Article
Biochemistry & Molecular Biology
Deblina Roy, Mohammad Anas, Ashan Manhas, Satyen Saha, Niti Kumar, Gautam Panda
Summary: In this study, a series of quinoline-imidazole hybrid compounds were synthesized and evaluated for their blood-stage antimalarial activity against Plasmodium falciparum. The results showed that one of the compounds exhibited significant antimalarial efficacy with low cytotoxicity and high selectivity. Furthermore, the study revealed the influence of substituents on the quinoline ring and the role of stereochemistry in the inhibitory activity.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Merve Saylam, Fadime Aydin Kose, Aysun Pabuccuoglu, Duygu Barut Celepci, Muhittin Aygun, Varol Pabuccuoglu
Summary: Myeloperoxidase (MPO) is a key factor in the human antimicrobial system, oxidizing microorganisms through the production of hypochlorous acid. However, MPO can also be released outside cells and cause tissue damage. It has been associated with inflammatory diseases and is considered a potential therapeutic target. In this study, various derivatives were designed and tested for their inhibitory activity on MPO. Among them, C19 was found to be the most active inhibitor on both chlorination and peroxidation cycles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Biao Xu, Zhi-Peng Wang, Qingwang Liu, Xiaohong Yang, Xuemin Li, Ding Huang, Yanfei Qiu, Kin Yip Tam, Shao-Lin Zhang, Yun He
Summary: This study reported a series of novel dichloroacetophenones as potent PDKs inhibitors, with compound 6u showing significant anti-proliferative effects on various cancer cells. In mouse models, 6u demonstrated potent antitumor activity without negative impact on body weight. The compound was also found to induce cancer cell apoptosis, arrest cell cycle progression, inhibit cell migration, and alter glucose metabolic pathways in cancer cells, showing potential as a modulator for reprogramming glycolysis in cancer cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Rongrong Li, Yan Zhang, Yi Le, Li Liu, Guangju Zhao
Summary: Quinazolone is a heterocyclic scaffold with diverse biological activities, including antidiabetic, antithrombotic, antiviral, antibacterial, and antitumor properties. A new series of quinazolone derivatives, characterized by 1H-NMR, 13C-NMR, HRMS, FT-IR, and X-ray, were designed and synthesized. The density functional theory (DFT) calculation of compound 3f at the B3LYP/6-311 level was also studied. The antitumor activity of all synthesized compounds was evaluated using the MTT assay.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Spectroscopy
Marco Mellado, Rafaela Sariego-Kluge, Franco Valdes-Navarro, Cesar Gonzalez, Rodrigo Sanchez-Gonzalez, Nancy Pizarro, Joan Villena, Carlos Jara-Gutierrez, Claudio Cordova, Manuel A. Bravo, Luis F. Aguilar
Summary: In this study, 11 new fluorescent pigments were synthesized and their photophysical properties were analyzed. It was found that the chemical structure of the compounds plays a crucial role in determining their properties. The compounds were also applied as fluorescent pigments in living cell imaging, with compound 12a showing potential as an alternative.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Tobias M. Bruetsch, Etienne Cotter, Daniel Lucena-Agell, Mariano Redondo-Horcajo, Carolina Davies, Bernhard Pfeiffer, Sandro Pagani, Simone Berardozzi, J. Fernando Diaz, John H. Miller, Karl-Heinz Altmann
Summary: In this study, five analogs of (-)-zampanolide (ZMP) were synthesized and their biochemical and cellular properties were evaluated. These analogs were derived from 13-desmethylene-(-)-zampanolide (DM-ZMP), which is as potent as ZMP in inhibiting cancer cell growth. Key steps in the synthesis of all compounds included the formation of a dioxabicyclo[15.3.1]heneicosane core and the establishment of the C(20) stereocenter. All modifications resulted in reduced cellular activity and microtubule-binding affinity compared to DM-ZMP, with varying degrees. The most potent analog, 2,3-dihydro-13-desmethylene zampanolide, showed cellular potency within a ninefold range of DM-ZMP.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Medicinal
Mingfeng Yu, Theodosia Teo, Yuchao Yang, Manjun Li, Yi Long, Stephen Philip, Benjamin Noll, Gary K. Heinemann, Sarah Diab, Preethi Eldi, Laychiluh Mekonnen, Abel T. Anshabo, Muhammed H. Rahaman, Robert Milne, John D. Hayball, Shudong Wang
Summary: CDK8 plays a crucial role in transcriptional regulation and its dysregulation is associated with various types of cancer. Inhibition of CDK8 with compound 38 showed potent anti-proliferative effects on acute myeloid leukaemia cells without systemic toxicity in preclinical studies. Further research on compound 38 as an anticancer agent is warranted.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Yan Zhang, Zhiwu Long, Nian Rao, Yi Le, Li Liu, Longjia Yan
Summary: A series of new phenylisoxazole derivatives were designed and synthesized for the development of antitumor compounds. The final compounds were characterized through various analytical techniques. The structure and properties of one specific compound (5a) were further confirmed using FT-IR and X-ray single crystal diffraction (XRD). The antitumor activity of all compounds was evaluated against A549 cell using MTT assay.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Inorganic & Nuclear
Janusz Szklarzewicz, Anna Jurowska, Maciej Hodorowicz, Grzegorz Kazek, Monika Gluch-Lutwin, Jacek Sapa
Summary: This study describes the syntheses of 16 vanadium(IV and V) complexes with ONO tridentate Schiff base ligands, with vanadium(IV) compounds synthesized using 1,10-phenantroline as a co-ligand. In the case of five complexes of vanadium(V), solvent molecules in the form of ethanol or ethoxy ligands fill the coordination sphere of V(V) to six. The crystal structures of selected complexes show a mixture of isomers in 1:1 ratio in the unit cell due to the asymmetry of the ligand forming both 5- and 6-membered rings in the complex.
INORGANICA CHIMICA ACTA
(2021)
Article
Agriculture, Multidisciplinary
Yu Zhang, Yuming Chen, Xiwei Xun, Shilin Chen, Yuxiu Liu, Qingmin Wang
Summary: A series of 2,4-diphenyl-1,3-oxazolines containing an ether moiety at the para position of the 4-phenyl group were synthesized and tested for acaricidal and insecticidal activity. The results showed that most of the compounds exhibited excellent acaricidal activity against both the larvae and the eggs of Tetranychus cinnabarinus, and some compounds also showed insecticidal activity against other pests. Compound Ic, in particular, showed superior activity compared to the commercial acaricide etoxazole, indicating its potential as a low-cost acaricide agent.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Takayuki Ohyoshi, Yiwen Zhao, Kei Akemoto, Takuma Ishihara, Ayaka Taniguchi, Menghua Zhang, Hideo Kigoshi
Summary: The total synthesis of aplaminal with a unique skeleton was achieved, and the effects of different substituents at the para-position on cytotoxicity were investigated.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2022)
Article
Chemistry, Medicinal
Michiko Jo, Keiichi Koizumi, Mizuho Suzuki, Daisuke Kanayama, Yurie Watanabe, Hiroaki Gouda, Hisashi Mori, Mineyuki Mizuguchi, Takayuki Obita, Yuko Nabeshima, Naoki Toyooka, Takuya Okada
Summary: This study aimed to identify GLS1 inhibitors through in silico screening and synthesis. Two compounds were found to exhibit equal potency as known inhibitors, which can contribute to the development of novel GLS1 inhibitors.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Sooheum Jo, Jin-Hee Kim, Jiyeon Lee, Youngjun Park, Jaebong Jang
Summary: This review provides an overview of the synthetic methods and structure-activity relationship of azumamides A-E, highlighting their potential as HDAC inhibitors and providing insights into the development of naturally occurring cyclic peptides in HDAC inhibition.
Article
Agriculture, Multidisciplinary
Liu Xu, Xiaocao Quan, Zhong Li, Peter Maienfisch
Summary: We conducted a research program to discover novel ethylsulfonylpyridines as insecticides with a broader spectrum, wider range of uses, and/or improved properties by introducing silicon motifs and studying their biological effects. We designed a series of Oxazosulfyl analogues in which the hydrogen atom at the 5-position of the pyridyl moiety is replaced by a trialkylsilyl group and prepared these compounds using denovo synthetic methodology. Our novel ethylsulfonylpyridines exhibited excellent insecticidal activities, with the best compound, A18, reaching the activity level of the commercial standard Oxazosulfyl against Plutella xylostella.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Physical
Yuyu Ding, Yan Zhang, Longjia Yan, Li Liu
Summary: Pyrimidine is an essential component of the organism and has significant antibacterial and anticancer properties. A series of pyrimidinothiophene derivatives were synthesized based on the broadly activity of pyrimidine. The structures of the final compounds were analyzed using various techniques, including 1HNMR, 13CNMR, HRMS, single crystal X-ray diffraction, and FT-IR. The intermolecular interactions and contacts of compound 3e were quantified through Hirshfeld surface and 2D fingerprinting analysis. Density functional theory (DFT) calculation and ADMET evaluation were also performed.
JOURNAL OF MOLECULAR STRUCTURE
(2023)