Inhibition of TLR4 Signaling Affects Mitochondrial Fitness and Overcomes Bortezomib Resistance in Myeloma Plasma Cells

Mitochondrial Functions, Energy Metabolism and Protein Glycosylation are Interconnected Processes Mediating Resistance to Bortezomib in Multiple Myeloma Cells

(2020) Daniele Tibullo et al.   Biomolecules

The Expanding and Unexpected Functions of Mitochondria Contact Sites

(2019) Laura L. Lackner   TRENDS IN CELL BIOLOGY

Neuromuscular Plasticity in a Mouse Neurotoxic Model of Spinal Motoneuronal Loss

(2019) Rosario Gulino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain

(2019) Nunzio Vicario et al.   MOLECULAR NEUROBIOLOGY

Compensatory changes in degenerating spinal motoneurons sustain functional sparing in the SOD1‐G93A mouse model of amyotrophic lateral sclerosis

(2019) Elena Giusto et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Mitochondrial dynamics and transport in Alzheimer's disease

(2019) Padraig J. Flannery et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Toll-like Receptor-4 Activation Boosts the Immunosuppressive Properties of Tumor Cells-derived Exosomes

(2019) Rossana Domenis et al.   Scientific Reports

Mitophagy in Parkinson’s Disease: From Pathogenesis to Treatment

(2019) Jia Liu et al.   Cells

Correction: TLR4 signaling drives mesenchymal stromal cells commitment to promote tumor microenvironment transformation in multiple myeloma

(2019) Cesarina Giallongo et al.   Cell Death & Disease

Toll-Like Receptor 4 (TLR4)/Cyclooxygenase-2 (COX-2) Regulates Prostate Cancer Cell Proliferation, Migration, and Invasion by NF-κB Activation

(2018) Wei Wang et al.   MEDICAL SCIENCE MONITOR

Exposure of Monocytic Cells to Lipopolysaccharide Induces Coordinated Endotoxin Tolerance, Mitochondrial Biogenesis, Mitophagy, and Antioxidant Defenses

(2018) John D. Widdrington et al.   Frontiers in Immunology

LPS promote Osteosarcoma invasion and migration through TLR4/HOTAIR

(2018) Ning Wang et al.   GENE

Pharmacological Inhibition of Toll-Like Receptor-4 Signaling by TAK242 Prevents and Induces Regression of Experimental Organ Fibrosis

(2018) Swati Bhattacharyya et al.   Frontiers in Immunology

Prosaposin promotes the proliferation and tumorigenesis of glioma through toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway

(2018) Yang Jiang et al.   EBioMedicine

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

(2017) Thomas Farge et al.   Cancer Discovery

Alteration of mitochondrial biogenesis promotes disease progression in multiple myeloma

(2017) Xin Zhan et al.   Oncotarget

Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells

(2017) Ravyn M. Thompson et al.   Oncotarget

Proteasome inhibitor-adapted myeloma cells are largely independent from proteasome activity and show complex proteomic changes, in particular in redox and energy metabolism

(2016) G P Soriano et al.   LEUKEMIA

The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation

(2016) Monica Molteni et al.   MEDIATORS OF INFLAMMATION

Heme oxygenase-1 nuclear translocation regulates bortezomib-induced cytotoxicity and mediates genomic instability in myeloma cells

(2016) Daniele Tibullo et al.   Oncotarget

The Role of TLR4 in Chemotherapy-Driven Metastasis

(2015) S. Ran   CANCER RESEARCH

Andrographolide inhibits multiple myeloma cells by inhibiting the TLR4/NF-κB signaling pathway

(2015) HUI GAO et al.   Molecular Medicine Reports

Is Reliance on Mitochondrial Respiration a “Chink in the Armor” of Therapy-Resistant Cancer?

(2014) Dieter A. Wolf   CANCER CELL

Toll-Like Receptor 4 Prompts Human Breast Cancer Cells Invasiveness via Lipopolysaccharide Stimulation and Is Overexpressed in Patients with Lymph Node Metastasis

(2014) Huan Yang et al.   PLoS One

Glycosylation of the Nuclear Pore

(2014) Bin Li et al.   TRAFFIC

Characterization of the Toll-like Receptor Expression Profile in Human Multiple Myeloma Cells

(2013) Jahangir Abdi et al.   PLoS One

TLR4 Signaling Promotes Immune Escape of Human Colon Cancer Cells by Inducing Immunosuppressive Cytokines and Apoptosis Resistance

(2012) Xiaoyan Tang et al.   ONCOLOGY RESEARCH

Triggering of toll-like receptor-4 in human multiple myeloma cells promotes proliferation and alters cell responses to immune and chemotherapy drug attack

(2011) Hanying Bao et al.   CANCER BIOLOGY & THERAPY

Toll-Like Receptor 4 Activation in Cancer Progression and Therapy

(2011) Alja Oblak et al.   Clinical & Developmental Immunology

Effects of second-generation tyrosine kinase inhibitors towards osteogenic differentiation of human mesenchymal cells of healthy donors

(2011) Daniele Tibullo et al.   HEMATOLOGICAL ONCOLOGY

Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk

(2011) Anton G. Kutikhin   HUMAN IMMUNOLOGY

The Interplay Between Mitochondrial Dynamics and Mitophagy

(2010) Gilad Twig et al.   ANTIOXIDANTS & REDOX SIGNALING

Expression and function of toll-like receptors in multiple myeloma patients: toll-like receptor ligands promote multiple myeloma cell growth and survival via activation of nuclear factor-κB

(2010) Yang Xu et al.   BRITISH JOURNAL OF HAEMATOLOGY

Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders

(2010) Martina Canestraro et al.   CANCER GENETICS AND CYTOGENETICS

Broad copy neutral-loss of heterozygosity regions and rare recurring copy number abnormalities in normal karyotype-acute myeloid leukemia genomes

(2010) Vincenza Barresi et al.   GENES CHROMOSOMES & CANCER

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

(2010) Kei Okatsu et al.   GENES TO CELLS

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cells

(2008) H. Gu et al.   MOLECULAR CANCER THERAPEUTICS