Mitochondrial dynamics and cancer

Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways

(2016) Qichao Huang et al.   Autophagy

Intersection of mitochondrial fission and fusion machinery with apoptotic pathways: Role of Mcl-1

(2016) Giampaolo Morciano et al.   BIOLOGY OF THE CELL

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Regulators of mitochondrial dynamics in cancer

(2016) Daniela Senft et al.   CURRENT OPINION IN CELL BIOLOGY

Restraining the Divider: A Drp1-Phospholipid Interaction Inhibits Drp1 Activity and Shifts the Balance from Mitochondrial Fission to Fusion

(2016) David F. Kashatus   MOLECULAR CELL

Coincident Phosphatidic Acid Interaction Restrains Drp1 in Mitochondrial Division

(2016) Yoshihiro Adachi et al.   MOLECULAR CELL

Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities

(2016) Emma M. Kerr et al.   NATURE

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer

(2015) Björn von Eyss et al.   CANCER CELL

Cell death decision by p53 via control of the mitochondrial membrane

(2015) Nurmaa Dashzeveg et al.   CANCER LETTERS

mTOR coordinates protein synthesis, mitochondrial activity and proliferation

(2015) Masahiro Morita et al.   CELL CYCLE

The Warburg effect: Evolving interpretations of an established concept

(2015) Xiaozhuo Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of the Mitochondrial Fragmentation Protein DRP1 Correlates with BRAF V600E Melanoma

(2015) Shira Y. Wieder et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mitochondrial Shape Governs BAX-Induced Membrane Permeabilization and Apoptosis

(2015) Thibaud T. Renault et al.   MOLECULAR CELL

Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors

(2015) Madhavika N. Serasinghe et al.   MOLECULAR CELL

Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth

(2015) Jennifer A. Kashatus et al.   MOLECULAR CELL

Mitochondrial control by DRP1 in brain tumor initiating cells

(2015) Qi Xie et al.   NATURE NEUROSCIENCE

The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression

(2015) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dynamin-related protein Drp1 is required for Bax translocation to mitochondria in response to irradiation-induced apoptosis

(2015) Ping Wang et al.   Oncotarget

Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition

(2015) Rebecca Lamb et al.   Oncotarget

Regulation of Hepatic Energy Metabolism and Gluconeogenesis by BAD

(2014) Alfredo Giménez-Cassina et al.   Cell Metabolism

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

Metastatic Stem Cells: Sources, Niches, and Vital Pathways

(2014) Thordur Oskarsson et al.   Cell Stem Cell

p53 Is Required for Cisplatin-induced Processing of the Mitochondrial Fusion Protein L-Opa1 That Is Mediated by the Mitochondrial Metallopeptidase Oma1 in Gynecologic Cancers

(2014) Bao Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidic Acid (PA)-preferring Phospholipase A1Regulates Mitochondrial Dynamics

(2014) Takashi Baba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251 cells

(2014) YU-YING WAN et al.   ONCOLOGY REPORTS

Metabolic regulation of the cell cycle

(2013) In Hye Lee et al.   CURRENT OPINION IN CELL BIOLOGY

Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NF B-Opa-1 Signaling Pathway

(2013) V. Parra et al.   DIABETES

The role of dynamin-related protein 1 in cancer growth: a promising therapeutic target?

(2013) Wei Qian et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The over-expression of ERbeta modifies estradiol effects on mitochondrial dynamics in breast cancer cell line

(2013) Jorge Sastre-Serra et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Tangled Circuitry of Metabolism and Apoptosis

(2013) Joshua L. Andersen et al.   MOLECULAR CELL

Mitochondrial Biogenesis through Activation of Nuclear Signaling Proteins

(2013) J. E. Dominy et al.   Cold Spring Harbor Perspectives in Biology

Mechanisms of Mitochondrial Fission and Fusion

(2013) A. M. van der Bliek et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial Dysfunction in Cancer

(2013) Michelle L. Boland et al.   Frontiers in Oncology

Depletion of mitochondrial fission factor DRP1 causes increased apoptosis in human colon cancer cells

(2012) Akane Inoue-Yamauchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proteolytic control of mitochondrial function and morphogenesis

(2012) Ruchika Anand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

(2012) Luis E. Raez et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer

(2012) Jalees Rehman et al.   FASEB JOURNAL

Mitochondrial dynamics is affected by 17β-estradiol in the MCF-7 breast cancer cell line. Effects on fusion and fission related genes

(2012) Jorge Sastre-Serra et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondria and cell signalling

(2012) Stephen W. G. Tait et al.   JOURNAL OF CELL SCIENCE

Stress-Induced Phosphorylation and Proteasomal Degradation of Mitofusin 2 Facilitates Mitochondrial Fragmentation and Apoptosis

(2012) Guillaume P. Leboucher et al.   MOLECULAR CELL

BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery

(2012) J Hagenbuchner et al.   ONCOGENE

Mitochondrial dynamics regulates migration and invasion of breast cancer cells

(2012) J Zhao et al.   ONCOGENE

Mitochondrial Structure, Function and Dynamics Are Temporally Controlled by c-Myc

(2012) J. Anthony Graves et al.   PLoS One

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The regulation of mitochondrial morphology: Intricate mechanisms and dynamic machinery

(2011) Catherine S. Palmer et al.   CELLULAR SIGNALLING

Novel Role of Androgens in Mitochondrial Fission and Apoptosis

(2011) V. Choudhary et al.   MOLECULAR CANCER RESEARCH

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1

(2010) Chuang-Rung Chang et al.   Annals of the New York Academy of Sciences

Electron microscopy morphology of the mitochondrial network in gliomas and their vascular microenvironment

(2010) Gabriel Arismendi-Morillo   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

p53 at a glance

(2010) C. A. Brady et al.   JOURNAL OF CELL SCIENCE

The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy

(2010) Stephen J. Ralph et al.   MOLECULAR ASPECTS OF MEDICINE

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

SLP-2 is required for stress-induced mitochondrial hyperfusion

(2009) Daniel Tondera et al.   EMBO JOURNAL

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Nuclear expression of dynamin-related protein 1 in lung adenocarcinomas

(2009) Yung-Yen Chiang et al.   MODERN PATHOLOGY

Preventing Mitochondrial Fission Impairs Mitochondrial Function and Leads to Loss of Mitochondrial DNA

(2008) Philippe A. Parone et al.   PLoS One

Mitochondrial Fusion Is Increased by the Nuclear Coactivator PGC-1β

(2008) Marc Liesa et al.   PLoS One

Mitochondria in cancer cells: what is so special about them?

(2008) Vladimir Gogvadze et al.   TRENDS IN CELL BIOLOGY