Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice

De Novo Designed Amphipathic α-Helical Antimicrobial Peptides Incorporating Dab and Dap Residues on the Polar Face To Treat the Gram-Negative Pathogen, Acinetobacter baumannii

(2019) Colin T. Mant et al.   JOURNAL OF MEDICINAL CHEMISTRY

Influence of hydrocarbon-stapling on membrane interactions of synthetic antimicrobial peptides

(2018) Tracy A. Stone et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hydrocarbon Stapled Antimicrobial Peptides

(2018) Dorian Migoń et al.   PROTEIN JOURNAL

Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries

(2017) Ana Gomes et al.   MOLECULES

Nephrotoxicity of Polymyxins: Is There Any Difference between Colistimethate and Polymyxin B?

(2016) Alexandre P. Zavascki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of Fourde NovoDesigned Antimicrobial Peptides

(2016) Brian Murray et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B

(2016) Alejandra Gallardo-Godoy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

(2016) Yi-Yun Liu et al.   LANCET INFECTIOUS DISEASES

Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices

(2016) Gregory H Bird et al.   Nature Chemical Biology

Real-time examination of aminoglycoside activity towards bacterial mimetic membranes using Quartz Crystal Microbalance with Dissipation monitoring (QCM-D)

(2015) Tanmaya Joshi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Antimicrobial activity of doubly-stapled alanine/lysine-based peptides

(2015) Thuy T.T. Dinh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Differentiating antimicrobial peptides interacting with lipid bilayer: Molecular signatures derived from quartz crystal microbalance with dissipation monitoring

(2015) Kathleen F. Wang et al.   BIOPHYSICAL CHEMISTRY

Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It

(2015) Helen I. Zgurskaya et al.   ACS Infectious Diseases

3D Hydrophobic Moment Vectors as a Tool to Characterize the Surface Polarity of Amphiphilic Peptides

(2014) Sabine Reißer et al.   BIOPHYSICAL JOURNAL

Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection

(2014) Gregory H. Bird et al.   JOURNAL OF CLINICAL INVESTIGATION

Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

(2014) Loren D. Walensky et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular mechanisms of antibiotic resistance

(2014) Jessica M. A. Blair et al.   NATURE REVIEWS MICROBIOLOGY

Hydrogen Exchange-Mass Spectrometry Measures Stapled Peptide Conformational Dynamics and Predicts Pharmacokinetic Properties

(2013) Xiangguo (Eric) Shi et al.   ANALYTICAL CHEMISTRY

Truncated and constrained helical analogs of antimicrobial esculentin-2EM

(2013) Thanh Kim Pham et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Analysis of Overlapped and Noisy Hydrogen/Deuterium Exchange Mass Spectra

(2013) Miklos Guttman et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Antimicrobial peptides stage a comeback

(2013) Jeffrey L Fox   NATURE BIOTECHNOLOGY

Effect of hydrocarbon stapling on the properties of α-helical antimicrobial peptides isolated from the venom of hymenoptera

(2012) Hubert Chapuis et al.   AMINO ACIDS

Rational Design of α-Helical Antimicrobial Peptides to Target Gram-negative Pathogens, Acinetobacter baumannii and Pseudomonas aeruginosa: Utilization of Charge, ‘Specificity Determinants,’ Total Hydrophobicity, Hydrophobe Type and Location as Design Para

(2011) Ziqing Jiang et al.   Chemical Biology & Drug Design

Designing antimicrobial peptides: form follows function

(2011) Christopher D. Fjell et al.   NATURE REVIEWS DRUG DISCOVERY

Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

(2010) J. H. Moffatt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

(2010) G. H. Bird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of Protein Conformation and Dynamics by Hydrogen/Deuterium Exchange MS

(2009) John R. Engen   ANALYTICAL CHEMISTRY

Computational Design of Highly Selective Antimicrobial Peptides

(2009) Davor Juretić et al.   Journal of Chemical Information and Modeling

Tackling antibiotic resistance: a dose of common antisense?

(2008) N. Woodford et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY