Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes

Do subjects with minimal motor features have prodromal Parkinson disease?

(2018) Yaping Chu et al.   ANNALS OF NEUROLOGY

Dopamine Transporter/α-Synuclein Complexes Are Altered in the Post Mortem Caudate Putamen of Parkinson’s Disease: An In Situ Proximity Ligation Assay Study

(2018) Francesca Longhena et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease

(2018) Jessika C. Bridi et al.   Frontiers in Neuroscience

α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons

(2018) Jessica M. Froula et al.   Acta Neuropathologica Communications

The reversible effects of glial cell line–derived neurotrophic factor (GDNF) in the human brain

(2018) Abiola Abdulrahman Ayanlaja et al.   SEMINARS IN CANCER BIOLOGY

Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain

(2017) Poonam Thakur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice

(2017) Mantia Karampetsou et al.   Scientific Reports

Nurr1-Based Therapies for Parkinson's Disease

(2016) Jie Dong et al.   CNS Neuroscience & Therapeutics

Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson’s disease

(2016) Mohamed-Bilal Fares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity

(2016) Kelvin C. Luk et al.   Cell Reports

The Prion Hypothesis of Parkinson’s Disease

(2015) Yaping Chu et al.   Current Neurology and Neuroscience Reports

Dopamine Transporter Activity Is Modulated by α-Synuclein

(2015) Brittany Butler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

(2015) Katrina L. Paumier et al.   NEUROBIOLOGY OF DISEASE

The prion hypothesis of Parkinson's disease: This hot topic just got hotter

(2014) Jeffrey H. Kordower   MOVEMENT DISORDERS

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

(2014) Laura A Volpicelli-Daley et al.   Nature Protocols

Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease

(2014) Yaping Chu et al.   NEUROBIOLOGY OF DISEASE

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys

(2013) Ariadna Recasens et al.   ANNALS OF NEUROLOGY

Selective degeneration of dopaminergic neurons by MPP+and its rescue by D2 autoreceptors inDrosophilaprimary culture

(2013) Lyle Wiemerslage et al.   JOURNAL OF NEUROCHEMISTRY

Investigating the use of nonattenuation corrected PET images for the attenuation correction of PET data

(2013) Tingting Chang et al.   MEDICAL PHYSICS

Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons

(2013) Xin Heng et al.   Molecular Neurodegeneration

NURR1 in Parkinson disease—from pathogenesis to therapeutic potential

(2013) Mickael Decressac et al.   Nature Reviews Neurology

In vivo evaluation of [123I]MNI-420: A novel single photon emission computed tomography radiotracer for imaging of adenosine 2A receptors in brain

(2013) Adriana Alexandre dos Santos Tavares et al.   NUCLEAR MEDICINE AND BIOLOGY

Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons

(2013) B. Kadkhodaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Alterations in axonal transport motor proteins in sporadic and experimental Parkinson’s disease

(2012) Yaping Chu et al.   BRAIN

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

 -Synuclein-Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons

(2012) M. Decressac et al.   Science Translational Medicine

A deadly spread: cellular mechanisms of α-synuclein transfer

(2011) J A Steiner et al.   CELL DEATH AND DIFFERENTIATION

α-Synuclein Stimulates a Dopamine Transporter-dependent Chloride Current and Modulates the Activity of the Transporter

(2011) Jarod Swant et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Progressive Neurodegeneration or Endogenous Compensation in an Animal Model of Parkinson's Disease Produced by Decreasing Doses of Alpha-Synuclein

(2011) James B. Koprich et al.   PLoS One

Redistribution of DAT/α-Synuclein Complexes Visualized by “In Situ” Proximity Ligation Assay in Transgenic Mice Modelling Early Parkinson's Disease

(2011) Arianna Bellucci et al.   PLoS One

Lewy body pathology in fetal grafts

(2009) Yaping Chu et al.   Annals of the New York Academy of Sciences

Propagation of host disease to grafted neurons: Accumulating evidence

(2009) Jeffrey H. Kordower et al.   EXPERIMENTAL NEUROLOGY

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

(2009) Yaping Chu et al.   NEUROBIOLOGY OF DISEASE

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE