Activation of CREB‐mediated autophagy by thioperamide ameliorates β‐amyloid pathology and cognition in Alzheimer’s disease

Dihydroartemisinin Ameliorates Learning and Memory in Alzheimer’s Disease Through Promoting Autophagosome-Lysosome Fusion and Autolysosomal Degradation for Aβ Clearance

(2020) Yueyang Zhao et al.   Frontiers in Aging Neuroscience

AdipoRon improves cognitive dysfunction of Alzheimer’s disease and rescues impaired neural stem cell proliferation through AdipoR1/AMPK pathway

(2020) Bin Liu et al.   EXPERIMENTAL NEUROLOGY

Dynamic changes of autophagic flux induced by Abeta in the brain of postmortem Alzheimer’s disease patients, animal models and cell models

(2020) Zhimin Long et al.   Aging-US

The Role of Beclin-1 Acetylation on Autophagic Flux in Alzheimer’s Disease

(2019) A. Raquel Esteves et al.   MOLECULAR NEUROBIOLOGY

TFEB-mediated enhancement of the autophagy-lysosomal pathway dually modulates the process of amyloid β-protein generation in neurons

(2019) Fumiko Yamamoto et al.   NEUROSCIENCE

Histamine H1 Receptors in Neural Stem Cells Are Required for the Promotion of Neurogenesis Conferred by H3 Receptor Antagonism following Traumatic Brain Injury

(2019) Rujia Liao et al.   Stem Cell Reports

Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model

(2019) Rongcan Luo et al.   Autophagy

Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway

(2019) Abubakar Wani et al.   Autophagy

Autophagy dysfunction in Alzheimer’s disease: mechanistic insights and new therapeutic opportunities

(2019) Antonio Di Meco et al.   BIOLOGICAL PSYCHIATRY

Histamine, histamine receptors and neuropathic pain relief

(2019) Ilona Obara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Autophagy in Alzheimer's disease and promising modulatory effects of herbal medicine

(2019) Qiang Zeng et al.   EXPERIMENTAL GERONTOLOGY

ERβ promotes Aβ degradation via the modulation of autophagy

(2019) Yong Wei et al.   Cell Death & Disease

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Targeting Autophagy for the Treatment of Alzheimer’s Disease: Challenges and Opportunities

(2019) Jie Liu et al.   Frontiers in Molecular Neuroscience

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Curcumin attenuates cognitive impairment by enhancing autophagy in chemotherapy

(2019) Li-Tao Yi et al.   NEUROBIOLOGY OF DISEASE

Resumption of Autophagy by Ubisol-Q10 in Presenilin-1 Mutated Fibroblasts and Transgenic AD Mice: Implications for Inhibition of Senescence and Neuroprotection

(2019) Caleb Vegh et al.   Oxidative Medicine and Cellular Longevity

BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology

(2018) Finn Peters et al.   ACTA NEUROPATHOLOGICA

The emerging roles of protein homeostasis-governing pathways in Alzheimer's disease

(2018) Ji Cheng et al.   AGING CELL

Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease

(2018) Daniel J. Colacurcio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Copper chelators promote nonamyloidogenic processing of AβPP via MT1/2 /CREB-dependent signaling pathways in AβPP/PS1 transgenic mice

(2018) Zhuo Wang et al.   JOURNAL OF PINEAL RESEARCH

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

(2018) Barry Boland et al.   NATURE REVIEWS DRUG DISCOVERY

Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling

(2018) Cheong-Meng Chong et al.   Cell Death & Disease

Histamine H3 Inverse Agonist BF 2649 or Antagonist with Partial H4 Agonist Activity Clobenpropit Reduces Amyloid Beta Peptide-Induced Brain Pathology in Alzheimer’s Disease

(2017) Ranjana Patnaik et al.   MOLECULAR NEUROBIOLOGY

Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2017) Jeff Sevigny et al.   NATURE

Autophagy Activation Alleviates Amyloid-β-Induced Oxidative Stress, Apoptosis and Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells

(2017) Abhishek Kumar Singh et al.   NEUROTOXICITY RESEARCH

BACE inhibition-dependent repair of Alzheimer’s pathophysiology

(2017) Aylin D. Keskin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

(2017) Altea Rocchi et al.   PLoS Genetics

The histamine H3 receptor antagonist thioperamide rescues circadian rhythm and memory function in experimental parkinsonism

(2017) D Masini et al.   Translational Psychiatry

The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats

(2017) Alaa Alachkar et al.   Frontiers in Pharmacology

Targeting neuronal MAPK14/p38α activity to modulate autophagy in the Alzheimer disease brain

(2016) John Alam et al.   Autophagy

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

(2016) Matteo Bordi et al.   Autophagy

Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases

(2016) Bassem Sadek et al.   BEHAVIOURAL BRAIN RESEARCH

Autophagy and Alzheimer’s Disease

(2016) Qian Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation

(2016) Tuancheng Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotection Through Rapamycin-Induced Activation of Autophagy and PI3K/Akt1/mTOR/CREB Signaling Against Amyloid-β-Induced Oxidative Stress, Synaptic/Neurotransmission Dysfunction, and Neurodegeneration in Adult Rats

(2016) Abhishek Kumar Singh et al.   MOLECULAR NEUROBIOLOGY

Reduced pCREB in Alzheimer’s disease prefrontal cortex is reflected in peripheral blood mononuclear cells

(2016) N Bartolotti et al.   MOLECULAR PSYCHIATRY

Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling

(2016) Yaling Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histamine H3receptor in primary mouse microglia inhibits chemotaxis, phagocytosis, and cytokine secretion

(2015) Tomomitsu Iida et al.   GLIA

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing A  Generation and Amyloid Plaque Pathogenesis

(2015) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis

(2014) Michela Guglielmotto et al.   Autophagy

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

(2014) Mi-Hyang Cho et al.   Autophagy

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease

(2014) Arun K. Ghosh et al.   CHEMICAL SOCIETY REVIEWS

Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature

(2014) A. Caccamo et al.   JOURNAL OF NEUROSCIENCE

Transcriptional regulation of autophagy by an FXR–CREB axis

(2014) Sunmi Seok et al.   NATURE

Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms

(2014) Haijing Yan et al.   Nature Communications

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

(2014) Robert Vassar   Alzheimers Research & Therapy

Identification and pharmacological characterization of the histamine H3 receptor in cultured rat astrocytes

(2013) Tina Mele et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Autophagic/lysosomal dysfunction in Alzheimer’s disease

(2013) Miranda E Orr et al.   Alzheimers Research & Therapy

Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions

(2012) Sung Min Son et al.   Autophagy

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

(2012) J W Steele et al.   MOLECULAR PSYCHIATRY

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus

(2011) Raquel Sanchez-Varo et al.   ACTA NEUROPATHOLOGICA

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

(2011) Dun-Sheng Yang et al.   Autophagy

Cyclic AMP response element-binding protein (CREB) phosphorylation: A mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics

(2011) R. Scott Bitner   BIOCHEMICAL PHARMACOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Implementation of a Fluorescence-Based Screening Assay Identifies Histamine H3 Receptor Antagonists Clobenpropit and Iodophenpropit as Subunit-Selective N-Methyl-D-Aspartate Receptor Antagonists

(2010) K. B. Hansen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Discovery of Histamine H3 Antagonists for the Treatment of Cognitive Disorders and Alzheimer's Disease

(2010) J. D. Brioni et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer’s disease

(2010) R. Scott Bitner et al.   NEUROPHARMACOLOGY

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Characterization of histamine H3 receptors in Alzheimer's Disease brain and amyloid over-expressing TASTPM mice

(2009) AD Medhurst et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amyloid β-Protein Toxicity and the Pathogenesis of Alzheimer Disease

(2008) Bruce A. Yankner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons

(2008) T Chiba et al.   MOLECULAR PSYCHIATRY

Histamine in the Nervous System

(2008) Helmut L. Haas et al.   PHYSIOLOGICAL REVIEWS