Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing

Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins

(2019) Jian Xiao et al.   Science China-Life Sciences

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

(2018) Michael S. Brown et al.   Annual Review of Biochemistry

Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase

(2018) Lu-Yi Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ALIMA1variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption

(2018) Ying-Yu Zhang et al.   SCIENCE

SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond

(2018) Russell A. DeBose-Boyd et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery

(2018) Yun Xia et al.   CELL

Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

(2018) Zita Hubler et al.   NATURE

Intracellular Cholesterol Transport by Sterol Transfer Proteins at Membrane Contact Sites

(2018) Jie Luo et al.   TRENDS IN BIOCHEMICAL SCIENCES

Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

(2018) Shi-You Jiang et al.   Nature Communications

Cholesterol-induced conformational changes in the sterol-sensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis

(2017) Yansong Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling

(2017) Xu Xiao et al.   MOLECULAR CELL

Lanosterol reverses protein aggregation in cataracts

(2015) Ling Zhao et al.   NATURE

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

(2015) Matthew A Mitsche et al.   eLife

Male germ cell-specific knockout of cholesterogenic cytochrome P450 lanosterol 14α-demethylase (Cyp51)

(2013) Rok Keber et al.   JOURNAL OF LIPID RESEARCH

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

(2012) Nathanael J. Spann et al.   CELL

Scientific Side Trips: Six Excursions from the Beaten Path

(2012) Michael S. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

(2011) Saloni Gill et al.   Cell Metabolism

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8

(2011) Y. Jo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly sensitive analysis of sterol profiles in human serum by LC-ESI-MS/MS

(2008) Akira Honda et al.   JOURNAL OF LIPID RESEARCH