Cooperative Catalysis and Activation with N-Heterocyclic Carbenes

Enantioselective N-Heterocyclic Carbene Catalysis by the Umpolung of α,β-Unsaturated Ketones

(2016) Yuji Nakano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A switchable dual organocatalytic system and the enantioselective total synthesis of the quadrane sesquiterpene suberosanone

(2016) Yajun Ren et al.   CHEMICAL COMMUNICATIONS

Chiral N-heterocyclic carbene/Lewis acid cooperative catalysis of the reaction of 2-aroylvinylcinnamaldehydes: a switch of the reaction pathway by Lewis acid activation

(2016) Zhan-Yong Wang et al.   CHEMICAL COMMUNICATIONS

An Enantioselective Assembly of Dihydropyranones through an NHC/LiCl-Mediated in situ Activation of α,β-Unsaturated Carboxylic Acids

(2016) Yonglei Que et al.   Chemistry-An Asian Journal

Cooperative N-Heterocyclic Carbene/Palladium-Catalyzed Enantioselective Umpolung Annulations

(2016) Chang Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic carbene-catalyzed [4 + 2] annulation of α,β-unsaturated carboxylic acids: enantioselective synthesis of dihydropyridinones and spirocyclic oxindolodihydropyridinones

(2016) Wen-Qiang Jia et al.   Organic Chemistry Frontiers

Aminomethylation of Enals through Carbene and Acid Cooperative Catalysis: Concise Access to β2-Amino Acids

(2015) Jianfeng Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cooperative catalysis of N-heterocyclic carbene and Brønsted acid for a highly enantioselective route to unprotected spiro-indoline-pyrans

(2015) Youqiang Lin et al.   CHEMICAL COMMUNICATIONS

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes

(2015) Darrin M. Flanigan et al.   CHEMICAL REVIEWS

Recent advances in employing homoenolates generated by N-heterocyclic carbene (NHC) catalysis in carbon–carbon bond-forming reactions

(2015) Rajeev S. Menon et al.   CHEMICAL SOCIETY REVIEWS

N-Heterocyclic Carbene Catalyzed Generation and [4+2] Annulation of Unsubstituted Dienolate - Enantioselective Synthesis of Spirocyclic Oxindolodihydropyranones

(2015) Jin-Tang Cheng et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective β-Protonation by a Cooperative Catalysis Strategy

(2015) Michael H. Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective cooperative catalysis

(2015) Suleman M. Inamdar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

γ-Carbon Activation through N-Heterocyclic Carbene/Brønsted Acids Cooperative Catalysis: A Highly Enantioselective Route to δ-Lactams

(2015) Yonglong Xiao et al.   ORGANIC LETTERS

Enantioselective Synthesis of Bicyclic δ-Lactones via N-Heterocyclic Carbene-Catalyzed Cascade Reaction

(2015) Zhi-Qin Liang et al.   ORGANIC LETTERS

Enantioselective Synthesis of Substituted δ-Lactones by Cooperative Oxidative N-Heterocyclic Carbene and Lewis Acid Catalysis

(2015) Srikrishna Bera et al.   ORGANIC LETTERS

Combined Asymmetric Aminocatalysis and Carbene Catalysis

(2015) Ying-Chun Chen et al.   SYNTHESIS-STUTTGART

On the Mechanism of N-Heterocyclic Carbene-Catalyzed Reactions Involving Acyl Azoliums

(2014) Jessada Mahatthananchai et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Cooperative N-Heterocyclic Carbene/Chiral Phosphate Catalysis System for Allenolate Annulations

(2014) Anna Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of Highly Substituted β-Lactones through Oxidative Carbene Catalysis with LiCl as Cooperative Lewis Acid

(2014) Srikrishna Bera et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intermolecular Dynamic Kinetic Resolution Cooperatively Catalyzed by an N-Heterocyclic Carbene and a Lewis Acid

(2014) Zijun Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conjugate Umpolung of β,β-Disubstituted Enals by Dual Catalysis with an N-Heterocyclic Carbene and a Brønsted Acid: Facile Construction of Contiguous Quaternary Stereocenters

(2014) Jun-Long Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereoselective synthesis of ε-lactones or spiro-heterocycles through NHC-catalyzed annulation: divergent reactivity by catalyst control

(2014) Min Wang et al.   CHEMICAL COMMUNICATIONS

Dual-function Pd/NHC catalysis: tandem allylation–isomerization–conjugate addition that allows access to pyrroles, thiophenes and furans

(2014) Yaguang Bai et al.   CHEMICAL COMMUNICATIONS

DFT Study on the Mechanisms and Stereoselectivities of the [4 + 2] Cycloadditions of Enals and Chalcones Catalyzed by N-Heterocyclic Carbene

(2014) Zhenyu Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Changing the Reaction Pathway by NHC/Brønsted Base Cooperative Catalysis: Highly Stereoselective Synthesis of Multifunctional Benzo[a]fluoren-11-ones from the Dimerization of 2-(Aroylvinyl)arylaldehydes

(2014) Yuan-feng Tong et al.   JOURNAL OF ORGANIC CHEMISTRY

An overview of N-heterocyclic carbenes

(2014) Matthew N. Hopkinson et al.   NATURE

NHC-catalyzed oxidative γ-addition of α,β-unsaturated aldehydes to isatins: a high-efficiency synthesis of spirocyclic oxindole-dihydropyranones

(2014) Rui Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cooperative N-heterocyclic carbene (NHC)–Lewis acid-mediated regioselective umpolung formal [3 + 2] annulations of alkynyl aldehydes with isatins

(2014) Yu Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-Heterocyclic Carbene/Lewis Acid Strategy for the Stereoselective Synthesis of Spirocyclic Oxindole–Dihydropyranones

(2014) Zhaoxin Xiao et al.   ORGANIC LETTERS

Asymmetric Domino Multicatalysis for the Synthesis of 3-Substituted Phthalides: Cinchonine/NHC Cooperative System

(2014) So Won Youn et al.   ORGANIC LETTERS

Changing Reaction Pathways of the Dimerization of 2-Formylcinnamates by N-Heterocyclic Carbene/Lewis Acid Cooperative Catalysis: An Unusual Cleavage of the Carbon–Carbon Bond

(2014) Hai-Yan Dang et al.   ORGANIC LETTERS

A cooperative N-heterocyclic carbene/palladium catalysis system

(2014) Kun Liu et al.   Chemical Science

Mechanistic Insights on Cooperative Catalysis through Computational Quantum Chemical Methods

(2014) Garima Jindal et al.   ACS Catalysis

Cooperative N-Heterocyclic Carbene (NHC) and Ruthenium Redox Catalysis: Oxidative Esterification of Aldehydes with Air as the Terminal Oxidant

(2013) Junfeng Zhao et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Sulfonation of Enones with Sulfonyl Imines by Cooperative N-Heterocyclic-Carbene/Thiourea/Tertiary-Amine Multicatalysis

(2013) Zhichao Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Efficient Approach to the Securinega Alkaloids Empowered by Cooperative N-Heterocyclic Carbene/Lewis Acid Catalysis

(2013) Adel M. ElSohly et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective N-Heterocyclic Carbene Catalyzed Annulation Reactions with Imidazolidinones

(2013) Elizabeth O'Bryan McCusker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Kinetic Resolution of Tertiary Alcohols: Highly Enantioselective Access to 3-Hydroxy-3-Substituted Oxindoles

(2013) Shenci Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct β-Activation of Saturated Aldehydes to Formal Michael Acceptors through Oxidative NHC Catalysis

(2013) Junming Mo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene (NHC)-Catalyzed/Lewis Acid Mediated Conjugate Umpolung of Alkynyl Aldehydes for the Synthesis of Butenolides: A Formal [3+2] Annulation

(2013) Jing Qi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalysis with N-Heterocyclic Carbenes under Oxidative Conditions

(2013) Suman De Sarkar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Divergent NHC-Catalyzed Oxidative Transformations of 3-Bromoenal: Selective Synthesis of 2H-Pyran-2-ones and Chiral Dihydropyranones

(2013) Gang Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

A DFT study on the NHC catalysed Michael addition of enols to α,β-unsaturated acyl-azoliums. A base catalysed C–C bond-formation step

(2013) Luis R. Domingo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Kinetic Resolution of 3-Hydroxy-3-Substituted Oxindoles through NHC-Catalyzed Oxidative Esterification

(2013) Yu Zhao et al.   SYNLETT

An N-Heterocyclic Carbene/Lewis Acid Strategy for the Stereoselective Synthesis of Spirooxindole Lactones

(2012) Julien Dugal-Tessier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium/NHC-catalyzed tandem benzylic oxidation/oxidative esterification of benzylic alcohols with phenols

(2012) Di Zhang et al.   CATALYSIS COMMUNICATIONS

Controlled β-protonation and [4+2] cycloaddition of enals and chalconesvia N-heterocyclic carbene/acid catalysis: toward substrate independent reaction control

(2012) Zhenqian Fu et al.   CHEMICAL COMMUNICATIONS

Organocatalytic umpolung: N-heterocyclic carbenes and beyond

(2012) Xavier Bugaut et al.   CHEMICAL SOCIETY REVIEWS

Oxidative γ-Addition of Enals to Trifluoromethyl Ketones: Enantioselectivity Control via Lewis Acid/N-Heterocyclic Carbene Cooperative Catalysis

(2012) Junming Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Asymmetric α-Acylation of Tertiary Amines Mediated by a Dual Catalysis Mode: N-Heterocyclic Carbene and Photoredox Catalysis

(2012) Daniel A. DiRocco et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Enantioselective Cyclizations of Conjugated Trienes with Low Catalyst Loadings: A Robust Chiral N-Heterocyclic Carbene Enabled by Acetic Acid Cocatalyst

(2012) Guansai Liu et al.   ORGANIC LETTERS

Lewis Acid Activated Synthesis of Highly Substituted Cyclopentanes by the N-Heterocyclic Carbene Catalyzed Addition of Homoenolate Equivalents to Unsaturated Ketoesters

(2011) Daniel T. Cohen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalyzed Domino Reactions

(2011) André Grossmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral Brønsted acids in enantioselective carbonyl activations – activation modes and applications

(2011) Magnus Rueping et al.   CHEMICAL SOCIETY REVIEWS

Employing homoenolates generated by NHC catalysis in carbon–carbon bond-forming reactions: state of the art

(2011) Vijay Nair et al.   CHEMICAL SOCIETY REVIEWS

Dual Activation in N-Heterocyclic Carbene-organocatalysis

(2011) Keiichi Hirano et al.   CHEMISTRY LETTERS

Oxidative Esterification, Thioesterification, and Amidation of Aldehydes by a Two-Component Organocatalyst System Using a Chiral N-Heterocyclic Carbene and Redox-Active Riboflavin

(2011) Soichiro Iwahana et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Heterocyclic Carbene and Brønsted Acid Cooperative Catalysis: Asymmetric Synthesis oftrans-γ-Lactams

(2011) Xiaodan Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Asymmetric Intermolecular Stetter Reaction of Enals with Nitroalkenes: Enhancement of Catalytic Efficiency through Bifunctional Additives

(2011) Daniel A. DiRocco et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NHC/Iron cooperative catalysis: aerobic oxidative esterification of aldehydes with phenols

(2011) R. Sudarshan Reddy et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Understanding the cooperative NHC/LA catalysis for stereoselective annulation reactions with homoenolates. A DFT study

(2011) Luis R. Domingo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-Heterocyclic carbene catalysed aerobic oxidation of aromatic aldehydes to aryl esters using boronic acids

(2011) Panjab Arde et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

NHC-Catalyzed/Titanium(IV)−Mediated Highly Diastereo- and Enantioselective Dimerization of Enals

(2011) Daniel T. Cohen et al.   ORGANIC LETTERS

EnantioselectiveN-Heterocyclic Carbene-Catalyzed Michael Addition to α,β-Unsaturated Aldehydes by Redox Oxidation

(2011) Zi-Qiang Rong et al.   ORGANIC LETTERS

Palladium/NHC-catalyzed oxidative esterification of aldehydes with phenols

(2011) Manli Zhang et al.   TETRAHEDRON LETTERS

Cooperative Lewis acid/N-heterocyclic carbene catalysis

(2011) Daniel T. Cohen et al.   Chemical Science

Unifying Metal and Brønsted Acid Catalysis-Concepts, Mechanisms, and Classifications

(2010) Magnus Rueping et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Heterocyclic Carbene-Catalyzed Conjugate Additions of Alcohols

(2010) Eric M. Phillips et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CooperativeN-Heterocyclic Carbene/Lewis Acid Catalysis for Highly Stereoselective Annulation Reactions with Homoenolates

(2010) Benoit Cardinal-David et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cooperative catalysis by carbenes and Lewis acids in a highly stereoselective route to γ-lactams

(2010) Dustin E. A. Raup et al.   Nature Chemistry

NHC−Iron-Catalyzed Aerobic Oxidative Aromatic Esterification of Aldehydes using Boronic Acids

(2010) João N. Rosa et al.   ORGANIC LETTERS

α′-Hydroxyenones as Mechanistic Probes and Scope-Expanding Surrogates for α,β-Unsaturated Aldehydes in N-Heterocyclic Carbene-Catalyzed Reactions

(2009) Pei-Chen Chiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereodivergency of Triazolium and Imidazolium-Derived NHCs for Catalytic, Enantioselective Cyclopentane Synthesis

(2009) Juthanat Kaeobamrung et al.   ORGANIC LETTERS

Nucleophilic Heterocyclic Carbene Catalyzed Annulation of Enals to Chalcones in Methanol: A Stereoselective Synthesis of Highly Functionalized Cyclopentanes§

(2009) Vijay Nair et al.   ORGANIC LETTERS

Bifunctional Asymmetric Catalysis: Cooperative Lewis Acid/Base Systems

(2008) Daniel H. Paull et al.   ACCOUNTS OF CHEMICAL RESEARCH

Palladium-Catalyzed C-Allylation of Benzoins and an NHC-Catalyzed Three Component Coupling Derived Thereof: Compatibility of NHC- and Pd-Catalysts

(2008) Raphaël Lebeuf et al.   ORGANIC LETTERS

Assembly of functionalized α-hydroxy carbonyl compounds via combination of N-heterocyclic carbene and Pd catalysts

(2008) Jinmei He et al.   TETRAHEDRON LETTERS