Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG Sites

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis

(2012) Catherine Bui et al.   FASEB JOURNAL

Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs

(2012) M.J. Barter et al.   OSTEOARTHRITIS AND CARTILAGE

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation

(2011) Louise N. Reynard et al.   HUMAN MOLECULAR GENETICS

E74-like Factor 3 (ELF3) Impacts on Matrix Metalloproteinase 13 (MMP13) Transcriptional Control in Articular Chondrocytes under Proinflammatory Stress

(2011) Miguel Otero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic alterations in autoimmune rheumatic diseases

(2011) Esteban Ballestar   Nature Reviews Rheumatology

Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis

(2011) Mary B. Goldring et al.   TRENDS IN MOLECULAR MEDICINE

Epigenetics and rheumatoid arthritis: The role of SENP1 in the regulation of MMP-1 expression

(2010) Hanna Maciejewska-Rodrigues et al.   JOURNAL OF AUTOIMMUNITY

Histone Deacetylase Inhibitors Suppress Inflammatory Activation of Rheumatoid Arthritis Patient Synovial Macrophages and Tissue

(2010) Aleksander M. Grabiec et al.   JOURNAL OF IMMUNOLOGY

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

HIF-2α as a possible therapeutic target of osteoarthritis

(2010) T. Saito et al.   OSTEOARTHRITIS AND CARTILAGE

CpG methylation of half-CRE sequences creates C/EBP  binding sites that activate some tissue-specific genes

(2010) V. Rishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis

(2010) Tomoko Kawabata et al.   ARTHRITIS RESEARCH & THERAPY

DNA demethylation at specific CpG sites in theIL1Bpromoter in response to inflammatory cytokines in human articular chondrocytes

(2009) Ko Hashimoto et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Expression and Function of Histone Deacetylases in Rheumatoid Arthritis Synovial Fibroblasts

(2009) M. HORIUCHI et al.   JOURNAL OF RHEUMATOLOGY

Correlation of COL10A1 induction during chondrogenesis of mesenchymal stem cells with demethylation of two CpG sites in the COL10A1 promoter

(2008) Peter Zimmermann et al.   ARTHRITIS AND RHEUMATISM

Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage

(2008) Marco A. da Silva et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The bHLH/Per-Arnt-Sim transcription factor SIM2 regulates muscle transcript myomesin2 via a novel, non-canonical E-box sequence

(2008) Susan Woods et al.   NUCLEIC ACIDS RESEARCH

Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage

(2008) R.F. Loeser et al.   OSTEOARTHRITIS AND CARTILAGE

DNA methylation is not responsible for p21WAF1/CIP1 down-regulation in osteoarthritic chondrocytes

(2008) S. Sesselmann et al.   OSTEOARTHRITIS AND CARTILAGE

Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation

(2008) Kelvin S. C. Cheung et al.   RHEUMATOLOGY INTERNATIONAL

Epigenetic modifications in rheumatoid arthritis

(2008) Simon Strietholt et al.   ARTHRITIS RESEARCH & THERAPY

ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes

(2007) Haibing Peng et al.   JOURNAL OF CELLULAR PHYSIOLOGY