Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease

Influence of gender and time diet exposure on endocrine pancreas remodeling in response to high fat diet-induced metabolic disturbances in mice

(2015) R.B. Oliveira et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

(2015) Paul Angulo et al.   GASTROENTEROLOGY

Large adipocytes function as antigen-presenting cells to activate CD4+ T cells via upregulating MHCII in obesity

(2015) L Xiao et al.   INTERNATIONAL JOURNAL OF OBESITY

The cell biology of fat expansion

(2015) Joseph M. Rutkowski et al.   JOURNAL OF CELL BIOLOGY

Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice

(2015) C H Wilson et al.   Cell Death & Disease

Caspase-2 regulates oncogene-induced senescence

(2015) Delphine Gitenay et al.   Oncotarget

A nonapoptotic role for CASP2/caspase 2

(2014) Meenakshi Tiwari et al.   Autophagy

Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis

(2014) M V Machado et al.   GUT

Pnpla3I148Mknockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis

(2014) Eriks Smagris et al.   HEPATOLOGY

Adipocyte morphology and implications for metabolic derangements in acquired obesity

(2014) S Heinonen et al.   INTERNATIONAL JOURNAL OF OBESITY

Adipocyte cell size, free fatty acids and apolipoproteins are associated with non-alcoholic liver injury progression in severely obese patients

(2014) Alexander Wree et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity

(2014) Pengpeng Bi et al.   NATURE MEDICINE

Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

(2014) Hanlin Tao et al.   NATURE MEDICINE

Caspase-2: the reinvented enzyme

(2014) M Olsson et al.   ONCOGENE

Adipocyte dysfunction, inflammation and metabolic syndrome

(2014) Nora Klöting et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Management of fatty liver disease with the metabolic syndrome

(2014) Mariana Verdelho Machado et al.   Expert Review of Gastroenterology & Hepatology

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

(2014) Hannele Yki-Järvinen   Lancet Diabetes & Endocrinology

Mechanism linking diabetes mellitus and obesity

(2014) Abdullah Algoblan et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation

(2013) Peng Yi et al.   CELL

Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity

(2013) S. Carobbio et al.   DIABETES

Metabolomic Profiling Reveals a Role for Caspase-2 in Lipoapoptosis

(2013) Erika Segear Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

(2013) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

Adipocyte size is associated with NAFLD independent of obesity, fat distribution, and PNPLA3 genotype

(2013) Elina M. Petäjä et al.   Obesity

TRAIL (TNF-related apoptosis-inducing ligand) regulates adipocyte metabolism by caspase-mediated cleavage of PPARgamma

(2013) M Keuper et al.   Cell Death & Disease

Protocol for effective differentiation of 3T3-L1 cells to adipocytes

(2012) Katja Zebisch et al.   ANALYTICAL BIOCHEMISTRY

Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice

(2012) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

Caspase Induction and BCL2 Inhibition in Human Adipose Tissue: A potential relationship with insulin signaling alteration

(2012) F. J. Tinahones et al.   DIABETES CARE

Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue

(2012) X. Julia Xu et al.   JOURNAL OF LIPID RESEARCH

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

(2012) Zheng Sun et al.   NATURE MEDICINE

Caspase-2: the orphan caspase

(2011) L Bouchier-Hayes et al.   CELL DEATH AND DIFFERENTIATION

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

(2011) Trudy G. Oliver et al.   MOLECULAR CELL

Liver X Receptor (LXR) Regulates Human Adipocyte Lipolysis

(2010) Britta M. Stenson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High fat feeding and dietary l-arginine supplementation differentially regulate gene expression in rat white adipose tissue

(2009) Wenjuan Jobgen et al.   AMINO ACIDS

Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2

(2009) Joshua L Andersen et al.   EMBO JOURNAL

Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis

(2009) Naim Alkhouri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase 2-mediated tumor suppression involves survivin gene silencing

(2009) M Guha et al.   ONCOGENE

A tumor suppressor function for caspase-2

(2009) L. H. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI

(2008) T. Khan et al.   MOLECULAR AND CELLULAR BIOLOGY