Making the longest sugars: a chemical synthesis of heparin-related [4]n oligosaccharides from 16-mer to 40-mer

Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology

(2015) Gordon C. Jayson et al.   CHEMICAL COMMUNICATIONS

Interactions That Influence the Binding of Synthetic Heparan Sulfate Based Disaccharides to Fibroblast Growth Factor-2

(2014) Yi-Ching Li et al.   ACS Chemical Biology

Synthesis of the Heparin-Based Anticoagulant Drug Fondaparinux

(2014) Cheng-Hsiu Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Biological Evaluation of a Unique Heparin Mimetic Hexasaccharide for Structure–Activity Relationship Studies

(2014) Sucharita Roy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Homogeneous low-molecular-weight heparins with reversible anticoagulant activity

(2014) Yongmei Xu et al.   Nature Chemical Biology

Principles of modern solid-phase oligosaccharide synthesis

(2014) Clay S. Bennett   ORGANIC & BIOMOLECULAR CHEMISTRY

Automated Polysaccharide Synthesis: Assembly of a 30mer Mannoside

(2013) Oliviana Calin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Simultaneously Enhancing Spectral Resolution and Sensitivity in Heteronuclear Correlation NMR Spectroscopy

(2013) Liladhar Paudel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of a Targeted Library of Heparan Sulfate Hexa- to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer’s Disease

(2013) Ralf Schwörer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthetic heparin and heparan sulfate oligosaccharides and their protein interactions

(2013) Medel Manuel L Zulueta et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Chemoenzymatic synthesis of glycosaminoglycans: Re-creating, re-modeling and re-designing nature's longest or most complex carbohydrate chains

(2013) P. L. DeAngelis et al.   GLYCOBIOLOGY

Pathophysiology of heparan sulphate: many diseases, few drugs

(2013) U. Lindahl et al.   JOURNAL OF INTERNAL MEDICINE

Toward the Solid-Phase Synthesis of Heparan Sulfate Oligosaccharides: Evaluation of Iduronic Acid and Idose Building Blocks

(2013) Nerea Guedes et al.   JOURNAL OF ORGANIC CHEMISTRY

Fluorous Supported Modular Synthesis of Heparan Sulfate Oligosaccharides

(2013) Chengli Zong et al.   ORGANIC LETTERS

A General Strategy for the Chemoenzymatic Synthesis of Asymmetrically Branched N-Glycans

(2013) Z. Wang et al.   SCIENCE

Efficient chemical synthesis of heparin-like octa-, deca- and dodecasaccharides and inhibition of FGF2- and VEGF165-mediated endothelial cell functions

(2013) Gavin J. Miller et al.   Chemical Science

Endothelial Heparan Sulfate 6-O-Sulfation Levels Regulate Angiogenic Responses of Endothelial Cells to Fibroblast Growth Factor 2 and Vascular Endothelial Growth Factor

(2012) Cristina Ferreras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Scalable Conversion of l-Iduronamides to Heparin-Related Di- and Tetrasaccharides

(2012) Steen U. Hansen et al.   JOURNAL OF ORGANIC CHEMISTRY

Divergent Synthesis of 48 Heparan Sulfate-Based Disaccharides and Probing the Specific Sugar–Fibroblast Growth Factor-1 Interaction

(2012) Yu-Peng Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Automated Solid-Phase Synthesis of Hyaluronan Oligosaccharides

(2012) Marthe T. C. Walvoort et al.   ORGANIC LETTERS

HPLC-Assisted Automated Oligosaccharide Synthesis

(2012) N. Vijaya Ganesh et al.   ORGANIC LETTERS

First Gram-Scale Synthesis of a Heparin-Related Dodecasaccharide

(2012) Steen U. Hansen et al.   ORGANIC LETTERS

Divergent Heparin Oligosaccharide Synthesis with Preinstalled Sulfate Esters

(2011) Gopinath Tiruchinapally et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of 3-O-sulfonated heparan sulfate octasaccharides that inhibit the herpes simplex virus type 1 host–cell interaction

(2011) Yu-Peng Hu et al.   Nature Chemistry

Synthesis of heparinoligosaccharides and their interaction with eosinophil-derived neurotoxin

(2011) Shang-Cheng Hung et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Chemoenzymatic Synthesis of Homogeneous Ultralow Molecular Weight Heparins

(2011) Y. Xu et al.   SCIENCE

Preactivation-Based, One-Pot Combinatorial Synthesis of Heparin-like Hexasaccharides for the Analysis of Heparin-Protein Interactions

(2010) Zhen Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Bioactive synthetic heparan sulfate and heparin derivatives: From long fragments mimetics to chimeras

(2010) David Bonnaffé   COMPTES RENDUS CHIMIE

Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer

(2010) Benito Casu et al.   MATRIX BIOLOGY

Modular Synthesis of Heparan Sulfate Oligosaccharides for Structure−Activity Relationship Studies

(2009) Sailaja Arungundram et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A synthetic CD4–heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry

(2009) Françoise Baleux et al.   Nature Chemical Biology

Disaccharide structure code for the easy representation of constituent oligosaccharides from glycosaminoglycans

(2008) Roger Lawrence et al.   NATURE METHODS