Elucidating the Interactions Between Heparin/Heparan Sulfate and SARS-CoV-2-Related Proteins—An Important Strategy for Developing Novel Therapeutics for the COVID-19 Pandemic

Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

(2020) Shuai Xia et al.   Cellular & Molecular Immunology

The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health — The latest 2019 novel coronavirus outbreak in Wuhan, China

(2020) David S. Hui et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Subunit Vaccines Against Emerging Pathogenic Human Coronaviruses

(2020) Ning Wang et al.   Frontiers in Microbiology

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

(2020) Canrong Wu et al.   Acta Pharmaceutica Sinica B

Computational Design of ACE2-Based Peptide Inhibitors of SARS-CoV-2

(2020) Yanxiao Han et al.   ACS Nano

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

(2020) B. Coutard et al.   ANTIVIRAL RESEARCH

Heparin – an old drug with multiple potential targets in Covid‐19 therapy

(2020) Ulf Lindahl et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

Heparin 2.0: A New Approach to the Infection Crisis

(2020) Malin-Theres Seffer et al.   BLOOD PURIFICATION

Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions

(2020) So Young Kim et al.   ANTIVIRAL RESEARCH

Comprehensive Landscape of Heparin Therapy for COVID-19

(2020) Chen Shi et al.   CARBOHYDRATE POLYMERS

Heparin Induced Thrombocytopenia in Severe COVID-19 Patients

(2020) Florence Daviet et al.   CIRCULATION

The potential of low molecular weight heparin to mitigate cytokine storm in severe COVID‐19 patients: a retrospective cohort study

(2020) Chen Shi et al.   CTS-Clinical and Translational Science

Advances in the preparation and synthesis of heparin and related products

(2020) Sultan N. Baytas et al.   DRUG DISCOVERY TODAY

Fondaparinux Use in Patients With COVID-19: A Preliminary Multicenter Real-World Experience

(2020) Vincenzo Russo et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Molecular dynamics insights into protein-glycosaminoglycan systems from microsecond-scale simulations

(2019) Krzysztof K. Bojarski et al.   BIOPOLYMERS

Chemoenzymatic Synthesis of Glycosaminoglycans

(2019) Xing Zhang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Surface plasmon resonance imaging coupled to on-chip mass spectrometry: a new tool to probe protein-GAG interactions

(2019) Cédric Przybylski et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Glycosaminoglycans in biological samples – Towards identification of novel biomarkers

(2019) Tianji Zhang et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

European guidelines on perioperative venous thromboembolism prophylaxis

(2017) Jacques Duranteau et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Inhaled Heparin: Therapeutic Efficacy and Recent Formulations

(2017) Ayca Yildiz-Pekoz et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Quantitative structure-activity relationship and molecular docking revealed a potency of anti-hepatitis C virus drugs against human corona viruses

(2017) Abdo A. Elfiky et al.   JOURNAL OF MEDICAL VIROLOGY

Heparan Sulfate Microarray Reveals That Heparan Sulfate–Protein Binding Exhibits Different Ligand Requirements

(2017) Chengli Zong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1

(2017) Xiuyuan Ou et al.   Nature Communications

MERS-CoV spike protein: a key target for antivirals

(2016) Lanying Du et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

SARS and MERS: recent insights into emerging coronaviruses

(2016) Emmie de Wit et al.   NATURE REVIEWS MICROBIOLOGY

Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses

(2016) Shuo Su et al.   TRENDS IN MICROBIOLOGY

Structure, Function, and Evolution of Coronavirus Spike Proteins

(2016) Fang Li   Annual Review of Virology

Making the longest sugars: a chemical synthesis of heparin-related [4]n oligosaccharides from 16-mer to 40-mer

(2015) Steen U. Hansen et al.   Chemical Science

Demystifying Heparan Sulfate–Protein Interactions

(2014) Ding Xu et al.   Annual Review of Biochemistry

Synthesis and Biological Evaluation of a Unique Heparin Mimetic Hexasaccharide for Structure–Activity Relationship Studies

(2014) Sucharita Roy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Human Coronavirus NL63 Utilizes Heparan Sulfate Proteoglycans for Attachment to Target Cells

(2014) A. Milewska et al.   JOURNAL OF VIROLOGY

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

(2014) Jean Kaoru Millet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

(2014) Lu Lu et al.   Nature Communications

FGF–FGFR Signaling Mediated through Glycosaminoglycans in Microtiter Plate and Cell-Based Microarray Platforms

(2013) Eric Sterner et al.   BIOCHEMISTRY

Heparan sulfate-protein binding specificity

(2013) M. A. Nugent et al.   BIOCHEMISTRY-MOSCOW

TMPRSS2 Activates the Human Coronavirus 229E for Cathepsin-Independent Host Cell Entry and Is Expressed in Viral Target Cells in the Respiratory Epithelium

(2013) S. Bertram et al.   JOURNAL OF VIROLOGY

The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies

(2013) S. Gierer et al.   JOURNAL OF VIROLOGY

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Structure-Based Virtual Screening for Drug Discovery: a Problem-Centric Review

(2012) Tiejun Cheng et al.   AAPS Journal

Array-Based Functional Screening of Heparin Glycans

(2012) Tania M. Puvirajesinghe et al.   CHEMISTRY & BIOLOGY

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural modelling and dynamics of proteins for insights into drug interactions

(2011) Tim Werner et al.   ADVANCED DRUG DELIVERY REVIEWS

Molecular modeling of the interaction between heparan sulfate and cellular growth factors: Bringing pieces together

(2011) Nicolas Sapay et al.   GLYCOBIOLOGY

Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease

(2011) S. Bertram et al.   JOURNAL OF VIROLOGY

Binding of Avian Coronavirus Spike Proteins to Host Factors Reflects Virus Tropism and Pathogenicity

(2011) I. N. A. Wickramasinghe et al.   JOURNAL OF VIROLOGY

Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans

(2011) Jianshe Lang et al.   PLoS One

MolDock Applied to Structure-Based Virtual Screening

(2010) Walter De Azevedo Jr.   CURRENT DRUG TARGETS

Towards Accurate Free Energy Calculations in Ligand Protein-Binding Studies

(2010) Thomas Steinbrecher et al.   CURRENT MEDICINAL CHEMISTRY

Guidelines for accurate EC50/IC50 estimation

(2010) J. L. Sebaugh   PHARMACEUTICAL STATISTICS

The Signature 3-O-Sulfo Group of the Anticoagulant Heparin Sequence Is Critical for Heparin Binding to Antithrombin but Is Not Required for Allosteric Activation

(2009) Benjamin Richard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Structural Insights into Immune Recognition of the Severe Acute Respiratory Syndrome Coronavirus S Protein Receptor Binding Domain

(2009) John E. Pak et al.   JOURNAL OF MOLECULAR BIOLOGY

The spike protein of SARS-CoV — a target for vaccine and therapeutic development

(2009) Lanying Du et al.   NATURE REVIEWS MICROBIOLOGY

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

(2009) S. Belouzard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Growth Factor Networks by Heparan Sulfate Proteoglycans

(2008) Kimberly Forsten-Williams et al.   ANNALS OF BIOMEDICAL ENGINEERING

Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species

(2008) Jiří Homola   CHEMICAL REVIEWS

CHARMMing: A New, Flexible Web Portal for CHARMM

(2008) Benjamin T. Miller et al.   Journal of Chemical Information and Modeling

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation