Mitochondrial Bioenergetics at the Onset of Drug Resistance in Hematological Malignancies: An Overview

FAM46C controls antibody production by the polyadenylation of immunoglobulin mRNAs and inhibits cell migration in multiple myeloma

(2020) Ana Belén Herrero et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma

(2020) Richa Bajpai et al.   Nature Communications

High-density neutrophils in MGUS and multiple myeloma are dysfunctional and immune-suppressive due to increased STAT3 downstream signaling

(2020) A. Romano et al.   Scientific Reports

Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic β-Cells

(2020) Yunxia Zhu et al.   Frontiers in Endocrinology

Mitochondrial Respiration Correlates with Prognostic Markers in Chronic Lymphocytic Leukemia and Is Normalized by Ibrutinib Treatment

(2020) Subir Roy Chowdhury et al.   Cancers

The Tumor Microenvironment of DLBCL in the Computational Era

(2020) Giuseppina Opinto et al.   Frontiers in Oncology

Mitochondrial Functions, Energy Metabolism and Protein Glycosylation are Interconnected Processes Mediating Resistance to Bortezomib in Multiple Myeloma Cells

(2020) Daniele Tibullo et al.   Biomolecules

Mitochondria: A Galaxy in the Hematopoietic and Leukemic Stem Cell Universe

(2020) Cristina Panuzzo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

(2020) Eman Khatib-Massalha et al.   Nature Communications

Inhibition of TLR4 Signaling Affects Mitochondrial Fitness and Overcomes Bortezomib Resistance in Myeloma Plasma Cells

(2020) Cesarina Giallongo et al.   Cancers

Amino acid starvation inhibits autophagy in lipid droplet-deficient cells through mitochondrial dysfunction

(2020) Pierre Voisin et al.   BIOCHEMICAL JOURNAL

SR18292 exerts potent antitumor effects in multiple myeloma via inhibition of oxidative phosphorylation

(2020) Yu Xiang et al.   LIFE SCIENCES

Iron regulates myeloma cell/macrophage interaction and drives resistance to bortezomib

(2020) Giuseppina Camiolo et al.   Redox Biology

CD38-driven mitochondrial trafficking promotes bioenergetic plasticity in multiple myeloma

(2019) Christopher R. Marlein et al.   CANCER RESEARCH

PET-adapted treatment for newly diagnosed advanced Hodgkin lymphoma (AHL2011): a randomised, multicentre, non-inferiority, phase 3 study

(2019) René-Olivier Casasnovas et al.   LANCET ONCOLOGY

Emerging Therapies for Acute Myelogenus Leukemia Patients Targeting Apoptosis and Mitochondrial Metabolism

(2019) Germana Castelli et al.   Cancers

The Impact of Tumor Heterogeneity on Diagnostics and Novel Therapeutic Strategies in Multiple Myeloma

(2019) Leo Rasche et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GAPDH Expression Predicts the Response to R-CHOP, the Tumor Metabolic Status, and the Response of DLBCL Patients to Metabolic Inhibitors

(2019) Johanna Chiche et al.   Cell Metabolism

Immune off-target effects of Brentuximab Vedotin in relapsed/refractory Hodgkin Lymphoma

(2019) Alessandra Romano et al.   BRITISH JOURNAL OF HAEMATOLOGY

Stromal Support of Metabolic Function through Mitochondrial Transfer in Multiple Myeloma

(2019) Lawrence H. Boise et al.   CANCER RESEARCH

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

(2019) Liang Zhang et al.   Science Translational Medicine

Role of Mitochondria in the Mechanism(s) of Action of Metformin

(2019) Guillaume Vial et al.   Frontiers in Endocrinology

SIRT3 deacetylase activity confers chemoresistance in AML via regulation of mitochondrial oxidative phosphorylation

(2019) Jiao Ma et al.   BRITISH JOURNAL OF HAEMATOLOGY

From old to new — Repurposing drugs to target mitochondrial energy metabolism in cancer

(2019) Sepideh Aminzadeh-Gohari et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

(2019) Romain Guièze et al.   CANCER CELL

Glycolytic enzyme hexokinase II is a putative therapeutic target in B cell malignant lymphoma

(2019) Kei Nakajima et al.   EXPERIMENTAL HEMATOLOGY

Oxidative phosphorylation inhibition induces anticancerous changes in therapy‐resistant–acute myeloid leukemia patient cells

(2019) Aida Vitkevičienė et al.   MOLECULAR CARCINOGENESIS

TLR4 signaling drives mesenchymal stromal cells commitment to promote tumor microenvironment transformation in multiple myeloma

(2019) Cesarina Giallongo et al.   Cell Death & Disease

Mitochondrial Dynamics and Its Involvement in Disease

(2019) David C. Chan   Annual Review of Pathology-Mechanisms of Disease

Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress

(2019) Richard Burt et al.   BLOOD

Tunneling nanotube-mediated intercellular vesicle and protein transfer in the stroma-provided imatinib resistance in chronic myeloid leukemia cells

(2019) Marta D. Kolba et al.   Cell Death & Disease

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

(2019) Vaishali Aggarwal et al.   Biomolecules

Reprogramming of fatty acid metabolism in cancer

(2019) Nikos Koundouros et al.   BRITISH JOURNAL OF CANCER

Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function

(2019) Cameron S. Field et al.   Cell Metabolism

Prognostic meaning of neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ration (LMR) in newly diagnosed Hodgkin lymphoma patients treated upfront with a PET-2 based strategy

(2018) Alessandra Romano et al.   ANNALS OF HEMATOLOGY

Biological Role and Therapeutic Potential of IDH Mutations in Cancer

(2018) Matthew S. Waitkus et al.   CANCER CELL

Intercellular mitochondria trafficking highlighting the dual role of mesenchymal stem cells as both sensors and rescuers of tissue injury

(2018) Anne-Marie Rodriguez et al.   CELL CYCLE

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion

(2018) Ilan Y. Benador et al.   Cell Metabolism

A Phase I Study of CPI-613 in Combination with High-Dose Cytarabine and Mitoxantrone for Relapsed or Refractory Acute Myeloid Leukemia

(2018) Timothy S. Pardee et al.   CLINICAL CANCER RESEARCH

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy

(2018) Thomas M. Ashton et al.   CLINICAL CANCER RESEARCH

PMN-MDSC and arginase are increased in myeloma and may contribute to resistance to therapy

(2018) Alessandra Romano et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Early Chemotherapy Intensification With Escalated BEACOPP in Patients With Advanced-Stage Hodgkin Lymphoma With a Positive Interim Positron Emission Tomography/Computed Tomography Scan After Two ABVD Cycles: Long-Term Results of the GITIL/FIL HD 0607 Trial

(2018) Andrea Gallamini et al.   JOURNAL OF CLINICAL ONCOLOGY

Cell adhesion-mediated mitochondria transfer contributes to mesenchymal stem cell-induced chemoresistance on T cell acute lymphoblastic leukemia cells

(2018) Jiancheng Wang et al.   Journal of Hematology & Oncology

Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma

(2018) Shamzah Araf et al.   LEUKEMIA

Heme Oxygenase Inhibition Sensitizes Neuroblastoma Cells to Carfilzomib

(2018) Ignazio Barbagallo et al.   MOLECULAR NEUROBIOLOGY

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

Targeting Mitochondrial Bioenergetics as a Therapeutic Strategy for Chronic Lymphocytic Leukemia

(2018) Subir Roy Chowdhury et al.   Oxidative Medicine and Cellular Longevity

Tying trafficking to fusion and fission at the mighty mitochondria

(2018) Trey Farmer et al.   TRAFFIC

Metabolic changes associated with metformin potentiates Bcl-2 inhibitor, Venetoclax, and CDK9 inhibitor, BAY1143572 and reduces viability of lymphoma cells

(2018) Vineela Chukkapalli et al.   Oncotarget

Author Correction: Role of hypoxia in Diffuse Large B-cell Lymphoma: Metabolic repression and selective translation of HK2 facilitates development of DLBCL

(2018) Kavita Bhalla et al.   Scientific Reports

B cell lymphoma with different metabolic characteristics show distinct sensitivities to metabolic inhibitors

(2018) Xiaoxia Liu et al.   Journal of Cancer

Inhibition of autophagy enhances the antitumour activity of tigecycline in multiple myeloma

(2018) Ruye Ma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting energy metabolism to eliminate cancer cells

(2018) Shazwin Hani Shahruzaman et al.   Cancer Management and Research

Oxidative Phosphorylation: A Target for Novel Therapeutic Strategies Against Ovarian Cancer

(2018) Amruta Nayak et al.   Cancers

Mitochondrial network structure homeostasis and cell death

(2018) Long-long Xie et al.   CANCER SCIENCE

Metformin and blood cancers

(2018) AD Cunha Júnior et al.   Clinics

Metabolic rewiring beyond Warburg in chronic lymphocytic leukemia: How much do we actually know?

(2018) Gabriela Galicia-Vázquez et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cells by a novel NF-κB inhibitor

(2017) Tiziana Vaisitti et al.   HAEMATOLOGICA

Regulation of glucose uptake in lymphoma cell lines by c-MYC- and PI3K-dependent signaling pathways and impact of glycolytic pathways on cell viability

(2017) Martina Broecker-Preuss et al.   Journal of Translational Medicine

The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition

(2017) Gabriele Varano et al.   NATURE

The mitochondrial dynamics in cancer and immune-surveillance

(2017) Luca Simula et al.   SEMINARS IN CANCER BIOLOGY

Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment

(2017) Lekha Mikkilineni et al.   SEMINARS IN ONCOLOGY

Mitochondrial and glycolytic metabolic compartmentalization in diffuse large B-cell lymphoma

(2017) Mahasweta Gooptu et al.   SEMINARS IN ONCOLOGY

Mitochondrial dynamics and cancer

(2017) Paola Maycotte et al.   TUMOR BIOLOGY

Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing

(2017) L. Rasche et al.   Nature Communications

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

(2017) Thomas Farge et al.   Cancer Discovery

Alteration of mitochondrial biogenesis promotes disease progression in multiple myeloma

(2017) Xin Zhan et al.   Oncotarget

Up-regulation of hexokinase II contributes to rituximab-chemotherapy resistance and is a clinically relevant target for therapeutic development

(2017) Juan J. Gu et al.   Oncotarget

Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells

(2017) Ravyn M. Thompson et al.   Oncotarget

The reverse Warburg effect is likely to be an Achilles’ heel of cancer that can be exploited for cancer therapy

(2017) Yaojie Fu et al.   Oncotarget

Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cells by a novel NF-κB inhibitor

(2017) Tiziana Vaisitti et al.   HAEMATOLOGICA

Functional Mitochondria in Health and Disease

(2017) Patries M. Herst et al.   Frontiers in Endocrinology

The Mitochondrial Complex(I)ty of Cancer

(2017) Félix A. Urra et al.   Frontiers in Oncology

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

(2017) Fernando Bartolome et al.   Scientific Reports

Genomic Analysis of the Emergence, Evolution, and Spread of Human Respiratory RNA Viruses

(2016) Tommy T.-Y. Lam et al.   Annual Review of Genomics and Human Genetics

Intersection of mitochondrial fission and fusion machinery with apoptotic pathways: Role of Mcl-1

(2016) Giampaolo Morciano et al.   BIOLOGY OF THE CELL

Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target

(2016) M. Bolzoni et al.   BLOOD

Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy

(2016) R. Moschoi et al.   BLOOD

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Differential contribution of the mitochondrial translation pathway to the survival of diffuse large B-cell lymphoma subsets

(2016) Erik Norberg et al.   CELL DEATH AND DIFFERENTIATION

Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation

(2016) Katrin Birkenmeier et al.   INTERNATIONAL JOURNAL OF CANCER

Circulating tumour DNA analysis demonstrates spatial mutational heterogeneity that coincides with disease relapse in myeloma

(2016) S Mithraprabhu et al.   LEUKEMIA

Proteasome inhibitor-adapted myeloma cells are largely independent from proteasome activity and show complex proteomic changes, in particular in redox and energy metabolism

(2016) G P Soriano et al.   LEUKEMIA

FOXO1 is a TXN- and p300-dependent sensor and effector of oxidative stress in diffuse large B-cell lymphomas characterized by increased oxidative metabolism

(2016) T Sewastianik et al.   ONCOGENE

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Basal autophagy is pivotal for Hodgkin and Reed-Sternberg cells’ survival and growth revealing a new strategy for Hodgkin lymphoma treatment

(2016) Katrin Birkenmeier et al.   Oncotarget

The prognostic value of the myeloid-mediated immunosuppression marker Arginase-1 in classic Hodgkin lymphoma

(2016) Alessandra Romano et al.   Oncotarget

Heme oxygenase-1 nuclear translocation regulates bortezomib-induced cytotoxicity and mediates genomic instability in myeloma cells

(2016) Daniele Tibullo et al.   Oncotarget

The combined role of biomarkers and interim PET scan in prediction of treatment outcome in classical Hodgkin's lymphoma: a retrospective, European, multicentre cohort study

(2016) Claudio Agostinelli et al.   Lancet Haematology

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

(2015) S. Sriskanthadevan et al.   BLOOD

Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo

(2015) F. Miraki-Moud et al.   BLOOD

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

Human mitochondrial COX1 assembly into cytochrome c oxidase at a glance

(2015) S. Dennerlein et al.   JOURNAL OF CELL SCIENCE

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

(2015) Shiran Rabinovich et al.   NATURE

Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins

(2015) Alfredo Giménez-Cassina et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Oxidative phosphorylation-dependent regulation of cancer cell apoptosis in response to anticancer agents

(2015) N Yadav et al.   Cell Death & Disease

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

(2015) Maria Maryanovich et al.   Nature Communications

Clinical Impact of the Immunome in Lymphoid Malignancies: The Role of Myeloid-Derived Suppressor Cells

(2015) Calogero Vetro et al.   Frontiers in Oncology

Chen W-L, Wang J-H, Zhao A-H, et al. A distinct glucose metabolism signature of acute myeloid leukemia with prognostic value. Blood. 2014;124(10):1645-1654.

(2014)   BLOOD

The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma

(2014) S. V. Glavey et al.   BLOOD

Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic lymphocytic leukemia

(2014) R. Jitschin et al.   BLOOD

Circulating myeloid-derived suppressor cells correlate with clinical outcome in Hodgkin Lymphoma patients treated up-front with a risk-adapted strategy

(2014) Alessandra Romano et al.   BRITISH JOURNAL OF HAEMATOLOGY

A Phase I Study of the First-in-Class Antimitochondrial Metabolism Agent, CPI-613, in Patients with Advanced Hematologic Malignancies

(2014) T. S. Pardee et al.   CLINICAL CANCER RESEARCH

Oxidative stress markers and mitochondrial antioxidant enzyme expression are increased in aggressive Hodgkin lymphomas

(2014) Hamid Bur et al.   HISTOPATHOLOGY

The mechanism of coupling between electron transfer and proton translocation in respiratory complex I

(2014) Leonid A. Sazanov   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Tumor Microenvironment and Metabolic Synergy in Breast Cancers: Critical Importance of Mitochondrial Fuels and Function

(2014) Ubaldo Martinez-Outschoorn et al.   SEMINARS IN ONCOLOGY

IMMUNOLOGICAL DEREGULATION IN HODGKIN’S DISEASE

(2014) Francesco Di Raimondo et al.   Mediterranean Journal of Hematology and Infectious Diseases

SYK Inhibition Modulates Distinct PI3K/AKT- Dependent Survival Pathways and Cholesterol Biosynthesis in Diffuse Large B Cell Lymphomas

(2013) Linfeng Chen et al.   CANCER CELL

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

Standard therapies versus novel therapies in Hodgkin lymphoma

(2013) A. Gallamini et al.   IMMUNOLOGY LETTERS

Mitochondrial modulation decreases the bortezomib-resistance in multiple myeloma cells

(2013) I.S. Song et al.   INTERNATIONAL JOURNAL OF CANCER

Plasma cells require autophagy for sustainable immunoglobulin production

(2013) Niccolò Pengo et al.   NATURE IMMUNOLOGY

Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan

(2012) Sören Mai et al.   Autophagy

Superoxide generation by complex III: From mechanistic rationales to functional consequences

(2012) Lea Bleier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial complex II, a novel target for anti-cancer agents

(2012) Katarina Kluckova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma

(2012) E. Tiacci et al.   BLOOD

Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma

(2012) Pilar Caro et al.   CANCER CELL

Mitochondrial metabolism in cancer metastasis

(2012) Federica Sotgia et al.   CELL CYCLE

Using the “reverse Warburg effect” to identify high-risk breast cancer patients

(2012) Agnieszka K. Witkiewicz et al.   CELL CYCLE

Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer

(2012) Jalees Rehman et al.   FASEB JOURNAL

Chronic myeloid leukemia stem cells display alterations in expression of genes involved in oxidative phosphorylation

(2012) Krzysztof Flis et al.   LEUKEMIA & LYMPHOMA

Deceleration of Fusion–Fission Cycles Improves Mitochondrial Quality Control during Aging

(2012) Marc Thilo Figge et al.   PLoS Computational Biology

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

(2011) Rasheduzzaman Chowdhury et al.   EMBO REPORTS

Stromal–epithelial metabolic coupling in cancer: Integrating autophagy and metabolism in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial ATP synthase: architecture, function and pathology

(2011) An I. Jonckheere et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation

(2010) A. S. Green et al.   BLOOD

The reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Cell death: Insights into the ultrastructure of mitochondria

(2010) C. Ulivieri   TISSUE & CELL

The Role of Mitochondria in Apoptosis

(2009) Chunxin Wang et al.   Annual Review of Genetics

Classification of lymphoid neoplasms: the microscope as a tool for disease discovery

(2008) E. S. Jaffe et al.   BLOOD

Acquirement of Rituximab Resistance in Lymphoma Cell Lines Is Associated with Both Global CD20 Gene and Protein Down-Regulation Regulated at the Pretranscriptional and Posttranscriptional Levels

(2008) M. S. Czuczman et al.   CLINICAL CANCER RESEARCH

Mitochondria in cancer: Not just innocent bystanders

(2008) Christian Frezza et al.   SEMINARS IN CANCER BIOLOGY