Immune cartography of macrophage activation syndrome in the COVID-19 era

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Moving towards a systems-based classification of innate immune-mediated diseases

(2020) Sinisa Savic et al.   Nature Reviews Rheumatology

Tocilizumab not associated with increased infection risk after CAR T - Implications for COVID-19?

(2020) Matthew J Frigault et al.   BLOOD

Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary Hemophagocytic Lymphohistiocytosis

(2020) George Dimopoulos et al.   Cell Host & Microbe

The genetics of macrophage activation syndrome

(2020) Grant S. Schulert et al.   GENES AND IMMUNITY

Safety and efficacy of early high-dose IV anakinra in severe COVID-19 lung disease

(2020) Emanuele Pontali et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Haemophagocytic lymphohistiocytosis (HLH) in patients with large B-cell lymphoma treated with standard of care (SOC) axicabtagene ciloleucel (Axi-cel).

(2020) Sairah Ahmed et al.   JOURNAL OF CLINICAL ONCOLOGY

Profiling COVID-19 pneumonia progressing into the cytokine storm syndrome: results from a single Italian Centre study on tocilizumab versus standard of care

(2020) Luca Quartuccio et al.   JOURNAL OF CLINICAL VIROLOGY

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis

(2020) Franco Locatelli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immune Checkpoint Inhibitor-Related Cytokine Release Syndrome: Analysis of WHO Global Pharmacovigilance Database

(2020) Alessandro Ceschi et al.   Frontiers in Pharmacology

Increased cardiovascular mortality in African Americans with COVID-19

(2020) Dennis McGonagle et al.   Lancet Respiratory Medicine

Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans

(2020) Sharon E Fox et al.   Lancet Respiratory Medicine

Diagnosis and Management of Secondary HLH/MAS Following HSCT and CAR-T Cell Therapy in Adults; A Review of the Literature and a Survey of Practice Within EBMT Centres on Behalf of the Autoimmune Diseases Working Party (ADWP) and Transplant Complications Working Party (TCWP)

(2020) Robert David Sandler et al.   Frontiers in Immunology

Lung involvement in macrophage activation syndrome and severe COVID-19: results from a cross-sectional study to assess clinical, laboratory and artificial intelligence–radiological differences

(2020) Piero Ruscitti et al.   ANNALS OF THE RHEUMATIC DISEASES

The Role of Cytokines including Interleukin-6 in COVID-19 induced Pneumonia and Macrophage Activation Syndrome-Like Disease

(2020) Dennis McGonagle et al.   AUTOIMMUNITY REVIEWS

Cytokine release syndrome and the prospects for immunotherapy with COVID-19. Part 2: The role of interleukin 1

(2020) Leonard H. Calabrese et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2

(2020) Elizabeth Whittaker et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Presence of Genetic Variants Among Young Men With Severe COVID-19

(2020) Caspar I. van der Made et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

SARS-CoV-2–Related Inflammatory Multisystem Syndrome in Children

(2020) Brian W. McCrindle et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Is macrophage activation syndrome in Kawasaki disease underrecognized?

(2020) Valentina Natoli et al.   JOURNAL OF RHEUMATOLOGY

Multisystem Inflammatory Syndrome in U.S. Children and Adolescents

(2020) Leora R. Feldstein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Childhood Multisystem Inflammatory Syndrome — A New Challenge in the Pandemic

(2020) Michael Levin   NEW ENGLAND JOURNAL OF MEDICINE

Multisystem Inflammatory Syndrome in Children in New York State

(2020) Elizabeth M. Dufort et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital

(2020) Tristan Ramcharan et al.   PEDIATRIC CARDIOLOGY

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Is a “Cytokine Storm” Relevant to COVID-19?

(2020) Pratik Sinha et al.   JAMA Internal Medicine

Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study

(2020) Patrick Davies et al.   Lancet Child & Adolescent Health

Recommendations for the management of hemophagocytic lymphohistiocytosis in adults

(2019) Paul La Rosée et al.   BLOOD

IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome

(2019) Shima Yasin et al.   RHEUMATOLOGY

Both HLA class I and II regions identified as genome-wide significant susceptibility loci for adult-onset Still's disease in Chinese individuals

(2019) Zhiqiang Li et al.   ANNALS OF THE RHEUMATIC DISEASES

Haemophagocytic lymphohistiocytosis (HLH) following allogeneic haematopoietic stem cell transplantation (HSCT)—time to reappraise with modern diagnostic and treatment strategies?

