Enantioselective Synthesis of N-Alkylamines through β-Amino C–H Functionalization Promoted by Cooperative Actions of B(C6F5)3 and a Chiral Lewis Acid Co-Catalyst

New Strategies for the Transition-Metal Catalyzed Synthesis of Aliphatic Amines

(2020) Aaron Trowbridge et al.   CHEMICAL REVIEWS

Pd(II)-Catalyzed Enantioselective γ-C(sp3)–H Functionalizations of Free Cyclopropylmethylamines

(2020) Zhe Zhuang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

cine-Silylative Ring-Opening of α-Methyl Azacycles Enabled by the Silylium-Induced C–N Bond Cleavage

(2020) Jianbo Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalysis, FLPs, and Beyond

(2020) Douglas W. Stephan   Chem

Direct Conversion of N-Alkylamines to N-Propargylamines through C–H Activation Promoted by Lewis Acid/Organocopper Catalysis: Application to Late-Stage Functionalization of Bioactive Molecules

(2020) Jessica Z. Chan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

B(C6F5)3-Catalyzed β-Functionalization of Pyrrolidines Using Isatins via Borrowing Hydrogen: Divergent Access to Substituted Pyrrolidines and Pyrroles

(2020) Yong Chen et al.   ORGANIC LETTERS

Development and Investigation of an Organocatalytic Enantioselective [10 + 2] Cycloaddition

(2020) David McLeod et al.   ACS Catalysis

The importance of synthetic chemistry in the pharmaceutical industry

(2019) Kevin R. Campos et al.   SCIENCE

Palladium-Catalyzed C(sp3)–H Bond Functionalization of Aliphatic Amines

(2019) Chuan He et al.   Chem

B(C6F5)3-Catalyzed C–H Alkylation of N-Alkylamines Using Silicon Enolates without External Oxidant

(2019) Jessica Z. Chan et al.   ORGANIC LETTERS

α-Functionalization of Cyclic Secondary Amines: Lewis Acid Promoted Addition of Organometallics to Transient Imines

(2019) Anirudra Paul et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dirhodium tetracarboxylates as catalysts for selective intermolecular C–H functionalization

(2019) Huw M. L. Davies et al.   Nature Reviews Chemistry

Catalytic Deuterium Incorporation within Metabolically Stable β-Amino C–H Bonds of Drug Molecules

(2019) Yejin Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regiodivergent enantioselective C–H functionalization of Boc-1,3-oxazinanes for the synthesis of β2- and β3-amino acids

(2019) Weilong Lin et al.   Nature Catalysis

Different Strategies for Designing Dual-Catalytic Enantioselective Processes: From Fully Cooperative to Non-cooperative Systems

(2019) Filippo Romiti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functionalization of Piperidine Derivatives for the Site Selective and Stereoselective Synthesis of Positional Analogs of Methylphenidate

(2019) Huw Davies et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic C(sp3)–H bond activation in tertiary alkylamines

(2019) Jesus Rodrigalvarez et al.   Nature Chemistry

Selective Reductive Elimination at Alkyl Palladium(IV) by Dissociative Ligand Ionization: Catalytic C(sp3 )−H Amination to Azetidines

(2018) Manuel Nappi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regioselective Synthesis of Acylated N-Heterocycles via the Cascade Reactions of Saturated Cyclic Amines with 2-Oxo-2-arylacetic Acids

(2018) Xiaonan Shi et al.   JOURNAL OF ORGANIC CHEMISTRY

Generation and Alkylation of α-Carbamyl Radicals via Organic Photoredox Catalysis

(2018) Joshua B. McManus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Borane-catalyzed synthesis of quinolines bearing tetrasubstituted stereocenters by hydride abstraction-induced electrocyclization

(2018) Alexander F. G. Maier et al.   CHEMISTRY-A EUROPEAN JOURNAL

C–H Functionalization of Amines via Alkene-Derived Nucleophiles through Cooperative Action of Chiral and Achiral Lewis Acid Catalysts: Applications in Enantioselective Synthesis

(2018) Ming Shang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct α-alkylation of primary aliphatic amines enabled by CO2 and electrostatics

(2018) Juntao Ye et al.   Nature Chemistry

Catalytic Access to Bridged Sila-N-heterocycles from Piperidines via Cascade sp3 and sp2 C–Si Bond Formation

(2018) Jianbo Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-Catalyzed, β-Selective C(sp3)–H Silylation of Aliphatic Amines To Form Silapyrrolidines and 1,2-Amino Alcohols

(2018) Bo Su et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intramolecular Cyclizations of Vinyl-Substituted N,N-Dialkyl Arylamines Enabled by Borane-Assisted Hydride Transfer

(2018) Jun-Jie Tian et al.   ACS Catalysis

Palladium-Catalyzed Enantioselective C–H Activation of Aliphatic Amines Using Chiral Anionic BINOL-Phosphoric Acid Ligands

(2017) Adam P. Smalley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective sp3 C–H alkylation via polarity-match-based cross-coupling

(2017) Chip Le et al.   NATURE

Direct α-C–H bond functionalization of unprotected cyclic amines

(2017) Weijie Chen et al.   Nature Chemistry

The α-tertiary amine motif drives remarkable selectivity for Pd-catalyzed carbonylation of β-methylene C–H bonds

(2017) Kirsten F. Hogg et al.   Chemical Science

Tris(pentafluorophenyl)borane-Catalyzed Acceptorless Dehydrogenation of N-Heterocycles

(2016) Masahiro Kojima et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Frustrated Lewis Pair Catalyzed Dehydrogenative Oxidation of Indolines and Other Heterocycles

(2016) Alexander F. G. Maier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic C(sp3)−H Arylation of Free Primary Amines with anexoDirecting Group Generated In Situ

(2016) Yan Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cooperative Catalysis and Activation with N-Heterocyclic Carbenes

(2016) Michael H. Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Hydrazone-Based exo -Directing-Group Strategy for β C−H Oxidation of Aliphatic Amines

(2016) Zhongxing Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Transformations of Alkyl C–H Bonds

(2016) Jian He et al.   CHEMICAL REVIEWS

Redox-Neutral Aromatization of Cyclic Amines: Mechanistic Insights and Harnessing of Reactive Intermediates for Amine α- and β-C−H Functionalization

(2016) Longle Ma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Isotope Effects Reveal the Mechanism of Enamine Formation in l-Proline-Catalyzed α-Amination of Aldehydes

(2016) Melissa A. Ashley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-catalysed transannular C–H functionalization of alicyclic amines

(2016) Joseph J. Topczewski et al.   NATURE

Oxidative diversification of amino acids and peptides by small-molecule iron catalysis

(2016) Thomas J. Osberger et al.   NATURE

Enantioselective amine α-functionalization via palladium-catalysed C–H arylation of thioamides

(2016) Pankaj Jain et al.   Nature Chemistry

A general catalytic β-C–H carbonylation of aliphatic amines to β-lactams

(2016) Darren Willcox et al.   SCIENCE

The broadening reach of frustrated Lewis pair chemistry

(2016) D. W. Stephan   SCIENCE

Bidentate, Monoanionic Auxiliary-Directed Functionalization of Carbon–Hydrogen Bonds

(2015) Olafs Daugulis et al.   ACCOUNTS OF CHEMICAL RESEARCH

ProPhenol-Catalyzed Asymmetric Additions by Spontaneously Assembled Dinuclear Main Group Metal Complexes

(2015) Barry M. Trost et al.   ACCOUNTS OF CHEMICAL RESEARCH

Phosphine-Catalyzed Remote β-CH Functionalization of Amines Triggered by Trifluoromethylation of Alkenes: One-Pot Synthesis of Bistrifluoromethylated Enamides and Oxazoles

(2015) Peng Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Frustrated Lewis Pair Chemistry: Development and Perspectives

(2015) Douglas W. Stephan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Role of Hydrogen-Bonding Acceptors in Organo-Enamine Catalysis

(2015) Junbin Han et al.   CHEMISTRY-A EUROPEAN JOURNAL

Palladium(II)-Catalyzed Highly Enantioselective C–H Arylation of Cyclopropylmethylamines

(2015) Kelvin S. L. Chan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Insights into the Palladium-Catalyzed Aziridination of Aliphatic Amines by C–H Activation

(2015) Adam P. Smalley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Conjugate Additions of α-Amino Radicals via Cooperative Photoredox and Lewis Acid Catalysis

(2015) Laura Ruiz Espelt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Frustrated Lewis Pairs

(2015) Douglas W. Stephan   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetic Profiling of Catalytic Organic Reactions as a Mechanistic Tool

(2015) Donna G. Blackmond   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CH Bond Functionalization through Intramolecular Hydride Transfer

(2014) Michael C. Haibach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand-Controlled α- and β-Arylation of Acyclic N-Boc Amines

(2014) Anthony Millet et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photoredox α-Vinylation of α-Amino Acids and N-Aryl Amines

(2014) Adam Noble et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-catalysed C–H activation of aliphatic amines to give strained nitrogen heterocycles

(2014) Andrew McNally et al.   NATURE

Evaluation of Achiral Templates with Fluxional Brønsted Basic Substituents in Enantioselective Conjugate Additions

(2014) Shinya Adachi et al.   ORGANIC LETTERS

Ligand-Controlled C(sp3)-H Arylation and Olefination in Synthesis of Unnatural Chiral  -Amino Acids

(2014) J. He et al.   SCIENCE

Metal-free asymmetric hydrogenation and hydrosilylation catalyzed by frustrated Lewis pairs

(2014) Xiangqing Feng et al.   TETRAHEDRON LETTERS

The Cross-Dehydrogenative Coupling of C sp 3H Bonds: A Versatile Strategy for CC Bond Formations

(2013) Simon A. Girard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioconvergent Cross-Couplings of Racemic Alkylmetal Reagents with Unactivated Secondary Alkyl Electrophiles: Catalytic Asymmetric Negishi α-Alkylations of N-Boc-pyrrolidine

(2013) Christopher J. Cordier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Beyond Classical Reactivity Patterns: Shifting from 1,4- to 1,6-Additions in Regio- and Enantioselective Organocatalyzed Vinylogous Reactions of Olefinic Lactones with Enals and 2,4-Dienals

(2013) Luca Dell’Amico et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-Catalyzed Oxidative C(3)–H Functionalization of Amines

(2013) Noriaki Takasu et al.   ORGANIC LETTERS

On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition-Metal Complexes

(2012) Eric M. Simmons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-Catalyzed Oxidant-Free Dehydrogenative CH Bond Functionalization: Selective Preparation of N-Arylpiperidines through Tandem Hydrogen Transfers

(2012) Kedong Yuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Ion-Pairing Catalysis

(2012) Katrien Brak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct α-Functionalization of Saturated Cyclic Amines

(2012) Emily A. Mitchell et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Asymmetric α-Acylation of Tertiary Amines Mediated by a Dual Catalysis Mode: N-Heterocyclic Carbene and Photoredox Catalysis

(2012) Daniel A. DiRocco et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The progression of chiral anions from concepts to applications in asymmetric catalysis

(2012) Robert J. Phipps et al.   Nature Chemistry

Catalytic Enantioselective Formation of C−C Bonds by Addition to Imines and Hydrazones: A Ten-Year Update

(2011) Shu̅ Kobayashi et al.   CHEMICAL REVIEWS

Transition metal-catalyzed arylation of unactivated C(sp3)–H bonds

(2011) Olivier Baudoin   CHEMICAL SOCIETY REVIEWS

sp3C–H Bond Activation with Ruthenium(II) Catalysts and C(3)-Alkylation of Cyclic Amines

(2011) Basker Sundararaju et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Activation of Enantiotopic C(sp3)−Hydrogen by Means of Chiral Phosphoric Acid: Asymmetric Synthesis of Tetrahydroquinoline Derivatives

(2011) Keiji Mori et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intramolecular frustrated N/B lewis pairs by enamine hydroboration

(2011) Sina Schwendemann et al.   Chemical Science

Ruthenium-Catalyzed Cascade N- and C(3)-Dialkylation of Cyclic Amines with Alcohols Involving Hydrogen Autotransfer Processes

(2010) Basker Sundararaju et al.   ADVANCED SYNTHESIS & CATALYSIS

Mechanisms in aminocatalysis

(2010) Martin Nielsen et al.   CHEMICAL COMMUNICATIONS

Recent advances in the catalytic asymmetric synthesis of β-amino acids

(2010) Barbara Weiner et al.   CHEMICAL SOCIETY REVIEWS

A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives

(2010) Nicholas A. McGrath et al.   JOURNAL OF CHEMICAL EDUCATION

Platinum-Catalyzed Michael Addition and Cyclization of Tertiary Amines with Nitroolefins by Dehydrogenation of α,β-sp3C−H Bonds

(2010) Xiao-Feng Xia et al.   JOURNAL OF ORGANIC CHEMISTRY

Fluorocyanation of Enamines

(2010) Alexander D. Dilman et al.   JOURNAL OF ORGANIC CHEMISTRY

Addition of Enamines or Pyrroles and B(C6F5)3“Frustrated Lewis Pairs” to Alkynes

(2010) Meghan A. Dureen et al.   ORGANOMETALLICS

Crystal structures of proline-derived enamines

(2010) D. A. Bock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iridium-Catalyzed Asymmetric Hydrogenation of Cyclic Enamines

(2009) Guo-Hua Hou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Enantioselective Intramolecular Redox Reactions: Ring-Fused Tetrahydroquinolines

(2009) Sandip Murarka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bifunctional Asymmetric Catalysis: Cooperative Lewis Acid/Base Systems

(2008) Daniel H. Paull et al.   ACCOUNTS OF CHEMICAL RESEARCH

Diphenylprolinol Silyl Ether as a Catalyst in an Enantioselective, Catalytic, Formal Aza [3+3] Cycloaddition Reaction for the Formation of Enantioenriched Piperidines

(2008) Yujiro Hayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic C–H functionalization by metal carbenoid and nitrenoid insertion

(2008) Huw M. L. Davies et al.   NATURE