How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?

Chemical hypoxia induces pro-inflammatory signals in fat-laden hepatocytes and contributes to cellular crosstalk with Kupffer cells through extracellular vesicles

(2020) Alejandra Hernandez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hepatocyte caveolin-1 modulates metabolic gene profiles and functions in non-alcoholic fatty liver disease

(2020) Mei Han et al.   Cell Death & Disease

Advanced fibrosis of non-alcoholic steatohepatitis affects the significance of lipoprotein(a) as a cardiovascular risk factor

(2020) Kanako Konishi et al.   ATHEROSCLEROSIS

Adipose tissue remodelling in obese subjects is a determinant of presence and severity of fatty liver disease.

(2020) Flavia Agata Cimini et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Mitochondrial DNA from hepatocytes induces upregulation of interleukin-33 expression of macrophages in nonalcoholic steatohepatitis

(2020) Yinjie Gao et al.   DIGESTIVE AND LIVER DISEASE

Lytic cell death in metabolic liver disease

(2020) Jérémie Gautheron et al.   JOURNAL OF HEPATOLOGY

Extracellular Vesicles in NAFLD/ALD: From Pathobiology to Therapy

(2020) Alejandra Hernández et al.   Cells

Microbiota and Fatty Liver Disease—the Known, the Unknown, and the Future

(2020) Sonja Lang et al.   Cell Host & Microbe

Hesperetin protects against palmitate-induced cellular toxicity via induction of GRP78 in hepatocytes

(2020) Yana Geng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Impaired mitophagy triggers NLRP3 inflammasome activation during the progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis

(2019) Ning-Ping Zhang et al.   LABORATORY INVESTIGATION

Autophagy in liver diseases: Time for translation?

(2019) Manon Allaire et al.   JOURNAL OF HEPATOLOGY

Calcium Signaling As a Therapeutic Target for Liver Steatosis

(2019) Eunüs S. Ali et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity

(2019) Tian Zhang et al.   CELL DEATH AND DIFFERENTIATION

Protective effect of metformin against palmitate-induced hepatic cell death

(2019) Yana Geng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hepatic FATP5 expression is associated with histological progression and loss of hepatic fat in NAFLD patients

(2019) Kenichiro Enooku et al.   JOURNAL OF GASTROENTEROLOGY

Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease

(2019) Amine Majdi et al.   JOURNAL OF HEPATOLOGY

Dietary lipids, gut microbiota and lipid metabolism

(2019) Marc Schoeler et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver Disease

(2018) Juan Pablo Arab et al.   Annual Review of Pathology-Mechanisms of Disease

Caspases in metabolic disease and their therapeutic potential

(2018) Claire H Wilson et al.   CELL DEATH AND DIFFERENTIATION

Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis

(2018) Xiaojuan Wang et al.   FASEB JOURNAL

Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis

(2018) Giovanni Musso et al.   GASTROENTEROLOGY

New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases

(2018) Sanda Win et al.   HEPATOLOGY

Hypoxia-inducible factor 2α drives nonalcoholic fatty liver progression by triggering hepatocyte release of histidine-rich glycoprotein

(2018) Elisabetta Morello et al.   HEPATOLOGY

Pyroptosis: An inflammatory link between NAFLD and NASH with potential therapeutic implications

(2018) Juliane I. Beier et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic fatty liver disease: A risk factor for myocardial dysfunction?

(2018) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease

(2018) Cynthia Lebeaupin et al.   JOURNAL OF HEPATOLOGY

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease

(2018) Thomas Jensen et al.   JOURNAL OF HEPATOLOGY

Oleic acid protects saturated fatty acid mediated lipotoxicity in hepatocytes and rat of non-alcoholic steatohepatitis

(2018) Xuanming Chen et al.   LIFE SCIENCES

Mitochondrial adaptation in steatotic mice

(2018) Claudia Einer et al.   MITOCHONDRION

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith–Wiedemann syndrome: an international consensus statement

(2018) Frédéric Brioude et al.   Nature Reviews Endocrinology

Circulating Phospholipid Patterns in NAFLD Patients Associated with a Combination of Metabolic Risk Factors

(2018) Shilpa Tiwari-Heckler et al.   Nutrients

Mitochondrial dysfunction-related lipid changes occur in non-alcoholic fatty liver disease progression

(2018) Kang-Yu Peng et al.   JOURNAL OF LIPID RESEARCH

Apoptosis and necroptosis in the liver: a matter of life and death

(2018) Robert F. Schwabe et al.   Nature Reviews Gastroenterology & Hepatology

HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver

(2018) Takatomo Arai et al.   Scientific Reports

Lipid mediators of liver injury in nonalcoholic fatty liver disease

(2018) Suthat Liangpunsakul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Obstructive Sleep Apnea, Hypoxia, and Nonalcoholic Fatty Liver Disease

(2018) Omar A Mesarwi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

(2018) Zobair M. Younossi et al.   TRANSPLANTATION

Moderate weight loss attenuates chronic endoplasmic reticulum stress and mitochondrial dysfunction in human obesity

(2018) Sandra López-Domènech et al.   Molecular Metabolism

Nonalcoholic fatty liver disease in chronic obstructive pulmonary disease

(2017) Damien Viglino et al.   EUROPEAN RESPIRATORY JOURNAL

A Relative Deficiency of Lysosomal Acid Lypase Activity Characterizes Non-Alcoholic Fatty Liver Disease

(2017) Francesco Tovoli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatic lipid accumulation: cause and consequence of dysregulated glucoregulatory hormones

(2017) Caroline E Geisler et al.   JOURNAL OF ENDOCRINOLOGY

Cytosolic lipolysis and lipophagy: two sides of the same coin

(2017) Rudolf Zechner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients

(2017) Franck Chiappini et al.   Scientific Reports

Prevalence and determinants of non-alcoholic fatty liver disease in lifelines: A large Dutch population cohort

(2017) Eline H. van den Berg et al.   PLoS One

Caveolin1 protects against diet induced hepatic lipid accumulation in mice

(2017) Meng Li et al.   PLoS One

Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis

(2017) Daniel Cabrera et al.   Scientific Reports

Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells

(2017) Young-Sun Lee et al.   Scientific Reports

Lipid-Induced Endoplasmic Reticulum Stress Impairs Selective Autophagy at the Step of Autophagosome-Lysosome Fusion in Hepatocytes

(2016) Koichiro Miyagawa et al.   AMERICAN JOURNAL OF PATHOLOGY

Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by 13 C Magnetic Resonance Spectroscopy

(2016) Kitt Falk Petersen et al.   Cell Metabolism

Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites

(2016) You Zhou et al.   Clinical Gastroenterology and Hepatology

Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator–Activated Receptor α

(2016) Xuqing Chen et al.   DIABETES

Reduced lysosomal acid lipase activity – A potential role in the pathogenesis of non alcoholic fatty liver disease in pediatric patients

(2016) Praveen Kumar Conjeevaram Selvakumar et al.   DIGESTIVE AND LIVER DISEASE

Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice

(2016) Camella G. Wilson et al.   ENDOCRINOLOGY

Physiological Mechanisms of Weight Gain−Induced Steatosis in People With Obesity

(2016) Elisa Fabbrini et al.   GASTROENTEROLOGY

Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes

(2016) Petra Hirsova et al.   GASTROENTEROLOGY

Systematic review of bariatric surgery liver biopsies clarifies the natural history of liver disease in patients with severe obesity

(2016) Pierre Bedossa et al.   GUT

The many faces of RIPK3: What about NASH?

(2016) Lily Dara et al.   HEPATOLOGY

Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury

(2016) Sanjoy Roychowdhury et al.   HEPATOLOGY

Lipotoxicity pathways intersect in hepatocytes: Endoplasmic reticulum stress, c-Jun N-terminal kinase-1, and death receptors

(2016) Yuko Akazawa et al.   HEPATOLOGY RESEARCH

Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease

(2016) Shikha S. Sundaram et al.   JOURNAL OF HEPATOLOGY

The role of ER stress in lipid metabolism and lipotoxicity

(2016) Jaeseok Han et al.   JOURNAL OF LIPID RESEARCH

Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis

(2016) Petra Hirsova et al.   JOURNAL OF LIPID RESEARCH

Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease

(2016) Manoela Mota et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Lysosomal Acid Lipase Deficiency Unmasked in Two Children With Nonalcoholic Fatty Liver Disease

(2016) R. W. Himes et al.   PEDIATRICS

XBP1: A Pivotal Transcriptional Regulator of Glucose and Lipid Metabolism

(2016) Christina Piperi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease

(2016) M V Machado et al.   Cell Death & Disease

Lipid signaling in adipose tissue: Connecting inflammation & metabolism

(2015) Mojgan Masoodi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes

(2015) Ana Paula Arruda et al.   Cell Metabolism

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis

(2015) Marta B. Afonso et al.   CLINICAL SCIENCE

Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up

(2015) Mattias Ekstedt et al.   HEPATOLOGY

Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes

(2015) Samar H. Ibrahim et al.   HEPATOLOGY

Hepatic lipase deficiency produces glucose intolerance, inflammation and hepatic steatosis

(2015) Irene Andrés-Blasco et al.   JOURNAL OF ENDOCRINOLOGY

TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess

(2015) Leila Idrissova et al.   JOURNAL OF HEPATOLOGY

Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner

(2015) Eiji Kakazu et al.   JOURNAL OF LIPID RESEARCH

Biomarkers of NAFLD progression: a lipidomics approach to an epidemic

(2015) D. Lee Gorden et al.   JOURNAL OF LIPID RESEARCH

The roles of c-Jun NH2-terminal kinases (JNKs) in obesity and insulin resistance

(2015) Martin Pal et al.   JOURNAL OF PHYSIOLOGY-LONDON

The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK

(2015) Jeng Yie Chan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Reduced Lysosomal Acid Lipase Activity in Adult Patients With Non-alcoholic Fatty Liver Disease

(2015) Francesco Baratta et al.   EBioMedicine

The role of visceral and subcutaneous adipose tissue fatty acid composition in liver pathophysiology associated with NAFLD

(2015) CL Gentile et al.   Adipocyte

RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction

(2014) Mark Luedde et al.   CARDIOVASCULAR RESEARCH

Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis

(2014) M V Machado et al.   GUT

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

(2014) Á González-Rodríguez et al.   Cell Death & Disease

Palmitate-induced Activation of Mitochondrial Metabolism Promotes Oxidative Stress and Apoptosis in H4IIEC3 Rat Hepatocytes

(2013) Robert A. Egnatchik et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Pex11α deficiency impairs peroxisome elongation and division and contributes to nonalcoholic fatty liver in mice

(2012) Huachun Weng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress-Mitochondrial Dialog Triggering Lipotoxic Rodent and Human  -Cell Apoptosis

(2012) D. A. Cunha et al.   DIABETES

Hepatic lipase activity is increased in non-alcoholic fatty liver disease beyond insulin resistance

(2012) V. Miksztowicz et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Lipid-Induced Endoplasmic Reticulum Stress in Liver Cells Results in Two Distinct Outcomes: Adaptation with Enhanced Insulin Signaling or Insulin Resistance

(2012) Caroline S. Achard et al.   ENDOCRINOLOGY

Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease

(2012) Carlos Jose Pirola et al.   GUT

Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor

(2012) Hyunsun Jo et al.   HEPATOLOGY

A hedgehog survival pathway in ‘undead’ lipotoxic hepatocytes

(2012) Keisuke Kakisaka et al.   JOURNAL OF HEPATOLOGY

Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis

(2011) Keisuke Kakisaka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

The plasma lipidomic signature of nonalcoholic steatohepatitis

(2009) Puneet Puri et al.   HEPATOLOGY

Hepatic Bax Inhibitor-1 Inhibits IRE1α and Protects from Obesity-associated Insulin Resistance and Glucose Intolerance

(2009) Béatrice Bailly-Maitre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity

(2008) ZhengZheng Li et al.   HEPATOLOGY

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance

(2008) Rajat Singh et al.   HEPATOLOGY

Steatosis Reversibly Increases Hepatocyte Sensitivity to Hypoxia-Reoxygenation Injury

(2008) François Berthiaume et al.   JOURNAL OF SURGICAL RESEARCH

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

(2008) Masato Furuhashi et al.   NATURE REVIEWS DRUG DISCOVERY

Alterations in Adipose Tissue and Hepatic Lipid Kinetics in Obese Men and Women With Nonalcoholic Fatty Liver Disease

(2007) Elisa Fabbrini et al.   GASTROENTEROLOGY