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Multidisciplinary Sciences
Yusuke Fujiwara, Yuki Yamanashi, Akiko Fujimura, Yuko Sato, Tomoya Kujirai, Hitoshi Kurumizaka, Hiroshi Kimura, Kenzo Yamatsugu, Shigehiro A. Kawashima, Motomu Kanai
Summary: The study developed a chemical catalyst that can achieve histone acetylation in living cells without genetic manipulation, offering a new tool for studying epigenetic regulation. This chemical method competes with and suppresses normal chromatin function markers, providing insights into epigenetic mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Naijin Zhang, Ying Zhang, Boquan Wu, Shaojun Wu, Shilong You, Saien Lu, Jingwei Liu, Xinyue Huang, Jiaqi Xu, Liu Cao, Yingxian Sun
Summary: This study revealed the important role of SIRT2 and PARP1 in regulating oxidative stress-induced vascular injury. SIRT2 interacted with and deacetylated PARP1, leading to its ubiquitination and degradation, ultimately alleviating vascular damage caused by oxidative stress.
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Microbiology
Teng Long, Robert D. Burk, Paul K. S. Chan, Zigui Chen
Summary: The study reveals the potential of host degradation by macaque PV types, emphasizing the complex interactions between viral oncogenes and host proteomes. These findings provide important insights into viral fitness and pathological consequences, expanding the understanding of the phenotype-genotype relationship from an evolutionary perspective.
Article
Biochemistry & Molecular Biology
Juan Hormazabal, Francisco Saavedra, Claudia Espinoza-Arratia, Nicolas W. Martinez, Tatiana Cruces, Ivan E. Alfaro, Alejandra Loyola
Summary: In this study, the researchers identified chaperone-mediated autophagy (CMA) as the main pathway for the degradation of histones H3 and H4. The protein tNASP stabilizes histone H3 levels by preventing its entry into lysosomes. The study also revealed that CMA degrades unfolded histone H3.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Naijin Zhang, Ying Zhang, Wei Miao, Chuning Shi, Zihan Chen, Boquan Wu, Yuanming Zou, Qiushi Ma, Shilong You, Saien Lu, Xinyue Huang, Jingwei Liu, Jiaqi Xu, Liu Cao, Yingxian Sun
Summary: Oxidative stress-associated endothelial damage is the initiation factor of cardiovascular disease, and protein posttranslational modifications play critical roles in this process. This study identifies key molecular interactions and protein modifications of Bcl-2-associated athanogene 3 (BAG3) in oxidative stress-associated endothelial damage. BAG3 promotes the ubiquitination and degradation of poly(ADP-ribose) polymerase 1 (PARP1) by enhancing the E3 ubiquitin ligase WWP2. Furthermore, BAG3 itself is regulated by the acetyltransferase CREB-binding protein (CBP) and the deacetylase Sirtuin 2 (SIRT2).
Article
Biochemistry & Molecular Biology
Patrick A. Grant, Fred Winston, Shelley L. Berger
Summary: This article reviews early genetic and biochemical experiments that led to the discovery of SAGA complex and the elucidation of its multiple activities in regulating gene transcription in eukaryotes.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2021)
Review
Cell Biology
Linbin Zhou, Danny Siu-Chun Ng, Jason C. Yam, Li Jia Chen, Clement C. Tham, Chi Pui Pang, Wai Kit Chu
Summary: This review summarizes recent findings on the impact of post-translational modifications (PTMs) on the functions of retinoblastoma protein (pRb). PTMs on pRb play crucial roles in cell cycle regulation, cell survival, and differentiation, and altered PTMs can lead to anomalies in cell proliferation and tumorigenesis. Understanding the post-translational modulation of pRb could facilitate the development of novel therapeutic strategies for various human diseases.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yoshihiro Morimoto, Atsushi Fushimi, Nami Yamashita, Masayuki Hagiwara, Atrayee Bhattacharya, Jingwei Cheng, Thomas C. Frost, Rehan Ahmad, Tatsuaki Daimon, Lei Huang, Tsuyoshi Hata, Hidekazu Takahashi, Masaaki Yamamoto, Yozo Suzuki, James A. DeCaprio, Donald Kufe
Summary: This study discovered that MUC1-C is broadly expressed in MCCs and has higher expression levels in MCPyV-positive MCCs. MUC1-C regulates signaling pathways related to RNA synthesis, processing, and transport and interacts with MYCL to drive MCC progression. It is also necessary for the expression of pluripotency factors and NE lineage transcription factors. MUC1-C is crucial for MCC cell survival by suppressing DNA replication stress, the p53 pathway, and apoptosis. Targeting MUC1-C inhibits MCC self-renewal capacity and tumorigenicity, making it a potential target for MCC treatment.
