacology & Pharmacy
Ali Vahabi, Jafar Rezaie, Mehdi Hassanpour, Yunes Panahi, Mohadeseh Nemati, Yousef Rasmi, Mahdieh Nemati
Summary: Recently, circRNAs have gained increasing interest due to their abundant expression and potential functions in cancer development. They may act as sponge for miRNAs and proteins, promoting cancer progression. CircRNAs frequently show tumor-specific expression and can serve as diagnostic and prognostic biomarkers for cancers. They can also be potential targets for cancer treatment as they can sponge oncogenic miRNAs and proteins. Exosomes, containing circRNAs, deliver them to target cells and induce cancer development through different signaling pathways. Exosomal circRNAs may serve as diagnostic and prognostic biomarker for cancers. Targeting exosomes may represent novel therapeutic approaches for cancer treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Theresa Akoto, Sharanjot Saini
Summary: Prostate cancer is a life-threatening disease among men globally, with metastasis being the major cause of mortality. Cell-to-cell communication plays a crucial role in the progression and metastasis of prostate cancer, with exosomes/extracellular vesicles demonstrating significant involvement in signaling pathways related to metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Laura Schneider, Temuujin Dansranjav, Elena Neumann, Hang Yan, Adrian Pilatz, Hans-Christian Schuppe, Florian Wagenlehner, Undraga Schagdarsurengin
Summary: The study found that urine exosomes of patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) contain microRNAs that are associated with prostate cancer (PCa) and lead to the upregulation of genes and pathways related to tumorigenesis. In contrast, blood exosomes showed similarity to those of healthy men. Therefore, CP/CPPS plays an important role in the development of PCa biomarkers and cancer screening programs.
MOLECULAR ONCOLOGY
(2023)
Review
Medicine, Research & Experimental
Yi Li, Wei Feng, Mingzhu Kong, Ruoyu Liu, Anqi Wu, Lei Shen, Zhiyuan Tang, Feng Wang
Summary: Circular RNAs (circRNAs), a stable closed loop RNA closely related to cancer, and exosomes, important mediators in cell communication and tumor development, have been found to play significant roles in cancer progression. Abnormally expressed circRNAs are associated with malignancies, making them potential diagnostic and prognostic biomarkers. Researchers are focusing on the functions, mechanisms, and values of exosomal circRNAs to provide new ideas for cancer diagnosis and treatment.
Review
Andrology
Koji Hatano, Kazutoshi Fujita
Summary: Remarkable progress has been made in prostate cancer biomarker discovery using liquid biopsies, with EVs showing potential as biomarkers for diagnosis and disease progression prediction in prostate cancer. EVs play a role in tumor microenvironment development and cancer progression.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Review
Oncology
Zihan Ran, Shaobo Wu, Zijng Ma, Xiuwen Chen, Jing Liu, Jingcheng Yang
Summary: Cervical cancer is one of the most common malignancies in females globally. Exosomes, a type of extracellular vesicles released by various cells, play a crucial role in biological processes through carrying proteins and genetic material from their parent cells. This review article focuses on the investigation of exosomes in cervical cancer, particularly their components. The findings suggest that exosomes in cervical cancer regulate the behavior of cancer cells by affecting various biological pathways. Additionally, exosomal RNAs and proteins show potential as biomarkers for cervical cancer. Furthermore, cancer-derived exosomes are found to play a critical role in the metastasis and progression of cervical cancer.
Article
Cell Biology
Michele Signore, Romina Alfonsi, Giulia Federici, Simona Nanni, Antonio Addario, Lucia Bertuccini, Aurora Aiello, Anna Laura Di Pace, Isabella Sperduti, Giovanni Muto, Alessandro Giacobbe, Devis Collura, Lidia Brunetto, Giuseppe Simone, Manuela Costantini, Lucio Crino, Stefania Rossi, Claudio Tabolacci, Marco Diociaiuti, Tania Merlino, Michele Gallucci, Steno Sentinelli, Rocco Papalia, Ruggero De Maria, Desiree Bonci
Summary: Extracellular vesicles (EVs) and their cargo are potential cancer biomarkers for liquid biopsy, and using antibody-based proteomic technology can help identify tumor-specific protein profiles in EVs. The analysis of EVs from prostate cancer patients' serum has shown promising results for tumor diagnosis and prognosis, indicating the potential of this innovative approach in translational medicine.
CELL DEATH & DISEASE
(2021)
Review
Obstetrics & Gynecology
Qianrun Chen, Jiayan Shi, Danhua Ruan, Ce Bian
Summary: This review provides a brief introduction to the biological characteristics of exosomes and the recent advances in isolating and detecting them. It also summarizes the various functions of exosomes in ovarian cancer, highlighting their potential as diagnostic biomarkers and therapeutic targets.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Oncology
Sreerenjini Lakshmi, Thomas A. Hughes, Sulochana Priya
Summary: Exosomes and their RNA have potential roles in breast cancer biology and treatment, participating in breast cancer tumorigenesis and progression through the transfer of miRNAs and LncRNAs. The diagnostic and therapeutic applications of exosomal miRNAs/LncRNAs in breast cancer have been highlighted in numerous publications.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Chemistry, Physical
Shichao Ding, Zhaoyuan Lyu, Erik Sarnello, Mingjie Xu, Lingzhe Fang, Hangyu Tian, Sam Ellery Karcher, Tao Li, Xiaoqing Pan, John McCloy, Guodong Ding, Qiang Zhang, Qiurong Shi, Dan Du, Jin-Cheng Li, Xiao Zhang, Yuehe Lin
Summary: In this study, a MnOx engineered Fe-N-C single-atom catalyst (Mn-Fe-N-C SAC) was developed to reduce oxidative corrosion and enhance the stability of the oxygen reduction reaction (ORR). The Mn-Fe-N-C SAC exhibited ultralow H2O2 yield and negligible potential shift after continuous potential cycles, demonstrating excellent ORR stability and improved activity compared to common Fe-N-C SACs. The interaction between MnOx and Fe-N-x sites enhanced the intrinsic activity of single iron sites, providing a promising solution for the stability issue of Fe-N-C SACs while maintaining high catalytic activity.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Biophysics
Xiaofan Ruan, Victoria Hulubei, Yijia Wang, Qiurong Shi, Nan Cheng, Limin Wang, Zhaoyuan Lyu, William C. Davis, Jordan N. Smith, Yuehe Lin, Dan Du
Summary: Increased use of pesticides in agriculture requires advanced techniques to monitor environmental levels and human exposure. This study developed a new sensor for rapid detection of the major metabolite of atrazine exposure. The use of mesoporous core-shell nanoparticles and a 3D printed readout device provides a promising tool for on-site and ultrasensitive detection of pesticide biomarkers.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Chemistry, Analytical
Weiqing Xu, Yu Wu, Lei Jiao, Wenling Gu, Dan Du, Yuehe Lin, Chengzhou Zhu
Summary: This article summarizes the fabrication and application of MOFs-based nanozymes. Various MOFs-based nanomaterials, including pristine MOFs, functionalized MOFs, MOFs-based composites, and MOFs derivatives, are introduced, with a focus on design strategy, enzyme-like activity, and catalytic mechanisms. Their applications in various target assays are summarized, and the challenges and research directions for the development and application of MOFs-based nanozymes are provided.
CURRENT ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xin Li, Shichao Ding, Zhaoyuan Lyu, Peter Tieu, Maoyu Wang, Zhenxing Feng, Xiaoqing Pan, Yang Zhou, Xiangheng Niu, Dan Du, Wenlei Zhu, Yuehe Lin
Summary: This work presents the design and synthesis of single-atomic iron doped carbon dots with tunable fluorescence and exceptional oxidase-mimetic activity. Phosphate ions can suppress the activity and restore the photoluminescence of the carbon dots, leading to the development of a dual-mode colorimetric and fluorescence assay for phosphate monitoring.
Article
Chemistry, Physical
Shichao Ding, Lin He, Lingzhe Fang, Yuanzhi Zhu, Tao Li, Zhaoyuan Lyu, Dan Du, Yuehe Lin, Jin-Cheng Li
Summary: This study proposes a carbon nanotube-bridging strategy to synthesize a highly efficient oxygen electrocatalyst for the development of high-performance and long-life rechargeable zinc-air batteries. The results show that the developed catalyst exhibits good electrochemical performance and cycle stability.
ADVANCED ENERGY MATERIALS
(2022)
Review
Chemistry, Inorganic & Nuclear
Guohai Yang, Fanglei Liu, Jiayi Zhao, Lijie Fu, Yingqiu Gu, Lulu Qu, Chengzhou Zhu, Jun-Jie Zhu, Yuehe Lin
Summary: In this review, the latest research on MXenes in the fields of biosensing and biomedicine is summarized. The synthesis strategies and unique properties of MXenes are introduced, and the biosensing applications of MXenes are divided into three subcategories based on the sensing mechanism: electrochemical, photochemical, and opto-electrochemical biosensors. The biomedical applications of MXenes are evaluated from four aspects: antibacterial activity, bioimaging, therapeutics, and theranostics. The specific chemical and physical properties of MXenes that influence the efficiency of biosensing and biomedicine are highlighted, as well as the structure-performance relationships determining detection sensitivity and material toxicity. The challenges, future prospects, and opportunities for MXenes are discussed.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Physical
Xiao-Qian Zhang, Zhaoyuan Lyu, Shichao Ding, Shiyong Zhao, Guangyu Chen, Yuehe Lin, Jin-Cheng Li
Summary: A molten-salt-assisted pyrolysis strategy was used to prepare two-dimensional porous metal-nitrogen/carbon materials with exposed metal-nitrogen sites, which showed excellent performance in both liquid-state and solid-state Zn-air fuel cells.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Electrochemistry
Daniel E. Molina, Nathalie A. Wall, Haluk Beyenal, Cornelius F. Ivory
Summary: We used an improved version of our hyphenated analysis technique, flow injection electrochemical quartz crystal microbalance with inductively coupled optical emission spectroscopy (FI-EQCM-ICP-OES), to investigate the electroprecipitation of lanthanum and neodymium from flowing solutions. The improved technique has two independent flow injection circuits, allowing different conditions for electrochemical precipitation and quick stripping. Lanthanum or neodymium ions were injected into a carrier stream and deposited onto an electrochemical quartz crystal microbalance (EQCM), and the deposits were subsequently stripped and analyzed using an ICP-OES. We found that using acidic solutions without supporting electrolyte leads to an increase in the amount of lanthanum detected.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Juan Liu, Xiaoxiao Guo, Zhaoyuan Lyu, Rong-Bin Song, Pengyu Zhou, Shichao Ding, Yang Zhou, Li-Ping Jiang, Yuehe Lin, Wenlei Zhu
Summary: By using copper electrocatalysts and microorganisms, an electro-bio tandem reactor was designed to convert CO2 into specific multicarbon compounds in both the gas and liquid phases. The reducing products from electrocatalysis can be consumed and recycled for selective acetate synthesis in Moorella thermoacetica. The results showed high faradaic selectivity for acetate in liquid products for Cu-based CO2 electroreduction and high electron conversion rate to ethylene and acetate for microbial electrosynthesis, presenting a green design for CO2 upcycling targeting multicarbon products through the parallel integration of electrocatalysis and fermentation.
Review
Chemistry, Multidisciplinary
Weiqing Xu, Yu Wu, Wenling Gu, Dan Du, Yuehe Lin, Chengzhou Zhu
Summary: Metal-organic frameworks (MOFs) have made significant advances as mimics of metalloenzymes in bioinspired catalysis, particularly in the field of active pocket engineering at the atomic level.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Yifan Chai, Zhaoyuan Lyu, Huitong Du, Pan Li, Shichao Ding, Yujing Jiang, Hua Wang, Qianhao Min, Dan Du, Yuehe Lin, Wenlei Zhu
Summary: This article introduces the fermentative hydrogen production method for biohydrogen and explores the principles of microbial dark fermentation and photo-fermentation in depth. It summarizes the strategies to increase the efficiency of fermentative hydrogen production and describes some recent representative works.
Article
Chemistry, Multidisciplinary
Shuo Feng, Rajesh Kumar Singh, Yucheng Fu, Zhuo Li, Yulong Wang, Jie Bao, Zhijie Xu, Guosheng Li, Cassidy Anderson, Lili Shi, Yuehe Lin, Peter G. Khalifah, Wei Wang, Jun Liu, Jie Xiao, Dongping Lu
Summary: In this study, a simple strategy was demonstrated for constructing low-tortuosity through-pores in both vertical and planar directions of electrodes by casting large particles into single-particle-layer electrodes. Through multi-scale characterizations and simulations, correlations between material/electrode structures, electrolyte permeability, polysulfide migration, and sulfur reactions were elucidated. The high-loading and dense sulfur cathode fabricated by this method delivers a high specific capacity at a very low electrolyte/sulfur ratio.
ENERGY & ENVIRONMENTAL SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Yu Wu, Weiqing Xu, Lei Jiao, Wenling Gu, Dan Du, Liuyong Hu, Yuehe Lin, Chengzhou Zhu
Summary: Enzymes have great potential in various fields due to their high activity and specificity for catalysis under mild conditions. However, they struggle to adapt to different environments outside of their familiar biological conditions. Nanobiocatalysis, which integrates nanotechnology and enzymatic catalysis, aims to design biocatalysis based on materials science. Nano-integrated biocatalysis and bio-inspired nanocatalysis are two effective nanobiocatalytic systems that can meet different design needs, and their combination opens up even more possibilities. This review summarizes the types, constructions, and functions of nanobiocatalytic systems, analyzing the pros and cons of different strategies. Additionally, it highlights their applications in bioassay, biotherapy, and environmental remediation.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Physical
Hangyu Tian, Wenlei Zhu, Qiurong Shi, Shichao Ding, Zhaoyuan Lyu, Mingjie Xu, Xiaoqing Pan, Mark H. Engelhard, Du Dan, Yuehe Lin
Summary: This work presents a facile method for synthesizing robust Ir-based bimetallic MNNs by chemical reduction. The optimized IrxPb catalyst delivers an enhanced oxygen evolution reaction (OER) performance in acid media, superior to that of the commercial IrO2 catalyst.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)