Epigenetic Mechanisms of Depression and Antidepressant Action

The road not taken: life experiences in monozygotic twin pairs discordant for major depression

(2012) K S Kendler et al.   MOLECULAR PSYCHIATRY

Hippocampus, amygdala, and stress: interacting systems that affect susceptibility to addiction

(2011) Pauline Belujon et al.   Annals of the New York Academy of Sciences

Paternal Transmission of Stress-Induced Pathologies

(2011) David M. Dietz et al.   BIOLOGICAL PSYCHIATRY

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

(2011) Junjie U. Guo et al.   CELL

SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive

(2011) Sergiy Libert et al.   CELL

No-Nonsense Functions for Long Noncoding RNAs

(2011) Takashi Nagano et al.   CELL

Maternal High-Fat Diet Effects on Third-Generation Female Body Size via the Paternal Lineage

(2011) Gregory A. Dunn et al.   ENDOCRINOLOGY

Minireview: NAD+, a Circadian Metabolite with an Epigenetic Twist*

(2011) Paolo Sassone-Corsi   ENDOCRINOLOGY

Allele-specific methylation in the human genome

(2011) Emma L. Meaburn et al.   Epigenetics

Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression

(2011) Philippe A. Melas et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

A Novel Role of the WNT-Dishevelled-GSK3  Signaling Cascade in the Mouse Nucleus Accumbens in a Social Defeat Model of Depression

(2011) M. B. Wilkinson et al.   JOURNAL OF NEUROSCIENCE

Early Prenatal Stress Epigenetically Programs Dysmasculinization in Second-Generation Offspring via the Paternal Lineage

(2011) C. P. Morgan et al.   JOURNAL OF NEUROSCIENCE

Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder

(2011) Tania L. Roth et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

The HSP90 Molecular Chaperone Cycle Regulates Cyclical Transcriptional Dynamics of the Glucocorticoid Receptor and Its Coregulatory Molecules CBP/p300 During Ultradian Ligand Treatment

(2011) Becky L. Conway-Campbell et al.   MOLECULAR ENDOCRINOLOGY

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10

(2011) Alastair S. Garfield et al.   NATURE

Mapping and analysis of chromatin state dynamics in nine human cell types

(2011) Jason Ernst et al.   NATURE

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

(2011) William A. Pastor et al.   NATURE

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

(2011) Keith E Szulwach et al.   NATURE NEUROSCIENCE

Transcriptional and epigenetic mechanisms of addiction

(2011) Alfred J. Robison et al.   NATURE REVIEWS NEUROSCIENCE

Early life stress triggers sustained changes in histone deacetylase expression and histone H4 modifications that alter responsiveness to adolescent antidepressant treatment

(2011) Amir Levine et al.   NEUROBIOLOGY OF DISEASE

Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events

(2011) Shusaku Uchida et al.   NEURON

Epigenetic Mechanisms in Cognition

(2011) Jeremy J. Day et al.   NEURON

A Role for Repressive Histone Methylation in Cocaine-Induced Vulnerability to Stress

(2011) Herbert E. Covington et al.   NEURON

Functional Biomarkers of Depression: Diagnosis, Treatment and Pathophysiology

(2011) Heath D Schmidt et al.   NEUROPSYCHOPHARMACOLOGY

Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition

(2011) Herbert E. Covington et al.   NEUROSCIENCE LETTERS

Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats

(2011) Patrick O. McGowan et al.   PLoS One

Chronic Stress Induces Sex-Specific Alterations in Methylation and Expression of Corticotropin-Releasing Factor Gene in the Rat

(2011) Linda Sterrenburg et al.   PLoS One

Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens

(2011) I. Maze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

The making of an organ

(2011) Minoo Rassoulzadegan et al.   Organogenesis

Genes, Environment, and Individual Differences in Responding to Treatment for Depression

(2011) Rudolf Uher   HARVARD REVIEW OF PSYCHIATRY

Allelic Skewing of DNA Methylation Is Widespread across the Genome

(2010) Leonard C. Schalkwyk et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Increased BDNF Promoter Methylation in the Wernicke Area of Suicide Subjects

(2010) Simona Keller et al.   ARCHIVES OF GENERAL PSYCHIATRY

Wnt2 Expression and Signaling Is Increased by Different Classes of Antidepressant Treatments

(2010) Hideki Okamoto et al.   BIOLOGICAL PSYCHIATRY

Epigenetic Transmission of the Impact of Early Stress Across Generations

(2010) Tamara B. Franklin et al.   BIOLOGICAL PSYCHIATRY

Early Life Programming and Neurodevelopmental Disorders

(2010) Tracy L. Bale et al.   BIOLOGICAL PSYCHIATRY

Long non-coding RNAs in nervous system function and disease

(2010) Irfan A. Qureshi et al.   BRAIN RESEARCH

Repeated Social Defeat Selectively Increases  FosB Expression and Histone H3 Acetylation in the Infralimbic Medial Prefrontal Cortex

(2010) M. Hinwood et al.   CEREBRAL CORTEX

Convergent integration of animal model and human studies of bipolar disorder (manic-depressive illness)

(2010) Helen Le-Niculescu et al.   CURRENT OPINION IN PHARMACOLOGY

Animal models of early life stress: Implications for understanding resilience

(2010) David M. Lyons et al.   DEVELOPMENTAL PSYCHOBIOLOGY

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses

(2010) Tim F. Oberlander et al.   Epigenetics

Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation

(2010) Eric Hervouet et al.   Epigenetics

Non-Mendelian epigenetic heredity: gametic RNAs as epigenetic regulators and transgenerational signals

(2010) François Cuzin et al.   Essays in Biochemistry

Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns

(2010) J. R. Edwards et al.   GENOME RESEARCH

Transgenerational epigenetic inheritance: More questions than answers

(2010) L. Daxinger et al.   GENOME RESEARCH

Epigenetics and gene expression

(2010) E R Gibney et al.   HEREDITY

Epigenetics and the origins of paternal effects

(2010) James P. Curley et al.   HORMONES AND BEHAVIOR

Individual differences in the effect of social defeat on anhedonia and histone acetylation in the rat hippocampus

(2010) F. Hollis et al.   HORMONES AND BEHAVIOR

Epigenetic marking of the BDNF gene by early-life adverse experiences

(2010) Tania L. Roth et al.   HORMONES AND BEHAVIOR

Mammalian circadian clock and metabolism - the epigenetic link

(2010) M. M. Bellet et al.   JOURNAL OF CELL SCIENCE

Setdb1 Histone Methyltransferase Regulates Mood-Related Behaviors and Expression of the NMDA Receptor Subunit NR2B

(2010) Y. Jiang et al.   JOURNAL OF NEUROSCIENCE

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

(2010) S. Michan et al.   JOURNAL OF NEUROSCIENCE

Gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models

(2010) B M Andrus et al.   MOLECULAR PSYCHIATRY

Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression

(2010) R C Shelton et al.   MOLECULAR PSYCHIATRY

Altered expression of glutamate signaling, growth factor and glia genes in the locus coeruleus of patients with major depression

(2010) R Bernard et al.   MOLECULAR PSYCHIATRY

L1 retrotransposition in neurons is modulated by MeCP2

(2010) Alysson R. Muotri et al.   NATURE

Brain function and chromatin plasticity

(2010) Catherine Dulac   NATURE

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

(2010) Jun Gao et al.   NATURE

Targets and dynamics of promoter DNA methylation during early mouse development

(2010) Julie Borgel et al.   NATURE GENETICS

A negative regulator of MAP kinase causes depressive behavior

(2010) Vanja Duric et al.   NATURE MEDICINE

Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice

(2010) Evan Elliott et al.   NATURE NEUROSCIENCE

MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212

(2010) Heh-In Im et al.   NATURE NEUROSCIENCE

ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses

(2010) Vincent Vialou et al.   NATURE NEUROSCIENCE

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens

(2010) Quincey LaPlant et al.   NATURE NEUROSCIENCE

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons

(2010) Jian Feng et al.   NATURE NEUROSCIENCE

Socioeconomic status and the brain: mechanistic insights from human and animal research

(2010) Daniel A. Hackman et al.   NATURE REVIEWS NEUROSCIENCE

Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa

(2010) Urszula Brykczynska et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CpG Methylation in Neurons: Message, Memory, or Mask?

(2010) Rajiv P Sharma et al.   NEUROPSYCHOPHARMACOLOGY

Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex

(2010) I. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic and inflammatory marker profiles associated with depression in a community-based epidemiologic sample

(2010) M. Uddin et al.   PSYCHOLOGICAL MEDICINE

The effects of repeated social defeat on long-term depressive-like behavior and short-term histone modifications in the hippocampus in male Sprague–Dawley rats

(2010) Fiona Hollis et al.   PSYCHOPHARMACOLOGY

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

High-Resolution Analysis of Parent-of-Origin Allelic Expression in the Mouse Brain

(2010) C. Gregg et al.   SCIENCE

Sex-Specific Parent-of-Origin Allelic Expression in the Mouse Brain

(2010) C. Gregg et al.   SCIENCE

MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to Antidepressants

(2010) A. Baudry et al.   SCIENCE

Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity

(2010) I. Maze et al.   SCIENCE

Epigenetic Reprogramming in Plant and Animal Development

(2010) Suhua Feng et al.   SCIENCE

LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes?

(2010) Tatjana Singer et al.   TRENDS IN NEUROSCIENCES

Epigenetics and the Environmental Regulation of the Genome and Its Function

(2009) Tie-Yuan Zhang et al.   Annual Review of Psychology

Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene

(2009) Tania L. Roth et al.   BIOLOGICAL PSYCHIATRY

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Epigenetics: heterochromatin meets RNAi

(2009) Ingela Djupedal et al.   CELL RESEARCH

Regulation of chromatin structure in memory formation

(2009) Tania L Roth et al.   CURRENT OPINION IN NEUROBIOLOGY

Maternal High-Fat Diet Promotes Body Length Increases and Insulin Insensitivity in Second-Generation Mice

(2009) Gregory A. Dunn et al.   ENDOCRINOLOGY

Environmental influence on L1 retrotransposons in the adult hippocampus

(2009) Alysson R. Muotri et al.   HIPPOCAMPUS

DNA methylation in vulnerability to post-traumatic stress in rats: evidence for the role of the post-synaptic density protein Dlgap2

(2009) Yael Chertkow-Deutsher et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Neuroscience, Molecular Biology, and the Childhood Roots of Health Disparities

(2009) Jack P. Shonkoff et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Antidepressant Actions of Histone Deacetylase Inhibitors

(2009) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

Imipramine Treatment and Resiliency Exhibit Similar Chromatin Regulation in the Mouse Nucleus Accumbens in Depression Models

(2009) M. B. Wilkinson et al.   JOURNAL OF NEUROSCIENCE

Non-coding RNAs: regulators of disease

(2009) Ryan J Taft et al.   JOURNAL OF PATHOLOGY

Altered gene expression of histone deacetylases in mood disorder patients

(2009) Teruyuki Hobara et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis

(2009) Tomoko Kuwabara et al.   NATURE NEUROSCIENCE

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

(2009) Patrick O McGowan et al.   NATURE NEUROSCIENCE

Dynamic DNA methylation programs persistent adverse effects of early-life stress

(2009) Chris Murgatroyd et al.   NATURE NEUROSCIENCE

CREB regulation of nucleus accumbens excitability mediates social isolation–induced behavioral deficits

(2009) Deanna L Wallace et al.   NATURE NEUROSCIENCE

Stress and disorders of the stress system

(2009) George P. Chrousos   Nature Reviews Endocrinology

Effects of stress throughout the lifespan on the brain, behaviour and cognition

(2009) Sonia J. Lupien et al.   NATURE REVIEWS NEUROSCIENCE

Psychobiology and molecular genetics of resilience

(2009) Adriana Feder et al.   NATURE REVIEWS NEUROSCIENCE

Epigenetic inheritance in mammals: Evidence for the impact of adverse environmental effects

(2009) Tamara B. Franklin et al.   NEUROBIOLOGY OF DISEASE

Maternal care determines rapid effects of stress mediators on synaptic plasticity in adult rat hippocampal dentate gyrus

(2009) Rosemary C. Bagot et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Translational Control of Long-Lasting Synaptic Plasticity and Memory

(2009) Mauro Costa-Mattioli et al.   NEURON

Effects of the histone deacetylase inhibitor sodium butyrate in models of depression and anxiety

(2009) Brigitta B. Gundersen et al.   NEUROPHARMACOLOGY

The Neurocircuitry of Fear, Stress and Anxiety Disorders

(2009) Lisa M Shin et al.   NEUROPSYCHOPHARMACOLOGY

Regulation of hippocampal H3 histone methylation by acute and chronic stress

(2009) R. G. Hunter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenerational effects of the endocrine disruptor vinclozolin on the methylation pattern of imprinted genes in the mouse sperm

(2009) Christelle Stouder et al.   REPRODUCTION

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

Neuronal Activity-Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis

(2009) D. K. Ma et al.   SCIENCE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Transgenerational Epigenetic Effects

(2008) Neil A. Youngson et al.   Annual Review of Genomics and Human Genetics

Generation and behavioral characterization of β-catenin forebrain-specific conditional knock-out mice

(2008) Todd D. Gould et al.   BEHAVIOURAL BRAIN RESEARCH

The methyl-CpG-binding protein MeCP2 and neurological disease

(2008) Adrian Bird   BIOCHEMICAL SOCIETY TRANSACTIONS

The cell biology of DNA methylation in mammals

(2008) Egor Prokhortchouk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

GABAA Receptor Promoter Hypermethylation in Suicide Brain: Implications for the Involvement of Epigenetic Processes

(2008) Michael O. Poulter et al.   BIOLOGICAL PSYCHIATRY

Epigenetic mechanisms in mammals

(2008) J. K. Kim et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators

(2008) Bruce S. McEwen   EUROPEAN JOURNAL OF PHARMACOLOGY

Epigenetic mechanisms and the transgenerational effects of maternal care

(2008) Frances A. Champagne   FRONTIERS IN NEUROENDOCRINOLOGY

Epigenetics in the Nervous System

(2008) Y. Jiang et al.   JOURNAL OF NEUROSCIENCE

Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy

(2008) B. R. Mueller et al.   JOURNAL OF NEUROSCIENCE

KAP1-Mediated Epigenetic Repression in the Forebrain Modulates Behavioral Vulnerability to Stress

(2008) Johan Jakobsson et al.   NEURON

Decoding the Epigenetic Language of Neuronal Plasticity

(2008) Emiliana Borrelli et al.   NEURON

Deletion of Mecp2 in Sim1-Expressing Neurons Reveals a Critical Role for MeCP2 in Feeding Behavior, Aggression, and the Response to Stress

(2008) Sharyl L. Fyffe et al.   NEURON

Corticolimbic Transcriptome Changes are State-Dependent and Region-Specific in a Rodent Model of Depression and of Antidepressant Reversal

(2008) Alexandre Surget et al.   NEUROPSYCHOPHARMACOLOGY

The long-term behavioural consequences of prenatal stress

(2008) Marta Weinstock   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Promoter-Wide Hypermethylation of the Ribosomal RNA Gene Promoter in the Suicide Brain

(2008) Patrick O. McGowan et al.   PLoS One

Transgenerational Epigenetic Programming of the Brain Transcriptome and Anxiety Behavior

(2008) Michael K. Skinner et al.   PLoS One

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE

Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300

(2008) Lei Zeng et al.   STRUCTURE

Synaptic plasticity, memory and the hippocampus: a neural network approach to causality

(2007) Guilherme Neves et al.   NATURE REVIEWS NEUROSCIENCE