Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization
出版年份 2021 全文链接
标题
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization
作者
关键词
-
出版物
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-02-10
DOI
10.1038/s41580-021-00328-y
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Human RAP 1 specifically protects telomeres of senescent cells from DNA damage
- (2020) Liudmyla Lototska et al. EMBO REPORTS
- Observation of processive telomerase catalysis using high-resolution optical tweezers
- (2020) Eric M. Patrick et al. Nature Chemical Biology
- Regulation of human telomerase in homeostasis and disease
- (2020) Caitlin M. Roake et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The human telomeric nucleosome displays distinct structural and dynamic properties
- (2020) Aghil Soman et al. NUCLEIC ACIDS RESEARCH
- Separable, Ctf4-mediated recruitment of DNA Polymerase α for initiation of DNA synthesis at replication origins and lagging-strand priming during replication elongation
- (2020) Sarina Y. Porcella et al. PLoS Genetics
- Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation
- (2020) Hadrien Laprade et al. MOLECULAR CELL
- Structural insights into telomere protection and homeostasis regulation by yeast CST complex
- (2020) Yunhui Ge et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The structure of human CST reveals a decameric assembly bound to telomeric DNA
- (2020) Ci Ji Lim et al. SCIENCE
- A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution
- (2020) Bishnu P Paudel et al. eLife
- The cryo-EM revolution: fueling the next phase
- (2019) Sriram Subramaniam IUCrJ
- Structures and operating principles of the replisome
- (2019) Yang Gao et al. SCIENCE
- Telomeres and telomerase: three decades of progress
- (2019) Jerry W. Shay et al. NATURE REVIEWS GENETICS
- Telomere DNA G-quadruplex folding within actively extending human telomerase
- (2019) Linnea I. Jansson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human Telomere Repeat Binding Factor TRF1 Replaces TRF2 Bound to Shelterin Core Hub TIN2 when TPP1 Is Absent
- (2019) Tomáš Janovič et al. JOURNAL OF MOLECULAR BIOLOGY
- Mammalian CST averts replication failure by preventing G-quadruplex accumulation
- (2019) Miaomiao Zhang et al. NUCLEIC ACIDS RESEARCH
- Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells
- (2019) Sherilyn Grill et al. Cell Reports
- Combining conservation and species-specific differences to determine how human telomerase binds telomeres
- (2019) Valerie M. Tesmer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of a novel truncating mutation in PALB2 gene by a multigene sequencing panel for mutational screening of breast cancer risk-associated and related genes
- (2018) Anna Guacci et al. JOURNAL OF CLINICAL LABORATORY ANALYSIS
- The C-Terminal Extension Unique to the Long Isoform of the Shelterin Component TIN2 Enhances Its Interaction with TRF2 in a Phosphorylation- and Dyskeratosis Congenita Cluster-Dependent Fashion
- (2018) Nya D. Nelson et al. MOLECULAR AND CELLULAR BIOLOGY
- Dynamics of human telomerase recruitment depend on template-telomere base pairing
- (2018) Jens C. Schmidt et al. MOLECULAR BIOLOGY OF THE CELL
- Cryo-EM structure of substrate-bound human telomerase holoenzyme
- (2018) Thi Hoang Duong Nguyen et al. NATURE
- Pathogenic CTC1 mutations cause global genome instabilities under replication stress
- (2018) Yuan Wang et al. NUCLEIC ACIDS RESEARCH
- The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells
- (2018) Marco Barazas et al. Cell Reports
- Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b
- (2018) Katja Kratz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- 53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in
- (2018) Zachary Mirman et al. NATURE
- Single-particle cryo-EM—How did it get here and where will it go
- (2018) Yifan Cheng SCIENCE
- Multigene panel sequencing of established and candidate melanoma susceptibility genes in a large cohort of Dutch non-CDKN2A/CDK4 melanoma families
- (2018) Thomas P. Potjer et al. INTERNATIONAL JOURNAL OF CANCER
- Structural Basis for Shelterin Bridge Assembly
- (2017) Jin-Kwang Kim et al. MOLECULAR CELL
- Telomeres in cancer: tumour suppression and genome instability
- (2017) John Maciejowski et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- TRF2 binds branched DNA to safeguard telomere integrity
- (2017) Isabelle Schmutz et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes
- (2017) Prashanth K Shastrula et al. NUCLEIC ACIDS RESEARCH
- Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it
- (2017) Ivona Nečasová et al. NUCLEIC ACIDS RESEARCH
- CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance
- (2017) Xuyang Feng et al. NUCLEIC ACIDS RESEARCH
- STN1–POLA2 interaction provides a basis for primase-pol α stimulation by human STN1
- (2017) Swapna Ganduri et al. NUCLEIC ACIDS RESEARCH
- Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST
- (2017) Anukana Bhattacharjee et al. NUCLEIC ACIDS RESEARCH
- TZAP: A telomere-associated protein involved in telomere length control
- (2017) Julia Su Zhou Li et al. SCIENCE
- TRF2 binds branched DNA to safeguard telomere integrity
- (2017) Isabelle Schmutz et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Telomere Recognition and Assembly Mechanism of Mammalian Shelterin
- (2017) Fabian Erdel et al. Cell Reports
- The human CTF4-orthologue AND-1 interacts with DNA polymerase α/primase via its unique C-terminal HMG box
- (2017) Mairi L. Kilkenny et al. Open Biology
- Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres
- (2016) Jens C. Schmidt et al. CELL
- TRF2 Protein Interacts with Core Histones to Stabilize Chromosome Ends
- (2016) Akimitsu Konishi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mutations inSTN1cause Coats plus syndrome and are associated with genomic and telomere defects
- (2016) Amos J. Simon et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Structural and functional consequences of a disease mutation in the telomere protein TPP1
- (2016) Kamlesh Bisht et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure and function of the telomeric CST complex
- (2016) Cory Rice et al. Computational and Structural Biotechnology Journal
- Whole exome sequencing in an Indian family links Coats plus syndrome and dextrocardia with a homozygous novel CTC1 and a rare HES7 variation
- (2015) Manjunath Netravathi et al. BMC Medical Genetics
- Human telomerase: biogenesis, trafficking, recruitment, and activation
- (2015) Jens C. Schmidt et al. GENES & DEVELOPMENT
- The Tetrahymena telomerase p75–p45–p19 subcomplex is a unique CST complex
- (2015) Bingbing Wan et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Control of telomerase action at human telomeres
- (2015) Dirk Hockemeyer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Human Rap1 modulates TRF2 attraction to telomeric DNA
- (2015) Eliška Janoušková et al. NUCLEIC ACIDS RESEARCH
- Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions
- (2015) J. Jiang et al. SCIENCE
- The Tetrahymena telomerase p75–p45–p19 subcomplex is a unique CST complex
- (2015) Bingbing Wan et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Control of telomerase action at human telomeres
- (2015) Dirk Hockemeyer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1
- (2014) Y. Guo et al. BLOOD
- Human CST abundance determines recovery from diverse forms of DNA damage and replication stress
- (2014) Feng Wang et al. CELL CYCLE
- The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres
- (2014) Adélaïde Saint-Léger et al. CELL CYCLE
- The Shelterin Component TPP1 Is a Binding Partner and Substrate for the Deubiquitinating Enzyme USP7
- (2014) Ivo Zemp et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nonsense Mutations in the Shelterin Complex Genes ACD and TERF2IP in Familial Melanoma
- (2014) Lauren G. Aoude et al. JNCI-Journal of the National Cancer Institute
- DNA-Directed Polymerase Subunits Play a Vital Role in Human Telomeric Overhang Processing
- (2014) Raffaella Diotti et al. MOLECULAR CANCER RESEARCH
- POT1 loss-of-function variants predispose to familial melanoma
- (2014) Carla Daniela Robles-Espinoza et al. NATURE GENETICS
- Functional characterization of human CTC1 mutations reveals novel mechanisms responsible for the pathogenesis of the telomere disease Coats plus
- (2013) Peili Gu et al. AGING CELL
- Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation
- (2013) Ylli Doksani et al. CELL
- The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening
- (2013) Verena Pfeiffer et al. EMBO JOURNAL
- Molecular basis of telomere syndrome caused by CTC1 mutations
- (2013) L.-Y. Chen et al. GENES & DEVELOPMENT
- TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres
- (2013) Jiangguo Lin et al. NUCLEIC ACIDS RESEARCH
- Telomeric repeats act as nucleosome-disfavouring sequences in vivo
- (2013) Yuichi Ichikawa et al. NUCLEIC ACIDS RESEARCH
- Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment
- (2013) Y. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A quantitative telomeric chromatin isolation protocol identifies different telomeric states
- (2013) Larissa Grolimund et al. Nature Communications
- TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human Telomeres
- (2013) Albert Ribes-Zamora et al. Cell Reports
- Mutations in CTC1 , Encoding the CTS Telomere Maintenance Complex Component 1, Cause Cerebroretinal Microangiopathy with Calcifications and Cysts
- (2012) Anne Polvi et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST
- (2012) Peng Wu et al. CELL
- TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends
- (2012) Franklin L. Zhong et al. CELL
- Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in
- (2012) Chenhui Huang et al. CELL RESEARCH
- Human CST promotes telomere duplex replication and general replication restart after fork stalling
- (2012) Jason A Stewart et al. EMBO JOURNAL
- Structure and conformational change of a replication protein A heterotrimer bound to ssDNA
- (2012) J. Fan et al. GENES & DEVELOPMENT
- Mutations in the telomere capping complex in bone marrow failure and related syndromes
- (2012) A. J. Walne et al. HAEMATOLOGICA
- Specificity Requirements for Human Telomere Protein Interaction with Telomerase Holoenzyme
- (2012) Alec N. Sexton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial Localization of Telomeric Protein TIN2 Links Telomere Regulation to Metabolic Control
- (2012) Liuh-Yow Chen et al. MOLECULAR CELL
- The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity
- (2012) Jayakrishnan Nandakumar et al. NATURE
- The human CST complex is a terminator of telomerase activity
- (2012) Liuh-Yow Chen et al. NATURE
- Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus
- (2012) Beverley H Anderson et al. NATURE GENETICS
- Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α
- (2012) Nausica Arnoult et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- CTC1 Mutations in a patient with dyskeratosis congenita
- (2012) Rachel B. Keller et al. PEDIATRIC BLOOD & CANCER
- TRF2 Controls Telomeric Nucleosome Organization in a Cell Cycle Phase-Dependent Manner
- (2012) Alessandra Galati et al. PLoS One
- POT1-TPP1 Regulates Telomeric Overhang Structural Dynamics
- (2012) Helen Hwang et al. STRUCTURE
- Human CST Has Independent Functions during Telomere Duplex Replication and C-Strand Fill-In
- (2012) Feng Wang et al. Cell Reports
- Three novel truncating TINF2 mutations causing severe dyskeratosis congenita in early childhood
- (2011) GS Sasa et al. CLINICAL GENETICS
- Xenopus laevisCtc1-Stn1-Ten1 (xCST) Protein Complex Is Involved in Priming DNA Synthesis on Single-stranded DNA Template inXenopusEgg Extract
- (2011) Hidenori Nakaoka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TIN2 Stability Is Regulated by the E3 Ligase Siah2
- (2011) M. Bhanot et al. MOLECULAR AND CELLULAR BIOLOGY
- TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA
- (2011) Rachel Litman Flynn et al. NATURE
- The N-terminal domains of TRF1 and TRF2 regulate their ability to condense telomeric DNA
- (2011) Anaïs Poulet et al. NUCLEIC ACIDS RESEARCH
- Characterization of the DNA binding specificity of Shelterin complexes
- (2011) Kyung H. Choi et al. NUCLEIC ACIDS RESEARCH
- Flexible tethering of primase and DNA Pol α in the eukaryotic primosome
- (2011) Rafael Núñez-Ramírez et al. NUCLEIC ACIDS RESEARCH
- Differences in Disease Severity but Similar Telomere Lengths in Genetic Subgroups of Patients with Telomerase and Shelterin Mutations
- (2011) Tom J. Vulliamy et al. PLoS One
- Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA
- (2011) Z. Zeng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase α
- (2010) Jia Sun et al. CELL RESEARCH
- Telomere length measurement can distinguish pathogenic from non-pathogenic variants in the shelterin component, TIN2
- (2010) T Vulliamy et al. CLINICAL GENETICS
- POT1–TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation
- (2010) Chrysa M Latrick et al. EMBO JOURNAL
- Single Molecule Studies of Physiologically Relevant Telomeric Tails Reveal POT1 Mechanism for Promoting G-quadruplex Unfolding
- (2010) Hong Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal
- (2010) A. Sfeir et al. SCIENCE
- Purification of Proteins Associated with Specific Genomic Loci
- (2009) Jérôme Déjardin et al. CELL
- Telomere Extension Occurs at Most Chromosome Ends and Is Uncoupled from Fill-In in Human Cancer Cells
- (2009) Yong Zhao et al. CELL
- A DNA Polymerase-α·Primase Cofactor with Homology to Replication Protein A-32 Regulates DNA Replication in Mammalian Cells
- (2009) Darren E. Casteel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- In VivoStoichiometry of Shelterin Components
- (2009) Kaori K. Takai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- OB Fold-containing Protein 1 (OBFC1), a Human Homolog of Yeast Stn1, Associates with TPP1 and Is Implicated in Telomere Length Regulation
- (2009) Ma Wan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RPA-like Mammalian Ctc1-Stn1-Ten1 Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Pot1 Pathway
- (2009) Yasuyuki Miyake et al. MOLECULAR CELL
- Conserved Telomere Maintenance Component 1 Interacts with STN1 and Maintains Chromosome Ends in Higher Eukaryotes
- (2009) Yulia V. Surovtseva et al. MOLECULAR CELL
- The effect of the TRF2 N-terminal and TRFH regions on telomeric G-quadruplex structures
- (2009) Ilene M. Pedroso et al. NUCLEIC ACIDS RESEARCH
- Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain
- (2009) A. D. Gelinas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- No Overt Nucleosome Eviction at Deprotected Telomeres
- (2008) P. Wu et al. MOLECULAR AND CELLULAR BIOLOGY
- A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins
- (2008) Y. Chen et al. SCIENCE
- Comparison between TRF2 and TRF1 of their telomeric DNA-bound structures and DNA-binding activities
- (2004) Shingo Hanaoka et al. PROTEIN SCIENCE
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