Evidence for Loss in Identity, De-Differentiation, and Trans-Differentiation of Islet β-Cells in Type 2 Diabetes

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas

(2016) Yue J. Wang et al.   Cell Metabolism

RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes

(2016) Yurong Xin et al.   Cell Metabolism

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes

(2016) Tehila Dahan et al.   DIABETES

Single-Cell Transcriptomics of the Human Endocrine Pancreas

(2016) Yue J. Wang et al.   DIABETES

Stress-induced adaptive islet cell identity changes

(2016) V. Cigliola et al.   DIABETES OBESITY & METABOLISM

β-Cell dysfunction in diabetes: a crisis of identity?

(2016) M. F. Brereton et al.   DIABETES OBESITY & METABOLISM

β-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of β-Cell Dedifferentiation and Degranulation

(2016) Alexandra E. Butler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes

(2016) Francesca Cinti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Stress-impaired transcription factor expression and insulin secretion in transplanted human islets

(2016) Chunhua Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of proliferative and mature β-cells in the islets of Langerhans

(2016) Erik Bader et al.   NATURE

Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice

(2016) Ja Young Kim-Muller et al.   Nature Communications

Human islets contain four distinct subtypes of β cells

(2016) Craig Dorrell et al.   Nature Communications

Loss of β-Cell Identity Occurs in Type 2 Diabetes and Is Associated With Islet Amyloid Deposits

(2015) H. Siebe Spijker et al.   DIABETES

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

(2014) Tao Gao et al.   Cell Metabolism

The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth

(2014) Yan Hang et al.   DIABETES

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

(2014) Simona Chera et al.   NATURE

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Pharmacological induction of pancreatic islet cell transdifferentiation: relevance to type I diabetes

(2014) R Piran et al.   Cell Death & Disease

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

(2014) Melissa F. Brereton et al.   Nature Communications

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

(2014) Barak Blum et al.   eLife

Metabolic Signaling in Fuel-Induced Insulin Secretion

(2013) Marc Prentki et al.   Cell Metabolism

Expression of Mesenchymal and  -Cell Phenotypic Markers in Islet  -Cells in Recently Diagnosed Diabetes

(2013) M. G. White et al.   DIABETES CARE

Global estimates of diabetes prevalence for 2013 and projections for 2035

(2013) L. Guariguata et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Hyperplasia of Pancreatic Beta Cells and Improved Glucose Tolerance in Mice Deficient in the FXYD2 Subunit of Na,K-ATPase

(2013) Elena Arystarkhova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of specific β cell transcription factors in type 2 diabetes

(2013) Shuangli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

(2013) Nuria C. Bramswig et al.   JOURNAL OF CLINICAL INVESTIGATION

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

(2013) Brandon L. Taylor et al.   Cell Reports

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity

(2013) Ashleigh E. Schaffer et al.   PLoS Genetics

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3

(2012) Barak Blum et al.   NATURE BIOTECHNOLOGY

Pancreatic β Cell Identity Is Maintained by DNA Methylation-Mediated Repression of Arx

(2011) Sangeeta Dhawan et al.   DEVELOPMENTAL CELL

Diabetes in Mice With Selective Impairment of Insulin Action in Glut4-Expressing Tissues

(2011) Hua V. Lin et al.   DIABETES

Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets

(2011) C. Dai et al.   DIABETOLOGIA

Context-specific  -to- -cell reprogramming by forced Pdx1 expression

(2011) Y.-P. Yang et al.   GENES & DEVELOPMENT

Differences between Human and Rodent Pancreatic Islets

(2011) Michael J. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Pancreatic β-Cell Neogenesis by Direct Conversion from Mature α-Cells

(2010) Cheng-Ho Chung et al.   STEM CELLS

Islet architecture: A comparative study

(2010) Abraham Kim et al.   Islets

Glucolipotoxicity of the pancreatic beta cell

(2009) Vincent Poitout et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas

(2008) Xiaobo Xu et al.   CELL

Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas

(2008) Yoshifumi Saisho et al.   JOURNAL OF MOLECULAR HISTOLOGY