Models of α-synuclein aggregation in Parkinson’s disease

Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice

(2014) Amanda N. Sacino et al.   ACTA NEUROPATHOLOGICA

Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation

(2014) Ianai Fishbein et al.   BRAIN

Substantia Nigra and Parkinson's Disease: A Brief History of Their Long and Intimate Relationship

(2014) Martin Parent et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Exogenous  -Synuclein Decreases Raft Partitioning of Cav2.2 Channels Inducing Dopamine Release

(2014) G. Ronzitti et al.   JOURNAL OF NEUROSCIENCE

Extracellular α-synuclein—a novel and crucial factor in Lewy body diseases

(2014) He-Jin Lee et al.   Nature Reviews Neurology

Differential aggregation properties of alpha-synuclein isoforms

(2014) May Bungeroth et al.   NEUROBIOLOGY OF AGING

LIMP-2 expression is critical for  -glucocerebrosidase activity and  -synuclein clearance

(2014) M. Rothaug et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intramuscular injection of  -synuclein induces CNS  -synuclein pathology and a rapid-onset motor phenotype in transgenic mice

(2014) A. N. Sacino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smad3 is required for the survival of proliferative intermediate progenitor cells in the dentate gyrus of adult mice

(2013) Silvia Tapia-González et al.   Cell Communication and Signaling

Mapping the Subcellular Distribution of  -Synuclein in Neurons using Genetically Encoded Probes for Correlated Light and Electron Microscopy: Implications for Parkinson's Disease Pathogenesis

(2013) D. Boassa et al.   JOURNAL OF NEUROSCIENCE

New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson's disease

(2013) Paolo Calabresi et al.   LANCET NEUROLOGY

Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction

(2013) Edward I. Ginns et al.   MOLECULAR GENETICS AND METABOLISM

Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases

(2013) Adamantios Mamais et al.   NEUROBIOLOGY OF DISEASE

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

Pale Body-Like Inclusion Formation and Neurodegeneration following Depletion of 26S Proteasomes in Mouse Brain Neurones are Independent of α-Synuclein

(2013) Simon M. L. Paine et al.   PLoS One

Ubiquitination Increases Parkin Activity to Promote Autophagic α-Synuclein Clearance

(2013) Irina Lonskaya et al.   PLoS One

Synthetic polyubiquitinated  -Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology

(2013) M. Haj-Yahya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neonatal exposure to lipopolysaccharide enhances accumulation of α-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life

(2013) Lu-Tai Tien et al.   TOXICOLOGY

The remarkable conformational plasticity of alpha-synuclein: blessing or curse?

(2013) Angélique Deleersnijder et al.   TRENDS IN MOLECULAR MEDICINE

A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease

(2013) Donald E. Spratt et al.   Nature Communications

The History of Parkinson's Disease: Early Clinical Descriptions and Neurological Therapies

(2013) C. G. Goetz   Cold Spring Harbor Perspectives in Medicine

Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity

(2012) Meret Nora Gaugler et al.   ACTA NEUROPATHOLOGICA

Two Different Binding Modes of α-Synuclein to Lipid Vesicles Depending on its Aggregation State

(2012) Tobias Högen et al.   BIOPHYSICAL JOURNAL

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

Role of  -Synuclein in Adult Neurogenesis and Neuronal Maturation in the Dentate Gyrus

(2012) B. Winner et al.   JOURNAL OF NEUROSCIENCE

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

(2012) M. J. Diogenes et al.   JOURNAL OF NEUROSCIENCE

Conditional Expression of Parkinson's Disease-Related Mutant  -Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1

(2012) X. Lin et al.   JOURNAL OF NEUROSCIENCE

Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of  -Synuclein and LRRK2 in the Brain

(2012) L. G. Friedman et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein Oligomers: an Amyloid Pore?

(2012) Martin T. Stöckl et al.   MOLECULAR NEUROBIOLOGY

Alpha-Synuclein Posttranslational Modification and Alternative Splicing as a Trigger for Neurodegeneration

(2012) Katrin Beyer et al.   MOLECULAR NEUROBIOLOGY

Dysregulated dopamine storage increases the vulnerability to α-synuclein in nigral neurons

(2012) Ayse Ulusoy et al.   NEUROBIOLOGY OF DISEASE

Animal models of the non-motor features of Parkinson's disease

(2012) Kimberly McDowell et al.   NEUROBIOLOGY OF DISEASE

Endosomal sorting related protein CHMP2B is localized in Lewy bodies and glial cytoplasmic inclusions in α-synucleinopathy

(2012) Satoshi Tanikawa et al.   NEUROSCIENCE LETTERS

High LRRK2 Levels Fail to Induce or Exacerbate Neuronal Alpha-Synucleinopathy in Mouse Brain

(2012) Martin C. Herzig et al.   PLoS One

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

 -Synuclein-Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons

(2012) M. Decressac et al.   Science Translational Medicine

GDNF fails to exert neuroprotection in a rat  -synuclein model of Parkinson's disease

(2011) M. Decressac et al.   BRAIN

Pale Neurites, Premature α-Synuclein Aggregates with Centripetal Extension from Axon Collaterals

(2011) Toshiro Kanazawa et al.   BRAIN PATHOLOGY

Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease

(2011) Susan Duty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of  -Synuclein

(2011) D. Ebrahimi-Fakhari et al.   JOURNAL OF NEUROSCIENCE

Modelling of Parkinson's disease in mice

(2011) Marie-Françoise Chesselet et al.   LANCET NEUROLOGY

Dopamine and α-synuclein dysfunction in Smad3 null mice

(2011) Silvia Tapia-González et al.   Molecular Neurodegeneration

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Familial Parkinson disease mutations influence α-synuclein assembly

(2011) Kenjiro Ono et al.   NEUROBIOLOGY OF DISEASE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Accumulation of histone deacetylase 6, an aggresome-related protein, is specific to Lewy bodies and glial cytoplasmic inclusions

(2011) Yasuo Miki et al.   NEUROPATHOLOGY

Characterisation of a novel model of Parkinson's disease by intra-striatal infusion of the pesticide rotenone

(2011) P. Mulcahy et al.   NEUROSCIENCE

Patterns of alpha-synuclein pathology in incidental cases and clinical subtypes of Parkinson's disease

(2011) Wilma D.J. van de Berg et al.   PARKINSONISM & RELATED DISORDERS

What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease

(2011) Olga Corti et al.   PHYSIOLOGICAL REVIEWS

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

(2011) David Ramonet et al.   PLoS One

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring the link between glucocerebrosidase mutations and parkinsonism

(2011) Wendy Westbroek et al.   TRENDS IN MOLECULAR MEDICINE

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

(2011) Michael J. Devine et al.   Nature Communications

Genome-Wide Association Study Confirms SNPs inSNCAand theMAPTRegion as Common Risk Factors for Parkinson Disease

(2010) Todd L. Edwards et al.   ANNALS OF HUMAN GENETICS

Leucine-Rich Repeat Kinase 2 Is Associated With the Endoplasmic Reticulum in Dopaminergic Neurons and Accumulates in the Core of Lewy Bodies in Parkinson Disease

(2010) Jérémie Vitte et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Distinct Region-Specific  -Synuclein Oligomers in A53T Transgenic Mice: Implications for Neurodegeneration

(2010) E. Tsika et al.   JOURNAL OF NEUROSCIENCE

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of  -synuclein, and apoptotic cell death in aged mice

(2010) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of animal models of neurobehavioral disorders

(2009) F Josef van der Staay et al.   Behavioral and Brain Functions

A clinico-pathological study of subtypes in Parkinson's disease

(2009) M. Selikhova et al.   BRAIN

Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

(2009) Juliane Neumann et al.   BRAIN

LRRK2gene variation and its contribution to Parkinson disease

(2009) Coro Paisán-Ruiz   HUMAN MUTATION

Differences between subacute and chronic MPTP mice models: investigation of dopaminergic neuronal degeneration and α-synuclein inclusions

(2009) Claire Gibrat et al.   JOURNAL OF NEUROCHEMISTRY

Unexpected Lack of Hypersensitivity in LRRK2 Knock-Out Mice to MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine)

(2009) E. Andres-Mateos et al.   JOURNAL OF NEUROSCIENCE

Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment

(2009) K Ray Chaudhuri et al.   LANCET NEUROLOGY

No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism

(2009) Glenda Halliday et al.   MOVEMENT DISORDERS

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology

(2009) Robert E. Drolet et al.   NEUROBIOLOGY OF DISEASE

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

(2009) Yaping Chu et al.   NEUROBIOLOGY OF DISEASE

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

(2009) Xian Lin et al.   NEURON

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice

(2009) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans

(2009) T. Arnesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?

(2009) Francesca Cicchetti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Clinical, neuropathological and genotypic variability in SNCA A53T familial Parkinson’s disease

(2008) K. Markopoulou et al.   ACTA NEUROPATHOLOGICA

The progression of pathology in longitudinally followed patients with Parkinson’s disease

(2008) Glenda Halliday et al.   ACTA NEUROPATHOLOGICA

Genomic investigation of α-synuclein multiplication and parkinsonism

(2008) Owen A. Ross et al.   ANNALS OF NEUROLOGY

A critical evaluation of the Braak staging scheme for Parkinson's disease

(2008) Robert E. Burke et al.   ANNALS OF NEUROLOGY

Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis

(2008) Rebecca Banerjee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Three-Layered Structure Shared Between Lewy Bodies and Lewy Neurites—Three-Dimensional Reconstruction of Triple-Labeled Sections

(2008) Toshiro Kanazawa et al.   BRAIN PATHOLOGY

Proteomic identification of novel proteins associated with Lewy bodies

(2008) Qiangwei Xia   Frontiers in Bioscience-Landmark

Comprehensive analysis ofLRRK2in publicly available Parkinson's disease cases and neurologically normal controls

(2008) Coro Paisán-Ruíz et al.   HUMAN MUTATION

α-Synuclein Aggregates Interfere with Parkin Solubility and Distribution

(2008) Kohichi Kawahara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modelling Parkinson-like neurodegeneration via osmotic minipump delivery of MPTP and probenecid

(2008) Daniel Alvarez-Fischer et al.   JOURNAL OF NEUROCHEMISTRY

Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies

(2008) L. Bedford et al.   JOURNAL OF NEUROSCIENCE

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

(2008) Daniel G Healy et al.   LANCET NEUROLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Silencing α-Synuclein Gene Expression Enhances Tyrosine Hydroxylase Activity in MN9D Cells

(2008) Dongmei Liu et al.   NEUROCHEMICAL RESEARCH

Review: Familial Parkinson's disease – genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease

(2008) Carola Schiesling et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Modeling PD pathogenesis in mice: Advantages of a chronic MPTP protocol

(2008) Gloria E. Meredith et al.   PARKINSONISM & RELATED DISORDERS

Loss of cholinergic neurons in the pedunculopontine nucleus in Parkinson's disease is related to disability of the patients

(2008) Juha O. Rinne et al.   PARKINSONISM & RELATED DISORDERS

The phosphorylation state of Ser-129 in human  -synuclein determines neurodegeneration in a rat model of Parkinson disease

(2008) O. S. Gorbatyuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

(2008) Tjakko J. van Ham et al.   PLoS Genetics

In vivo alpha-synuclein overexpression in rodents: A useful model of Parkinson's disease?

(2007) Marie-Francoise Chesselet   EXPERIMENTAL NEUROLOGY

Cell systems and the toxic mechanism(s) of α-synuclein

(2007) Mark R. Cookson et al.   EXPERIMENTAL NEUROLOGY