The functional organization of axonal mRNA transport and translation

Axonal precursor mi RNA s hitchhike on endosomes and locally regulate the development of neural circuits

(2020) Eloina Corradi et al.   EMBO JOURNAL

Monosomes actively translate synaptic mRNAs in neuronal processes

(2020) Anne Biever et al.   SCIENCE

Cataloguing and Selection of mRNAs Localized to Dendrites in Neurons and Regulated by RNA-Binding Proteins in RNA Granules

(2020) Ohashi et al.   Biomolecules

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

(2020) Peiguo Yang et al.   CELL

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

(2020) Jordina Guillén-Boixet et al.   CELL

Schwann cell reprogramming into repair cells increases exosome-loaded miRNA-21 promoting axonal growth

(2020) Rodrigo López-Leal et al.   JOURNAL OF CELL SCIENCE

Zipcode RNA-binding Proteins and Membrane Trafficking Proteins Cooperate to Transport Glutelin mRNAs in Rice Endosperm

(2020) Li Tian et al.   PLANT CELL

Association of microtubules and axonal RNA transferred from myelinating Schwann cells in rat sciatic nerve

(2020) Lucía Canclini et al.   PLoS One

Dysregulation of RNA-Binding Proteins in Amyotrophic Lateral Sclerosis

(2020) Yuan Chao Xue et al.   Frontiers in Molecular Neuroscience

Intra-axonal mechanisms driving axon regeneration

(2020) Terika P. Smith et al.   BRAIN RESEARCH

A Ca2+-Dependent Switch Activates Axonal Casein Kinase 2α Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration

(2020) Pabitra K. Sahoo et al.   CURRENT BIOLOGY

Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons

(2019) Jean-Michel Cioni et al.   CELL

Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity

(2019) Vidhya Rangaraju et al.   CELL

Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex

(2019) Alexandros Poulopoulos et al.   NATURE

Drosophila mRNA Localization During Later Development: Past, Present, and Future

(2019) Sarah C. Hughes et al.   Frontiers in Genetics

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation

(2019) Brian Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneous translational landscape of the endoplasmic reticulum revealed by ribosome proximity labeling and transcriptome analysis

(2019) Alyson M. Hoffman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition

(2019) Ashley L. Kalinski et al.   JOURNAL OF CELL BIOLOGY

Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments

(2019) Anne-Sophie Hafner et al.   SCIENCE

Emerging Evidence of Translational Control by AU-Rich Element-Binding Proteins

(2019) Hiroshi Otsuka et al.   Frontiers in Genetics

Local translation in neurons: visualization and function

(2019) Christine E. Holt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons

(2019) Rui O. Costa et al.   Cell Reports

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

(2019) Ya-Cheng Liao et al.   CELL

The travels of mRNAs in neurons: do they know where they are going?

(2019) Sulagna Das et al.   CURRENT OPINION IN NEUROBIOLOGY

Inhibition of Axon Regeneration by Liquid-like TIAR-2 Granules

(2019) Matthew G. Andrusiak et al.   NEURON

mRNA localization in plant cells

(2019) Li Tian et al.   PLANT PHYSIOLOGY

Single mRNP Analysis Reveals that Small Cytoplasmic mRNP Granules Represent mRNA Singletons

(2019) Àngels Mateu-Regué et al.   Cell Reports

Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons

(2019) Max Koppers et al.   eLife

Mechanism and role of the intra-axonal Calreticulin translation in response to axonal injury

(2019) Almudena Pacheco et al.   EXPERIMENTAL NEUROLOGY

Pum2 Shapes the Transcriptome in Developing Axons through Retention of Target mRNAs in the Cell Body

(2019) José C. Martínez et al.   NEURON

On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons

(2019) Toshiaki Shigeoka et al.   Cell Reports

Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala

(2019) Linnaea E Ostroff et al.   eLife

Revisiting LAMP1 as a marker for degradative autophagy-lysosomal organelles in the nervous system

