Cannabidiol as a Potential Treatment for Anxiety and Mood Disorders: Molecular Targets and Epigenetic Insights from Preclinical Research
出版年份 2021 全文链接
标题
Cannabidiol as a Potential Treatment for Anxiety and Mood Disorders: Molecular Targets and Epigenetic Insights from Preclinical Research
作者
关键词
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出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 4, Pages 1863
出版商
MDPI AG
发表日期
2021-02-14
DOI
10.3390/ijms22041863
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- CBD modulates DNA methylation in the prefrontal cortex and hippocampus of mice exposed to forced swim
- (2020) Amanda J. Sales et al. BEHAVIOURAL BRAIN RESEARCH
- Subacute cannabidiol alters genome‐wide DNA methylation in adult mouse hippocampus
- (2020) Nicole M Wanner et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
- Jmjd3 is involved in the susceptibility to depression induced by maternal separation via enhancing the neuroinflammation in the prefrontal cortex and hippocampus of male rats
- (2020) Rui Wang et al. EXPERIMENTAL NEUROLOGY
- Social defeat stress in adult mice causes alterations in gene expression, alternative splicing, and the epigenetic landscape of H3K4me3 in the prefrontal cortex: An impact of early-life stress
- (2020) V.V. Reshetnikov et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- DNA Methyltransferases in Depression: An Update
- (2020) Zhenghao Duan et al. Frontiers in Psychiatry
- Antidepressant mechanisms of venlafaxine involving increasing histone acetylation and modulating tyrosine hydroxylase and tryptophan hydroxylase expression in hippocampus of depressive rats
- (2019) Min Qiao et al. NEUROREPORT
- The Roles of Human DNA Methyltransferases and Their Isoforms in Shaping the Epigenome
- (2019) Hemant Gujar et al. Genes
- miRNA expression profiles and molecular networks in resting and LPS-activated BV-2 microglia—Effect of cannabinoids
- (2019) Ana Juknat et al. PLoS One
- The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid (SAHA) Alleviates Depression-Like Behavior and Normalizes Epigenetic Changes in the Hippocampus During Ethanol Withdrawal
- (2019) Wei-Yang Chen et al. ALCOHOL
- Epigenetic Regulations in Neuropsychiatric Disorders
- (2019) Janise N. Kuehner et al. Frontiers in Genetics
- Stress, epigenetics and depression: A systematic review
- (2019) Caroline Park et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Aberrant Expression of Intracellular let-7e, miR-146a, and miR-155 Correlates with Severity of Depression in Patients with Major Depressive Disorder and Is Ameliorated after Antidepressant Treatment
- (2019) Yi-Yung Hung et al. Cells
- Cannabidiol (CBD) use in psychiatric disorders: A systematic review
- (2019) Stefania Bonaccorso et al. NEUROTOXICOLOGY
- Cannabidiol Regulates Gene Expression in Encephalitogenic T cells Using Histone Methylation and noncoding RNA during Experimental Autoimmune Encephalomyelitis
- (2019) Xiaoming Yang et al. Scientific Reports
- Antidepressant administration modulates stress-induced DNA methylation and DNA methyltransferase expression in rat prefrontal cortex and hippocampus
- (2018) Amanda J. Sales et al. BEHAVIOURAL BRAIN RESEARCH
- Evidence for the implication of the histone code in building the genome structure
- (2018) Kirti Prakash et al. BIOSYSTEMS
- Novel insights into mitochondrial molecular targets of iron-induced neurodegeneration: Reversal by cannabidiol
- (2018) Vanessa Kappel da Silva et al. BRAIN RESEARCH BULLETIN
- Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex
- (2018) Amanda J. Sales et al. MOLECULAR NEUROBIOLOGY
- H3K9 Acetylation of Tph 2 Involved in Depression-like Behavior in Male, but not Female, Juvenile Offspring Rat Induced by Prenatal Stress
- (2018) Shaokang Dang et al. NEUROSCIENCE
- Antidepressant-like effect induced by Cannabidiol is dependent on brain serotonin levels
- (2018) Amanda J. Sales et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Cannabidiol modulates serotonergic transmission and prevents allodynia and anxiety-like behavior in a model of neuropathic pain
- (2018) Danilo De Gregorio et al. PAIN
- Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
- (2018) Jacob O'Brien et al. Frontiers in Endocrinology
- Effects of cannabidiol in males and females in two different rat models of depression
- (2018) Liat Shbiro et al. PHYSIOLOGY & BEHAVIOR
- Interactions between cannabidiol and Δ9-THC following acute and repeated dosing: Rebound hyperactivity, sensorimotor gating and epigenetic and neuroadaptive changes in the mesolimbic pathway
- (2017) Stephanie M. Todd et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline
- (2017) Hong-Tao Wang et al. NEUROTOXICITY RESEARCH
- Cannabidiol: State of the art and new challenges for therapeutic applications
- (2017) Simona Pisanti et al. PHARMACOLOGY & THERAPEUTICS
- Effect of prior foot shock stress and Δ9-tetrahydrocannabinol, cannabidiolic acid, and cannabidiol on anxiety-like responding in the light-dark emergence test in rats
- (2017) Erin M. Rock et al. PSYCHOPHARMACOLOGY
- MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes
- (2017) Juan Pablo Lopez et al. Nature Communications
- Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders
- (2017) Alline C. Campos et al. Frontiers in Pharmacology
- How Stress Gets Under the Skin: Early Life Adversity and Glucocorticoid Receptor Epigenetic Regulation
- (2017) Patrick Z. Liu et al. CURRENT GENOMICS
- Antidepressant-like effect of cannabidiol injection into the ventral medial prefrontal cortex—Possible involvement of 5-HT1A and CB1 receptors
- (2016) A.G. Sartim et al. BEHAVIOURAL BRAIN RESEARCH
- Peripheral whole blood microRNA alterations in major depression and bipolar disorder
- (2016) Elisabetta Maffioletti et al. JOURNAL OF AFFECTIVE DISORDERS
- Dnmt3a in the Medial Prefrontal Cortex Regulates Anxiety-Like Behavior in Adult Mice
- (2016) E. Elliott et al. JOURNAL OF NEUROSCIENCE
- The microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression
- (2016) Joshua A. Azevedo et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Effects of lack of microRNA-34 on the neural circuitry underlying the stress response and anxiety
- (2016) Diego Andolina et al. NEUROPHARMACOLOGY
- Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors
- (2016) Raquel Linge et al. NEUROPHARMACOLOGY
- Prohedonic Effect of Cannabidiol in a Rat Model of Depression
- (2016) Gal Shoval et al. NEUROPSYCHOBIOLOGY
- Histone Lysine Demethylases of JMJD2 or KDM4 Family are Important Epigenetic Regulators in Reward Circuitry in the Etiopathology of Depression
- (2016) Salil Saurav Pathak et al. NEUROPSYCHOPHARMACOLOGY
- The role of DNA methylation in the pathophysiology and treatment of bipolar disorder
- (2016) Gabriel R. Fries et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology
- (2016) Alessia Ligresti et al. PHYSIOLOGICAL REVIEWS
- MicroRNA-155 deletion reduces anxiety- and depressive-like behaviors in mice
- (2016) Laura K. Fonken et al. PSYCHONEUROENDOCRINOLOGY
- DNA Methylation, Its Mediators and Genome Integrity
- (2015) Huan Meng et al. International Journal of Biological Sciences
- Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder
- (2015) S Bavamian et al. MOLECULAR PSYCHIATRY
- Identification of Differential MicroRNAs in Cerebrospinal Fluid and Serum of Patients with Major Depressive Disorder
- (2015) Yunqiang Wan et al. PLoS One
- Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa
- (2014) Alexandre Schier et al. CNS & Neurological Disorders-Drug Targets
- The Effect of Cannabidiol on Ischemia/Reperfusion-Induced Ventricular Arrhythmias
- (2014) Ersöz Gonca et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
- Involvement of Nrf2 in Development of Anxiety-Like Behavior by Linking Bcl2 to Oxidative Phosphorylation: Estimation in Rat Hippocampus, Amygdala, and Prefrontal Cortex
- (2014) Solmaz Khalifeh et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Epigenetic modulation of chronic anxiety and pain by histone deacetylation
- (2014) L Tran et al. MOLECULAR PSYCHIATRY
- Amygdala-Dependent Fear Memory Consolidation via miR-34a and Notch Signaling
- (2014) Brian George Dias et al. NEURON
- Expression of microRNAs and Other Small RNAs in Prefrontal Cortex in Schizophrenia, Bipolar Disorder and Depressed Subjects
- (2014) Neil R. Smalheiser et al. PLoS One
- Epigenetic Mechanisms of Depression
- (2014) Eric J. Nestler JAMA Psychiatry
- Epigenetic control of skin differentiation genes by phytocannabinoids
- (2013) Mariangela Pucci et al. BRITISH JOURNAL OF PHARMACOLOGY
- Microglial Dysregulation in Psychiatric Disease
- (2013) Luciana Romina Frick et al. Clinical & Developmental Immunology
- Effects of intra-prelimbic prefrontal cortex injection of cannabidiol on anxiety-like behavior: Involvement of 5HT1A receptors and previous stressful experience
- (2013) M.V. Fogaça et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system
- (2013) Alline C. Campos et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- miR-449a Contributes to Glucocorticoid-Induced CRF-R1 Downregulation in the Pituitary During Stress
- (2013) Takahiro Nemoto et al. MOLECULAR ENDOCRINOLOGY
- Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+Cells Through PPARγ Involvement
- (2013) Caterina Scuderi et al. PHYTOTHERAPY RESEARCH
- P5-HT1A receptors in mood and anxiety: recent insights into autoreceptor versus heteroreceptor function
- (2013) Alvaro L. Garcia-Garcia et al. PSYCHOPHARMACOLOGY
- Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels
- (2012) Nicole Zimmermann et al. BIOCHEMICAL JOURNAL
- Combinatorial complexity in chromatin structure and function: revisiting the histone code
- (2012) Oliver J Rando CURRENT OPINION IN GENETICS & DEVELOPMENT
- H3K4 tri-methylation in synapsin genes leads to different expression patterns in bipolar disorder and major depression
- (2012) Cristiana Cruceanu et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Epigenetics of the Depressed Brain: Role of Histone Acetylation and Methylation
- (2012) HaoSheng Sun et al. NEUROPSYCHOPHARMACOLOGY
- Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders
- (2012) A. C. Campos et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test
- (2012) Valéria Almeida et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats
- (2012) Alline Cristina Campos et al. PSYCHOPHARMACOLOGY
- Administration of cannabidiol and imipramine induces antidepressant-like effects in the forced swimming test and increases brain-derived neurotrophic factor levels in the rat amygdala.
- (2011) Gislaine Z. Réus et al. ACTA NEUROPSYCHIATRICA
- Epigenetic Mechanisms of Depression and Antidepressant Action
- (2011) Vincent Vialou et al. Annual Review of Pharmacology and Toxicology
- Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression
- (2011) Philippe A. Melas et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats
- (2011) Yi-Tse Hsiao et al. NEUROPHARMACOLOGY
- Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition
- (2011) Herbert E. Covington et al. NEUROSCIENCE LETTERS
- Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress
- (2011) Érica M. Granjeiro et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- DNA Methylation of the First Exon Is Tightly Linked to Transcriptional Silencing
- (2011) Fabienne Brenet et al. PLoS One
- Anxiogenic-like effects of chronic cannabidiol administration in rats
- (2011) Maha M. ElBatsh et al. PSYCHOPHARMACOLOGY
- Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors
- (2010) Vanessa de Paula Soares et al. BEHAVIOURAL BRAIN RESEARCH
- Effects of cannabinoids and cannabinoid-enrichedCannabisextracts on TRP channels and endocannabinoid metabolic enzymes
- (2010) Luciano De Petrocellis et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cannabidiol injected into the bed nucleus of the stria terminalis reduces the expression of contextual fear conditioning via 5-HT1A receptors
- (2010) Felipe V Gomes et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Genetic Deletion of Fatty Acid Amide Hydrolase Alters Emotional Behavior and Serotonergic Transmission in the Dorsal Raphe, Prefrontal Cortex and Hippocampus
- (2010) Francis Rodriguez Bambico et al. NEUROPSYCHOPHARMACOLOGY
- Antidepressant-like effect of Δ9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.
- (2010) Abir T. El-Alfy et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors
- (2010) Felipe V. Gomes et al. PSYCHOPHARMACOLOGY
- 5-HT1Areceptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats
- (2009) Leonardo B.M. Resstel et al. BRITISH JOURNAL OF PHARMACOLOGY
- Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors
- (2009) TV Zanelati et al. BRITISH JOURNAL OF PHARMACOLOGY
- Antidepressant Actions of Histone Deacetylase Inhibitors
- (2009) H. E. Covington et al. JOURNAL OF NEUROSCIENCE
- Imipramine Treatment and Resiliency Exhibit Similar Chromatin Regulation in the Mouse Nucleus Accumbens in Depression Models
- (2009) M. B. Wilkinson et al. JOURNAL OF NEUROSCIENCE
- Linking DNA methylation and histone modification: patterns and paradigms
- (2009) Howard Cedar et al. NATURE REVIEWS GENETICS
- Regulation of hippocampal H3 histone methylation by acute and chronic stress
- (2009) R. G. Hunter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Evidence for a potential role for TRPV1 receptors in the dorsolateral periaqueductal gray in the attenuation of the anxiolytic effects of cannabinoids
- (2009) Alline Cristina Campos et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications
- (2008) Srijan Sen et al. BIOLOGICAL PSYCHIATRY
- Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats
- (2008) Alline Cristina Campos et al. PSYCHOPHARMACOLOGY
- The diverse CB1and CB2receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin
- (2007) R G Pertwee BRITISH JOURNAL OF PHARMACOLOGY
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