Icariin protects against iron overload-induced bone loss via suppressing oxidative stress

Iron overload promotes erythroid apoptosis through regulating HIF-1a/ROS signaling pathway in patients with myelodysplastic syndrome

(2017) Qing-qing Zheng et al.   LEUKEMIA RESEARCH

Clinical Impact and Cellular Mechanisms of Iron Overload-Associated Bone Loss

(2017) Viktória Jeney   Frontiers in Pharmacology

Icariin attenuated oxidative stress induced-cardiac apoptosis by mitochondria protection and ERK activation

(2016) Yao-Hong Song et al.   BIOMEDICINE & PHARMACOTHERAPY

Wnt5a is a key target for the pro-osteogenic effects of iron chelation on osteoblast progenitors

(2016) U. Baschant et al.   HAEMATOLOGICA

Energy metabolism in osteoclast formation and activity

(2016) Silvia Lemma et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Icariin regulates systemic iron metabolism by increasing hepatic hepcidin expression through Stat3 and Smad1/5/8 signaling

(2016) MIAO ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress

(2016) A. Camacho et al.   OSTEOARTHRITIS AND CARTILAGE

Dual Role of ROS as Signal and Stress Agents: Iron Tips the Balance in favor of Toxic Effects

(2016) Elena Gammella et al.   Oxidative Medicine and Cellular Longevity

Wnt5a is a key target for the pro-osteogenic effects of iron chelation on osteoblast progenitors

(2016) U. Baschant et al.   HAEMATOLOGICA

Iron overload induced death of osteoblasts in vitro: involvement of the mitochondrial apoptotic pathway

(2016) Qing Tian et al.   PeerJ

Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage Repair

(2016) Pengzhen Wang et al.   PLoS One

Icariin: A promising osteoinductive compound for repairing bone defect and osteonecrosis

(2015) Xiaowei Xie et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Iron overload increases osteoclastogenesis and aggravates the effects of ovariectomy on bone mass

(2015) Wang Xiao et al.   JOURNAL OF ENDOCRINOLOGY

Effect of excess iron on oxidative stress and gluconeogenesis through hepcidin during mitochondrial dysfunction

(2015) Hyo Jung Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effects of dietary resveratrol on excess-iron-induced bone loss via antioxidative character

(2015) Lu Zhao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Icariin Promotes Angiogenic Differentiation and Prevents Oxidative Stress-Induced Autophagy in Endothelial Progenitor Cells

(2015) Yubo Tang et al.   STEM CELLS

The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review

(2015) Fatemeh Atashi et al.   STEM CELLS AND DEVELOPMENT

Icariin attenuates hypoxia-induced oxidative stress and apoptosis in osteoblasts and preserves their osteogenic differentiation potentialin vitro

(2014) H.-P. Ma et al.   CELL PROLIFERATION

Iron overload and chelation therapy in myelodysplastic syndromes

(2014) Sally Temraz et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Iron, Oxidative Stress and Gestational Diabetes

(2014) Taifeng Zhuang et al.   Nutrients

Iron Overload Inhibits Osteoblast Biological Activity Through Oxidative Stress

(2013) Yin-Feng He et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Icariin induces osteoblast proliferation, differentiation and mineralization through estrogen receptor-mediated ERK and JNK signal activation

(2013) Lige Song et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Steap4 Plays a Critical Role in Osteoclastogenesisin Vitroby Regulating Cellular Iron/Reactive Oxygen Species (ROS) Levels and cAMP Response Element-binding Protein (CREB) Activation

(2013) Jian Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prevention and treatment of postmenopausal osteoporosis

(2013) Sri Harsha Tella et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Icariin: Does It Have An Osteoinductive Potential for Bone Tissue Engineering?

(2013) Xin Zhang et al.   PHYTOTHERAPY RESEARCH

Postmenopausal osteoporosis

(2013) Dima L. Diab et al.   Current Opinion in Endocrinology Diabetes and Obesity

Iron overload accelerates bone loss in healthy postmenopausal women and middle-aged men: A 3-year retrospective longitudinal study

(2012) Beom-Jun Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species

(2012) Peng Jia et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Iron Overload

(2011) Mary M. Hulihan et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Bone disease in adult patients with β-thalassaemia major: a case–control study

(2011) Marina Baldini et al.   Internal and Emergency Medicine

Bone loss caused by iron overload in a murine model: importance of oxidative stress

(2010) J. Tsay et al.   BLOOD

Icariin inhibits osteoclast differentiation and bone resorption by suppression of MAPKs/NF-κB regulated HIF-1α and PGE2 synthesis

(2010) Tsai-Pei Hsieh et al.   PHYTOMEDICINE

Iron overload alters iron-regulatory genes and proteins, down-regulates osteoblastic phenotype, and is associated with apoptosis in fetal rat calvaria cultures

(2009) Jonathan G. Messer et al.   BONE

Osteoclasts Pump Iron

(2009) G. David Roodman   Cell Metabolism

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

(2009) Kiyo-aki Ishii et al.   NATURE MEDICINE

Role of iron metabolism and oxidative damage in postmenopausal bone loss

(2008) Patrizia D'Amelio et al.   BONE

Association between iron overload and osteoporosis in patients with hereditary hemochromatosis

(2008) L. Valenti et al.   OSTEOPOROSIS INTERNATIONAL

Effects of colloidal iron overload on renal and hepatic siderosis and the femur in male rats

(2008) H. Kudo et al.   TOXICOLOGY

Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1α/2α is mediated through chelation of iron

(2007) Sung-Soo Park et al.   JOURNAL OF CELLULAR BIOCHEMISTRY