Cholesterol metabolism pathways – are the intermediates more important than the products?
出版年份 2021 全文链接
标题
Cholesterol metabolism pathways – are the intermediates more important than the products?
作者
关键词
-
出版物
FEBS Journal
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2021-01-28
DOI
10.1111/febs.15727
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism
- (2020) Eylan Yutuc et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neuro‐oxysterols and neuro‐sterols as ligands to nuclear receptors, GPCRs, ligand‐gated ion channels and other protein receptors
- (2020) Yuqin Wang et al. BRITISH JOURNAL OF PHARMACOLOGY
- THE CHOLESTEROL METABOLITE 27-HYDROXYCHOLESTEROL INHIBITS SARS-CoV-2 AND IS MARKEDLY DECREASED IN COVID-19 PATIENTS
- (2020) Alessandro Marcello et al. Redox Biology
- 25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor
- (2020) Shulong Zu et al. CELL RESEARCH
- Cholesterol 25‐Hydroxylase inhibits SARS ‐CoV‐2 and other coronaviruses by depleting membrane cholesterol
- (2020) Shaobo Wang et al. EMBO JOURNAL
- Insulin resistance dysregulates CYP7B1 leading to oxysterol accumulation: a pathway for NAFL to NASH transition
- (2020) Genta Kakiyama et al. JOURNAL OF LIPID RESEARCH
- Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling
- (2020) Xiaofeng Qi et al. Nature Chemical Biology
- Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion
- (2020) Ruochen Zang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates
- (2020) Jonas Abdel-Khalik et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- 24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo
- (2019) Spyridon Theofilopoulos et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders
- (2019) William J. Griffiths et al. FREE RADICAL BIOLOGY AND MEDICINE
- Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2
- (2019) Katharina R. Beck et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi
- (2019) Xiaofeng Qi et al. NATURE
- Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing
- (2019) Liang Chen et al. JOURNAL OF LIPID RESEARCH
- A fast UPLC–HILIC method for an accurate quantification of dendrogenin A in human tissues
- (2019) Régis Soulès et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites
- (2019) William J. Griffiths et al. PROSTAGLANDINS & OTHER LIPID MEDIATORS
- Identification of 7α,24-dihydroxy-3-oxocholest-4-en-26-oic and 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acids in human cerebrospinal fluid and plasma
- (2018) Jonas Abdel-Khalik et al. BIOCHIMIE
- Identification of unusual oxysterols and bile acids with 7-oxo or 3β,5α,6β-trihydroxy functions in human plasma by charge-tagging mass spectrometry with multistage fragmentation
- (2018) William J. Griffiths et al. JOURNAL OF LIPID RESEARCH
- Circulating 27-Hydroxycholesterol and Breast Cancer Risk: Results From the EPIC-Heidelberg Cohort
- (2018) Da-Lin Lu et al. JNCI-Journal of the National Cancer Institute
- The significance of cholesterol and its metabolite, 27-hydroxycholesterol in breast cancer
- (2018) Erik R. Nelson MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Circulating 27-Hydroxycholesterol and Breast Cancer Risk: Results From the EPIC-Heidelberg Cohort
- (2018) Da-Lin Lu et al. JNCI-Journal of the National Cancer Institute
- 24S-Hydroxycholesterol Correlates With Tau and Is Increased in Cerebrospinal Fluid in Parkinson's Disease and Corticobasal Syndrome
- (2018) Ingemar Björkhem et al. Frontiers in Neurology
- Lucky, times ten: A career in Texas science
- (2018) David W. Russell JOURNAL OF BIOLOGICAL CHEMISTRY
- Cilia-Associated Oxysterols Activate Smoothened
- (2018) David R. Raleigh et al. MOLECULAR CELL
- Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1−/− mouse brain and plasma
- (2018) William J. Griffiths et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients
- (2018) William J. Griffiths et al. FREE RADICAL BIOLOGY AND MEDICINE
- Cholesterol and related sterols autoxidation
- (2017) Chiara Zerbinati et al. FREE RADICAL BIOLOGY AND MEDICINE
- Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients
- (2017) William J. Griffiths et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor
- (2017) Maud Voisin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dendrogenin A drives LXR to trigger lethal autophagy in cancers
- (2017) Gregory Segala et al. Nature Communications
- Central Nervous System LipoproteinsHighlights
- (2016) Robert W. Mahley ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Identification of novel bile acids as biomarkers for the early diagnosis of Niemann-Pick C disease
- (2016) Francesca Mazzacuva et al. FEBS LETTERS
- Defective cholesterol metabolism in amyotrophic lateral sclerosis
- (2016) Jonas Abdel-Khalik et al. JOURNAL OF LIPID RESEARCH
- Diagnostic tests for Niemann-Pick disease type C (NP-C): A critical review
- (2016) Marie T. Vanier et al. MOLECULAR GENETICS AND METABOLISM
- Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols
- (2016) Navdar Sever et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Development of a bile acid–based newborn screen for Niemann-Pick disease type C
- (2016) Xuntian Jiang et al. Science Translational Medicine
- Cholesterol and breast cancer risk: a systematic review and meta-analysis of prospective studies
- (2015) Mathilde Touvier et al. BRITISH JOURNAL OF NUTRITION
- A validated LC-MS/MS assay for quantification of 24(S)-hydroxycholesterol in plasma and cerebrospinal fluid
- (2015) Rohini Sidhu et al. JOURNAL OF LIPID RESEARCH
- 24S,25-Epoxycholesterol in mouse and rat brain
- (2014) Yuchen Wang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse
- (2014) Anna Meljon et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Role of AMACR (α-methylacyl-CoA racemase) and MFE-1 (peroxisomal multifunctional enzyme-1) in bile acid synthesis in mice
- (2014) Kaija J. Autio et al. BIOCHEMICAL JOURNAL
- Quantitative Charge-Tags for Sterol and Oxysterol Analysis
- (2014) P. J. Crick et al. CLINICAL CHEMISTRY
- Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain
- (2014) Ahmed A. Saeed et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cholestenoic acids regulate motor neuron survival via liver X receptors
- (2014) Spyridon Theofilopoulos et al. JOURNAL OF CLINICAL INVESTIGATION
- Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1
- (2014) Sandeep Goyal et al. JOURNAL OF LIPID RESEARCH
- On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO
- (2014) Ingemar Björkhem et al. JOURNAL OF LIPID RESEARCH
- Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades
- (2014) Alan F. Hofmann et al. JOURNAL OF LIPID RESEARCH
- Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels
- (2014) A. R. Stiles et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oxysterols are agonist ligands of ROR t and drive Th17 cell differentiation
- (2014) P. Soroosh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon
- (2014) A. Reboldi et al. SCIENCE
- Methods for oxysterol analysis: Past, present and future
- (2013) William J. Griffiths et al. BIOCHEMICAL PHARMACOLOGY
- The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate Receptors
- (2013) S. M. Paul et al. JOURNAL OF NEUROSCIENCE
- Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression
- (2013) Valerio Leoni et al. NEUROBIOLOGY OF DISEASE
- Oxysterols and Parkinson's disease: Evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease
- (2013) Ingemar Björkhem et al. NEUROSCIENCE LETTERS
- 27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology
- (2013) E. R. Nelson et al. SCIENCE
- LC/ESI-MS/MS analysis of urinary 3β-sulfooxy-7β-N-acetylglucosaminyl-5-cholen-24-oic acid and its amides: New biomarkers for the detection of Niemann–Pick type C disease
- (2013) Masamitsu Maekawa et al. STEROIDS
- Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties
- (2013) Philippe de Medina et al. Nature Communications
- 27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth
- (2013) Qian Wu et al. Cell Reports
- On the formation and possible biological role of 25-hydroxycholesterol
- (2012) Ulf Diczfalusy BIOCHIMIE
- Five decades with oxysterols
- (2012) Ingemar Björkhem BIOCHIMIE
- Interferon-Inducible Cholesterol-25-Hydroxylase Broadly Inhibits Viral Entry by Production of 25-Hydroxycholesterol
- (2012) Su-Yang Liu et al. IMMUNITY
- The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response
- (2012) Mathieu Blanc et al. IMMUNITY
- A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma
- (2012) Jeffrey G. McDonald et al. JOURNAL OF LIPID RESEARCH
- Analysis of bioactive oxysterols in newborn mouse brain by LC/MS
- (2012) Anna Meljon et al. JOURNAL OF LIPID RESEARCH
- Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
- (2012) Spyridon Theofilopoulos et al. Nature Chemical Biology
- Oxysterols are allosteric activators of the oncoprotein Smoothened
- (2012) Sigrid Nachtergaele et al. Nature Chemical Biology
- Conversion of 7-Dehydrocholesterol to 7-Ketocholesterol Is Catalyzed by Human Cytochrome P450 7A1 and Occurs by Direct Oxidation without an Epoxide Intermediate
- (2011) Raku Shinkyo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma
- (2011) Xuntian Jiang et al. JOURNAL OF LIPID RESEARCH
- Cholesterol 25-hydroxylation activity of CYP3A
- (2011) Akira Honda et al. JOURNAL OF LIPID RESEARCH
- Regulation of the NPC2 protein-mediated cholesterol trafficking by membrane lipids
- (2011) Hichem D. Gallala et al. JOURNAL OF NEUROCHEMISTRY
- Role of a Disordered Steroid Metabolome in the Elucidation of Sterol and Steroid Biosynthesis
- (2011) Cedric H. L. Shackleton LIPIDS
- Oxysterols direct B-cell migration through EBI2
- (2011) Changlu Liu et al. NATURE
- Oxysterols direct immune cell migration via EBI2
- (2011) Sébastien Hannedouche et al. NATURE
- Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system
- (2011) N. Strushkevich et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of Surface Residues on Niemann-Pick C2 Essential for Hydrophobic Handoff of Cholesterol to NPC1 in Lysosomes
- (2010) Michael L. Wang et al. Cell Metabolism
- Structural Basis for Three-step Sequential Catalysis by the Cholesterol Side Chain Cleavage Enzyme CYP11A1
- (2010) Natalia Mast et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Editorial: 25-Hydroxycholesterol: a new life in immunology
- (2010) Jeffrey G. McDonald et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons
- (2010) Kiwon Park et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Malformation syndromes caused by disorders of cholesterol synthesis
- (2010) Forbes D. Porter et al. JOURNAL OF LIPID RESEARCH
- Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands
- (2010) P. de Medina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain
- (2009) David W. Russell et al. Annual Review of Biochemistry
- Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
- (2009) Ulf Diczfalusy et al. JOURNAL OF LIPID RESEARCH
- Oxysterols and neurodegenerative diseases
- (2009) Ingemar Björkhem et al. MOLECULAR ASPECTS OF MEDICINE
- Targeted lipidomic analysis of oxysterols in the embryonic central nervous system
- (2009) Yuqin Wang et al. Molecular BioSystems
- 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
- (2009) D. R. Bauman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease
- (2008) Valerio Leoni et al. BRAIN
- Cholesterol, Reactive Oxygen Species, and the Formation of Biologically Active Mediators
- (2008) Robert C. Murphy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins
- (2008) Veronica Hirsch-Reinshagen et al. JOURNAL OF LIPID RESEARCH
- Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS
- (2008) Akira Honda et al. JOURNAL OF LIPID RESEARCH
- Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation
- (2008) T. Kotti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sterol regulators of cholesterol homeostasis and beyond: The oxysterol hypothesis revisited and revised
- (2008) S GILL et al. PROGRESS IN LIPID RESEARCH
- 27-Hydroxycholesterol Is an Endogenous Selective Estrogen Receptor Modulator
- (2007) Carolyn D. DuSell et al. MOLECULAR ENDOCRINOLOGY
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