Helix–loop–helix proteins and the advent of cellular diversity: 30 years of discovery

Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging

(2018) Satyendra K. Singh et al.   Cell Stem Cell

Dynamic EBF1 occupancy directs sequential epigenetic and transcriptional events in B-cell programming

(2018) Rui Li et al.   GENES & DEVELOPMENT

Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells

(2018) Tomohiro Miyai et al.   GENES & DEVELOPMENT

Transformation of Accessible Chromatin and 3D Nucleome Underlies Lineage Commitment of Early T Cells

(2018) Gangqing Hu et al.   IMMUNITY

Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8+T cells

(2018) Kyla D. Omilusik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transdifferentiation of human adult peripheral blood T cells into neurons

(2018) Koji Tanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Regulation of the Drosophila ID protein Extra macrochaetae by proneural dimerization partners

(2018) Ke Li et al.   eLife

Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen

(2018) Karina K. Sanchez et al.   CELL

TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotency

(2018) Takashi Yamazaki et al.   GENES & DEVELOPMENT

Pancreas regeneration

(2018) Qiao Zhou et al.   NATURE

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

(2018) Patrick A. Carroll et al.   Frontiers of Medicine

Hand Factors in Cardiac Development

(2018) Rajani M. George et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Phylogenetics of Lophotrochozoan bHLH Genes and the Evolution of Lineage-Specific Gene Duplicates

(2017) Yongbo Bao et al.   Genome Biology and Evolution

The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development

(2017) Masaki Miyazaki et al.   IMMUNITY

Isoform-Specific Expression and Feedback Regulation of E Protein TCF4 Control Dendritic Cell Lineage Specification

(2017) Lucja T. Grajkowska et al.   IMMUNITY

Downregulation of E Protein Activity Augments an ILC2 Differentiation Program in the Thymus

(2017) Hong-Cheng Wang et al.   JOURNAL OF IMMUNOLOGY

Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation

(2017) Kyong-Rim Kieffer-Kwon et al.   MOLECULAR CELL

Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network

(2017) William J. R. Longabaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shaping Innate Lymphoid Cell Diversity

(2017) Qiutong Huang et al.   Frontiers in Immunology

Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis

(2016) Xiao-Jiang Quan et al.   CELL

Distinct Activities of Myf5 and MyoD Indicate Separate Roles in Skeletal Muscle Lineage Specification and Differentiation

(2016) Melissa L. Conerly et al.   DEVELOPMENTAL CELL

Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis

(2016) Hiromi Shimojo et al.   GENES & DEVELOPMENT

Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development

(2016) Miriam Wöhner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development

(2016) Renee Gloury et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Id3 Orchestrates Germinal Center B Cell Development

(2016) Shuwen Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

An ID2-dependent mechanism for VHL inactivation in cancer

(2016) Sang Bae Lee et al.   NATURE

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation

(2016) Laura A Shaw et al.   NATURE IMMUNOLOGY

CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles

(2016) Yew Ann Leong et al.   NATURE IMMUNOLOGY

Tissue-specific DNA demethylation is required for proper B-cell differentiation and function

(2016) Shari Orlanski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility

(2016) Chan-Wang Lio et al.   eLife

Different Levels of Twist1 Regulate Skin Tumor Initiation, Stemness, and Progression

(2015) Benjamin Beck et al.   Cell Stem Cell

The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes

(2015) C. Bohrer et al.   EMBO JOURNAL

Dimerization-driven degradation ofC. elegansand human E proteins

(2015) Maria D. Sallee et al.   GENES & DEVELOPMENT

The E–Id protein axis modulates the activities of the PI3K–AKT–mTORC1–Hif1a and c-myc/p19Arf pathways to suppress innate variant TFHcell development, thymocyte expansion, and lymphomagenesis

(2015) Masaki Miyazaki et al.   GENES & DEVELOPMENT

Structural integration in hypoxia-inducible factors

(2015) Dalei Wu et al.   NATURE

The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth

(2015) Claudia Bossen et al.   NATURE IMMUNOLOGY

New roles for DNA cytosine modification, eRNA, anchors, and superanchors in developing B cell progenitors

(2015) Christopher Benner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conversion of MyoD to a Neurogenic Factor: Binding Site Specificity Determines Lineage

(2015) Abraham P. Fong et al.   Cell Reports

Id proteins in the vasculature: from molecular biology to cardiopulmonary medicine

(2014) J. Yang et al.   CARDIOVASCULAR RESEARCH

Transcription Factor ABF-1 Suppresses Plasma Cell Differentiation but Facilitates Memory B Cell Formation

(2014) Yi-Kai Chiu et al.   JOURNAL OF IMMUNOLOGY

E and Id Proteins Influence Invariant NKT Cell Sublineage Differentiation and Proliferation

(2014) L. M. D'Cruz et al.   JOURNAL OF IMMUNOLOGY

Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease

(2014) Masaki Miyazaki et al.   NATURE IMMUNOLOGY

Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries

(2014) Uyen T T Nguyen et al.   NATURE METHODS

Remembering one's ID/E-ntity: E/ID protein regulation of T cell memory

(2013) Kyla D Omilusik et al.   CURRENT OPINION IN IMMUNOLOGY

A TAF4 coactivator function for E proteins that involves enhanced TFIID binding

(2013) W.-Y. Chen et al.   GENES & DEVELOPMENT

Oscillatory Control of Factors Determining Multipotency and Fate in Mouse Neural Progenitors

(2013) I. Imayoshi et al.   SCIENCE

Structural Basis for LMO2-Driven Recruitment of the SCL:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets

(2013) Kamel El Omari et al.   Cell Reports

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Genetic and Epigenetic Determinants of Neurogenesis and Myogenesis

(2012) Abraham P. Fong et al.   DEVELOPMENTAL CELL

E Protein Transcription Factors Are Required for the Development of CD4+ Lineage T Cells

(2012) Mary Elizabeth Jones-Mason et al.   IMMUNITY

Biochemical and Phosphoproteomic Analysis of the Helix-Loop-Helix Protein E47

(2012) R. Teachenor et al.   MOLECULAR AND CELLULAR BIOLOGY

Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

(2012) Roland Schmitz et al.   NATURE

The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors

(2012) Fabian Zohren et al.   NATURE IMMUNOLOGY

Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate

(2012) Yin C Lin et al.   NATURE IMMUNOLOGY

Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex

(2012) N. Huang et al.   SCIENCE

Novel links between HIFs, type 2 diabetes, and metabolic syndrome

(2012) Christian M. Girgis et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

USP1 Deubiquitinates ID Proteins to Preserve a Mesenchymal Stem Cell Program in Osteosarcoma

(2011) Samuel A. Williams et al.   CELL

Combinatorial coding of Drosophila muscle shape by Collier and Nautilus

(2011) Jonathan Enriquez et al.   DEVELOPMENTAL BIOLOGY

Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex

(2011) Sonia V Forcales et al.   EMBO JOURNAL

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Multilineage Priming of Enhancer Repertoires Precedes Commitment to the B and Myeloid Cell Lineages in Hematopoietic Progenitors

(2011) Elinore M. Mercer et al.   IMMUNITY

The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells

(2011) Masaki Miyazaki et al.   NATURE IMMUNOLOGY

The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor

(2011) E. Welinder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation

(2010) E. Soler et al.   GENES & DEVELOPMENT

SAP Protein-Dependent Natural Killer T-like Cells Regulate the Development of CD8+ T Cells with Innate Lymphocyte Characteristics

(2010) Mihalis Verykokakis et al.   IMMUNITY

Synergy between IL-15 and Id2 Promotes the Expansion of Human NK Progenitor Cells, Which Can Be Counteracted by the E Protein HEB Required To Drive T Cell Development

(2010) R. Schotte et al.   JOURNAL OF IMMUNOLOGY

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells

(2010) Louise M D'Cruz et al.   NATURE IMMUNOLOGY

A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

(2010) Yin C Lin et al.   NATURE IMMUNOLOGY

An Early T Cell Lineage Commitment Checkpoint Dependent on the Transcription Factor Bcl11b

(2010) L. Li et al.   SCIENCE

An Essential Developmental Checkpoint for Production of the T Cell Lineage

(2010) T. Ikawa et al.   SCIENCE

Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons

(2010) Christophe Heinrich et al.   PLOS BIOLOGY

Adult Hematopoietic Stem and Progenitor Cells Require Either Lyl1 or Scl for Survival

(2009) George P. Souroullas et al.   Cell Stem Cell

Early evolution of metazoan transcription factors

(2009) Bernard M Degnan et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development

(2009) M. A. Inlay et al.   GENES & DEVELOPMENT

Marked Induction of the Helix-Loop-Helix Protein Id3 Promotes the γδ T Cell Fate and Renders Their Functional Maturation Notch Independent

(2009) Jens Peter Holst Lauritsen et al.   IMMUNITY

Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci

(2009) Kristina Beck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Id3 Restricts the Developmental Potential of    Lineage during Thymopoiesis

(2009) I. Ueda-Hayakawa et al.   JOURNAL OF IMMUNOLOGY

Origin and Diversification of Basic-Helix-Loop-Helix Proteins in Plants

(2009) N. Pires et al.   MOLECULAR BIOLOGY AND EVOLUTION

A bHLH Code for Cardiac Morphogenesis

(2009) Simon J. Conway et al.   PEDIATRIC CARDIOLOGY

E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors

(2009) Craig L. Semerad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription Factor E2-2 Is an Essential and Specific Regulator of Plasmacytoid Dendritic Cell Development

(2008) Babacar Cisse et al.   CELL

E2A Proteins Promote Development of Lymphoid-Primed Multipotent Progenitors

(2008) Sheila Dias et al.   IMMUNITY

Instructive Role of the Transcription Factor E2A in Early B Lymphopoiesis and Germinal Center B Cell Development

(2008) Kyongrim Kwon et al.   IMMUNITY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE