Coordination chemistry of ligands: Insights into the design of amyloid beta/tau-PET imaging probes and nanoparticles-based therapies for Alzheimer’s disease

PET Radiopharmaceuticals for Alzheimer’s Disease and Parkinson’s Disease Diagnosis, the Current and Future Landscape

(2020) Bright Chukwunwike Uzuegbunam et al.   MOLECULES

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease

(2020) Sílvia Chaves et al.   MOLECULES

Intermediate flortaucipir uptake is associated with Aβ-PET and CSF-tau in asymptomatic adults

(2020) Melissa McSweeney et al.   NEUROLOGY

A Multifunctional Chemical Agent as an Attenuator of Amyloid Burden and Neuroinflammation in Alzheimer’s Disease

(2020) Hong-Jun Cho et al.   ACS Chemical Neuroscience

Gadolinium-based bimodal probes to enhance T1-Weighted magnetic resonance/optical imaging

(2020) Chang-Tong Yang et al.   Acta Biomaterialia

Metal-organic framework-based materials as an emerging platform for advanced electrochemical sensing

(2020) Chun-Sen Liu et al.   COORDINATION CHEMISTRY REVIEWS

Curcumin in Health and Diseases: Alzheimer’s Disease and Curcumin Analogues, Derivatives, and Hybrids

(2020) Eirini Chainoglou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Current advances in the development of novel polymeric nanoparticles for the treatment of neurodegenerative diseases

(2020) Amanda Cano et al.   Nanomedicine

Metal complexes that bind to the amyloid-β peptide of relevance to Alzheimer’s disease

(2020) Luiza M.F. Gomes et al.   COORDINATION CHEMISTRY REVIEWS

Probing the aggregation and immune response of human islet amyloid polypeptide with ligand-stabilized gold nanoparticles

(2019) Ibrahim Javed et al.   ACS Applied Materials & Interfaces

Tau PET imaging in neurodegenerative tauopathies—still a challenge

(2019) Antoine Leuzy et al.   MOLECULAR PSYCHIATRY

The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention?

(2019) Yann Fichou et al.   Acta Neuropathologica Communications

Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue

(2019) Cinthya Aguero et al.   Acta Neuropathologica Communications

A walk through tau therapeutic strategies

(2019) Santosh Jadhav et al.   Acta Neuropathologica Communications

Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging

(2019) Janina Krell-Roesch et al.   Translational Psychiatry

Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers

(2019) Gemma Salvadó et al.   Alzheimers Research & Therapy

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

Effect of off-target binding on 18F-Flortaucipir variability in healthy controls across the lifespan

(2019) Suzanne L Baker et al.   JOURNAL OF NUCLEAR MEDICINE

Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer

(2019) Frederik J. R. Rombouts et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potential Diagnostic Imaging of Alzheimer’s Disease with Copper-64 Complexes That Bind to Amyloid-β Plaques

(2019) Lachlan E. McInnes et al.   INORGANIC CHEMISTRY

Cross-interaction of tau PET tracers with monoamine oxidase B: evidence from in silico modelling and in vivo imaging

(2019) N. Arul Murugan et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Characterization of the binding of tau imaging ligands to melanin-containing cells: putative off-target-binding site

(2019) Tetsuro Tago et al.   ANNALS OF NUCLEAR MEDICINE

Predicting diagnosis and cognition with 18F-AV-1451 tau PET and structural MRI in Alzheimer's disease

(2019) Niklas Mattsson et al.   Alzheimers & Dementia

Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia

(2019) Gil D. Rabinovici et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

(2019) Nicolai Franzmeier et al.   Nature Communications

Interplay between Amyloid Fibrillation Delay and Degradation by Magnetic Zinc-Doped Ferrite Nanoparticles

(2019) Kleoniki Giannousi et al.   ACS Chemical Neuroscience

Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies

(2019) Heiko Kroth et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Associations of Amyloid, Tau, and Neurodegeneration Biomarker Profiles With Rates of Memory Decline Among Individuals Without Dementia

(2019) Clifford R. Jack et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

18F-FDG Is a Superior Indicator of Cognitive Performance Compared to 18F-Florbetapir in Alzheimer’s Disease and Mild Cognitive Impairment Evaluation: A Global Quantitative Analysis

(2019) Mohsen Khosravi et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroimaging Biomarkers for Alzheimer’s Disease

(2019) Freddie Márquez et al.   Molecular Neurodegeneration

Neuroprotective Effect of Nerve Growth Factor Loaded in Porous Silicon Nanostructures in an Alzheimer's Disease Model and Potential Delivery to the Brain

(2019) Neta Zilony‐Hanin et al.   Small

[18F]FDG, [11C]PiB, and [18F]AV-1451 PET Imaging of Neurodegeneration in Two Subjects With a History of Repetitive Trauma and Cognitive Decline

(2019) David O. Okonkwo et al.   Frontiers in Neurology

Nanotechnology-Based Diagnostics and Therapy for Pathogen-Related Infections in the CNS

(2019) Subramanian Tamil Selvan et al.   ACS Chemical Neuroscience

Enhancement of the Antioxidant Activity and Neurotherapeutic Features through Pyridol Addition to Tetraazamacrocyclic Molecules

(2019) Hannah M. Johnston et al.   INORGANIC CHEMISTRY

[18F]-AV-1451 tau PET imaging in Alzheimer’s disease and suspected non-AD tauopathies using a late acquisition time window

(2019) Julien Lagarde et al.   JOURNAL OF NEUROLOGY

Predictive Value of 18F-Florbetapir and 18F-FDG PET for Conversion from Mild Cognitive Impairment to Alzheimer Dementia

(2019) Ganna Blazhenets et al.   JOURNAL OF NUCLEAR MEDICINE

Targeting soluble tumor necrosis factor as a potential intervention to lower risk for late-onset Alzheimer’s disease associated with obesity, metabolic syndrome, and type 2 diabetes

(2019) Maria Elizabeth De Sousa Rodrigues et al.   Alzheimers Research & Therapy

Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement

(2019) Gabriela Dumitrita Stanciu et al.   Biomolecules

Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer’s Disease

(2018) Qing Chen et al.   ACS Nano

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Inhibition of amyloid aggregation of bovine serum albumin by sodium dodecyl sulfate at submicellar concentrations

(2018) Xue-Jiao Ma et al.   BIOCHEMISTRY-MOSCOW

Inhibition of tau-derived hexapeptide aggregation and toxicity by a self-assembled cyclic d,l-α-peptide conformational inhibitor

(2018) A. Belostozky et al.   CHEMICAL COMMUNICATIONS

Dual tracer tau PET imaging reveals different molecular targets for 11C-THK5351 and 11C-PBB3 in the Alzheimer brain

(2018) Konstantinos Chiotis et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In vivo characterization and quantification of neurofibrillary tau PET radioligand [18F]MK-6240 in humans from Alzheimer’s disease dementia to young controls

(2018) Tobey J Betthauser et al.   JOURNAL OF NUCLEAR MEDICINE

First in-human PET study of 3 novel tau radiopharmaceuticals: [11C]RO6924963, [11C]RO6931643, and [18F]RO6958948

(2018) Dean F. Wong et al.   JOURNAL OF NUCLEAR MEDICINE

Peripheral Biomarkers for Early Detection of Alzheimer’s and Parkinson’s Diseases

(2018) Thein Than Htike et al.   MOLECULAR NEUROBIOLOGY

Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions

(2018) Victor L. Villemagne et al.   Nature Reviews Neurology

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade

(2018) Masha G. Savelieff et al.   CHEMICAL REVIEWS

Examining the effects of dextran-based polymer-coated nanoparticles on amyloid fibrillogenesis of human insulin

(2018) Ning-Hui Lu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Theranostic applications of nanoparticles in neurodegenerative disorders

(2018) Sahana Ramanathan et al.   International Journal of Nanomedicine

A Highly Selective and Specific PET Tracer for Imaging of Tau Pathologies

(2018) Wei Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

PET Imaging of Neuropathology in Tauopathies: Progressive Supranuclear Palsy

(2018) Vladimir Kepe et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain [18F]FDDNP Binding and Glucose Metabolism in Advanced Elderly Healthy Subjects and Alzheimer's Disease Patients

(2018) Clovis Tauber et al.   JOURNAL OF ALZHEIMERS DISEASE

Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807

(2018) David T. Chien et al.   JOURNAL OF ALZHEIMERS DISEASE

Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808

(2018) David T. Chien et al.   JOURNAL OF ALZHEIMERS DISEASE

Evaluation of18F-RO-948 (18F-RO6958948) for quantitative assessment of tau accumulation in the human brain with positron emission tomography

(2018) Hiroto Kuwabara et al.   JOURNAL OF NUCLEAR MEDICINE

Misfolded Protein Linked Strategies Toward Biomarker Development for Neurodegenerative Diseases

(2018) Sundramurthy Kumar et al.   MOLECULAR NEUROBIOLOGY

Dual-phase [18F]florbetapir in frontotemporal dementia

(2018) Michael Asghar et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Assessing Amyloid Pathology in Cognitively Normal Subjects using [18F]Flutemetamol PET: Comparing Visual Reads and Quantitative Methods

(2018) Lyduine Collij et al.   JOURNAL OF NUCLEAR MEDICINE

ScFv-conjugated superparamagnetic iron oxide nanoparticles for MRI-based diagnosis in transgenic mouse models of Parkinson’s and Huntington’s diseases

(2018) Xiao-ge Liu et al.   BRAIN RESEARCH

Coordination Chemistry of Bifunctional Chemical Agents Designed for Applications in 64Cu PET Imaging for Alzheimer’s Disease

(2017) Anuj K. Sharma et al.   INORGANIC CHEMISTRY

Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer’s Disease with Positron Emission Tomography

(2017) Luca C. Gobbi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preclinical Evaluation of18F-RO6958948,11C-RO6931643, and11C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease

(2017) Michael Honer et al.   JOURNAL OF NUCLEAR MEDICINE

Morphological Effects of CuO Nanostructures on Fibrillation of Human Serum Albumin

(2017) Suraj Konar et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Tau PET imaging: present and future directions

(2017) Laure Saint-Aubert et al.   Molecular Neurodegeneration

Structure-based inhibitors of tau aggregation

(2017) P. M. Seidler et al.   Nature Chemistry

Cerium oxide nanoparticles could ameliorate behavioral and neurochemical impairments in 6-hydroxydopamine induced Parkinson's disease in rats

(2017) Maha A. Hegazy et al.   NEUROCHEMISTRY INTERNATIONAL

Development of [11C]/[3H]THK-5351 – A potential novel carbon-11 tau imaging PET radioligand

(2017) Vladimir Stepanov et al.   NUCLEAR MEDICINE AND BIOLOGY

Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains

(2017) Laetitia Lemoine et al.   Alzheimers Research & Therapy

Nanotechnology Solutions for Alzheimer's Disease: Advances in Research Tools, Diagnostic Methods and Therapeutic Agents

(2017) Amir Nazem et al.   JOURNAL OF ALZHEIMERS DISEASE

Efficient Inhibition of Protein Aggregation, Disintegration of Aggregates, and Lowering of Cytotoxicity by Green Tea Polyphenol-Based Self-Assembled Polymer Nanoparticles

(2016) Koushik Debnath et al.   ACS Applied Materials & Interfaces

Nano Zinc Oxide Inhibits Fibrillar Growth and Suppresses Cellular Toxicity of Lysozyme Amyloid

(2016) Deependra Kumar Ban et al.   ACS Applied Materials & Interfaces

Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer’s Disease

(2016) Hyek Jin Kwon et al.   ACS Nano

AV-1451 tau and β-amyloid positron emission tomography imaging in dementia with Lewy bodies

(2016) Kejal Kantarci et al.   ANNALS OF NEUROLOGY

Hexa (ethylene glycol) derivative of benzothiazole aniline promotes dendritic spine formation through the RasGRF1–Ras dependent pathway

(2016) Nathanael J. Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology inMAPTmutation carriers

(2016) Ruben Smith et al.   BRAIN

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

Pharmacological, toxicological and neuronal localization assessment of galantamine/chitosan complex nanoparticles in rats: future potential contribution in Alzheimer’s disease management

(2016) Amira S. Hanafy et al.   DRUG DELIVERY

Imaging in-vivo tau pathology in Alzheimer’s disease with THK5317 PET in a multimodal paradigm

(2016) Konstantinos Chiotis et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Posterior Accumulation of Tau and Concordant Hypometabolism in an Early-Onset Alzheimer’s Disease Patient with Presenilin-1 Mutation

(2016) Ruben Smith et al.   JOURNAL OF ALZHEIMERS DISEASE

Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies

(2016) Ian R. A. Mackenzie et al.   JOURNAL OF NEUROCHEMISTRY

Kinetic Modeling of the Tau PET Tracer 18 F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects

(2016) Olivier Barret et al.   JOURNAL OF NUCLEAR MEDICINE

Pharmacokinetic Evaluation of the Tau PET Radiotracer 18 F-T807 ( 18 F-AV-1451) in Human Subjects

(2016) Dustin W. Wooten et al.   JOURNAL OF NUCLEAR MEDICINE

Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

(2016) E. D. Hostetler et al.   JOURNAL OF NUCLEAR MEDICINE

Optimization and Biodistribution of [11C]-TKF, An Analog of Tau Protein Imaging Agent [18F]-THK523

(2016) Yanyan Kong et al.   MOLECULES

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

Tau Imaging in Alzheimer’s Disease Diagnosis and Clinical Trials

(2016) Jared R. Brosch et al.   Neurotherapeutics

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

(2016) Matthew R. Brier et al.   Science Translational Medicine

Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins

(2016) Xia-Chun Li et al.   Scientific Reports

Assessment of the Incremental Diagnostic Value of Florbetapir F 18 Imaging in Patients With Cognitive Impairment

(2016) Marina Boccardi et al.   JAMA Neurology

A new method to quantify tau pathologies with 11C-PBB3 PET using reference tissue voxels extracted from brain cortical gray matter

(2016) Yasuyuki Kimura et al.   EJNMMI Research

Comparison of New Tau PET-Tracer Candidates With [18F]T808 and [18F]T807

(2016) Lieven Declercq et al.   Molecular Imaging

Highly Selective Tau-SPECT Imaging Probes for Detection of Neurofibrillary Tangles in Alzheimer’s Disease

(2016) Masahiro Ono et al.   Scientific Reports

Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

(2016) Valentina Cappello et al.   Scientific Reports

Sialic acid (SA)-modified selenium nanoparticles coated with a high blood–brain barrier permeability peptide-B6 peptide for potential use in Alzheimer’s disease

(2015) Tiantian Yin et al.   Acta Biomaterialia

Patterns of tau binding in T807-PET imaging

(2015) Karl A. Friedrichsen et al.   Alzheimers & Dementia

First in-human PET study of 3 novel tau radiopharmaceuticals: [11C]RO6924963, [11C]RO6931643, and [18F]RO6958948

(2015) Dean F. Wong et al.   Alzheimers & Dementia

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

(2015) Marta Marquié et al.   ANNALS OF NEUROLOGY

Tau positron emission tomographic imaging in aging and early Alzheimer disease

(2015) Keith A. Johnson et al.   ANNALS OF NEUROLOGY

Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI)

(2015) Kwok Kin Cheng et al.   BIOMATERIALS

Synthesis of a PET tau tracer [ 11 C]PBB3 for imaging of Alzheimer’s disease

(2015) Min Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

GWAS of longitudinal amyloid accumulation on18F-florbetapir PET in Alzheimer’s disease implicates microglial activation geneIL1RAP

(2015) Vijay K Ramanan et al.   BRAIN

[18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer’s disease

(2015) Ryuichi Harada et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Structure–Activity Relationship Study of Heterocyclic Phenylethenyl and Pyridinylethenyl Derivatives as Tau-Imaging Agents That Selectively Detect Neurofibrillary Tangles in Alzheimer’s Disease Brains

(2015) Kenji Matsumura et al.   JOURNAL OF MEDICINAL CHEMISTRY

PET Quantification of Tau Pathology in Human Brain with 11C-PBB3

(2015) Y. Kimura et al.   JOURNAL OF NUCLEAR MEDICINE

Genetic and Environmental Influences on Regional Brain Uptake of 18F-FDG: A PET Study on Monozygotic and Dizygotic Twins

(2015) S. Watanabe et al.   JOURNAL OF NUCLEAR MEDICINE

Measurement of Longitudinal  -Amyloid Change with 18F-Florbetapir PET and Standardized Uptake Value Ratios

(2015) S. M. Landau et al.   JOURNAL OF NUCLEAR MEDICINE

18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease

(2015) R. Harada et al.   JOURNAL OF NUCLEAR MEDICINE

Structure-Activity Relationship of 2-Arylquinolines as PET Imaging Tracers for Tau Pathology in Alzheimer Disease

(2015) T. Tago et al.   JOURNAL OF NUCLEAR MEDICINE

Preclinical Evaluation of [18F]THK-5105 Enantiomers: Effects of Chirality on Its Effectiveness as a Tau Imaging Radiotracer

(2015) Tetsuro Tago et al.   MOLECULAR IMAGING AND BIOLOGY

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

Invited review: Frontotemporal dementia caused bymicrotubule-associated protein taugene (MAPT) mutations: a chameleon for neuropathology and neuroimaging

(2015) Bernardino Ghetti et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Identification of a major radiometabolite of [ 11 C]PBB3

(2015) Hiroki Hashimoto et al.   NUCLEAR MEDICINE AND BIOLOGY

In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging

(2015) Jorge R. Barrio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent advances in molecular imaging probes for β-amyloid plaques

(2015) Masahiro Ono et al.   MedChemComm

Synthesis of antibacterial and magnetic nanocomposites by decorating graphene oxide surface with metal nanoparticles

(2015) Razieh Moosavi et al.   RSC Advances

Grafting of ZnS:Mn-Doped Nanocrystals and an Anticancer Drug onto Graphene Oxide for Delivery and Cell Labeling

(2015) Sanghamitra Dinda et al.   ChemPlusChem

Phase 3 Trial of Flutemetamol Labeled With Radioactive Fluorine 18 Imaging and Neuritic Plaque Density

(2015) Craig Curtis et al.   JAMA Neurology

PET Imaging of Tau Pathology in Alzheimer’s Disease and Tauopathies

(2015) Olga G. James et al.   Frontiers in Neurology

High Affinity Radiopharmaceuticals Based Upon Lansoprazole for PET Imaging of Aggregated Tau in Alzheimer’s Disease and Progressive Supranuclear Palsy: Synthesis, Preclinical Evaluation, and Lead Selection

(2014) Maria V. Fawaz et al.   ACS Chemical Neuroscience

Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophy

(2014) Rik Ossenkoppele et al.   ANNALS OF NEUROLOGY

Non-invasive assessment of Alzheimer’s disease neurofibrillary pathology using 18F-THK5105 PET

(2014) Nobuyuki Okamura et al.   BRAIN

Developments in Tau PET Imaging

(2014) Eduardo Rigon Zimmer et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Radiolabeled bioactive benzoheterocycles for imaging β-amyloid plaques in Alzheimer's disease

(2014) Yanping Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In vivo evaluation of a novel tau imaging tracer for Alzheimer’s disease

(2014) Victor L. Villemagne et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Radiosynthesis, Photoisomerization, Biodistribution, and Metabolite Analysis of 11C-PBB3 as a Clinically Useful PET Probe for Imaging of Tau Pathology

(2014) H. Hashimoto et al.   JOURNAL OF NUCLEAR MEDICINE

Effect of Functionalized Magnetic MnFe2O4 Nanoparticles on Fibrillation of Human Serum Albumin

(2014) Shubhatam Sen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Models of β-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism

(2014) Ilie-Cosmin Stancu et al.   Molecular Neurodegeneration

Multifunctional Iron Oxide Nanoparticles for Diagnostics, Therapy and Macromolecule Delivery

(2014) Swee Kuan Yen et al.   Theranostics

Assessing THK523 selectivity for tau deposits in Alzheimer’s disease and non–Alzheimer’s disease tauopathies

(2014) Michelle T Fodero-Tavoletti et al.   Alzheimers Research & Therapy

A review of β-amyloid neuroimaging in Alzheimer's disease

(2014) Paul A. Adlard et al.   Frontiers in Neuroscience

Design and Synthesis of Polymer-Functionalized NIR Fluorescent Dyes–Magnetic Nanoparticles for Bioimaging

(2013) Swee Kuan Yen et al.   ACS Nano

Cerebral amyloid PET imaging in Alzheimer’s disease

(2013) Clifford R. Jack et al.   ACTA NEUROPATHOLOGICA

[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

(2013) Chun-Fang Xia et al.   Alzheimers & Dementia

Dual-functional nanoparticles targeting amyloid plaques in the brains of Alzheimer's disease mice

(2013) Chi Zhang et al.   BIOMATERIALS

Synthesis and biological evaluation of novel styryl benzimidazole derivatives as probes for imaging of neurofibrillary tangles in Alzheimer’s disease

(2013) Kenji Matsumura et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Coordination polymer nanoparticles in medicine

(2013) F. Novio et al.   COORDINATION CHEMISTRY REVIEWS

Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer’s disease patients

(2013) Anton Forsberg et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

A tetra(ethylene glycol) derivative of benzothiazole aniline ameliorates dendritic spine density and cognitive function in a mouse model of Alzheimer's disease

(2013) Jung Min Song et al.   EXPERIMENTAL NEUROLOGY

A concise radiosynthesis of the tau radiopharmaceutical, [18F]T807

(2013) Timothy M. Shoup et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging

(2013) Tetsuro Tago et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

A Tetra(Ethylene Glycol) Derivative of Benzothiazole Aniline Enhances Ras-Mediated Spinogenesis

(2013) A. Megill et al.   JOURNAL OF NEUROSCIENCE

Head-to-Head Comparison of 11C-PiB and 18F-AZD4694 (NAV4694) for  -Amyloid Imaging in Aging and Dementia

(2013) C. C. Rowe et al.   JOURNAL OF NUCLEAR MEDICINE

Novel 18F-Labeled Arylquinoline Derivatives for Noninvasive Imaging of Tau Pathology in Alzheimer Disease

(2013) N. Okamura et al.   JOURNAL OF NUCLEAR MEDICINE

PET Quantification of 18F-Florbetaben Binding to  -Amyloid Deposits in Human Brains

(2013) G. A. Becker et al.   JOURNAL OF NUCLEAR MEDICINE

[11C]PBB3—a new PET ligand that identifies tau pathology in the brains of patients with AD

(2013) Heather Wood   Nature Reviews Neurology

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

(2013) Masahiro Maruyama et al.   NEURON

Mimicking cellular transport mechanism in stem cells through endosomal escape of new peptide-coated quantum dots

(2013) Karthikeyan Narayanan et al.   Scientific Reports

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer’s disease

(2012) Hiroyuki Watanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Autophagy impairment: a crossroad between neurodegeneration and tauopathies

(2012) Melissa Nassif et al.   BMC BIOLOGY

Diagnostic imaging of Alzheimer's disease with copper and technetium complexes

(2012) James L. Hickey et al.   COORDINATION CHEMISTRY REVIEWS

Pharmacokinetic behavior and efficiency of acetylcholinesterase inhibition in rat brain after intranasal administration of galanthamine hydrobromide loaded flexible liposomes

(2012) Weize Li et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer’s disease pathology

(2012) Ryuichi Harada et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET

(2012) Rik Ossenkoppele et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting

(2012) Mohammad Fazil et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Clinical Validation of 18F-AZD4694, an Amyloid- -Specific PET Radioligand

(2012) Z. Cselenyi et al.   JOURNAL OF NUCLEAR MEDICINE

Meta-analysis based SVM classification enables accurate detection of Alzheimer's disease across different clinical centers using FDG-PET and MRI

(2012) Juergen Dukart et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Evaluation of [11C]N-Methyl Lansoprazole as a Radiopharmaceutical for PET Imaging of Tau Neurofibrillary Tangles

(2012) Xia Shao et al.   ACS Medicinal Chemistry Letters

Rhodanine and Thiohydantoin Derivatives for Detecting Tau Pathology in Alzheimer’s Brains

(2011) Masahiro Ono et al.   ACS Chemical Neuroscience

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

2-Arylimidazo[2,1-b]benzothiazoles: A new family of amyloid binding agents with potential for PET and SPECT imaging of Alzheimer’s brain

(2011) David Alagille et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

(2011) M. T. Fodero-Tavoletti et al.   BRAIN

Single-Phase Dy2O3:Tb3+Nanocrystals as Dual-Modal Contrast Agent for High Field Magnetic Resonance and Optical Imaging

(2011) Gautom Kumar Das et al.   CHEMISTRY OF MATERIALS

Use of Florbetapir-PET for Imaging β-Amyloid Pathology

(2011) Christopher M. Clark   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Amyloid Imaging with 18F-Florbetaben in Alzheimer Disease and Other Dementias

(2011) V. L. Villemagne et al.   JOURNAL OF NUCLEAR MEDICINE

Detection of amyloid plaques targeted by USPIO-Aβ1–42 in Alzheimer's disease transgenic mice using magnetic resonance microimaging

(2011) Jing Yang et al.   NEUROIMAGE

Phenyldiazenyl benzothiazole derivatives as probes for in vivo imaging of neurofibrillary tangles in Alzheimer's disease brains

(2011) Kenji Matsumura et al.   MedChemComm

18F-Labeled Phenyldiazenyl Benzothiazole for in Vivo Imaging of Neurofibrillary Tangles in Alzheimer's Disease Brains

(2011) Kenji Matsumura et al.   ACS Medicinal Chemistry Letters

The history of the cholinergic hypothesis

(2010) Antonio Contestabile   BEHAVIOURAL BRAIN RESEARCH

Silica-coated quantum dots and magnetic nanoparticles for bioimaging applications (Mini-Review)

(2010) Subramanian Tamil Selvan   Biointerphases

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Design and Development of Molecular Imaging Probes

(2010) Kai Chen et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Molecular imaging in the diagnosis of Alzheimer's disease: visual assessment of [11C]PIB and [18F]FDDNP PET images

(2010) N. Tolboom et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Voxel-based analysis of Alzheimer's disease PET imaging using a triplet of radiotracers: PIB, FDDNP, and FDG

(2010) Jonghan Shin et al.   NEUROIMAGE

Development of Tau Aggregation Inhibitors for Alzheimer's Disease

(2009) Bruno Bulic et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quantitative analysis of [18F]FDDNP PET using subcortical white matter as reference region

(2009) Koon-Pong Wong et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Interaction of the amyloid imaging tracer FDDNP with hallmark Alzheimer’s disease pathologies

(2009) Paul W. Thompson et al.   JOURNAL OF NEUROCHEMISTRY

Functional and Multifunctional Nanoparticles for Bioimaging and Biosensing

(2009) Subramanian Tamil Selvan et al.   LANGMUIR

Limitations of Small Animal PET Imaging with [18F]FDDNP and FDG for Quantitative Studies in a Transgenic Mouse Model of Alzheimer’s Disease

(2009) Claudia Kuntner et al.   MOLECULAR IMAGING AND BIOLOGY

Small-Molecule Mediated Neuroprotection in an In Situ Model of Tauopathy

(2009) Nicolette S. Honson et al.   NEUROTOXICITY RESEARCH

Imaging Alzheimer Pathology in Late-Life Depression With PET and Pittsburgh Compound-B

(2008) Meryl A. Butters et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

(2008) Milos D. Ikonomovic et al.   BRAIN

Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer's disease

(2008) Barnabas Wilson et al.   BRAIN RESEARCH

Tau exon 10 alternative splicing and tauopathies

(2008) Fei Liu et al.   Molecular Neurodegeneration

Multitracer PET imaging of amyloid plaques and neurofibrillary tangles in Alzheimer's disease

(2008) Jonghan Shin et al.   NEUROIMAGE