Article
Biology
Satoshi Takahashi, Akinori Kanai, Hiroshi Okuda, Ryo Miyamoto, Yosuke Komata, Takeshi Kawamura, Hirotaka Matsui, Toshiya Inaba, Akifumi Takaori-Kondo, Akihiko Yokoyama
Summary: Leukemic MLL fusion proteins associate with the HBO1 histone acetyltransferase complex through their THD2 domain, playing a critical role in leukemic transformation. The interaction between the HBO1 complex and MLL is a key factor in leukemic development and may serve as a potential therapeutic target for drug development.
Review
Endocrinology & Metabolism
Huimei Wei, Peng Huo, Shun Liu, Hua Huang, Shun Zhang
Summary: PCOS is a lifelong disorder affecting a significant number of women and associated with increased risk of various diseases. Posttranslational modifications play a crucial role in PCOS development, and understanding their roles and mechanisms can provide insights for future research and treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Yizeng Yang, Dharmendra Bhargava, Xiao Chen, Taicheng Zhou, Gizem Dursuk, Wenpeng Jiang, Jinshen Wang, Zhen Zong, Sharyn I. Katz, Gwen A. Lomberk, Raul A. Urrutia, Jonathan P. Katz
Summary: In non-transformed human squamous epithelial cells, the decision of whether to arrest or undergo apoptosis in response to stress is mediated by the interaction between p53 and the zinc-finger transcription factor KLF5. The levels of cellular stress determine the specific outcome, with moderate stress leading to cell survival and severe stress resulting in apoptosis.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Xiaoling Hong, Ning Ma, Danjie Li, Mengwen Zhang, Wenqiuzi Dong, Jie Huang, Xinxin Ci, Songling Zhang
Summary: Dissemination of ovarian cancer cells can lead to poor prognosis. This study identified UBE2E2 as an upregulated protein in ovarian cancer and showed that it is associated with poor prognosis. UBE2E2 was found to promote ovarian cancer cell migration, epithelial-mesenchymal transition (EMT), and metastasis through the activation of the Nrf2-p62-Snail signaling pathway. The deletion of UBE2E2 reduced tumorigenicity and metastasis in mice models. These findings provide novel therapeutic targets for preventing ovarian cancer metastasis.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Siyi Zhang, Tingting Zhou, Zhuo Wang, Fei Yi, Chunlu Li, Wendong Guo, Hongde Xu, Hongyan Cui, Xiang Dong, Jingwei Liu, Xiaoyu Song, Liu Cao
Summary: Faithful DNA replication is crucial for cell survival and inheritance, but damage can lead to replication stalling and DNA lesions. Post-translational modifications of PCNA regulate DNA synthesis and damage tolerance to maintain genomic stability. Dysregulation of PCNA PTMs can result in DNA breaks, affecting cell response and causing mutations.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Christopher R. McEvoy, Holly Holliday, Niko Thio, Catherine Mitchell, David Y. Choong, Bhargavi Yellapu, Hui San Leong, Huiling Xu, Stephen Lade, Judy Browning, Elena A. Takano, David J. Byrne, Anthony J. Gill, Cuong P. Duong, Jason Li, Andrew P. Fellowes, Stephen B. Fox, Alexander Swarbrick, Owen W. J. Prall
Summary: This study describes a small round cell malignancy from the gastro-esophageal junction with a novel fusion between NUTM1 and MAD family member MXI1. In contrast to typical NUT carcinomas, this MXI1-NUTM1 tumor did not exhibit squamous differentiation and showed MYC-like characteristics without MYC expression. The findings suggest that MAD family members can be transformed into MYC-like mimics through fusion with NUTM1, indicating potential implications for diagnostic classification and therapeutic strategies for some NRN subtypes.
LABORATORY INVESTIGATION
(2021)
Article
Cell Biology
Xing Feng, Heng Zhang, Lingbing Meng, Huiwen Song, Qingxin Zhou, Chao Qu, Pan Zhao, Qinghua Li, Chang Zou, Xing Liu, Zhiyong Zhang
Summary: The study reveals that PAK1 plays a critical role in promoting autophagy in GBM, especially under hypoxic conditions. Acetylation and phosphorylation of PAK1 are crucial for regulating autophagy and facilitating GBM growth.
Article
Multidisciplinary Sciences
Mozhgan Farshbaf, Mikael J. Lindberg, Anh Truong, Zachery Bevens, Elaina Chambers, Angeliki Pournara, Annika E. Wallberg, J. Brandon White
Article
Multidisciplinary Sciences
Michael Hall, Christin Grundstrom, Afshan Begum, Mikael J. Lindberg, Uwe H. Sauer, Fredrik Almqvist, Jorgen Johansson, A. Elisabeth Sauer-Eriksson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Biochemistry & Molecular Biology
Anita E. Popko-Scibor, Mikael J. Lindberg, Magnus L. Hansson, Teresa Holmlund, Annika E. Wallberg
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2011)
Article
Engineering, Environmental
Jin Zhang, Christin Grundstrom, Kristoffer Brannstrom, Irina Iakovleva, Mikael Lindberg, Anders Olofsson, Patrik L. Andersson, A. Elisabeth Sauer-Eriksson
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Mikael J. Lindberg, Anita E. Popko-Scibor, Magnus L. Hansson, Annika E. Wallberg
Article
Biochemistry & Molecular Biology
Mariana Saint Just Ribeiro, Magnus L. Hansson, Mikael J. Lindberg, Anita E. Popko-Scibor, Annika E. Wallberg
NUCLEIC ACIDS RESEARCH
(2009)
Article
Biochemistry & Molecular Biology
Magnus L. Hansson, Anita E. Popko-Scibor, Mariana Saint Just Ribeiro, Beverley M. Dancy, Mikael J. Lindberg, Philip A. Cole, Annika E. Wallberg
NUCLEIC ACIDS RESEARCH
(2009)
Article
Multidisciplinary Sciences
Tobias Karlberg, Peter Hornyak, Ana Filipa Pinto, Stefina Milanova, Mahsa Ebrahimi, Mikael Lindberg, Nikolai Pullen, Axel Nordstrom, Elinor Loverli, Remi Caraballo, Emily V. Wong, Katja Nareoja, Ann-Gerd Thorsell, Mikael Elofsson, Enrique M. De la Cruz, Camilla Bjorkegren, Herwig Schuler
NATURE COMMUNICATIONS
(2018)
Article
Biochemical Research Methods
Artur P. G. Dingeldein, Mikael J. Lindberg, Jorgen Aden, Xueyin Zhong, Raphael Stoll, Gerhard Grobner
PROTEIN EXPRESSION AND PURIFICATION
(2019)
Article
Clinical Neurology
PA Jonsson, KS Graffmo, PM Andersen, T Brännström, M Lindberg, M Oliveberg, SL Marklund
Article
Multidisciplinary Sciences
MJ Lindberg, R Byström, N Boknäs, PM Andersen, M Oliveberg
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2005)
Article
Multidisciplinary Sciences
MJ Lindberg, J Normark, A Holmgren, M Oliveberg
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2004)
Article
Biochemical Research Methods
IM Ahl, MJ Lindberg, LAE Tibell
PROTEIN EXPRESSION AND PURIFICATION
(2004)
Article
Multidisciplinary Sciences
MJ Lindberg, L Tibell, M Oliveberg
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2002)