(2018) Xiu-Tang Cheng et al.   Autophagy

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

(2018) Ke Zhang et al.   CELL

Molecular control of local translation in axon development and maintenance

(2018) Jean-Michel Cioni et al.   CURRENT OPINION IN NEUROBIOLOGY

Cytoplasmic RNA Granules in Somatic Maintenance

(2018) Ossama Moujaber et al.   GERONTOLOGY

A predominantly glial origin of axonal ribosomes after nerve injury

(2018) Kerstin Müller et al.   GLIA

Axonal mRNA transport and translation at a glance

(2018) Pabitra K. Sahoo et al.   JOURNAL OF CELL SCIENCE

The cytoplasmic dynein transport machinery and its many cargoes

(2018) Samara L. Reck-Peterson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HITS-CLIP in various brain areas reveals new targets and new modalities of RNA binding by fragile X mental retardation protein

(2018) Thomas Maurin et al.   NUCLEIC ACIDS RESEARCH

Locally translated mTOR controls axonal local translation in nerve injury

(2018) Marco Terenzio et al.   SCIENCE

A New Lens for RNA Localization: Liquid-Liquid Phase Separation

(2018) Erin M. Langdon et al.   Annual Review of Microbiology

hnRNPs interacting with mRNA localization motifs define axonal RNA regulons

(2018) Seung Joon Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration

(2018) Pabitra K. Sahoo et al.   Nature Communications

Post-transcriptional Processing of mRNA in Neurons: The Vestiges of the RNA World Drive Transcriptome Diversity

(2018) Catia Andreassi et al.   Frontiers in Molecular Neuroscience

Localization of RNAi Machinery to Axonal Branch Points and Growth Cones Is Facilitated by Mitochondria and Is Disrupted in ALS

(2018) Noga Gershoni-Emek et al.   Frontiers in Molecular Neuroscience

Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring

(2018) Roberta Cagnetta et al.   MOLECULAR CELL

PIWI-interacting RNAs: small RNAs with big functions

(2018) Deniz M. Ozata et al.   NATURE REVIEWS GENETICS

Specialized ribosomes and specific ribosomal protein paralogs control translation of mitochondrial proteins

(2017) Nadav Segev et al.   JOURNAL OF CELL BIOLOGY

Differential roles of α-, β-, and γ-actin in axon growth and collateral branch formation in motoneurons

(2017) Mehri Moradi et al.   JOURNAL OF CELL BIOLOGY

Axonal localization of neuritin/CPG15 mRNA is limited by competition for HuD binding

(2017) Cynthia Gomes et al.   JOURNAL OF CELL SCIENCE

The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules

(2017) Anthony Khong et al.   MOLECULAR CELL

N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis

(2017) Raghu R Edupuganti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Getting mRNA-Containing Ribonucleoprotein Granules Out of a Nuclear Back Door

(2017) Anup Parchure et al.   NEURON

Paclitaxel Reduces Axonal Bclw to Initiate IP 3 R1-Dependent Axon Degeneration

(2017) Sarah E. Pease-Raissi et al.   NEURON

Compartmentalized Signaling in Neurons: From Cell Biology to Neuroscience

(2017) Marco Terenzio et al.   NEURON

Expanding Axonal Transcriptome Brings New Functions for Axonally Synthesized Proteins in Health and Disease

(2017) Amar N. Kar et al.   NEUROSCIENTIST

Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells

(2017) Gal Haimovich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons

(2017) Pallavi P. Gopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mRNA localization in metazoans: A structural perspective

(2017) Daniela Lazzaretti et al.   RNA Biology

Activity-dependent spatially localized miRNA maturation in neuronal dendrites

(2017) Sivakumar Sambandan et al.   SCIENCE

Hitchhiking: A Non-Canonical Mode of Microtubule-Based Transport

(2017) John Salogiannis et al.   TRENDS IN CELL BIOLOGY

N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis

(2017) Raghu R Edupuganti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly

(2017) Paul G. Donlin-Asp et al.   Cell Reports

miR-182 Regulates Slit2-Mediated Axon Guidance by Modulating the Local Translation of a Specific mRNA

(2017) Anaïs Bellon et al.   Cell Reports

ALS Along the Axons – Expression of Coding and Noncoding RNA Differs in Axons of ALS models

(2017) Nimrod Rotem et al.   Scientific Reports

Single Molecule Translation Imaging Visualizes the Dynamics of Local β-Actin Synthesis in Retinal Axons

(2017) Florian Ströhl et al.   Scientific Reports

Dynamic Axonal Translation in Developing and Mature Visual Circuits

(2016) Toshiaki Shigeoka et al.   CELL

Axonal localization and mitochondrial association of precursor microRNA 338

(2016) Jose Norberto S. Vargas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

There and back again: coordinated transcription, translation and transport in axonal survival and regeneration

(2016) Ozge E Tasdemir-Yilmaz et al.   CURRENT OPINION IN NEUROBIOLOGY

Endosomal assembly and transport of heteromeric septin complexes promote septin cytoskeleton formation

(2016) Sabrina Zander et al.   JOURNAL OF CELL SCIENCE

Preferential binding of a stable G3BP ribonucleoprotein complex to intron-retaining transcripts in mouse brain and modulation of their expression in the cerebellum

(2016) Sophie Martin et al.   JOURNAL OF NEUROCHEMISTRY

Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons

(2016) Claudia Fallini et al.   JOURNAL OF NEUROSCIENCE

Analysis of piRNA-Like Small Non-coding RNAs Present in Axons of Adult Sensory Neurons

(2016) Monichan Phay et al.   MOLECULAR NEUROBIOLOGY

The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability

(2016) Katharina E Cosker et al.   NATURE NEUROSCIENCE

Life at Low Copy Number: How Dendrites Manage with So Few mRNAs

(2016) Kenneth S. Kosik   NEURON

Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size

(2016) Rotem Ben-Tov Perry et al.   Cell Reports

Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival

(2016) Anne E. Conway et al.   Cell Reports

ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis

(2016) Filip A. Konopacki et al.   Open Biology

Tracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: A Link between Stalled Polyribosomes and RNA Granules

(2016) Rachid El Fatimy et al.   PLoS Genetics

Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury

(2016) Maritza Oñate et al.   Scientific Reports

Identification of precursor microRNAs within distal axons of sensory neuron

(2015) Hak Hee Kim et al.   JOURNAL OF NEUROCHEMISTRY

The Unfolded Protein Response and Cholesterol Biosynthesis Link Luman/CREB3 to Regenerative Axon Growth in Sensory Neurons

(2015) Z. Ying et al.   JOURNAL OF NEUROSCIENCE

It’s Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles

(2015) Lin Guo et al.   MOLECULAR CELL

Paclitaxel inhibits mRNA transport in axons

(2015) Ilja Bobylev et al.   NEUROBIOLOGY OF DISEASE

Whole transcriptome profiling reveals the RNA content of motor axons

(2015) Michael Briese et al.   NUCLEIC ACIDS RESEARCH

FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1

(2015) Bin Wang et al.   Cell Reports

A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking

(2015) Thomas Pohlmann et al.   eLife

APC Is an RNA-Binding Protein, and Its Interactome Provides a Link to Neural Development and Microtubule Assembly

(2014) Nicolas Preitner et al.   CELL

MicroRNA-132 Is Enriched in Developing Axons, Locally Regulates Rasa1 mRNA, and Promotes Axon Extension

(2014) M. L. Hancock et al.   JOURNAL OF NEUROSCIENCE

Calcium Release from Intra-Axonal Endoplasmic Reticulum Leads to Axon Degeneration through Mitochondrial Dysfunction

(2014) R. Villegas et al.   JOURNAL OF NEUROSCIENCE

Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations

(2014) Nael H. Alami et al.   NEURON

Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation

(2014) Sandra Maday et al.   NEURON

Subcellular transcriptome alterations in a cell culture model of spinal muscular atrophy point to widespread defects in axonal growth and presynaptic differentiation

(2014) Lena Saal et al.   RNA

Endosome maturation, transport and functions

(2014) Cameron C. Scott et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Translation and silencing in RNA granules: a tale of sand grains

(2014) Jerónimo Pimentel et al.   Frontiers in Molecular Neuroscience

Protein targeting via mRNA in bacteria

(2013) Shanmugapriya Kannaiah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of Axon Guidance by Compartmentalized Nonsense-Mediated mRNA Decay

(2013) Dilek Colak et al.   CELL

Dysregulation of the axonal trafficking of nuclear-encoded mitochondrial mRNA alters neuronal mitochondrial activity and mouse behavior

(2013) Amar N. Kar et al.   Developmental Neurobiology

Subcellular transcriptomics-Dissection of the mRNA composition in the axonal compartment of sensory neurons

(2013) Adi Minis et al.   Developmental Neurobiology

Endosomal transport of septin mRNA and protein indicates local translation on endosomes and is required for correct septin filamentation

(2013) Sebastian Baumann et al.   EMBO REPORTS

The DEAH-box helicase DHX36 mediates dendritic localization of the neuronal precursor-microRNA-134

(2013) S. Bicker et al.   GENES & DEVELOPMENT

Association of the Yeast RNA-binding Protein She2p with the Tubular Endoplasmic Reticulum Depends on Membrane Curvature

(2013) Christian Genz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A HuD-ZBP1 ribonucleoprotein complex localizes GAP-43 mRNA into axons through its 3′ untranslated region AU-rich regulatory element

(2013) Soonmoon Yoo et al.   JOURNAL OF NEUROCHEMISTRY

Intra-axonal Synthesis of Eukaryotic Translation Initiation Factors Regulates Local Protein Synthesis and Axon Growth in Rat Sympathetic Neurons

(2013) A. N. Kar et al.   JOURNAL OF NEUROSCIENCE

The MicroRNA-17-92 Cluster Enhances Axonal Outgrowth in Embryonic Cortical Neurons

(2013) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Mitochondria Coordinate Sites of Axon Branching through Localized Intra-axonal Protein Synthesis

(2013) Mirela Spillane et al.   Cell Reports

Local Translation of Extranuclear Lamin B Promotes Axon Maintenance

(2012) Byung C. Yoon et al.   CELL

MicroRNA-338 regulates the axonal expression of multiple nuclear-encoded mitochondrial mRNAs encoding subunits of the oxidative phosphorylation machinery

(2012) Armaz Aschrafi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nerve Growth Factor-Induced Formation of Axonal Filopodia and Collateral Branches Involves the Intra-Axonal Synthesis of Regulators of the Actin-Nucleating Arp2/3 Complex

(2012) M. Spillane et al.   JOURNAL OF NEUROSCIENCE

Lysophosphatidic acid differentially regulates axonal mRNA translation through 5′UTR elements

(2012) Deepika Vuppalanchi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons

(2012) Federico Dajas-Bailador et al.   NATURE NEUROSCIENCE

Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair

(2012) Hosung Jung et al.   NATURE REVIEWS NEUROSCIENCE

Subcellular Knockout of Importin β1 Perturbs Axonal Retrograde Signaling

(2012) Rotem Ben-Tov Perry et al.   NEURON

Neuronal mRNAs travel singly into dendrites

(2012) M. Batish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1

(2011) Cláudia Rosa-Ferreira et al.   DEVELOPMENTAL CELL

Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity

(2011) Christopher J Donnelly et al.   EMBO JOURNAL

Morphological evidence for a transport of ribosomes from Schwann cells to regenerating axons

(2011) Felipe A. Court et al.   GLIA

Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits

(2011) B. Akten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation

(2010) Joseph Tcherkezian et al.   CELL

The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal β-actin mRNA translocation in spinal motor neurons

(2010) Michael Glinka et al.   HUMAN MOLECULAR GENETICS

Conserved 3′-Untranslated Region Sequences Direct Subcellular Localization of Chaperone Protein mRNAs in Neurons

(2010) Deepika Vuppalanchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of axonal trafficking of cytochrome c oxidase IV mRNA

(2010) Armaz Aschrafi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization

(2010) L. F. Gumy et al.   RNA

Control of RNA silencing and localization by endolysosomes

(2010) Derrick Gibbings et al.   TRENDS IN CELL BIOLOGY

The Eukaryotic Ribosome: Current Status and Challenges

(2009) Jonathan D. Dinman   JOURNAL OF BIOLOGICAL CHEMISTRY

The ESCRT machinery at a glance

(2009) T. Wollert et al.   JOURNAL OF CELL SCIENCE

The FXG: A Presynaptic Fragile X Granule Expressed in a Subset of Developing Brain Circuits

(2009) S. B. Christie et al.   JOURNAL OF NEUROSCIENCE

Combinations of DEAD box proteins distinguish distinct types of RNA: Protein complexes in neurons

(2009) Linda C. Miller et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets

(2009) Federico Bolognani et al.   NUCLEIC ACIDS RESEARCH

Schwann Cell to Axon Transfer of Ribosomes: Toward a Novel Understanding of the Role of Glia in the Nervous System

(2008) F. A. Court et al.   JOURNAL OF NEUROSCIENCE

Genome-wide screen reveals APC-associated RNAs enriched in cell protrusions

(2008) Stavroula Mili et al.   NATURE