Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily

The architecture of EMC reveals a path for membrane protein insertion

(2020) John P O'Donnell et al.   eLife

Structure of the ER membrane complex, a transmembrane-domain insertase

(2020) Lin Bai et al.   NATURE

Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex

(2020) Melanie A. McDowell et al.   MOLECULAR CELL

An ER translocon for multi-pass membrane protein biogenesis

(2020) Philip T McGilvray et al.   eLife

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

(2020) Lakshmi E Miller-Vedam et al.   eLife

Polarity/charge as a determinant of translocase requirements for membrane protein insertion

(2020) Balasubramani Hariharan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Ways of Tails: the GET Pathway and more

(2019) Nica Borgese et al.   PROTEIN JOURNAL

Tracking the Stepwise Movement of a Membrane-inserting Protein In Vivo

(2019) Haoze He et al.   JOURNAL OF MOLECULAR BIOLOGY

Transmembrane Domain Recognition during Membrane Protein Biogenesis and Quality Control

(2018) Alina Guna et al.   CURRENT BIOLOGY

Structure of YidC from Thermotoga maritima and its implications for YidC-mediated membrane protein insertion

(2018) Yanlong Xin et al.   FASEB JOURNAL

Oxa1 Superfamily: New Members Found in the ER

(2018) Yuanyuan Chen et al.   TRENDS IN BIOCHEMICAL SCIENCES

The interaction network of the YidC insertase with the SecYEG translocon, SRP and the SRP receptor FtsY

(2018) Narcis-Adrian Petriman et al.   Scientific Reports

Each protomer of a dimeric YidC functions as a single membrane insertase

(2018) Dirk Spann et al.   Scientific Reports

The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

(2018) Matthew J Shurtleff et al.   eLife

2.8-Å crystal structure of Escherichia coli YidC revealing all core regions, including flexible C2 loop

(2018) Yoshiki Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

EMC Is Required to Initiate Accurate Membrane Protein Topogenesis

(2018) Patrick J. Chitwood et al.   CELL

The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis

(2018) Norbert Volkmar et al.   JOURNAL OF CELL SCIENCE

TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions

(2017) Heonjong Han et al.   NUCLEIC ACIDS RESEARCH

The ER membrane protein complex is a transmembrane domain insertase

(2017) Alina Guna et al.   SCIENCE

YidC Insertase of Escherichia coli : Water Accessibility and Membrane Shaping

(2017) Yuanyuan Chen et al.   STRUCTURE

Tail-Anchored Protein Insertion by a Single Get1/2 Heterodimer

(2017) Benjamin E. Zalisko et al.   Cell Reports

Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum

(2017) S. Andrei Anghel et al.   Cell Reports

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A central cavity within the holo-translocon suggests a mechanism for membrane protein insertion

(2016) Mathieu Botte et al.   Scientific Reports

Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis

(2016) Alexej Kedrov et al.   Cell Reports

In vitroreconstitution of co-translational D1 insertion reveals a role of the cpSec–Alb3 translocase and Vipp1 in photosystem II biogenesis

(2015) Björn Walter et al.   BIOCHEMICAL JOURNAL

YidC/Alb3/Oxa1 Family of Insertases

(2015) Seth W. Hennon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Get3 targeting factor in complex with its membrane protein cargo

(2015) A. Mateja et al.   SCIENCE

A YidC-like Protein in the Archaeal Plasma Membrane

(2015) Marta T. Borowska et al.   STRUCTURE

Cross-Linking-Based Flexibility and Proximity Relationships between the TM Segments of the Escherichia coli YidC

(2014) Seth W. Hennon et al.   BIOCHEMISTRY

Structural basis of Sec-independent membrane protein insertion by YidC

(2014) Kaoru Kumazaki et al.   NATURE

The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase

(2014) Fei Wang et al.   NATURE

How YidC inserts and folds proteins across a membrane

(2014) Ross E Dalbey et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential gradients of interaction affinities drive efficient targeting and recycling in the GET pathway

(2014) Michael E. Rome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of Escherichia coli YidC, a membrane protein chaperone and insertase

(2014) Kaoru Kumazaki et al.   Scientific Reports

A structural model of the active ribosome-bound membrane protein insertase YidC

(2014) Stephan Wickles et al.   eLife

YidC Occupies the Lateral Gate of the SecYEG Translocon and Is Sequentially Displaced by a Nascent Membrane Protein

(2013) Ilie Sachelaru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidating the Native Architecture of the YidC: Ribosome Complex

(2013) Alexej Kedrov et al.   JOURNAL OF MOLECULAR BIOLOGY

The C-terminal regions of YidC fromRhodopirellula balticaandOceanicaulis alexandriibind to ribosomes and partially substitute for SRP receptor function inEscherichia coli

(2013) Ines Seitl et al.   MOLECULAR MICROBIOLOGY

Structural insight into the biogenesis of β-barrel membrane proteins

(2013) Nicholas Noinaj et al.   NATURE

Structural model for the protein-translocating element of the twin-arginine transport system

(2013) F. Rodriguez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Targeting and Insertion of Tail-Anchored Membrane Proteins by the GET Pathway

(2013) V. Denic et al.   Cold Spring Harbor Perspectives in Biology

Get1 Stabilizes an Open Dimer Conformation of Get3 ATPase by Binding Two Distinct Interfaces

(2012) Keiko Kubota et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Machinery for Insertion of Tail-Anchored Membrane Proteins into the Endoplasmic Reticulum Membrane in Mammalian Cells

(2012) Yasunori Yamamoto et al.   MOLECULAR CELL

Dynamic Disulfide Scanning of the Membrane-inserting Pf3 Coat Protein Reveals Multiple YidC Substrate Contacts

(2011) Christian Klenner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Promiscuous targeting of polytopic membrane proteins to SecYEG or YidC by the Escherichia coli signal recognition particle

(2011) Thomas Welte et al.   MOLECULAR BIOLOGY OF THE CELL

The Mechanism of Tail-Anchored Protein Insertion into the ER Membrane

(2011) Fei Wang et al.   MOLECULAR CELL

The mechanism of membrane-associated steps in tail-anchored protein insertion

(2011) Malaiyalam Mariappan et al.   NATURE

Structural Basis for Tail-Anchored Membrane Protein Biogenesis by the Get3-Receptor Complex

(2011) S. Stefer et al.   SCIENCE

The C Terminus of the Alb3 Membrane Insertase Recruits cpSRP43 to the Thylakoid Membrane

(2009) Sebastian Falk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualization of Distinct Entities of the SecYEG Translocon during Translocation and Integration of Bacterial Proteins

(2009) Diana Boy et al.   MOLECULAR BIOLOGY OF THE CELL

YidC and Oxa1 Form Dimeric Insertion Pores on the Translating Ribosome

(2009) Rebecca Kohler et al.   MOLECULAR CELL

The structural basis of tail-anchored membrane protein recognition by Get3

(2009) Agnieszka Mateja et al.   NATURE

The Crystal Structures of Yeast Get3 Suggest a Mechanism for Tail-Anchored Protein Membrane Insertion

(2009) Junbin Hu et al.   PLoS One

Homozygous frameshift mutation in TMCO1 causes a syndrome with craniofacial dysmorphism, skeletal anomalies, and mental retardation

(2009) B. Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into tail-anchored protein binding and membrane insertion by Get3

(2009) Gunes Bozkurt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Model for eukaryotic tail-anchored protein binding based on the structure of Get3

(2009) C. J. M. Suloway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane

(2008) Maya Schuldiner et al.   CELL

The Conserved Third Transmembrane Segment of YidC Contacts NascentEscherichia coliInner Membrane Proteins

(2008) Zhong Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY