Separable, Ctf4-mediated recruitment of DNA Polymerase α for initiation of DNA synthesis at replication origins and lagging-strand priming during replication elongation

Defective DNA Polymerase α-Primase Leads to X-Linked Intellectual Disability Associated with Severe Growth Retardation, Microcephaly, and Hypogonadism

(2019) Hilde Van Esch et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Initial Response of a Eukaryotic Replisome to DNA Damage

(2018) Martin R.G. Taylor et al.   MOLECULAR CELL

Evidence that DNA polymerase δ contributes to initiating leading strand DNA replication in Saccharomyces cerevisiae

(2018) Marta A. Garbacz et al.   Nature Communications

Histone H2A‐H2B binding by Pol α in the eukaryotic replisome contributes to the maintenance of repressive chromatin

(2018) Cecile Evrin et al.   EMBO JOURNAL

Transcription shapes DNA replication initiation and termination in human cells

(2018) Yu-Hung Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ctf4 Prevents Genome Rearrangements by Suppressing DNA Double-Strand Break Formation and Its End Resection at Arrested Replication Forks

(2017) Mariko Sasaki et al.   MOLECULAR CELL

Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates

(2017) Christoph F. Kurat et al.   MOLECULAR CELL

Chromatin Constrains the Initiation and Elongation of DNA Replication

(2017) Sujan Devbhandari et al.   MOLECULAR CELL

How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication

(2017) Joseph T.P. Yeeles et al.   MOLECULAR CELL

PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes

(2017) Phong Lan Thao Tran et al.   Nature Communications

Ctf4 Links DNA Replication with Sister Chromatid Cohesion Establishment by Recruiting the Chl1 Helicase to the Replisome

(2016) Catarina P. Samora et al.   MOLECULAR CELL

Ctf4 Is a Hub in the Eukaryotic Replisome that Links Multiple CIP-Box Proteins to the CMG Helicase

(2016) Fabrizio Villa et al.   MOLECULAR CELL

Pif1-family helicases cooperatively suppress widespread replication-fork arrest at tRNA genes

(2016) Joseph S Osmundson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Replication landscape of the human genome

(2016) Nataliya Petryk et al.   Nature Communications

Pif1-family helicases cooperatively suppress widespread replication-fork arrest at tRNA genes

(2016) Joseph S Osmundson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

rDNA Copy Number Variants Are Frequent Passenger Mutations in Saccharomyces cerevisiae Deletion Collections and de Novo Transformants

(2016) Elizabeth X. Kwan et al.   G3-Genes Genomes Genetics

Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication

(2016) Maksym Shyian et al.   PLoS Genetics

Spatiotemporal coupling and decoupling of gene transcription with DNA replication origins during embryogenesis in C. elegans

(2016) Ehsan Pourkarimi et al.   eLife

Error-Free DNA Damage Tolerance and Sister Chromatid Proximity during DNA Replication Rely on the Polα/Primase/Ctf4 Complex

(2015) Marco Fumasoni et al.   MOLECULAR CELL

Lagging-strand replication shapes the mutational landscape of the genome

(2015) Martin A. M. Reijns et al.   NATURE

Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation

(2015) Anders R Clausen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A global profile of replicative polymerase usage

(2015) Yasukazu Daigaku et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polymerase δ replicates both strands after homologous recombination–dependent fork restart

(2015) Izumi Miyabe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation

(2015) Anders R Clausen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A global profile of replicative polymerase usage

(2015) Yasukazu Daigaku et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polymerase δ replicates both strands after homologous recombination–dependent fork restart

(2015) Izumi Miyabe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetic Networks Required to Coordinate Chromosome Replication by DNA Polymerases α, δ, and ε in Saccharomyces cerevisiae

(2015) Marion Dubarry et al.   G3-Genes Genomes Genetics

The Histone Deacetylases Sir2 and Rpd3 Act on Ribosomal DNA to Control the Replication Program in Budding Yeast

(2014) Kazumasa Yoshida et al.   MOLECULAR CELL

A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome

(2014) Aline C. Simon et al.   NATURE

Genome-wide high-resolution mapping of chromosome fragile sites in Saccharomyces cerevisiae

(2014) W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Eco1-independent sister chromatid cohesion establishment pathway in S. cerevisiae

(2013) Vanessa Borges et al.   CHROMOSOMA

Quantitative, Genome-Wide Analysis of Eukaryotic Replication Initiation and Termination

(2013) Sean R. McGuffee et al.   MOLECULAR CELL

Okazaki Fragment Metabolism

(2013) L. Balakrishnan et al.   Cold Spring Harbor Perspectives in Biology

Eukaryotic Replisome Components Cooperate to Process Histones During Chromosome Replication

(2013) Magdalena Foltman et al.   Cell Reports

Intrinsic coupling of lagging-strand synthesis to chromatin assembly

(2012) Duncan J. Smith et al.   NATURE

Role of DNA Polymerases in Repeat-Mediated Genome Instability

(2012) Kartik A. Shah et al.   Cell Reports

Balancing eukaryotic replication asymmetry with replication fidelity

(2011) Thomas A Kunkel   CURRENT OPINION IN CHEMICAL BIOLOGY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase α within the eukaryotic replisome

(2009) Agnieszka Gambus et al.   EMBO JOURNAL

Ctf4 coordinates the progression of helicase and DNA polymerase α

(2009) Hirokazu Tanaka et al.   GENES TO CELLS

A compiled and systematic reference map of nucleosome positions across the Saccharomyces cerevisiae genome

(2009) Cizhong Jiang et al.   GENOME BIOLOGY

The Anchor-Away Technique: Rapid, Conditional Establishment of Yeast Mutant Phenotypes

(2008) Hirohito Haruki et al.   MOLECULAR CELL

Dividing the workload at a eukaryotic replication fork

(2008) Thomas A. Kunkel et al.   TRENDS IN CELL BIOLOGY