(2019) Robert David Sandler et al.   BONE MARROW TRANSPLANTATION

Extensive serum biomarker analysis in patients with macrophage activation syndrome associated with systemic lupus erythematosus

(2019) Masaaki Usami et al.   CLINICAL IMMUNOLOGY

Genetic deficiency of IFN γ reveals IFN γ‐independent manifestations of murine Hemophagocytic Lymphohistiocytosis

(2019) Thomas N Burn et al.   Arthritis & Rheumatology

Ruxolitinib in adult patients with secondary haemophagocytic lymphohistiocytosis: an open-label, single-centre, pilot trial

(2019) Asra Ahmed et al.   Lancet Haematology

Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome

(2018) Eric S. Weiss et al.   BLOOD

Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis

(2018) Ivan K. Chinn et al.   BLOOD

Anakinra treatment in macrophage activation syndrome: a single center experience and systemic review of literature

(2018) Hafize Emine Sönmez et al.   CLINICAL RHEUMATOLOGY

Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells

(2018) Margherita Norelli et al.   NATURE MEDICINE

CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

(2018) Theodoros Giavridis et al.   NATURE MEDICINE

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Features, Treatment, and Outcomes of Macrophage Activation Syndrome in Childhood-Onset Systemic Lupus Erythematosus

(2018) R. Ezequiel Borgia et al.   Arthritis & Rheumatology

Cytokine release syndrome

(2018) Alexander Shimabukuro-Vornhagen et al.   Journal for ImmunoTherapy of Cancer

Capillary leak syndrome: etiologies, pathophysiology, and management

(2017) Eric Siddall et al.   KIDNEY INTERNATIONAL

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

(2017) Sattva S. Neelapu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications

(2016) Michael J Ombrello et al.   ANNALS OF THE RHEUMATIC DISEASES

Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis

(2016) Claudia Bracaglia et al.   ANNALS OF THE RHEUMATIC DISEASES

2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis

(2016) Angelo Ravelli et al.   ANNALS OF THE RHEUMATIC DISEASES

Diagnosing haemophagocytic syndrome

(2016) Ethan S Sen et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Cytokine profile in adult-onset Still's disease: Comparison with systemic juvenile idiopathic arthritis

(2016) Natsumi Inoue et al.   CLINICAL IMMUNOLOGY

Macrophage activation syndrome in the era of biologic therapy

(2016) Alexei A. Grom et al.   Nature Reviews Rheumatology

Hemophagocytic Lymphohistiocytosis in Children: Pathogenesis and Treatment

(2016) Eiichi Ishii   Frontiers in Pediatrics

Pathogenesis of Macrophage Activation Syndrome and Potential for Cytokine- Directed Therapies

(2015) Grant S. Schulert et al.   Annual Review of Medicine

Malignancy-associated haemophagocytic lymphohistiocytosis in children and adolescents

(2015) Kai Lehmberg et al.   BRITISH JOURNAL OF HAEMATOLOGY

Interleukin-18 for predicting the development of macrophage activation syndrome in systemic juvenile idiopathic arthritis

(2015) Masaki Shimizu et al.   CLINICAL IMMUNOLOGY

Hemophagocytic lymphohistiocytosis in 2 patients with underlying IFN-γ receptor deficiency

(2015) Bianca Tesi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time

(2015) Misty R. Jenkins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Whole-Exome Sequencing Reveals Mutations in Genes Linked to Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome in Fatal Cases of H1N1 Influenza

(2015) Grant S. Schulert et al.   JOURNAL OF INFECTIOUS DISEASES

Does Viral Hemorrhagic Fever Represent Reactive Hemophagocytic Syndrome?

(2015) R. Q. CRON et al.   JOURNAL OF RHEUMATOLOGY

Macrophage Activation Syndrome in Patients with Systemic Juvenile Idiopathic Arthritis under Treatment with Tocilizumab

(2015) S. Yokota et al.   JOURNAL OF RHEUMATOLOGY

Autoinflammation and autoimmunity in systemic juvenile idiopathic arthritis

(2015) Peter A. Nigrovic   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HLA-DRB1*11and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis

(2015) Michael J. Ombrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathophysiology and epidemiology of hemophagocytic lymphohistiocytosis

(2015) C. E. Allen et al.   Hematology-American Society of Hematology Education Program

Rate and Clinical Presentation of Macrophage Activation Syndrome in Patients With Systemic Juvenile Idiopathic Arthritis Treated With Canakinumab

(2015) Alexei A. Grom et al.   Arthritis & Rheumatology

Inherited defects in lymphocyte cytotoxic activity

(2015) Jana P. Schmid et al.   IMMUNOLOGICAL REVIEWS

Macrophage activation syndrome and cytokine-directed therapies

(2014) Grant S. Schulert et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

fHLH: becoming a blended family

(2014) C. E. Allen et al.   BLOOD

Benefit and a possible risk of tocilizumab therapy for adult-onset Still’s disease accompanied by macrophage-activation syndrome

(2014) Masafumi Kobayashi et al.   Modern Rheumatology

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

(2014) Neil Romberg et al.   NATURE GENETICS

Gout in a 15-year-old boy with juvenile idiopathic arthritis: a case study

(2014) Hallie Morris et al.   Pediatric Rheumatology

Whole-Exome Sequencing Reveals Overlap Between Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis and Familial Hemophagocytic Lymphohistiocytosis

(2014) Kenneth M. Kaufman et al.   Arthritis & Rheumatology

Development and Validation of the HScore, a Score for the Diagnosis of Reactive Hemophagocytic Syndrome

(2014) Laurence Fardet et al.   Arthritis & Rheumatology

Hemophagocytic Lymphohistiocytosis

(2013) Flavia G. N. Rosado et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Interferon-γ Mediates Anemia but Is Dispensable for Fulminant Toll-like Receptor 9-Induced Macrophage Activation Syndrome and Hemophagocytosis in Mice

(2013) Scott W. Canna et al.   ARTHRITIS AND RHEUMATISM

Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy

(2013) D. T. Teachey et al.   BLOOD

Monocyte-Derived Dendritic Cells Perform Hemophagocytosis to Fine-Tune Excessive Immune Responses

(2013) Hideaki Ohyagi et al.   IMMUNITY

How should we approach classification of autoinflammatory diseases?

(2013) Gilles Grateau et al.   Nature Reviews Rheumatology

Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection

(2013) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

It is time to rethink juvenile idiopathic arthritis classification and nomenclature

(2012) Alberto Martini   ANNALS OF THE RHEUMATIC DISEASES

Regulation of inflammation by interleukin-4: a review of “alternatives”

(2012) Irina G. Luzina et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Randomized Trial of Tocilizumab in Systemic Juvenile Idiopathic Arthritis

(2012) Fabrizio De Benedetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Making Sense of the Cytokine Storm: A Conceptual Framework for Understanding, Diagnosing, and Treating Hemophagocytic Syndromes

(2012) Scott W. Canna et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Amplification of the response to Toll-like receptor ligands by prolonged exposure to interleukin-6 in mice: Implication for the pathogenesis of macrophage activation syndrome

(2011) Raffaele Strippoli et al.   ARTHRITIS AND RHEUMATISM

Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH

(2011) K. Zhang et al.   BLOOD

Repeated TLR9 stimulation results in macrophage activation syndrome–like disease in mice

(2011) Edward M. Behrens et al.   JOURNAL OF CLINICAL INVESTIGATION

Review of haemophagocytic lymphohistiocytosis

(2010) H. R. Freeman et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation

(2010) J. D. Milner et al.   BLOOD

Cytotoxic therapy for severe swine flu A/H1N1

(2010) Jan-Inge Henter et al.   LANCET

Ebola haemorrhagic fever

(2010) Heinz Feldmann et al.   LANCET

Macrophage activation syndrome in juvenile systemic lupus erythematosus: A multinational multicenter study of thirty-eight patients

(2009) Alessandro Parodi et al.   ARTHRITIS AND RHEUMATISM

Presentation and management of intravascular large B-cell lymphoma

(2009) Kazuyuki Shimada et al.   LANCET ONCOLOGY

Secondary hemophagocytic lymphohistiocytosis and severe sepsis/systemic inflammatory response syndrome/multiorgan dysfunction syndrome/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation

(2009) Leticia Castillo et al.   Pediatric Critical Care Medicine

Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis

(2009) Sebastiaan J. Vastert et al.   RHEUMATOLOGY

Clinical significance of 18F-fluoro-dexoxyglucose positron emission tomography in patients with adult-onset Still’s disease: report of two cases and review of literatures

(2009) Jung-Yoon Choe et al.   RHEUMATOLOGY INTERNATIONAL

Macrophage activation syndrome in rheumatic disease: What is the role of the antigen presenting cell?

(2008) Edward M. Behrens   AUTOIMMUNITY REVIEWS

Hodgkin Lymphoma–Associated Hemophagocytic Syndrome: A Disorder Strongly Correlated with Epstein‐Barr Virus

(2008) Fanny Ménard et al.   CLINICAL INFECTIOUS DISEASES

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark