Article
Chemistry, Multidisciplinary
Maochao Zheng, Xiaolei Wu, Chao Lu, Wancong Zhang, Shijie Tang, Ying Luo, Daojun Liu
Summary: The development of alternative antimicrobial therapeutics is needed due to the emergence of antibiotic resistance in bacterial pathogens. Polypept(o)ide-based bactericides, which mimic antimicrobial host defense peptides, have shown promise in the treatment of antibiotic-resistant and recurring infections. This review summarizes recent advances in membrane-active polypept(o)ide-based bactericides, focusing on their ability to disrupt bacterial cell walls/membranes and combat acquired antibiotic resistance and biofilm formation.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Maria S. Zharkova, Aleksey S. Komlev, Tatiana A. Filatenkova, Maria S. Sukhareva, Elizaveta V. Vladimirova, Andrey S. Trulioff, Dmitriy S. Orlov, Alexander V. Dmitriev, Anna G. Afinogenova, Anna A. Spiridonova, Olga V. Shamova
Summary: Antimicrobial peptides (AMPs) are a promising template for new antimicrobials, and their interaction with antiseptics is an interesting topic that requires further attention.
Review
Chemistry, Medicinal
Yiyun Zhu, Weijing Hao, Xia Wang, Jianhong Ouyang, Xinyi Deng, Haining Yu, Yipeng Wang
Summary: Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important immune defense molecules in multicellular organisms. AMPs have great potential as new generation antimicrobial agents and can be used in combination with conventional antibiotics to kill drug-resistant pathogens and improve therapeutic effects.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Engineering, Biomedical
Tomislav Roncevic, Marco Gerdol, Mario Mardirossian, Matko Males, Svjetlana Cvjetan, Monica Benincasa, Ana Maravic, Goran Gajski, Lucija Krce, Ivica Aviani, Jerko Hrabar, Zeljka Trumbic, Maik Derks, Alberto Pallavicini, Markus Weingarth, Larisa Zoranic, Alessandro Tossi, Ivona Mladineo
Summary: This study reveals the important role of antimicrobial peptides in the survival of the marine parasite Anisakis and elucidates their mechanism of action against bacterial infections. These peptides exhibit potent bactericidal activity against Gram-negative bacteria, including multi-drug resistant strains, making them promising candidates for further drug development.
ACTA BIOMATERIALIA
(2022)
Article
Multidisciplinary Sciences
Shira Mandel, Janna Michaeli, Noa Nur, Isabelle Erbetti, Jonathan Zazoun, Livia Ferrari, Antonio Felici, Moshe Cohen-Kutner, Niv Bachnoff
Summary: The new antimicrobial agent OMN6 shows high efficacy against multidrug resistant Gram-negative bacteria, targeting the bacterial membrane and being insensitive to genotype or resistance-phenotype. It displays low likelihood of resistance development, high stability, and safety on human cells, making it a promising novel therapy for humans.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Jiaqi Xuan, Weiguo Feng, Jiaye Wang, Ruichen Wang, Bowen Zhang, Letao Bo, Zhe-Sheng Chen, Hui Yang, Leming Sun
Summary: The long-term use of antibiotics leading to drug resistance has become a major concern. As the problem worsens, infections caused by multiple bacteria are increasing rapidly and posing serious threats to human health. Antimicrobial peptides (AMPs) offer a promising alternative to traditional antibiotics as they exhibit strong antimicrobial activity and unique mechanisms against drug-resistant bacterial infections. Current research on AMPs focuses on integrating new technologies, such as modifying the amino acid structure and exploring different delivery methods. This article provides valuable insights into the properties, mechanisms, and advancements of AMPs in combating drug-resistant bacterial infections.
DRUG RESISTANCE UPDATES
(2023)
Article
Engineering, Biomedical
Yongjie Zhu, Muhammad Usman Akhtar, Bowen Li, Shuli Chou, Changxuan Shao, Jiawei Li, Anshan Shan
Summary: Antimicrobial peptides (AMPs) are powerful tools in combating antibiotic resistance. This study introduces hydrophilic uncharged residues into the design of AMPs, improving their cell selectivity and antibacterial activity.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Claudiane Almeida, Caio F. R. de Oliveira, Edson L. dos Santos, Helder F. dos Santos, Edson C. Junior, Reinaldo Marchetto, Leticia A. da Cruz, Alda Maria T. Ferreira, Valdirene M. Gomes, Gabriel B. Taveira, Bruna O. Costa, Octavio L. Franco, Marlon H. Cardoso, Maria Ligia R. Macedo
Summary: The study introduced an antimicrobial peptide called RQ18, which exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, as well as yeasts from the Candida genus, without being cytotoxic to mammalian cells. The research highlighted RQ18 as a membrane-active peptide with dual antibacterial and antifungal activities, emphasizing its therapeutic potential.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Materials Science, Biomaterials
Wenjing Zhang, Shuai Deng, Min Zhou, Jingcheng Zou, Jiayang Xie, Ximian Xiao, Ling Yuan, Zhemin Ji, Sheng Chen, Ruxin Cui, Zhengjie Luo, Guixue Xia, Runhui Liu
Summary: This study designed amphiphilic peptoid polymers by mimicking the structure of HDPs and synthesized a series of cyclic peptoid polymers. The optimal polymer exhibited strong antibacterial activity and potential application against drug-resistant bacteria.
BIOMATERIALS SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Tzu-Tang Lin, Li-Yen Yang, Chung-Yen Lin, Ching-Tien Wang, Chia-Wen Lai, Chi-Fong Ko, Yang-Hsin Shih, Shu-Hwa Chen
Summary: Due to the increase in clinical antibiotic resistance cases recent years, novel antimicrobial peptides (AMPs) may serve as ideal next-generation antibiotics. This study used a Wasserstein generative adversarial network with gradient penalty (WGAN-GP) trained on known AMPs to generate new AMP candidates. The quality of the generated AMPs was evaluated in silico and eight peptides, named GAN-pep 1-8, were selected, synthesized, and tested for antibacterial activity. Seven of the synthesized peptides demonstrated antibacterial effects, with GAN-pep 3 and GAN-pep 8 exhibiting broad-spectrum activity against antibiotic-resistant bacteria strains. GAN-pep 3, the most promising candidate, displayed low minimum inhibitory concentrations (MICs) against all tested bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Janaina Teixeira Costa de Pontes, Anna Beatriz Toledo Borges, Cesar Augusto Roque-Borda, Fernando Rogerio Pavan
Summary: Bacterial resistance is a global public health emergency, exacerbated by biofilm formation in bacteria. Studying new molecules such as antimicrobial peptides is important for combating multi-drug resistant and extensively drug-resistant bacteria.
Article
Chemistry, Multidisciplinary
Bo Zhang, Meng Zhang, Min Lin, Xinzhe Dong, Xutao Ma, Yuanhong Xu, Jing Sun
Summary: This study reports the development of an innovative cationic copolypeptoid antimicrobial that exhibits a wide spectrum of antibacterial activity and low hemolytic properties. It effectively inhibits biofilm formation and eradicates bacteria embedded in mature biofilms. The antimicrobial also shows potent activity against drug-resistant bacteria without developing visible resistance after repeated usage.
Article
Immunology
Tanay Bhatt, Binita Dam, Sneha Uday Khedkar, Sahil Lall, Subhashini Pandey, Sunny Kataria, Johan Ajnabi, Shah-E-Jahan Gulzar, Paul M. Dias, Morris Waskar, Janhavi Raut, Varadharajan Sundaramurthy, Praveen Kumar Vemula, Naresh Ghatlia, Amitabha Majumdar, Colin Jamora
Summary: The emergence of SARS-CoV-2 variants poses a threat to global vaccination programs, necessitating the exploration of additional strategies for containment. Human cathelicidin (LL37), an antimicrobial peptide, has been found to neutralize multiple strains of SARS-CoV-2 by disrupting the viral membrane. This antiviral activity can be enhanced by niacinamide, and there is an inverse correlation between LL37 levels and COVID-19 disease severity, suggesting its potential as a therapeutic avenue.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Mario R. Felicio, Gislaine G. O. S. Silveira, Karen G. N. Oshiro, Beatriz T. Meneguetti, Octavio L. Franco, Nuno C. Santos, Sonia Goncalves
Summary: This study evaluated the applicability and mechanisms of action of two synthetic AMPs against a clinically isolated multidrug-resistant Escherichia coli strain. The results showed that both peptides have potential antimicrobial activity, but with different mechanisms of action, with Pa-MAP 1.9 being more effective than Pa-MAP 2. These findings highlight the potential use of these AMPs as antimicrobial agents against MDR bacteria.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Rong Sheng Li, Jiahui Liu, Cong Wen, Yaru Shi, Jian Ling, Qiue Cao, Lei Wang, Hu Shi, Cheng Zhi Huang, Na Li
Summary: This article introduces a transformable nano-antibiotics (TNA) that can target the bactericidal properties of Gram-negative bacteria by binding to BamA and LPSs. The TNA can kill Gram-negative bacteria through multiple modes of action and induce immune responses to protect against reinfections.
Article
Chemistry, Multidisciplinary
Changxuan Shao, Yongjie Zhu, Qiao Jian, Zhenheng Lai, Peng Tan, Guoyu Li, Anshan Shan
Summary: Novel antimicrobial peptides have been developed as potential antibiotic substitutes, with a focus on a progressive beta-hairpin solution to reveal the balance between function and toxicity of structural moieties. Lead amphiphiles have shown promising antimicrobial efficacy and potential inflammation-limiting capabilities without observed toxicity, providing renewed innovation in beta-sheet peptide-based antimicrobial biomaterials.
Review
Engineering, Environmental
Huiyang Fu, Peng Tan, Renjie Wang, Senlin Li, Haozhen Liu, Ying Yang, Zhenlong Wu
Summary: This review systematically reviewed the classification, characteristics, applications, and impact of organophosphorus pesticides on the ecological environment and animal health, and introduced methods for degrading OPPs. Proposed solutions for addressing the environmental and ecological problems caused by OPPs.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Peng Tan, Qi Tang, Shenrui Xu, Yucheng Zhang, Huiyang Fu, Xi Ma
Summary: In this study, self-assembling chimeric peptide nanoparticles with excellent stability have been constructed and applied to the treatment of bacterial infections. These nanoparticles show broad-spectrum antibacterial activity, desirable biocompatibility, and resistance to degradation. They can alleviate systemic bacterial infections with negligible toxicity, and their mechanism differs from antibiotics, reducing the risk of drug resistance.
Review
Gastroenterology & Hepatology
Yucheng Zhang, Peng Tan, Ying Zhao, Xi Ma
Summary: This review focuses on recent discoveries about the etiology, pathogenesis, and clinical manifestation of enterotoxigenic Escherichia coli (ETEC), as well as the colonization resistances mediated by gut microbiota and preventative strategies against ETEC.
Article
Microbiology
Guoyu Li, Xiaojie Yuan, Hongyu Chen, Bowen Li, Changxuan Shao, Yongjie Zhu, Zhenheng Lai, Anshan Shan
Summary: This study investigates the effect of systematic mutations in the hydrogen bond formation site of an alpha-helical antimicrobial peptide on its activity and cell selectivity. The optimized peptide showed excellent antibacterial ability and selectivity, and significantly reduced bacterial loads in vivo. These findings contribute to the design and optimization of highly active and low-toxicity antimicrobial peptides.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Engineering, Biomedical
Yongjie Zhu, Muhammad Usman Akhtar, Bowen Li, Shuli Chou, Changxuan Shao, Jiawei Li, Anshan Shan
Summary: Antimicrobial peptides (AMPs) are powerful tools in combating antibiotic resistance. This study introduces hydrophilic uncharged residues into the design of AMPs, improving their cell selectivity and antibacterial activity.
ACTA BIOMATERIALIA
(2022)
Review
Biotechnology & Applied Microbiology
Zhenheng Lai, Xiaojie Yuan, Hongyu Chen, Yunhui Zhu, Na Dong, Anshan Shan
Summary: Due to the fast development of multidrug-resistant bacterial pathogens, the development and modification of antimicrobial peptides (AMPs) are highly active. However, the clinical translation of peptide antibiotics is still inadequate despite considerable efforts. Improving the proteolytic stability of AMPs is crucial and various design strategies have been explored.
BIOTECHNOLOGY ADVANCES
(2022)
Review
Food Science & Technology
Yucheng Zhang, Ning Ma, Peng Tan, Xi Ma
Summary: This review provides an overview of how gut bacteria use quorum sensing (QS) to communicate and coordinate their activities, and the role of QS in the interaction between the gut host and microbiota. Understanding the communication network of gut microbiota is crucial for developing strategies against bacterial illnesses and improving gut health.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Engineering, Biomedical
Qi Tang, Peng Tan, Zhaolai Dai, Tao Wang, Shenrui Xu, Yakun Ding, Junqi Jin, Xin Zhang, Yucheng Zhang, Chenlong Zhou, Zitian Yue, Huiyang Fu, Junshu Yan, Xi Ma
Summary: This study investigates the association between hydrophobicity and cell-penetrating peptide delivery efficiency, and successfully develops chimeric peptides P3I7 and P3L7 with strong antibacterial activity and low cytotoxicity. These peptides can effectively penetrate cells to eliminate intracellular pathogens mainly through endocytosis. The mechanism of membrane destruction makes them fast sterilizers and less prone to drug resistance. In vivo trials confirm their good biocompatibility and antibacterial infection effects, indicating their potential as affordable and effective antimicrobial agents against intracellular bacterial infections.
ACTA BIOMATERIALIA
(2023)
Article
Microbiology
Zhenheng Lai, Hongyu Chen, Xiaojie Yuan, Jiahui Tian, Na Dong, Xingjun Feng, Anshan Shan
Summary: The rapid development of antimicrobial resistance and slow progress in developing new antibiotics have led to a serious threat of multidrug-resistant bacterial infections. Antimicrobial peptides (AMPs) offer a promising alternative, but further research is needed to address their limitations. In this study, we designed a series of novel double-site lipidated peptide amphiphiles with a broad spectrum of antimicrobial activities. One specific peptide, WL-C-6, exhibited strong inhibition of multidrug-resistant bacteria without significant toxicity towards mammalian cells. Furthermore, WL-C-6 maintained its antibacterial properties even at physiological salt ion concentrations and remained intact after exposure to different proteases. The study also revealed that WL-C-6 rapidly disrupts bacterial membranes, leading to bacterial death. Overall, WL-C-6 shows great promise as a substitute for conventional antibiotics in combating the growing threat of multidrug-resistant bacterial infections.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Guoyu Li, Zhenheng Lai, Anshan Shan
Summary: Due to the increase in multidrug-resistant bacterial isolates and lack of effective antimicrobial agents, antibiotic resistant bacterial infections have risen significantly. There is an urgent need to develop new antimicrobial drugs and formulations. Recent advancements in natural antimicrobial peptides (AMPs), such as AMP optimization, self-assembled AMPs, AMP hydrogels, and biomaterial-assisted delivery, have shown promise in treating bacterial infections. This review focuses on the development prospects and limitations of AMP-based biomaterials for animal model infections like abdominal, skin, and eye infections, aiming to inspire further innovation and accelerate their commercialization.
Article
Chemistry, Multidisciplinary
Peng Tan, Chenchen Wu, Qi Tang, Tao Wang, Chenlong Zhou, Yakun Ding, Huiyang Fu, Shenrui Xu, Yuqing Feng, Yucheng Zhang, Qing Dai, Xi Ma
Summary: Drug-resistant bacteria and biofilm-associated infections pose significant challenges in antibacterial medicine. Researchers have designed self-assembling chimeric peptide nanoassemblies as a potential solution. These nanoassemblies transform from nanofibers to nanoparticles in acidic biofilm-infected environments, allowing for improved penetration and killing of drug-resistant bacteria. In vivo infection models confirm the effectiveness of these nanoassemblies in reducing bacterial load within biofilms. This study holds promise for the development of high-performance antibacterial nanomaterials and their application in medicine and animal husbandry.
ADVANCED MATERIALS
(2023)
Article
Engineering, Environmental
Huiyang Fu, Haozhen Liu, Yao Ge, Yinfeng Chen, Peng Tan, Jun Bai, Zhaolai Dai, Ying Yang, Zhenlong Wu
Summary: The abuse of chlorpyrifos has led to environmental pollution and toxicological effects on non-target organisms. It enters the ecosystem through the food chain and directly affects non-target organisms in water environments. The study demonstrates the toxic effects of chlorpyrifos on rats and the mitigating effects of chitosan oligosaccharide. Chitosan oligosaccharide shows significant biological effects in mitigating the toxic damage in rats induced by chlorpyrifos.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Peng Tan, Zhihong Sun, Qi Tang, Shenrui Xu, Tao Wang, Yakun Ding, Huiyang Fu, Chenlong Zhou, Yucheng Zhang, Zitian Yue, Xi Ma
Summary: The risk of antibiotic resistance has prompted the exploration of novel antimicrobial biomaterials, such as antimicrobial peptides (AMPs). However, limitations in stability and toxicity have hindered the translation of AMPs from the laboratory to practical applications. By designing an original motif and using a comprehensive screening process, target peptides HLFP-5 and HLWP-4 were identified as AMPs with excellent antibacterial activity, stability, and resistance to drug resistance. These findings highlight the potential of AMPs as replacement materials for antibiotics in animal husbandry.