Review
Biochemistry & Molecular Biology
Simran Rastogi, Vaibhav Sharma, Prahalad Singh Bharti, Komal Rani, Gyan P. Modi, Fredrik Nikolajeff, Saroj Kumar
Summary: Exosomes, small extracellular vesicles of 30-150 nm in diameter, have recently been found to play a role in the initiation and progression of neurodegenerative diseases. They carry specific proteins, lipids, functional mRNAs, and various non-coding RNAs, making them potential diagnostic biomarkers for early disease detection. Their composition and function vary depending on their originating and recipient cells, and they have been highlighted as a novel field for early diagnosis in neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Patrycja Pawlik, Katarzyna Blochowiak
Summary: Neurodegenerative diseases result in progressive neuronal degeneration, emphasizing the need for early screening and diagnosis. Biomarkers show promise for early detection, with saliva being explored as a potential non-invasive diagnostic tool. Research on salivary biomarkers for Alzheimer's and Parkinson's diseases continues, aiming to identify correlations between specific biomarkers and early clinical symptoms for improved treatment strategies.
Review
Genetics & Heredity
Chiara Villa, Andrea Stoccoro
Summary: Alzheimer's disease is a progressive neurodegenerative disorder that leads to cognitive impairment and dementia in older individuals. Detection of altered epigenetic signatures in blood may assist in the early diagnosis and treatment of the disease.
Review
Biochemistry & Molecular Biology
Dorota Konickova, Katerina Mensikova, Lucie Tuckova, Eva Henykova, Miroslav Strnad, David Friedecky, David Stejskal, Radoslav Matej, Petr Kanovsky
Summary: The understanding of neurodegenerative diseases has shifted in the past 20 years, from being seen as well-defined entities to complex and heterogeneous processes. Diagnosis primarily requires brain imaging techniques or invasive tests, but identifying specific proteinopathies is difficult due to overlap in clinical diagnoses. Laboratory methods to identify biomarkers are urgently needed to improve diagnosis, monitor disease progression, and evaluate treatment effects.
Article
Endocrinology & Metabolism
Hai Duc Nguyen, Byung Pal Yu, Ngoc Hong Minh Hoang, Won Hee Jo, Hae Young Chung, Min-Sun Kim
Summary: PRL is a promising molecule for the treatment of neurodegenerative disorders like Alzheimer's disease and Parkinson's disease, but the mechanisms responsible for its effects are still not fully understood. Modulating PRL functions and targeting immune mechanisms are key strategies for developing preventive or therapeutic approaches.
NEUROENDOCRINOLOGY
(2022)
Review
Immunology
Austin P. Passaro, Abraham L. Lebos, Yao Yao, Steven L. Stice
Summary: Neuroinflammation plays a crucial role in neurological disorders, with recent recognition of the importance of interactions between central and peripheral immune cells. Traditional approaches often separate these systems, but there is significant crosstalk between central and peripheral immune cells in the context of neurological disorders. Targeting these interactions may offer a potential improved therapeutic strategy for addressing failures in clinical translation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Riccardo Goldoni, Carolina Dolci, Elisa Boccalari, Francesco Inchingolo, Alessandro Paghi, Lucanos Strambini, Daniela Galimberti, Gianluca Martino Tartaglia
Summary: Salivary analysis is a novel and promising field of research for the diagnosis of neurodegenerative and demyelinating diseases related to aging. Collection of saliva is noninvasive, stress-free, and repeatable, offering advantages for early diagnosis and timely treatment. Advanced biosensors have been proposed for detecting salivary biomarkers associated with various neurodegenerative diseases.
AGEING RESEARCH REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Fatimah K. Khalaf, Jacob Connolly, Bella Khatib-Shahidi, Abdulsahib Albehadili, Iman Tassavvor, Meghana Ranabothu, Noha Eid, Prabhatchandra Dube, Samer J. Khouri, Deepak Malhotra, Steven T. Haller, David J. Kennedy
Summary: Paraoxonase enzymes are an important redox system that protect cells against oxidative stress. The PON enzymes family, consisting of PON-1, PON-2, and PON-3, play a role in preventing cardiovascular disease and are associated with neurological disorders and neurodegenerative diseases. This review summarizes the evidence on the role of PONs in these diseases and their ability to modify risk factors for neurological disorders, focusing on Alzheimer's disease, Parkinson's disease, and other neurodegenerative and neurological diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Marthe Smedinga, Sirwan K. L. Darweesh, Bastiaan R. Bloem, Bart Post, Edo Richard
Summary: Research on Parkinson's disease (PD) is increasingly focusing on early disease modification and prevention, similar to strategies seen in Alzheimer's disease research. Challenges faced in Alzheimer's prevention trials, including insufficiently robust trial results and trial design flaws, also apply to PD research and need to be addressed for optimal trial design.
JOURNAL OF NEUROLOGY
(2021)
Review
Neurosciences
Ke-Ru Li, An-Guo Wu, Yong Tang, Xiao-Peng He, Chong-Lin Yu, Jian-Ming Wu, Guang-Qiang Hu, Lu Yu
Summary: Neurodegenerative diseases are characterized by progressive degeneration, brain tissue damage, and neuronal loss, accompanied by behavioral and cognitive dysfunctions. MRI has become an advanced medical imaging technique widely used in the clinical examination of NDs, playing a crucial role in the early diagnosis and treatment.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Medicine, General & Internal
Agnieszka Kulczynska-Przybik, Maciej Dulewicz, Agnieszka Slowik, Renata Borawska, Alina Kulakowska, Jan Kochanowicz, Barbara Mroczko
Summary: The study evaluated the concentrations of the RTN4 protein in the cerebrospinal fluid of patients with neurodegenerative diseases, finding significantly higher levels in AD, PD, and MS patients compared to controls. Additionally, the highest concentration of RTN4A was found in AD patients, with a significant difference between AD vs. PD and AD vs. MS groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Neurosciences
Mohammad Rafi Khezri, Keyvan Yousefi, Naime Majidi Zolbanin, Morteza Ghasemnejad-Berenji
Summary: Neurodegenerative diseases, a major cause of mortality and functional dependence among the elderly, have a low success rate in clinical pipelines. MicroRNAs play a crucial role in regulating the occurrence of neurodegenerative diseases, and alterations in certain microRNA levels in clinical samples may have significant clinical implications.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Keelan Jagaran, Moganavelli Singh
Summary: Neurodegenerative disorders result in the gradual degeneration of axons and neurons in the central nervous system, causing major disruptions in patients' lives. Current treatments are only palliative, highlighting the need for a therapeutic strategy targeting the root cause of the diseases. The synergistic use of gene therapy and nanomedicine shows promise in effectively treating these diseases by targeting the causative mutated genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Genetics & Heredity
Egle Jakubauskiene, Arvydas Kanopka
Summary: Alternative pre-mRNA splicing is essential for generating protein diversity and is implicated in the pathogenesis of neurological disorders. The splicing machinery also plays a role in cellular adaptation to different microenvironments, such as hypoxia. Understanding the alternative splicing of genes associated with Alzheimer's and Parkinson's diseases can provide insights into the development of these neurodegenerative conditions, including the influence of cellular hypoxic microenvironments.
Review
Biochemistry & Molecular Biology
Paola Piscopo, Maria Bellenghi, Valeria Manzini, Alessio Crestini, Giada Pontecorvi, Massimo Corbo, Elena Ortona, Alessandra Care, Annamaria Confaloni
Summary: Sex is a significant factor in the prevalence and incidence of neurological disorders, with sex differences in neurodegenerative diseases like Alzheimer's and Parkinson's. Recent studies suggest that miRNA could serve as sex-specific biomarkers for identifying these diseases, and it is important to consider possible differences between males and females in miRNA evaluation to avoid sex bias.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Krishna Kanta Ghosh, Parasuraman Padmanabhan, Chang-Tong Yang, David Chee Eng Ng, Mathangi Palanivel, Sachin Mishra, Christer Halldin, Balazs Gulyas
Summary: Positron emission tomography (PET) is a widely used nuclear functional imaging technique, particularly in central nervous system (CNS) and oncological disorders. It can accelerate drug discovery and development by monitoring drug distribution and effects, providing important references for clinical application.
DRUG DISCOVERY TODAY
(2022)
Article
Chemistry, Multidisciplinary
Durairaj Siva, Subramanian Abinaya, Durairaj Rajesh, Govindaraju Archunan, Parasuraman Padmanabhan, Balazs Gulyas, Shanmugam Achiraman
Summary: This study investigates the possible mechanism of doxorubicin-mediated cardiotoxicity and explores the use of chitosan nanoparticles conjugated with doxorubicin and supplemented with propionic acid to reduce the cardiotoxicity. The results show that DCNPs and propionic acid have a protective effect against doxorubicin-induced cardiotoxicity.
Review
Chemistry, Multidisciplinary
Kumar Babu Busi, Mathangi Palanivel, Krishna Kanta Ghosh, Writoban Basu Ball, Balazs Gulyas, Parasuraman Padmanabhan, Sabyasachi Chakrabortty
Summary: Nanoclusters with ultrasmall size and high fluorescence are advantageous for use in biological systems, particularly in early disease diagnosis. Copper nanoclusters (Cu NCs) have several advantages over other metallic nanoclusters, making them ideal for bioimaging purposes. Optical imaging technology, utilizing the fluorescent properties of Cu NCs, has promising applications in early cancer diagnosis and imaging-guided treatment.
Article
Chemistry, Multidisciplinary
Soner Karabacak, Alagappan Palaniappan, Tsang Siu Hon Tony, Teo Hang Tong Edwin, Balazs Gulyas, Parasuraman Padmanabhan, Umit Hakan Yildiz
Summary: A rapid one-pot synthesis of PTAA functionalized polyurea polymer dots was achieved, and the resulting dots were further functionalized with gadolinium nanoparticles for fluorescence and magnetic properties. The synthesized dual-functional Gd3+-Pdots showed detectable fluorescent signals even at lower concentrations and could be easily manipulated via an external magnetic field.
Article
Immunology
Vaikundamoorthy Ramalingam, Rajendran Rajaram, Govindaraju Archunan, Parasuraman Padmanabhan, Balazs Gulyas
Summary: This study aimed to isolate and identify potential drugs from marine actinomycete Nocardiopsis exhalans, and screen them for biomedical applications. NHP, identified as N-(2-hydroxyphenyl)-2-phenazinamine, showed significant activity against human clinical pathogens and excellent biofilm inhibitory activity. It also exhibited antioxidant activity and anti-proliferative activity against human breast cancer cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mahalingam Srinivasan, Subramanian Muthukumar, Durairaj Rajesh, Vinod Kumar, Rajamanickam Rajakumar, Mohammad Abdulkader Akbarsha, Balazs Gulyas, Parasuraman Padmanabhan, Govindaraju Archunan
Summary: The presence of S. pasteuri in the cervical mucus of water buffaloes is associated with physiological and reproductive states. Analysis using LC-MS/MS suggests that the extracellular proteins of S. pasteuri may play an important role in sexual communication during the estrus phase of the buffalo host.
Article
Multidisciplinary Sciences
Nikolett Hegedus, Laszlo Forgach, Balint Kiss, Zoltan Varga, Balint Jezso, Ildiko Horvath, Noemi Kovacs, Polett Hajdrik, Parasuraman Padmanabhan, Balazs Gulyas, Krisztian Szigeti, Domokos Mathe
Summary: The aim of this study was to develop and characterize a biocompatible and chemically stable MRI contrast agent based on Prussian Blue, which also provides near infrared optical contrast for preclinical application. The physical properties of the synthesized Prussian blue nanoparticles were analyzed and confirmed through techniques such as dynamic light scattering, zeta potential measurement, atomic force microscopy, and transmission electron microscopy. The in vitro and in vivo experiments demonstrated the enhanced T1-weighted contrast effect of the prepared Prussian Blue nanoparticles, suggesting its potential as a new diagnostic agent.
Article
Cardiac & Cardiovascular Systems
Laszlo Kiraly, Balazs Gulyas
Summary: The study found consistent parallels between Aristotle's/Galen's tripartite concept and the structure of Gothic cathedrals, suggesting a common philosophical and symbolic foundation. The interpretation of this tripartite concept effectively delayed the recognition of circulation and the role of the heart.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Bindiya Lakshmi Raghunath, Kelly Hwee Leng Sng, S. H. Annabel Chen, Vimalan Vijayaragavan, Balazs Gulyas, Peipei Setoh, Gianluca Esposito
Summary: Specific facial features in infants automatically elicit attention, affection, and nurturing behavior of adults, known as the baby schema effect. There is also an innate tendency to categorize people into in-group and out-group members based on salient features such as ethnicity. This study used fMRI to examine parents' neural responses to infants of different ethnicities and kinship relationships. The findings revealed that parents showed similar brain activations, regardless of ethnicity and kinship, in regions associated with attention, reward processing, empathy, memory, goal-directed action planning, and social cognition. These regions were activated to a higher degree when viewing the parents' own infant.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Nivedhitha Kabeerdass, Karthikeyan Murugesan, Natarajan Arumugam, Abdulrahman Almansour, Raju Suresh Kumar, Sinouvassane Djearamane, Ashok Kumar Kumaravel, Palanivel Velmurugan, Vinayagam Mohanavel, Subbiah Suresh Kumar, Selvaraj Vijayanand, Parasuraman Padmanabhan, Balazs Gulyas, Maghimaa Mathanmohun
Summary: This study demonstrates the potential of green synthesis of silver nanoparticles from Alternanthera sessilis in treating wound infections. Various analysis methods were used to show the inhibitory effect of As-AgNPs on Klebsiella pneumoniae and its embedding in fabrics. Cell experiments confirmed the non-toxicity of As-AgNPs on cell survival and proliferation.
Review
Neurosciences
Alfred Lenin Fred, Subbiahpillai Neelakantapillai Kumar, Ajay Kumar Haridhas, Sayantan Ghosh, Harishita Purushothaman Bhuvana, Wei Khang Jeremy Sim, Vijayaragavan Vimalan, Fredin Arun Sedly Givo, Veikko Jousmaki, Parasuraman Padmanabhan, Balazs Gulyas
Summary: Magnetoencephalography (MEG) plays a crucial role in diagnosing brain disorders, offering higher signal-to-noise ratio and spatial resolution compared to electroencephalography (EEG). MEG signals reflect the physiological state of neurological disorders and aid in disease diagnosis. Analysis of MEG data during resting state and specific tasks allows for the diagnosis of various neurological disorders. Furthermore, computer-aided algorithms are expected to play a significant role in diagnosing and predicting neurological diseases in the future.
Review
Biochemistry & Molecular Biology
Imre Hegedus, Kitti Andreidesz, Jozsef L. Szentpeteri, Zoltan Kaleta, Laszlo Szabo, Krisztian Szigeti, Balizs Gulyas, Parasuraman Padmanabhan, Ferenc Budan, Domokos Mathe
Summary: This article emphasizes the importance of nutritional interventions in maintaining or restoring human health, with grapes being recognized as a beneficial source of polyphenols that enhance human health. The review provides detailed information on the molecular mechanisms and biological activities of polyphenol molecules in grapes, highlighting their potential roles in diabetes, cancer, viral infections, vascular protection, and neuroprotection. Furthermore, the article explores the therapeutic applications of polyphenols derived from grapes and their byproducts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Kumar Babu Busi, Subhalaxmi Das, Mathangi Palanivel, Krishna Kanta Ghosh, Balazs Gulyas, Parasuraman Padmanabhan, Sabyasachi Chakrabortty
Summary: We have developed a simple and cost-effective method for the synthesis of red-/green-color-emitting protein/amino acid-mediated copper nanoclusters (Cu NCs) in water. These Cu NCs exhibited strong fluorescence, aqueous colloidal stability, and low toxicity, making them suitable for applications in biology and environmental science. The optical properties of the Cu NCs responded linearly to changes in pH, and they showed a robust pH reversible nature between pH 7 and 11, which has potential for rapid and localized pH sensing. Additionally, the Cu NCs were found to be efficient optical probes for fluoride ion detection, with different limits of detection for protein-Cu NCs and amino acid-Cu NCs.
Review
Computer Science, Information Systems
Satya P. Singh, Sachin Mishra, Sukrit Gupta, Parasuraman Padmanabhan, Lu Jia, Teo Kok Ann Colin, Yeo Tseng Tsai, Teo Kejia, Pramod Sankarapillai, Anand Mohan, Balazs Gulyas
Summary: This review examines the application of brain-computer interfacing in rehabilitation, neuro-prosthetics, and neurofeedback. By analyzing research and neuroimaging experiments, the functionally active areas of the brain in non-invasive brain-computer interfacing are identified. The paper also discusses the challenges and limitations of BCI and proposes ways to overcome security issues and design implementations.
Review
Engineering, Biomedical
Fong LaiGuan Zoey, Krishna Kanta Ghosh, Mathangi Palanivel, Balazs Gulyas, Parasuraman Padmanabhan
Summary: Traumatic brain injury (TBI) is a common cause of disability and mortality worldwide, but there are currently no effective treatments to prevent TBI secondary injuries. This review explores the potential use of nanotechnology in improving TBI recovery.
ADVANCED NANOBIOMED RESEARCH
(2023)
