Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme

Reduced Insulin Clearance and Insulin-Degrading Enzyme Activity Contribute to Hyperinsulinemia in African Americans

(2020) Andin Fosam et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Bacitracin attenuates haemolysis‐induced insulin degradation during insulin sensitivity testing: Repurposing an old drug for use in metabolic research

(2020) Andrew P. Demidowich et al.   DIABETES OBESITY & METABOLISM

FAK Family Kinases in Vascular Diseases

(2020) James M. Murphy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insulin degrading enzyme (IDE) expressed by Chinese hamster ovary (CHO) cells is responsible for degradation of insulin in culture media

(2020) Salina Louie et al.   JOURNAL OF BIOTECHNOLOGY

Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40

(2020) Caitlin N. Suire et al.   Alzheimers Research & Therapy

Paracrine regulation of insulin secretion

(2020) Mark O. Huising   DIABETOLOGIA

Integrating Old and New Paradigms of G1/S Control

(2020) Seth M. Rubin et al.   MOLECULAR CELL

Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice

(2020) Beatriz Merino et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

SIRT4 regulates PTEN stability through IDE in response to cellular stresses

(2019) Minghui Liu et al.   FASEB JOURNAL

Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis

(2019) Hilda E. Ghadieh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Knockout of insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality

(2019) Maria João Meneses et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme

(2019) Juan Pablo Maianti et al.   Nature Chemical Biology

Hepatic Insulin Clearance: Mechanism and Physiology

(2019) Sonia M. Najjar et al.   PHYSIOLOGY

Pancreatic beta-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and beta-cell functional immaturity

(2019) Cristina M Fernandez-Diaz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

IDE Degrades Nociceptin/Orphanin FQ through an Insulin Regulated Mechanism

(2019) Gabriele Antonio Zingale et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening

(2019) Florence Leroux et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses

(2019) Kateřina Macháčková et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

(2019) Maria Lytrivi et al.   JOURNAL OF MOLECULAR BIOLOGY

Cooperative function of Pdx1 and Oc1 in multipotent pancreatic progenitors impacts postnatal islet maturation and adaptability

(2018) Peter A. Kropp et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Molecular determinants of substrate specificity in human insulin-degrading enzyme

(2018) Lazaros Stefanidis et al.   BIOCHEMISTRY

Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca 2+ Sensitivity of Insulin Secretion Vesicles

(2018) Chen Huang et al.   DEVELOPMENTAL CELL

Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display

(2018) Caitlin N. Suire et al.   PLoS One

Replication confers β cell immaturity

(2018) Sapna Puri et al.   Nature Communications

Insulin-degrading enzyme is not secreted from cultured cells

(2018) Eun Suk Song et al.   Scientific Reports

Development and Characterization of Quantitative, High-Throughput-Compatible Assays for Proteolytic Degradation of Glucagon

(2018) Caitlin N. Suire et al.   SLAS Discovery

Cytoplasmic Intermediate Filaments in Cell Biology

(2018) Sandrine Etienne-Manneville   Annual Review of Cell and Developmental Biology

Target discovery of ebselen with a biotinylated probe

(2018) Zhenzhen Chen et al.   CHEMICAL COMMUNICATIONS

Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice

(2018) Pablo Villa-Pérez et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Vitamin E supplementation and caloric restriction promotes regulation of insulin secretion and glycemic homeostasis by different mechanisms in rats

(2018) Paula R. Venturini et al.   Biochemistry and Cell Biology

Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme

(2018) Valerie A. Ivancic et al.   BIOSCIENCE REPORTS

The N-Terminus of the HIV-1 p6 Gag Protein Regulates Susceptibility to Degradation by IDE

(2018) Adrian Schmalen et al.   Viruses-Basel

Proteases and glycosidases on the surface of exosomes: Newly discovered mechanisms for extracellular remodeling

(2017) Ralph D. Sanderson et al.   MATRIX BIOLOGY

Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner

(2017) Friedrich Hahn et al.   PLoS One

Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes

(2017) Eun Suk Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for Loss in Identity, De-Differentiation, and Trans-Differentiation of Islet β-Cells in Type 2 Diabetes

(2017) Chad S. Hunter et al.   Frontiers in Genetics

Interleukin-6 increases the expression and activity of insulin-degrading enzyme

(2017) Mirian A. Kurauti et al.   Scientific Reports

Apoptosis in pancreatic β-islet cells in Type 2 diabetes

(2016) Tatsuo Tomita   Bosnian Journal of Basic Medical Sciences

Nardilysin Is Required for Maintaining Pancreatic β-Cell Function

(2016) Kiyoto Nishi et al.   DIABETES

β-Cell dysfunction in diabetes: a crisis of identity?

(2016) M. F. Brereton et al.   DIABETES OBESITY & METABOLISM

Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin

(2016) Grazia R. Tundo et al.   FEBS Journal

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hyperinsulinemia caused by dexamethasone treatment is associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme

(2016) André Otávio Peres Protzek et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Acute Exercise Improves Insulin Clearance and Increases the Expression of Insulin-Degrading Enzyme in the Liver and Skeletal Muscle of Swiss Mice

(2016) Mirian A. Kurauti et al.   PLoS One

Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus

(2016) Wei-Jen Tang   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors

(2015) Samer O. Abdul-Hay et al.   ACS Chemical Biology

Insulin-degrading enzyme is activated by the C-terminus of α-synuclein

(2015) Sandeep K. Sharma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insulin/receptor binding: The last piece of the puzzle?

(2015) Pierre De Meyts   BIOESSAYS

A neglected modulator of insulin-degrading enzyme activity and conformation: The pH

(2015) Giuseppe Grasso et al.   BIOPHYSICAL CHEMISTRY

Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia

(2015) Fátima O Martins et al.   BRITISH JOURNAL OF PHARMACOLOGY

Modulation of insulin degrading enzyme activity and liver cell proliferation

(2015) Olga Pivovarova et al.   CELL CYCLE

Microtubules Negatively Regulate Insulin Secretion in Pancreatic β Cells

(2015) Xiaodong Zhu et al.   DEVELOPMENTAL CELL

Sorting Nexin 5 and Dopamine D1Receptor Regulate the Expression of the Insulin Receptor in Human Renal Proximal Tubule Cells

(2015) Fengmin Li et al.   ENDOCRINOLOGY

Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearancein Vivo

(2015) Timothy B. Durham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of Human CCL18, CCL3, and CCL4 Reveal Molecular Determinants for Quaternary Structures and Sensitivity to Insulin-Degrading Enzyme

(2015) Wenguang G. Liang et al.   JOURNAL OF MOLECULAR BIOLOGY

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

(2015) Rebecca Deprez-Poulain et al.   Nature Communications

Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner

(2015) Sandeep K. Sharma et al.   Scientific Reports

Reduced insulin clearance and lower insulin-degrading enzyme expression in the liver might contribute to the thrifty phenotype of protein-restricted mice

(2014) Luiz F. Rezende et al.   BRITISH JOURNAL OF NUTRITION

Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis

(2014) Julie Charton et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils

(2014) S. Park et al.   FREE RADICAL RESEARCH

From cytokine to myokine: the emerging role of interleukin-6 in metabolic regulation

(2014) Martin Pal et al.   IMMUNOLOGY AND CELL BIOLOGY

Metabolism of Cryptic Peptides Derived from Neuropeptide FF Precursors: The Involvement of Insulin-Degrading Enzyme

(2014) Giuseppe Grasso et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

(2014) Juan Pablo Maianti et al.   NATURE

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

(2014) Simona Chera et al.   NATURE

No Major Role for Insulin-Degrading Enzyme in Antigen Presentation by MHC Molecules

(2014) Slobodan Culina et al.   PLoS One

Regulation of Insulin Degrading Enzyme Activity by Obesity-Associated Factors and Pioglitazone in Liver of Diet-Induced Obese Mice

(2014) Xiuqing Wei et al.   PLoS One

Deletion of Nardilysin Prevents the Development of Steatohepatitis and Liver Fibrotic Changes

(2014) Shoko Ishizu-Higashi et al.   PLoS One

Critical roles of nardilysin in the maintenance of body temperature homoeostasis

(2014) Yoshinori Hiraoka et al.   Nature Communications

Truncated and modified amyloid-beta species

(2014) Markus P Kummer et al.   Alzheimers Research & Therapy

Glutathione Peroxidase Mimic Ebselen Improves Glucose-Stimulated Insulin Secretion in Murine Islets

(2013) Xinhui Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Insulin-degrading enzyme deficiency in bone marrow cells increases atherosclerosis in LDL receptor-deficient mice

(2013) Justin W. Caravaggio et al.   CARDIOVASCULAR PATHOLOGY

The Type 2 Diabetes-Associated Gene Ide Is Required for Insulin Secretion and Suppression of  -Synuclein Levels in  -Cells

(2013) P. Steneberg et al.   DIABETES

Systemic inhibition of nitric oxide synthesis in non-diabetic individuals produces a significant deterioration in glucose tolerance by increasing insulin clearance and inhibiting insulin secretion

(2013) A. Natali et al.   DIABETOLOGIA

Beta-Cell Dedifferentiation and Type 2 Diabetes

(2013) Yuval Dor et al.   NEW ENGLAND JOURNAL OF MEDICINE

Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

(2013) Lauren A. McCord et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

Ebselen reduces hyperglycemia temporarily-induced by diazinon: A compound with insulin-mimetic properties

(2012) Michael D. Costa et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Effects of Short and Prolonged Mild Intracellular Nitric Oxide Manipulations on Various Aspects of Insulin Secretion in INS-1E β-Cells

(2012) A. Natali et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Hepatic Cannabinoid Receptor-1 Mediates Diet-Induced Insulin Resistance via Inhibition of Insulin Signaling and Clearance in Mice

(2012) Jie Liu et al.   GASTROENTEROLOGY

Insulin-degrading Enzyme (IDE)

(2012) Grazia Raffaella Tundo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

(2012) Barak Blum et al.   NATURE BIOTECHNOLOGY

Visceral fat and metabolic inflammation: the portal theory revisited

(2012) F. Item et al.   Obesity Reviews

Postprandial Hepatic Lipid Metabolism Requires Signaling through Akt2 Independent of the Transcription Factors FoxA2, FoxO1, and SREBP1c

(2011) Min Wan et al.   Cell Metabolism

Hepatic Suppression ofFoxo1andFoxo3Causes Hypoglycemia and Hyperlipidemia in Mice

(2011) Kebin Zhang et al.   ENDOCRINOLOGY

The SNXy flavours of endosomal sorting

(2011) Ludger Johannes et al.   NATURE CELL BIOLOGY

Sorting nexins provide diversity for retromer-dependent trafficking events

(2011) Peter J. Cullen et al.   NATURE CELL BIOLOGY

Redox Regulation of Insulin Degradation by Insulin-Degrading Enzyme

(2011) Crystal M. Cordes et al.   PLoS One

Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance

(2011) Samer O. Abdul-Hay et al.   PLoS One

Identification of the Allosteric Regulatory Site of Insulysin

(2011) Nicholas Noinaj et al.   PLoS One

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin metabolism in human adipocytes from subcutaneous and visceral depots

(2010) Janet Fawcett et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Retinoblastoma protein co-purifies with proteasomal insulin-degrading enzyme: Implications for cell proliferation control

(2010) Razvan T. Radulescu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Specific Roles of the p110α Isoform of Phosphatidylinsositol 3-Kinase in Hepatic Insulin Signaling and Metabolic Regulation

(2010) Victoria Rotter Sopasakis et al.   Cell Metabolism

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Production of an antigenic peptide by insulin-degrading enzyme

(2010) Nicolas Parmentier et al.   NATURE IMMUNOLOGY

A Monomeric Variant of Insulin Degrading Enzyme (IDE) Loses Its Regulatory Properties

(2010) Eun Suk Song et al.   PLoS One

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin

(2010) Malcolm A. Leissring et al.   PLoS One

Insulin Degrading Enzyme Induces a Conformational Change in Varicella-Zoster Virus gE, and Enhances Virus Infectivity and Stability

(2010) Qingxue Li et al.   PLoS One

Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance

(2009) Karla F. Leavens et al.   Cell Metabolism

Insulin-Degrading Enzyme: Structure-Function Relationship and its Possible Roles in Health and Disease

(2009) A. Fernandez-Gamba et al.   CURRENT PHARMACEUTICAL DESIGN

Endosomal proteolysis of internalised [ArgA0]-human insulin at neutral pH generates the mature insulin peptide in rat liver in vivo

(2009) M. Kouach et al.   DIABETOLOGIA

Glucose inhibits the insulin-induced activation of the insulin-degrading enzyme in HepG2 cells

(2009) O. Pivovarova et al.   DIABETOLOGIA

Endocannabinoids and Their Receptors as Targets for Obesity Therapy

(2009) Annette D. de Kloet et al.   ENDOCRINOLOGY

Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme

(2009) Ying-Hao Chou et al.   FASEB JOURNAL

Expression and Regulation of Insulin and the Glucose Transporter GLUT8 in the Testes of Diabetic Rats

(2009) O. Gómez et al.   HORMONE AND METABOLIC RESEARCH

Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

(2009) Marika Manolopoulou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway

(2009) Ji Zhao et al.   Molecular Neurodegeneration

Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening

(2009) Christelle Cabrol et al.   PLoS One

Functions of the unique N-terminal region of glycoprotein E in the pathogenesis of varicella-zoster virus infection

(2009) B. Berarducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation

(2008) Crystal M. Cordes et al.   BIOCHEMICAL PHARMACOLOGY

Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme†

(2008) Enrico Malito et al.   BIOCHEMISTRY

Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding

(2008) Naoto Kubota et al.   Cell Metabolism

Pleiotropic effects of thiazolidinediones

(2008) CV Rizos et al.   EXPERT OPINION ON PHARMACOTHERAPY

Supplementation ofα-tocopherol improves cardiovascular risk factors via the insulin signalling pathway and reduction of mitochondrial reactive oxygen species in type II diabetic rats

(2008) Yukiko Minamiyama et al.   FREE RADICAL RESEARCH

Somatostatin: A Novel Substrate and a Modulator of Insulin-Degrading Enzyme Activity

(2008) Chiara Ciaccio et al.   JOURNAL OF MOLECULAR BIOLOGY

Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis

(2008) Shidong Jia et al.   NATURE

Molecular basis for the thiol sensitivity of insulin-degrading enzyme

(2008) M. Neant-Fery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA