Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor

Glucocorticoid Receptor:MegaTrans Switching Mediates the Repression of an ERα-Regulated Transcriptional Program

(2017) Feng Yang et al.   MOLECULAR CELL

Glucocorticoid receptor control of transcription: precision and plasticity via allostery

(2017) Emily R. Weikum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glucocorticoid receptor signalling activates YAP in breast cancer

(2017) Giovanni Sorrentino et al.   Nature Communications

Biased signalling from the glucocorticoid receptor: Renewed opportunity for tailoring glucocorticoid activity

(2016) Christine R. Keenan et al.   BIOCHEMICAL PHARMACOLOGY

An analysis of glucocorticoid receptor-mediated gene expression in BEAS-2B human airway epithelial cells identifies distinct, ligand-directed, transcription profiles with implications for asthma therapeutics

(2015) T Joshi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Estrogen receptors in breast carcinogenesis and endocrine therapy

(2015) Bo Huang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Cholesterol metabolites exported from human brain

(2015) Luigi Iuliano et al.   STEROIDS

Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer

(2015) Zhong Chen et al.   Nature Communications

One step synthesis of 6-oxo-cholestan-3β,5α-diol

(2014) Maud Voisin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxysterols are agonist ligands of ROR t and drive Th17 cell differentiation

(2014) P. Soroosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol and Cancer, in the Balance

(2014) S. Silvente-Poirot et al.   SCIENCE

Steroid signaling: Ligand-binding promiscuity, molecular symmetry, and the need for gating

(2014) Richard Lathe et al.   STEROIDS

5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells

(2013) Gregory Segala et al.   BIOCHEMICAL PHARMACOLOGY

Glucocorticoid Receptor Antagonism as a Novel Therapy for Triple-Negative Breast Cancer

(2013) M. N. Skor et al.   CLINICAL CANCER RESEARCH

Interaction of Glucocorticoid Receptor (GR) with Estrogen Receptor (ER) α and Activator Protein 1 (AP1) in Dexamethasone-mediated Interference of ERα Activity

(2013) Sudipan Karmakar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

11β-Hydroxysteroid Dehydrogenases: Intracellular Gate-Keepers of Tissue Glucocorticoid Action

(2013) Karen Chapman et al.   PHYSIOLOGICAL REVIEWS

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

(2013) E. R. Nelson et al.   SCIENCE

Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties

(2013) Philippe de Medina et al.   Nature Communications

bc-GenExMiner 3.0: new mining module computes breast cancer gene expression correlation analyses

(2013) P. Jezequel et al.   Database-The Journal of Biological Databases and Curation

27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth

(2013) Qian Wu et al.   Cell Reports

Cholesterol-5,6-epoxides: Chemistry, biochemistry, metabolic fate and cancer

(2012) Marc Poirot et al.   BIOCHIMIE

Cholesterol metabolism and cancer: the good, the bad and the ugly

(2012) Sandrine Silvente-Poirot et al.   CURRENT OPINION IN PHARMACOLOGY

How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering

(2012) Dariusz Ratman et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Glucocorticoid receptor and breast cancer

(2011) Myriam Vilasco et al.   BREAST CANCER RESEARCH AND TREATMENT

Activation of the Glucocorticoid Receptor Is Associated with Poor Prognosis in Estrogen Receptor-Negative Breast Cancer

(2011) D. Pan et al.   CANCER RESEARCH

A refined molecular taxonomy of breast cancer

(2011) M Guedj et al.   ONCOGENE

Identification of SR1078, a Synthetic Agonist for the Orphan Nuclear Receptors RORα and RORγ

(2010) Yongjun Wang et al.   ACS Chemical Biology

Expression Profiling of Nuclear Receptors in the NCI60 Cancer Cell Panel Reveals Receptor-Drug and Receptor-Gene Interactions

(2010) Susan Holbeck et al.   MOLECULAR ENDOCRINOLOGY

Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands

(2010) P. de Medina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Modulation of Retinoic Acid Receptor-related Orphan Receptor α and γ Activity by 7-Oxygenated Sterol Ligands

(2009) Yongjun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis of New Alkylaminooxysterols with Potent Cell Differentiating Activities: Identification of Leads for the Treatment of Cancer and Neurodegenerative Diseases

(2009) Philippe de Medina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glucocorticoids Antagonize Estrogens by Glucocorticoid Receptor-Mediated Activation of Estrogen Sulfotransferase

(2008) H. Gong et al.   CANCER RESEARCH

Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism

(2008) B. Payre et al.   MOLECULAR CANCER THERAPEUTICS