4.8 Correction

The antibody aducanumab reduces Aβ plaques in Alzheimer's disease (vol 537, pg 50, 2016)

期刊

NATURE
卷 546, 期 7659, 页码 564-564

出版社

NATURE PUBLISHING GROUP
DOI: 10.1038/nature22809

关键词

-

向作者/读者索取更多资源

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Clinical Neurology

Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS

Benedetta Parodi, Silvia Rossi, Sara Morando, Christian Cordano, Alberto Bragoni, Caterina Motta, Cesare Usai, Brian T. Wipke, Robert H. Scannevin, Giovanni L. Mancardi, Diego Centonze, Nicole Kerlero de Rosbo, Antonio Uccelli

ACTA NEUROPATHOLOGICA (2015)

Article Biochemistry & Molecular Biology

Pharmacodynamics of Dimethyl Fumarate Are Tissue Specific and Involve NRF2-Dependent and -Independent Mechanisms

Melanie S. Brennan, Hiral Patel, Norm Allaire, Alice Thai, Patrick Cullen, Sarah Ryan, Matvey Lukashev, Pradeep Bista, Ron Huang, Kenneth J. Rhodes, Robert H. Scannevin

ANTIOXIDANTS & REDOX SIGNALING (2016)

Article Biochemistry & Molecular Biology

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

Isabel Lastres-Becker, Angel J. Garcia-Yague, Robert H. Scannevin, Maria J. Casarejos, Sebastian Kuegler, Alberto Rabano, Antonio Cuadrado

ANTIOXIDANTS & REDOX SIGNALING (2016)

Article Immunology

Dimethyl fumarate alters microglia phenotype and protects neurons against proinflammatory toxic microenvironments

Haiyan Peng, Huo Li, Adam Sheehy, Patrick Cullen, Norm Allaire, Robert H. Scannevin

JOURNAL OF NEUROIMMUNOLOGY (2016)

Article Multidisciplinary Sciences

The antibody aducanumab reduces Aβ plaques in Alzheimer's disease

Jeff Sevigny, Ping Chiao, Thierry Bussiere, Paul H. Weinreb, Leslie Williams, Marcel Maier, Robert Dunstan, Stephen Salloway, Tianle Chen, Yan Ling, John O'Gorman, Fang Qian, Mahin Arastu, Mingwei Li, Sowmya Chollate, Melanie S. Brennan, Omar Quintero-Monzon, Robert H. Scannevin, H. Moore Arnold, Thomas Engber, Kenneth Rhodes, James Ferrero, Yaming Hang, Alvydas Mikulskis, Jan Grimm, Christoph Hock, Roger M. Nitsch, Alfred Sandrock

NATURE (2016)

Article Neurosciences

BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease

Robert H. Scannevin, Sowmya Chollate, Melanie S. Brennan, Pamela A. Snodgrass-Belt, Hairuo Peng, Lin Xu, Mi-young Jung, Thierry Bussiere, Mahin F. Arastu, Tina Talreja, Zhili Xin, Robert W. Dunstan, Diana Fahrer, Ellen Rohde, Anthone W. Dunah, Joy Wang, Gnanasambandam Kumaravel, Arthur G. Taveras, H. Moore Arnold, Kenneth J. Rhodes

NEUROPHARMACOLOGY (2016)

Article Multidisciplinary Sciences

Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2

Ulf Schulze-Topphoff, Michel Varrin-Doyer, Kara Pekarek, Collin M. Spencer, Aparna Shetty, Sharon A. Sagan, Bruce A. C. Cree, Raymond A. Sobel, Brian T. Wipke, Lawrence Steinman, Robert H. Scannevin, Scott S. Zamvil

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemistry & Molecular Biology

Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation

Robert H. Scannevin, Richard Alexander, Tara Mezzasalma Haarlander, Sharon L. Burke, Monica Singer, Cuifen Huo, Yue-Mei Zhang, Diane Maguire, John Spurlino, Ingrid Deckman, Karen I. Carroll, Frank Lewandowski, Eric Devine, Keli Dzordzorme, Brett Tounge, Cindy Milligan, Shariff Bayoumy, Robyn Williams, Celine Schalk-Hihi, Kristi Leonard, Paul Jackson, Matthew Todd, Lawrence C. Kuo, Kenneth J. Rhodes

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Endocrinology & Metabolism

Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators

Jill H. Fowler, Jamie McQueen, Philip R. Holland, Yasmina Manso, Martina Marangoni, Fiona Scott, Emma Chisholm, Robert H. Scannevin, Giles E. Hardingham, Karen Horsburgh

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2018)

Review Biochemistry & Molecular Biology

Therapeutic strategies for targeting neurodegenerative protein misfolding disorders

Robert H. Scannevin

CURRENT OPINION IN CHEMICAL BIOLOGY (2018)

Article Multidisciplinary Sciences

The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes

Melanie S. Brennan, Maria F. Matos, Karl E. Richter, Bing Li, Robert H. Scannevin

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction

Edward Y. S. Lin, Laura F. Silvian, Douglas J. Marcotte, Charles C. Banos, Flora Jow, Timothy R. Chan, Robert M. Arduini, Fang Qian, Darren P. Baker, Chris Bergeron, Catherine A. Hession, Richard L. Huganir, Cassandra F. Borenstein, Istvan Enyedy, Jinming Zou, Ellen Rohde, Marion Wittmann, Gnanasambandam Kumaravel, Kenneth J. Rhodes, Robert H. Scannevin, AnthoneW. Dunah, Kevin M. Guckian

SCIENTIFIC REPORTS (2018)

Article Cell Biology

Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity

Benjamin M. Vincent, Daniel F. Tardiff, Jeff S. Piotrowski, Rebecca Aron, Matthew C. Lucas, Chee Yeun Chung, Helene Bacherman, YiQun Chen, Michelle Pires, Radha Subramaniam, Dimple B. Doshi, Heather Sadlish, Waseem K. Raja, Eric J. Solis, Vikram Khurana, Bertrand Le Bourdonnec, Robert H. Scannevin, Kenneth J. Rhodes

CELL REPORTS (2018)

Article Clinical Neurology

Dimethyl fumarate impairs differentiated B cells and fosters central nervous system integrity in treatment of multiple sclerosis

Jan Traub, Sarah Traffehn, Jasmin Ochs, Silke Haeusser-Kinzel, Schirin Stephan, Robert Scannevin, Wolfgang Brueck, Inke Metz, Martin S. Weber

BRAIN PATHOLOGY (2019)

暂无数据