Transcription factor 4 and its association with psychiatric disorders

A myelin-related transcriptomic profile is shared by Pitt–Hopkins syndrome models and human autism spectrum disorder

(2020) BaDoi N. Phan et al.   NATURE NEUROSCIENCE

Tcf4 encodes correct brain development during embryogenesis

(2020) Simone Mesman et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation

(2020) Miriam Wedel et al.   NUCLEIC ACIDS RESEARCH

Region and Cell Type Distribution of TCF4 in the Postnatal Mouse Brain

(2020) Hyojin Kim et al.   Frontiers in Neuroanatomy

Helix–loop–helix proteins and the advent of cellular diversity: 30 years of discovery

(2019) Cornelis Murre   GENES & DEVELOPMENT

Disruption of TCF4 regulatory networks leads to abnormal cortical development and mental disabilities

(2019) Hong Li et al.   MOLECULAR PSYCHIATRY

Diagnosis and management in Pitt-Hopkins syndrome: First international consensus statement

(2019) Marcella Zollino et al.   CLINICAL GENETICS

Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine

(2019) Jie Yang et al.   NUCLEIC ACIDS RESEARCH

Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans

(2019) Joel Gelernter et al.   NATURE NEUROSCIENCE

Homotypic cooperativity and collective binding are determinants of bHLH specificity and function

(2019) Christian A. Shively et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mediator complex interaction partners organize the transcriptional network that defines neural stem cells

(2019) Marti Quevedo et al.   Nature Communications

The subcellular localization of bHLH transcription factor TCF4 is mediated by multiple nuclear localization and nuclear export signals

(2019) Beata Greb-Markiewicz et al.   Scientific Reports

Transcription Factor 4 Safeguards Hippocampal Dentate Gyrus Development by Regulating Neural Progenitor Migration

(2019) Yafei Wang et al.   CEREBRAL CORTEX

Pitt-Hopkins Syndrome: A Review of Current Literature, Clinical Approach, and 23-Patient Case Series

(2018) Kimberly Goodspeed et al.   JOURNAL OF CHILD NEUROLOGY

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons

(2018) Matthias Jung et al.   Molecular Autism

Pitt-Hopkins Syndrome: A Unique Case Study

(2018) Alexander Tan et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis

(2018) Na Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

(2018) Mingfeng Li et al.   SCIENCE

Impairment of different protein domains causes variable clinical presentation within Pitt-Hopkins syndrome and suggests intragenic molecular syndromology of TCF4

(2017) Maria Francesca Bedeschi et al.   European Journal of Medical Genetics

The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A

(2017) Mari Sepp et al.   JOURNAL OF NEUROSCIENCE

Common pathophysiology in multiple mouse models of Pitt-Hopkins syndrome

(2017) Courtney Thaxton et al.   JOURNAL OF NEUROSCIENCE

Knockdown of the schizophrenia susceptibility gene TCF4 alters gene expression and proliferation of progenitor cells from the developing human neocortex

(2017) Matthew J. Hill et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

The schizophrenia- and autism-associated gene, transcription factor 4 regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity-dependent manner

(2017) S C Page et al.   MOLECULAR PSYCHIATRY

The Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual Disability

(2017) Marc P Forrest et al.   SCHIZOPHRENIA BULLETIN

An interaction network of mental disorder proteins in neural stem cells

(2017) M J Moen et al.   Translational Psychiatry

Partial deletion of TCF4 in three generation family with non-syndromic intellectual disability, without features of Pitt-Hopkins syndrome

(2016) Mira Kharbanda et al.   European Journal of Medical Genetics

5-Hydroxymethylcytosine in E-box motifs ACAT|GTG and ACAC|GTG increases DNA-binding of the B-HLH transcription factor TCF4

(2016) Syed Khund-Sayeed et al.   Integrative Biology

Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1

(2016) Matthew D. Rannals et al.   NEURON

Complex translocation disrupting TCF4 and altering TCF4 isoform expression segregates as mild autosomal dominant intellectual disability

(2016) Valerie Maduro et al.   Orphanet Journal of Rare Diseases

Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons

(2016) Mitchell D’Rozario et al.   Cell Reports

Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function

(2016) Andrew J. Kennedy et al.   Cell Reports

Investigation of the role ofTCF4rare sequence variants in schizophrenia

(2015) F. Buket Basmanav et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

E Proteins and ID Proteins: Helix-Loop-Helix Partners in Development and Disease

(2015) Lan-Hsin Wang et al.   DEVELOPMENTAL CELL

RNA Toxicity and Missplicing in the Common Eye Disease Fuchs Endothelial Corneal Dystrophy

(2015) Jintang Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Convergence of Neurodevelopmental Disorders

(2014) Elizabeth S. Chen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Transcription factor 4 (TCF4) and schizophrenia: integrating the animal and the human perspective

(2014) Boris B. Quednow et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Zac1 Regulates Cell Cycle Arrest in Neuronal Progenitors via Tcf4

(2014) U. Schmidt-Edelkraut et al.   MOLECULAR AND CELLULAR BIOLOGY

E-proteins orchestrate the progression of neural stem cell differentiation in the postnatal forebrain

(2014) Bruno Fischer et al.   Neural Development

bHLH Factors in Self-Renewal, Multipotency, and Fate Choice of Neural Progenitor Cells

(2014) Itaru Imayoshi et al.   NEURON

Functional redundancy between the transcriptional activation domains of E2A is mediated by binding to the KIX domain of CBP/p300

(2014) C. M. Denis et al.   NUCLEIC ACIDS RESEARCH

A TAF4 coactivator function for E proteins that involves enhanced TFIID binding

(2013) W.-Y. Chen et al.   GENES & DEVELOPMENT

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

A survey of rare coding variants in candidate genes in schizophrenia by deep sequencing

(2013) X Hu et al.   MOLECULAR PSYCHIATRY

The Ventral Hippocampus Is the Embryonic Origin for Adult Neural Stem Cells in the Dentate Gyrus

(2013) Guangnan Li et al.   NEURON

Knockdown of Human TCF4 Affects Multiple Signaling Pathways Involved in Cell Survival, Epithelial to Mesenchymal Transition and Neuronal Differentiation

(2013) Marc P. Forrest et al.   PLoS One

TCF4 gene polymorphism and cognitive performance in patients with first episode psychosis

(2013) Ammar Albanna et al.   SCHIZOPHRENIA RESEARCH

Deficits in trace fear memory in a mouse model of the schizophrenia risk gene TCF4

(2012) Magdalena M. Brzózka et al.   BEHAVIOURAL BRAIN RESEARCH

Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1

(2012) C. M. Denis et al.   BLOOD

Somatic mosaicism in a mother of two children with Pitt-Hopkins syndrome

(2012) CVM Steinbusch et al.   CLINICAL GENETICS

Development, cognition, and behaviour in Pitt-Hopkins syndrome

(2012) INGRID D C VAN BALKOM et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Genome-wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci atGPR35andTCF4

(2012) David Ellinghaus et al.   HEPATOLOGY

Pitt–Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects

(2012) Mari Sepp et al.   HUMAN MOLECULAR GENETICS

Functional analysis ofTCF4missense mutations that cause Pitt-Hopkins syndrome

(2012) Marc Forrest et al.   HUMAN MUTATION

GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia

(2012) T Holmlund et al.   LEUKEMIA

Associations between TCF4 Gene Polymorphism and Cognitive Functions in Schizophrenia Patients and Healthy Controls

(2012) Xianghua Zhu et al.   NEUROPSYCHOPHARMACOLOGY

A Common Trinucleotide Repeat Expansion within the Transcription Factor 4 (TCF4, E2-2) Gene Predicts Fuchs Corneal Dystrophy

(2012) Eric D. Wieben et al.   PLoS One

Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating

(2012) B. B. Quednow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCF4 sequence variants and mRNA levels are associated with neurodevelopmental characteristics in psychotic disorders

(2012) K V Wirgenes et al.   Translational Psychiatry

A Network of Broadly Expressed HLH Genes Regulates Tissue-Specific Cell Fates

(2011) Abhishek Bhattacharya et al.   CELL

Novel comprehensive diagnostic strategy in Pitt-Hopkins syndrome: Clinical score and further delineation of the TCF4 mutational spectrum

(2011) Sandra Whalen et al.   HUMAN MUTATION

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

Novel Schizophrenia Risk Gene TCF4 Influences Verbal Learning and Memory Functioning in Schizophrenia Patients

(2011) Leonhard Lennertz et al.   NEUROPSYCHOBIOLOGY

Using a structural and logics systems approach to infer bHLH–DNA binding specificity determinants

(2011) Federico De Masi et al.   NUCLEIC ACIDS RESEARCH

Functional Diversity of Human Basic Helix-Loop-Helix Transcription Factor TCF4 Isoforms Generated by Alternative 5′ Exon Usage and Splicing

(2011) Mari Sepp et al.   PLoS One

Cognitive and Sensorimotor Gating Impairments in Transgenic Mice Overexpressing the Schizophrenia Susceptibility Gene Tcf4 in the Brain

(2010) Magdalena M. Brzózka et al.   BIOLOGICAL PSYCHIATRY

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis

(2010) A. Tanaka et al.   BLOOD

E proteins and the regulation of early lymphocyte development

(2010) Renée F. De Pooter et al.   IMMUNOLOGICAL REVIEWS

E2-2 Protein and Fuchs's Corneal Dystrophy

(2010) Keith H. Baratz et al.   NEW ENGLAND JOURNAL OF MEDICINE

CNTNAP2 and NRXN1 Are Mutated in Autosomal-Recessive Pitt-Hopkins-like Mental Retardation and Determine the Level of a Common Synaptic Protein in Drosophila

(2009) Christiane Zweier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genotype–phenotype analysis of TCF4 mutations causing Pitt-Hopkins syndrome shows increased seizure activity with missense mutations

(2009) Jill A Rosenfeld et al.   GENETICS IN MEDICINE

Mutational, functional, and expression studies of theTCF4gene in Pitt-Hopkins syndrome

(2009) Lo��c de Pontual et al.   HUMAN MUTATION

The Spt-Ada-Gcn5-acetyltransferase complex interaction motif of E2a is essential for a subset of transcriptional and oncogenic properties of E2a-Pbx1

(2009) Jürgen S. Scheele et al.   LEUKEMIA & LYMPHOMA

Multivalent Binding of the ETO Corepressor to E Proteins Facilitates Dual Repression Controls Targeting Chromatin and the Basal Transcription Machinery

(2009) C. Guo et al.   MOLECULAR AND CELLULAR BIOLOGY

Common variants conferring risk of schizophrenia

(2009) Hreinn Stefansson et al.   NATURE

A conserved domain in the transcription factor ITF-2B attenuates its activity

(2008) A. Herbst et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS