Hepatic lipase deficiency produces glucose intolerance, inflammation and hepatic steatosis

Ink4/Arf locus restores glucose tolerance and insulin sensitivity by reducing hepatic steatosis and inflammation in mice with impaired IRS2-dependent signalling

(2015) Ángela Vinué et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Non-esterified fatty acids activate the ROS–p38–p53/Nrf2 signaling pathway to induce bovine hepatocyte apoptosis in vitro

(2014) Yuxiang Song et al.   APOPTOSIS

Nonalcoholic fatty liver disease: A main driver of insulin resistance or a dangerous liaison?

(2014) Nanda Gruben et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis

(2014) Sergio Martínez-Hervás et al.   CARDIOVASCULAR RESEARCH

Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice

(2014) L. Goedeke et al.   EMBO Molecular Medicine

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

(2014) Radha Ramesh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes

(2014) Nishika Sahini et al.   PROGRESS IN LIPID RESEARCH

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

(2014) Hannele Yki-Järvinen   Lancet Diabetes & Endocrinology

Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties

(2013) Joan Carles Escolà-Gil et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

(2013) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

Increased dosage ofInk4/Arfprotects against glucose intolerance and insulin resistance associated with aging

(2012) Herminia González-Navarro et al.   AGING CELL

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

TIMP3 Overexpression in Macrophages Protects From Insulin Resistance, Adipose Inflammation, and Nonalcoholic Fatty Liver Disease in Mice

(2012) R. Menghini et al.   DIABETES

Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice

(2012) Y. Nio et al.   DIABETOLOGIA

Simultaneous activation of p38 and JNK by arachidonic acid stimulates the cytosolic phospholipase A2-dependent synthesis of lipid droplets in human monocytes

(2012) Carlos Guijas et al.   JOURNAL OF LIPID RESEARCH

The effect of hepatic lipase on coronary artery disease in humans is influenced by the underlying lipoprotein phenotype

(2011) John D. Brunzell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Dynamic Modification of Sphingomyelin in Lipid Microdomains Controls Development of Obesity, Fatty Liver, and Type 2 Diabetes

(2011) Susumu Mitsutake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β3-adrenergic receptor induction of adipocyte inflammation requires lipolytic activation of stress kinases p38 and JNK

(2010) Emilio P. Mottillo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Loss of TGH/Ces3 in Mice Decreases Blood Lipids, Improves Glucose Tolerance, and Increases Energy Expenditure

(2010) Enhui Wei et al.   Cell Metabolism

Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice

(2010) S. M. Turpin et al.   DIABETOLOGIA

Mice Lacking Hepatic Lipase Are Lean and Protected against Diet-Induced Obesity and Hepatic Steatosis

(2010) Harvey K. Chiu et al.   ENDOCRINOLOGY

Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning

(2010) Kuok Teong Ong et al.   HEPATOLOGY

A Case of Adolescent Hyperlipoproteinemia with Xanthoma and Acute Pancreatitis, Associated with Decreased Activities of Lipoprotein Lipase and Hepatic Triglyceride Lipase

(2010) Koichi Fujita et al.   INTERNAL MEDICINE

p19ARFDeficiency Reduces Macrophage and Vascular Smooth Muscle Cell Apoptosis and Aggravates Atherosclerosis

(2010) Herminia González-Navarro et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A First-in-Man, Randomized, Placebo-Controlled Study to Evaluate the Safety and Feasibility of Autologous Delipidated High-Density Lipoprotein Plasma Infusions in Patients With Acute Coronary Syndrome

(2010) Ron Waksman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Lipid-induced insulin resistance: unravelling the mechanism

(2010) Varman T Samuel et al.   LANCET

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

MiR-33 Contributes to the Regulation of Cholesterol Homeostasis

(2010) K. J. Rayner et al.   SCIENCE

The role of free fatty acids, pancreatic lipase and Ca2+signalling in injury of isolated acinar cells and pancreatitis model in lipoprotein lipase-deficient mice

(2008) F. Yang et al.   Acta Physiologica

Molecular Mechanisms of Atherosclerosis in Metabolic Syndrome

(2008) Herminia González-Navarro et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Metabolic Syndrome and All-Cause and Cardiovascular Mortality in an Italian Elderly Population: The Progetto Veneto Anziani (Pro.V.A.) Study

(2008) S. Zambon et al.   DIABETES CARE

Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance

(2008) Rajat Singh et al.   HEPATOLOGY

Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

(2008) Kristiaan Wouters et al.   HEPATOLOGY

Hepatic Overexpression of Hormone-sensitive Lipase and Adipose Triglyceride Lipase Promotes Fatty Acid Oxidation, Stimulates Direct Release of Free Fatty Acids, and Ameliorates Steatosis

(2008) Brendan N. Reid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced hepatic expression of adipose tissue triglyceride lipase and CGI-58 may contribute to the development of non-alcoholic fatty liver disease in patients with insulin resistance

(2008) Masaki Kato et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

(2008) G. Sabio et al.   SCIENCE